Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog PerR - Staphylococcaceae

Properties
Regulator type: Transcription factor
Regulator family: FUR
Regulation mode: repressor
Biological process: Oxidative stress response
Effector: Hydrogen peroxide; Manganese ion, (Mn2+); Iron ion, (Fe2+)
Phylum: Firmicutes
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 69 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Staphylococcus aureus subsp. aureus N315 17 10
Staphylococcus capitis SK14 15 8
Staphylococcus epidermidis ATCC 12228 11 6
Staphylococcus carnosus subsp. carnosus TM300 14 7
Staphylococcus haemolyticus JCSC1435 17 9
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 14 7
Macrococcus caseolyticus JCSC5402 14 7
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
sufC
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -56
score = 5.67115
sequence = TTAAAATTATTATAA

Gene: SA0774: hypothetical protein
*
Staphylococcus capitis SK14

Site:
position = -55
score = 5.67115
sequence = TTAAAATTATTATAA

Gene: STACA0001_0212: FeS assembly ATPase SufC
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -55
score = 5.67115
sequence = TTAAAATTATTATAA

Gene: SE0606: ABC transporter (ATP-binding protein)
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -58
score = 5.67115
sequence = TTAAAATTATTATAA

Gene: Sca_0458: putative ABC transporter ATP-binding protein
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -55
score = 5.67115
sequence = TTAAAATTATTATAA

Gene: SH2039: ABC transporter ATP-binding protein
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -57
score = 5.67115
sequence = TTAAAATTATTATAA

Gene: SSP1861: putative Iron-regulated ABC transporter ATPase component
*
Macrococcus caseolyticus JCSC5402

Site:
position = -57
score = 5.67115
sequence = TTAAAATTATTATAA

Gene: MCCL_0542: ABC transporter, ATP-binding protein involved in Fe-S cluster formation YurY
hypothetical protein
sufD
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0775: hypothetical protein
 
Staphylococcus capitis SK14

Gene: STACA0001_0211: FeS assembly protein SufD
 
Staphylococcus epidermidis ATCC 12228

Gene: SE0607: conserved hypothetical protein
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0459: hypothetical protein
 
Staphylococcus haemolyticus JCSC1435

Gene: SH2038: hypothetical protein
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP1860: hypothetical protein
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0543: hypothetical protein
hypothetical protein
sufS
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0776: hypothetical protein
 
Staphylococcus capitis SK14

Gene: STACA0001_0210: cysteine desulfurase (Selenocysteine lyase) (Selenocysteine reductase) (Selenocysteine beta-lyase) (SCL)
 
Staphylococcus epidermidis ATCC 12228

Gene: SE0608: aminotransferase NifS-like protein
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0460: putative selenocysteine lyase
 
Staphylococcus haemolyticus JCSC1435

Gene: SH2037: hypothetical protein
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP1859: putative selenocysteine lyase
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0544: hypothetical protein
hypothetical protein
nifU
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0777: hypothetical protein
 
Staphylococcus capitis SK14

Gene: STACA0001_0209: SUF system FeS assembly protein, NifU family
 
Staphylococcus epidermidis ATCC 12228

Gene: SE0609: nitrogen fixation protein NifU
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0461: NifU-like protein
 
Staphylococcus haemolyticus JCSC1435

Gene: SH2036: hypothetical protein
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP1858: NifU homolog involved in Fe-S cluster formation
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0545: nitrogen fixation protein NifU
hypothetical protein
sufB
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -104
score = 4.825
sequence = TAAAAATTTTTATAA

Gene: SA0778: hypothetical protein
 
Staphylococcus capitis SK14

Gene: STACA0001_0208: FeS assembly protein SufB
 
Staphylococcus epidermidis ATCC 12228

Gene: SE0610: conserved hypothetical protein
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0462: putative FeS assembly protein SufB
 
Staphylococcus haemolyticus JCSC1435

Gene: SH2035: hypothetical protein
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP1857: hypothetical protein
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0546: FeS assembly protein SufB
hypothetical protein
 
CRON 2.
perR
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -37
score = 5.62786
sequence = TAATAATAATTATTA

Gene: SA1678: peroxide-responsive repressor PerR
*
Staphylococcus capitis SK14

Site:
position = -36
score = 5.62786
sequence = TAATAATTATTATTA

Gene: STACA0001_1914: peroxide-responsive repressor PerR
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -36
score = 5.62786
sequence = TAATAATAATTATTA

Gene: SE1545: peroxide-responsive repressor PerR
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -36
score = 5.62786
sequence = TAATAATTATTATTA

Gene: Sca_1434: peroxide-responsive repressor PerR
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -35
score = 5.62786
sequence = TAATAATTATTATTA

Gene: SH1102: peroxide-responsive repressor PerR
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -36
score = 5.47011
sequence = TAATAATAATTCTTA

Gene: SSP0932: peroxide-responsive repressor PerR
*
Macrococcus caseolyticus JCSC5402

Site:
position = -33
score = 4.81383
sequence = ATAGAATTACTATAA

Gene: MCCL_1591: peroxide-responsive repressor PerR
peroxide-responsive repressor PerR
 
CRON 3.
katA
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -26
score = 5.98145
sequence = TTATAATTATTATAA

Gene: SA1170: catalase
*
Staphylococcus capitis SK14

Site:
position = -42
score = 5.46321
sequence = TTATAATTATTACAA

Gene: STACA0001_1577: catalase
 
Staphylococcus epidermidis ATCC 12228

Gene: SE1016: catalase
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -33
score = 5.82369
sequence = TTATAATTATTCTAA

Gene: Sca_2336: catalase
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -37
score = 5.98145
sequence = TTATAATTATTATAA

Gene: SH1573: catalase
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -41
score = 5.62786
sequence = TAATAATTATTATTA

Gene: SSP1432: catalase
*
Macrococcus caseolyticus JCSC5402

Site:
position = -29
score = 5.36849
sequence = AAATAATTATTATAA

Site:
position = -46
score = 5.35669
sequence = TTATAATAATTATCA

Gene: MCCL_0056: catalase
catalase
 
CRON 4.
hemE
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -29
score = 5.12515
sequence = TAAGAATGATTTTAA

Site:
position = -191
score = 5.09745
sequence = TTAAAATTACTATAA

Gene: SA1652: uroporphyrinogen-III decarboxylase
*
Staphylococcus capitis SK14

Site:
position = -32
score = 5.12515
sequence = TAAGAATGATTTTAA

Gene: STACA0001_0695: uroporphyrinogen-III decarboxylase
 
Staphylococcus epidermidis ATCC 12228

Gene: SE1513: uroporphyrinogen-III decarboxylase
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -32
score = 4.86577
sequence = TTAGAATGATTTTAT

Gene: Sca_1408: uroporphyrinogen-III decarboxylase
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -32
score = 5.12515
sequence = TAAGAATGATTTTAA

Gene: SH1128: uroporphyrinogen-III decarboxylase
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -32
score = 4.86584
sequence = CAAGAATGATTATAA

Gene: SSP0965: uroporphyrinogen-III decarboxylase
*
Macrococcus caseolyticus JCSC5402

Site:
position = -138
score = 5.0732
sequence = TAATAGTTATTCTAA

Gene: MCCL_1550: uroporphyrinogen-III decarboxylase
uroporphyrinogen-III decarboxylase
hemH
 
Staphylococcus aureus subsp. aureus N315

Gene: SA1651: ferrochelatase
 
Staphylococcus capitis SK14

Gene: STACA0001_0694: ferrochelatase
 
Staphylococcus epidermidis ATCC 12228

Gene: SE1512: ferrochelatase
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_1407: ferrochelatase
 
Staphylococcus haemolyticus JCSC1435

Gene: SH1129: ferrochelatase
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP0966: protoheme ferro-lyase
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_1549: ferrochelatase
ferrochelatase
hemY
 
Staphylococcus aureus subsp. aureus N315

Gene: SA1650: protoporphyrinogen oxidase
 
Staphylococcus capitis SK14

Gene: STACA0001_0693: protoporphyrinogen oxidase
 
Staphylococcus epidermidis ATCC 12228

Gene: SE1511: protoporphyrinogen oxidase
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_1406: protoporphyrinogen oxidase
 
Staphylococcus haemolyticus JCSC1435

Gene: SH1130: protoporphyrinogen oxidase
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP0967: protoporphyrinogen oxidase
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_1548: protoporphyrinogen oxidase
protoporphyrinogen oxidase
 
CRON 5.
fur
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -122
score = 5.61223
sequence = TTATAATcATTcTAA

Gene: SA1329: iron uptake regulatory protein Fur
*
Staphylococcus capitis SK14

Site:
position = -40
score = 5.45969
sequence = TTAAAATGATTATAA

Gene: STACA0001_1739: iron uptake regulatory protein Fur
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -40
score = 5.45969
sequence = TTAAAATGATTATAA

Gene: SE1182: iron uptake regulatory protein Fur
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -40
score = 5.45969
sequence = TTAAAATGATTATAA

Gene: Sca_1124: iron uptake regulatory protein Fur
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -40
score = 5.45969
sequence = TTAAAATGATTATAA

Gene: SH1418: iron uptake regulatory protein Fur
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -40
score = 5.45969
sequence = TTAAAATGATTATAA

Gene: SSP1254: iron uptake regulatory protein Fur
*
Macrococcus caseolyticus JCSC5402

Site:
position = -95
score = 5.6469
sequence = TAATAATTATTCTAA

Gene: MCCL_1147: iron uptake regulatory protein Fur
iron uptake regulatory protein Fur
 
CRON 6.
ftnA
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -92
score = 5.80465
sequence = TTATAATTATTATTA

Gene: SA1709: ferritin
*
Staphylococcus capitis SK14

Site:
position = -89
score = 5.6469
sequence = TTAGAATAATTATTA

Site:
position = -132
score = 5.5134
sequence = TTAGAATAATTTTAA

Gene: STACA0001_1946: ferritin
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -84
score = 5.6469
sequence = TTAGAATAATTATTA

Site:
position = -126
score = 5.6469
sequence = TTAGAATAATTATTA

Gene: SE1578: ferritin
 
Staphylococcus carnosus subsp. carnosus TM300
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -99
score = 5.80465
sequence = TTATAATAATTATTA

Gene: SH1060: ferritin
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP0898: ferritin
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_1624: ferritin
ferritin
 
CRON 7.
dps
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -71
score = 5.61223
sequence = TTAGAATCATTATAA

Site:
position = -54
score = 5.23096
sequence = TAATAATTAATATAA

Site:
position = -112
score = 5.82369
sequence = TTAGAATAATTATAA

Gene: SA1941: metalloregulation DNA-binding stress protein
*
Staphylococcus capitis SK14

Site:
position = -54
score = 4.79889
sequence = ATATAATAATTATTG

Site:
position = -109
score = 5.15292
sequence = TTGAAATAATTATAA

Site:
position = -68
score = 5.82369
sequence = TTAGAATTATTATAA

Gene: STACA0001_0845: metalloregulation DNA-binding stress protein
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -58
score = 5.82369
sequence = TTAGAATTATTATAA

Gene: SE1738: metalloregulation DNA-binding stress protein
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -111
score = 5.5134
sequence = TTAGAATTATTTTAA

Site:
position = -70
score = 5.82369
sequence = TTAGAATTATTATAA

Site:
position = -53
score = 5.23096
sequence = TAATAGTTATTATAA

Gene: Sca_1644: metalloregulation DNA-binding stress protein
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -71
score = 5.76999
sequence = TTATAATCATTATAA

Site:
position = -54
score = 5.19894
sequence = TAATAATAATTGTAA

Gene: SH0895: metalloregulation DNA-binding stress protein
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -71
score = 5.19894
sequence = TAATAATTATTGTAA

Site:
position = -129
score = 5.30194
sequence = TTAAAATGATTCTAA

Site:
position = -88
score = 5.82369
sequence = TTAGAATTATTATAA

Gene: SSP0745: metalloregulation DNA-binding stress protein
*
Macrococcus caseolyticus JCSC5402

Site:
position = -38
score = 5.23096
sequence = TAATAATTAATATAA

Site:
position = -55
score = 5.61223
sequence = TTAGAATGATTATAA

Gene: MCCL_1798: metalloregulation DNA-binding stress protein
metalloregulation DNA-binding stress protein
 
CRON 8.
bcp
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -34
score = 5.23499
sequence = ATAAAATTATTATAA

Gene: SA1680: bacterioferritin comigratory protein
 
Staphylococcus capitis SK14

Gene: STACA0001_1916: bacterioferritin comigratory protein
 
Staphylococcus epidermidis ATCC 12228

Gene: SE1547: bacterioferritin comigratory protein
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_1436: bacterioferritin comigratory protein
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -34
score = 4.97158
sequence = ATATAATTAATATAA

Gene: SH1098: bacterioferritin comigratory protein
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP0930: bacterioferritin comigratory protein
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_1593: bacterioferritin comigratory protein
bacterioferritin comigratory protein
SA1679
 
Staphylococcus aureus subsp. aureus N315

Gene: SA1679: putative phosphoglycerate dehydrogenase
 
Staphylococcus capitis SK14

Gene: STACA0001_1915: putative phosphoglycerate dehydrogenase
 
Staphylococcus epidermidis ATCC 12228

Gene: SE1546: putative phosphoglycerate dehydrogenase
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_1435: putative phosphoglycerate dehydrogenase
 
Staphylococcus haemolyticus JCSC1435

Gene: SH1099: putative phosphoglycerate dehydrogenase
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP0931: putative phosphoglycerate dehydrogenase
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_1592: putative phosphoglycerate dehydrogenase
putative phosphoglycerate dehydrogenase
 
CRON 9.
ahpC
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -74
score = 5.82369
sequence = TTAGAATTATTATAA

Gene: SA0366: alkyl hydroperoxide reductase subunit C
*
Staphylococcus capitis SK14

Site:
position = -76
score = 5.82369
sequence = TTAGAATTATTATAA

Gene: STACA0001_1447: alkyl hydroperoxide reductase subunit C
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -75
score = 5.82369
sequence = TTAGAATTATTATAA

Gene: SE2357: alkyl hydroperoxide reductase subunit C
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -95
score = 5.82369
sequence = TTAGAATTATTATAA

Gene: Sca_0039: alkyl hydroperoxide reductase subunit C
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -77
score = 5.82369
sequence = TTAGAATTATTATAA

Gene: SH2592: alkyl hydroperoxide reductase subunit C
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -86
score = 5.82369
sequence = TTAGAATTATTATAA

Gene: SSP2333: alkyl hydroperoxide reductase subunit C
*
Macrococcus caseolyticus JCSC5402

Site:
position = -52
score = 5.66593
sequence = TTAGAATTATTCTAA

Site:
position = -125
score = 5.15292
sequence = TTGAAATAATTATAA

Gene: MCCL_0098: alkyl hydroperoxide reductase subunit C
alkyl hydroperoxide reductase subunit C
ahpF
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0365: alkyl hydroperoxide reductase subunit F
 
Staphylococcus capitis SK14

Gene: STACA0001_1446: alkyl hydroperoxide reductase subunit F
 
Staphylococcus epidermidis ATCC 12228

Gene: SE2358: alkyl hydroperoxide reductase subunit F
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0038: alkyl hydroperoxide reductase subunit F
 
Staphylococcus haemolyticus JCSC1435

Gene: SH2593: alkyl hydroperoxide reductase subunit F
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP2334: alkyl hydroperoxide reductase subunit F
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0099: alkyl hydroperoxide reductase subunit F
alkyl hydroperoxide reductase subunit F
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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