Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog CblR - Sulfolobales

Properties
Regulator type: Transcription factor
Regulator family:
Regulation mode:
Biological process: Cobalamin biosynthesis
Effector:
Phylum: Crenarchaeota
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 28 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Metallosphaera sedula DSM 5348 11 6
Sulfolobus tokodaii str. 7 10 6
Sulfolobus solfataricus P2 13 4
Sulfolobus islandicus Y.N.15.51 13 4
Sulfolobus acidocaldarius DSM 639 11 5
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
btuF
*
Metallosphaera sedula DSM 5348

Site:
position = -1
score = 6.4987
sequence = TATGGATAGCCTATCCATC

Gene: Msed_0807: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Sulfolobus tokodaii str. 7

Site:
position = -64
score = 4.94422
sequence = TTAGGATAACTTAACCATA

Site:
position = -1
score = 5.71788
sequence = TATGGATGACTTATCCATA

Gene: ST0840: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Sulfolobus solfataricus P2

Site:
position = -23
score = 6.50944
sequence = TTTGGATAGTCTATCCAGA

Gene: SSO0485: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Sulfolobus islandicus Y.N.15.51

Site:
position = -23
score = 6.50944
sequence = TTTGGATAGTCTATCCAGA

Gene: YN1551_1191: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Sulfolobus acidocaldarius DSM 639

Site:
position = -24
score = 5.78266
sequence = TATGGATAGCCTATCCTAC

Gene: Saci_1220: Vitamin B12 ABC transporter, B12-binding component BtuF
Vitamin B12 ABC transporter, B12-binding component BtuF
btuC
 
Metallosphaera sedula DSM 5348

Gene: Msed_0806: Vitamin B12 ABC transporter, permease component BtuC
*
Sulfolobus tokodaii str. 7

Site:
position = -85
score = 5.71788
sequence = TATGGATAAGTCATCCATA

Site:
position = -22
score = 4.94422
sequence = TATGGTTAAGTTATCCTAA

Gene: ST0841: Vitamin B12 ABC transporter, permease component BtuC
 
Sulfolobus solfataricus P2

Gene: SSO0486: Vitamin B12 ABC transporter, permease component BtuC
 
Sulfolobus islandicus Y.N.15.51

Gene: YN1551_1192: Vitamin B12 ABC transporter, permease component BtuC
*
Sulfolobus acidocaldarius DSM 639

Site:
position = -24
score = 6.16447
sequence = TATGGATAAGCTATCCACA

Gene: Saci_1221: Vitamin B12 ABC transporter, permease component BtuC
Vitamin B12 ABC transporter, permease component BtuC
btuD
 
Metallosphaera sedula DSM 5348

Gene: Msed_0805: Vitamin B12 ABC transporter, ATPase component BtuD
 
Sulfolobus tokodaii str. 7

Gene: ST0842: Vitamin B12 ABC transporter, ATPase component BtuD
 
Sulfolobus solfataricus P2

Gene: SSO0487: Vitamin B12 ABC transporter, ATPase component BtuD
 
Sulfolobus islandicus Y.N.15.51

Gene: YN1551_1193: Vitamin B12 ABC transporter, ATPase component BtuD
 
Sulfolobus acidocaldarius DSM 639

Gene: Saci_1222: Vitamin B12 ABC transporter, ATPase component BtuD
Vitamin B12 ABC transporter, ATPase component BtuD
 
CRON 2.
cobN
*
Metallosphaera sedula DSM 5348

Site:
position = -20
score = 5.81713
sequence = TATGGATAGGCTAACCAGG

Gene: Msed_2089: CobN component of cobalt chelatase involved in B12 biosynthesis
 
Sulfolobus tokodaii str. 7
 
Sulfolobus solfataricus P2
 
Sulfolobus islandicus Y.N.15.51
 
Sulfolobus acidocaldarius DSM 639
CobN component of cobalt chelatase involved in B12 biosynthesis
chlID
 
Metallosphaera sedula DSM 5348

Gene: Msed_2088: ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis
 
Sulfolobus tokodaii str. 7
 
Sulfolobus solfataricus P2
 
Sulfolobus islandicus Y.N.15.51
 
Sulfolobus acidocaldarius DSM 639
ChlI component of cobalt chelatase involved in B12 biosynthesis / ChlD component of cobalt chelatase involved in B12 biosynthesis
 
CRON 3.
hoxN
*
Metallosphaera sedula DSM 5348

Site:
position = -23
score = 6.42953
sequence = TATGGATAGCCTATCCAAC

Gene: Msed_1305: HoxN/HupN/NixA family cobalt transporter
*
Sulfolobus tokodaii str. 7

Site:
position = 20
score = 6.06065
sequence = TATGGATAACTTATCCAAA

Site:
position = 49
score = 5.79414
sequence = TGTGGATAACTTATCCAAA

Gene: ST2443: HoxN/HupN/NixA family cobalt transporter
*
Sulfolobus solfataricus P2

Site:
position = 29
score = 6.09849
sequence = GATGGATAGACAATCCATA

Gene: SSO1018: HoxN/HupN/NixA family cobalt transporter
*
Sulfolobus islandicus Y.N.15.51

Site:
position = 2
score = 6.09849
sequence = GATGGATAGACAATCCATA

Gene: YN1551_1651: HoxN/HupN/NixA family cobalt transporter
*
Sulfolobus acidocaldarius DSM 639

Site:
position = -23
score = 6.31821
sequence = ATTGGATAGGCTATCCATA

Gene: Saci_2028: HoxN/HupN/NixA family cobalt transporter
HoxN/HupN/NixA family cobalt transporter
 
CRON 4.
potE
*
Metallosphaera sedula DSM 5348

Site:
position = -1
score = 6.19342
sequence = TATGGCTAGCCTATCCAAA

Gene: Msed_0588: Amino acid permease related protein
*
Sulfolobus tokodaii str. 7

Site:
position = 5
score = 5.71588
sequence = TATGGATAACTTATCCAAG

Gene: ST2455: Amino acid permease related protein
 
Sulfolobus solfataricus P2
 
Sulfolobus islandicus Y.N.15.51
 
Sulfolobus acidocaldarius DSM 639
Amino acid permease related protein
 
CRON 5.
cbiC
 
Metallosphaera sedula DSM 5348
*
Sulfolobus tokodaii str. 7

Site:
position = -22
score = 5.94788
sequence = TTTGGATAAGCTATCCAAT

Gene: ST1824: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
*
Sulfolobus solfataricus P2

Site:
position = -1
score = 5.65151
sequence = TGTGGATAGACAATCCAAT

Gene: SSO2308: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
*
Sulfolobus islandicus Y.N.15.51

Site:
position = -1
score = 5.65151
sequence = TGTGGATAGACAATCCAAT

Gene: YN1551_0113: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
*
Sulfolobus acidocaldarius DSM 639

Site:
position = -1
score = 5.90954
sequence = TTTGGATACCCTATCCATC

Gene: Saci_0399: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
cbiH
 
Metallosphaera sedula DSM 5348

Gene: Msed_2092: Cobalt-precorrin-3b C17-methyltransferase
 
Sulfolobus tokodaii str. 7

Gene: ST1823: Cobalt-precorrin-3b C17-methyltransferase
 
Sulfolobus solfataricus P2

Gene: SSO2306: Cobalt-precorrin-3b C17-methyltransferase
 
Sulfolobus islandicus Y.N.15.51

Gene: YN1551_0112: Cobalt-precorrin-3b C17-methyltransferase
 
Sulfolobus acidocaldarius DSM 639

Gene: Saci_0398: Cobalt-precorrin-3b C17-methyltransferase
Cobalt-precorrin-3b C17-methyltransferase
cbiD
 
Metallosphaera sedula DSM 5348
 
Sulfolobus tokodaii str. 7

Gene: ST1821: Cobalt-precorrin-6 synthase, anaerobic
 
Sulfolobus solfataricus P2

Gene: SSO2305: Cobalt-precorrin-6 synthase, anaerobic
 
Sulfolobus islandicus Y.N.15.51

Gene: YN1551_0111: Cobalt-precorrin-6 synthase, anaerobic
 
Sulfolobus acidocaldarius DSM 639

Gene: Saci_0397: Cobalt-precorrin-6 synthase, anaerobic
Cobalt-precorrin-6 synthase, anaerobic
cbiT
 
Metallosphaera sedula DSM 5348

Gene: Msed_2108: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
 
Sulfolobus tokodaii str. 7

Gene: ST1819: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
 
Sulfolobus solfataricus P2

Gene: SSO2303: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
 
Sulfolobus islandicus Y.N.15.51

Gene: YN1551_0110: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
 
Sulfolobus acidocaldarius DSM 639

Gene: Saci_0396: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
cbiL
 
Metallosphaera sedula DSM 5348

Gene: Msed_0693: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
 
Sulfolobus tokodaii str. 7

Gene: ST1817: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
 
Sulfolobus solfataricus P2

Gene: SSO2301: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
 
Sulfolobus islandicus Y.N.15.51

Gene: YN1551_0109: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
 
Sulfolobus acidocaldarius DSM 639

Gene: Saci_0395: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
cbiF
 
Metallosphaera sedula DSM 5348

Gene: Msed_0694: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
 
Sulfolobus tokodaii str. 7

Gene: ST1816: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
 
Sulfolobus solfataricus P2

Gene: SSO2299: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
 
Sulfolobus islandicus Y.N.15.51

Gene: YN1551_0108: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
 
Sulfolobus acidocaldarius DSM 639

Gene: Saci_0394: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
cbiG
 
Metallosphaera sedula DSM 5348

Gene: Msed_2091: Cobalamin biosynthesis protein CbiG
 
Sulfolobus tokodaii str. 7

Gene: ST1826: Cobalamin biosynthesis protein CbiG
 2
Sulfolobus solfataricus P2

Gene: SSO2297: Cobalamin biosynthesis protein CbiG

Gene: SSO0129: Cobalamin biosynthesis protein CbiG
 2
Sulfolobus islandicus Y.N.15.51

Gene: YN1551_0798: Cobalamin biosynthesis protein CbiG

Gene: YN1551_0107: Cobalamin biosynthesis protein CbiG
 
Sulfolobus acidocaldarius DSM 639

Gene: Saci_0401: Cobalamin biosynthesis protein CbiG
Cobalamin biosynthesis protein CbiG
cbiE
 
Metallosphaera sedula DSM 5348
 
Sulfolobus tokodaii str. 7

Gene: ST1825: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
 
Sulfolobus solfataricus P2

Gene: SSO2296: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
 
Sulfolobus islandicus Y.N.15.51

Gene: YN1551_0106: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
 
Sulfolobus acidocaldarius DSM 639

Gene: Saci_0400: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
Msed_2090
*
Metallosphaera sedula DSM 5348

Site:
position = -119
score = 5.81713
sequence = CCTGGTTAGCCTATCCATA

Gene: Msed_2090: Signal peptidase, type IV - prepilin/preflagellin
 
Sulfolobus tokodaii str. 7

Gene: ST2258: Signal peptidase, type IV - prepilin/preflagellin
 
Sulfolobus solfataricus P2

Gene: SSO0131: Signal peptidase, type IV - prepilin/preflagellin
 
Sulfolobus islandicus Y.N.15.51
 
Sulfolobus acidocaldarius DSM 639
Signal peptidase, type IV - prepilin/preflagellin
 
CRON 6.
bluB
*
Metallosphaera sedula DSM 5348

Site:
position = -18
score = 5.71385
sequence = CCTGGATACTCTATCCATA

Gene: Msed_1226: Cob(II)yrinic acid a,c-diamide reductase
*
Sulfolobus tokodaii str. 7

Site:
position = -1
score = 6.08621
sequence = TATGGATAACCTATCCATG

Gene: ST0601: Cob(II)yrinic acid a,c-diamide reductase
*
Sulfolobus solfataricus P2

Site:
position = -22
score = 6.398
sequence = GCTGGATAGCCTATCCATA

Gene: SSO2560: Cob(II)yrinic acid a,c-diamide reductase
*
Sulfolobus islandicus Y.N.15.51

Site:
position = -22
score = 6.5786
sequence = TCTGGATAGTCTATCCATA

Gene: YN1551_3111: Cob(II)yrinic acid a,c-diamide reductase
*
Sulfolobus acidocaldarius DSM 639

Site:
position = -18
score = 6.14469
sequence = GATGGATAATCTATCCATA

Gene: Saci_0250: Cob(II)yrinic acid a,c-diamide reductase
Cob(II)yrinic acid a,c-diamide reductase
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
Export
Regulated Genes [ Tab delimited format ] DOWNLOAD
Regulatory Sites [ FASTA format ] DOWNLOAD