Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog HypR2 - Rhodobacterales

Properties
Regulator type: Transcription factor
Regulator family: GntR/Others
Regulation mode:
Biological process: Proline and 4-hydrohyproline utilization
Effector: 4-hydroxyproline
Phylum: Proteobacteria/alpha
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 17 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Hyphomonas neptunium ATCC 15444
Jannaschia sp. CCS1
Loktanella vestfoldensis SKA53
Oceanicaulis alexandrii HTCC2633
Oceanicola batsensis HTCC2597
Oceanicola granulosus HTCC2516
Paracoccus denitrificans PD1222 3 2
Rhodobacter sphaeroides 2.4.1
Rhodobacterales bacterium HTCC2654
Roseobacter sp. MED193 3 3
Roseovarius nubinhibens ISM 4 3
Roseovarius sp. 217
Silicibacter TM1040 7 4
Silicibacter pomeroyi DSS-3 8 2
Sulfitobacter sp. EE-36
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
hypR2
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516
*
Paracoccus denitrificans PD1222

Site:
position = -178
score = 4.25769
sequence = TTTCGTATACTATA

Gene: Pden_1183: Predicted regulator for proline and hydrohyproline utilization, GntR family
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Sulfitobacter sp. EE-36
Predicted regulator for proline and hydrohyproline utilization, GntR family
 
CRON 2.
hypY
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516
 
Paracoccus denitrificans PD1222
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
*
Roseobacter sp. MED193

Site:
position = -39
score = 4.48484
sequence = GATTGGATACAATA

Gene: MED193_08463: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Sulfitobacter sp. EE-36
Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
CRON 3.
hypR2
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516
 
Paracoccus denitrificans PD1222
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
*
Roseobacter sp. MED193

Site:
position = -86
score = 4.6297
sequence = TATTGGATCCAATT

Gene: MED193_09635: Predicted regulator for proline and hydrohyproline utilization, GntR family
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Sulfitobacter sp. EE-36
Predicted regulator for proline and hydrohyproline utilization, GntR family
 
CRON 4.
hypS
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516

Gene: OG2516_07021: Putative L-lactate/Malate dehydrogenase
 3
Paracoccus denitrificans PD1222

Gene: Pden_4855: Putative L-lactate/Malate dehydrogenase

Gene: Pden_4866: Putative L-lactate/Malate dehydrogenase

Gene: Pden_0941: Putative L-lactate/Malate dehydrogenase
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217

Gene: ROS217_16560: Putative L-lactate/Malate dehydrogenase
*
Silicibacter TM1040

Site:
position = -127
score = 4.83735
sequence = TTTTGGATACGTTA

Site:
position = -41
score = 4.26549
sequence = TGATGTATCCGATA

Gene: TM1040_3323: Putative L-lactate/Malate dehydrogenase
 
Silicibacter pomeroyi DSS-3
 
Sulfitobacter sp. EE-36
Putative L-lactate/Malate dehydrogenase
 
CRON 5.
hypH
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516
 
Paracoccus denitrificans PD1222
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193
*
Roseovarius nubinhibens ISM

Site:
position = -59
score = 5.19986
sequence = TTTTGGATACATTA

Gene: ISM_08240: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
Roseovarius sp. 217

Gene: ROS217_16585: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Sulfitobacter sp. EE-36
Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
CRON 6.
hypH
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516

Gene: OG2516_08177: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
Paracoccus denitrificans PD1222
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217
*
Silicibacter TM1040

Site:
position = -55
score = 4.75144
sequence = ATATGTATACATTA

Gene: TM1040_3325: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
*
Silicibacter pomeroyi DSS-3

Site:
position = -64
score = 5.19986
sequence = TTTTGGATACATTA

Gene: SPOA0260: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
Sulfitobacter sp. EE-36
Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
CRON 7.
hypD
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516

Gene: OG2516_07031: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Paracoccus denitrificans PD1222

Gene: Pden_4867: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
*
Roseobacter sp. MED193

Site:
position = -151
score = 4.6297
sequence = AATTGGATCCAATA

Gene: MED193_09625: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
*
Roseovarius nubinhibens ISM

Site:
position = -165
score = 5.19986
sequence = TTTTGTATCCATTA

Gene: ISM_08255: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Roseovarius sp. 217

Gene: ROS217_16545: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
*
Silicibacter TM1040

Site:
position = -158
score = 5.3043
sequence = TTTTGGATACAAAA

Gene: TM1040_3198: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
*
Silicibacter pomeroyi DSS-3

Site:
position = -172
score = 4.9554
sequence = TTCTGTATCCAAAA

Gene: SPOA0267: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Sulfitobacter sp. EE-36
1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
hypE
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516

Gene: OG2516_07016: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Paracoccus denitrificans PD1222

Gene: Pden_4859: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193

Gene: MED193_09620: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217

Gene: ROS217_16540: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Silicibacter TM1040

Gene: TM1040_3199: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Silicibacter pomeroyi DSS-3

Gene: SPOA0266: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Sulfitobacter sp. EE-36
Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
COG4663
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516
 
Paracoccus denitrificans PD1222
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193
 
Roseovarius nubinhibens ISM

Gene: ISM_10311: TRAP-type C4-dicarboxylate transport system, periplasmic component
 
Roseovarius sp. 217
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3

Gene: SPOA0265: TRAP-type C4-dicarboxylate transport system, periplasmic component
 
Sulfitobacter sp. EE-36
TRAP-type C4-dicarboxylate transport system, periplasmic component
COG3090
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516
 
Paracoccus denitrificans PD1222
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193
 
Roseovarius nubinhibens ISM

Gene: ISM_10306: TRAP-type C4-dicarboxylate transport system, small permease component
 
Roseovarius sp. 217
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3

Gene: SPOA0264: TRAP-type C4-dicarboxylate transport system, small permease component
 
Sulfitobacter sp. EE-36
TRAP-type C4-dicarboxylate transport system, small permease component
COG4664
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516
 
Paracoccus denitrificans PD1222
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193
 
Roseovarius nubinhibens ISM

Gene: ISM_10301: TRAP-type C4-dicarboxylate transport system, large permease component
 
Roseovarius sp. 217
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3

Gene: SPOA0263: TRAP-type C4-dicarboxylate transport system, large permease component
 
Sulfitobacter sp. EE-36
TRAP-type C4-dicarboxylate transport system, large permease component
hypO
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516

Gene: OG2516_08202: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Paracoccus denitrificans PD1222

Gene: Pden_4860: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193

Gene: MED193_09610: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217

Gene: ROS217_16535: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Silicibacter TM1040

Gene: TM1040_3200: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Silicibacter pomeroyi DSS-3

Gene: SPOA0262: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Sulfitobacter sp. EE-36
D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
hypR2
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516
 
Paracoccus denitrificans PD1222
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193
*
Roseovarius nubinhibens ISM

Site:
position = -13
score = 5.19986
sequence = TAATGTATCCAAAA

Gene: ISM_08245: Predicted regulator for proline and hydrohyproline utilization, GntR family
 
Roseovarius sp. 217
*
Silicibacter TM1040

Site:
position = -129
score = 4.26549
sequence = TATCGGATACATCA

Site:
position = -43
score = 4.83735
sequence = TAACGTATCCAAAA

Gene: TM1040_3324: Predicted regulator for proline and hydrohyproline utilization, GntR family
*
Silicibacter pomeroyi DSS-3

Site:
position = -38
score = 4.12505
sequence = ATCTGTATCCGAAA

Gene: SPOA0261: Predicted regulator for proline and hydrohyproline utilization, GntR family
 
Sulfitobacter sp. EE-36
Predicted regulator for proline and hydrohyproline utilization, GntR family
hypY
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1

Gene: Jann_1529: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516

Gene: OG2516_07011: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
*
Paracoccus denitrificans PD1222

Site:
position = -50
score = 4.25769
sequence = TATAGTATACGAAA

Gene: Pden_1184: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193
 
Roseovarius nubinhibens ISM

Gene: ISM_08250: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Roseovarius sp. 217

Gene: ROS217_16530: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Silicibacter TM1040

Gene: TM1040_3201: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Silicibacter pomeroyi DSS-3

Gene: SPO0607: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Sulfitobacter sp. EE-36
Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
COG2423
 
Hyphomonas neptunium ATCC 15444
 
Jannaschia sp. CCS1
 
Loktanella vestfoldensis SKA53
 
Oceanicaulis alexandrii HTCC2633
 
Oceanicola batsensis HTCC2597
 
Oceanicola granulosus HTCC2516
 
Paracoccus denitrificans PD1222

Gene: Pden_1185: Predicted ornithine cyclodeaminase, mu-crystallin homolog
 
Rhodobacter sphaeroides 2.4.1
 
Rhodobacterales bacterium HTCC2654
 
Roseobacter sp. MED193
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Sulfitobacter sp. EE-36
Predicted ornithine cyclodeaminase, mu-crystallin homolog
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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