Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog ThiR - Thermococcales

Properties
Regulator type: Transcription factor
Regulator family: [Other]
Regulation mode: repressor
Biological process: Thiamine transport; Thiamine biosynthesis
Effector: Thiamine phosphate
Phylum: Euryarchaeota
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 35 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Pyrococcus abyssi GE5 9 4
Pyrococcus furiosus DSM 3638 9 4
Pyrococcus horikoshii OT3 6 3
Thermococcus gammatolerans EJ3 4 3
Thermococcus kodakaraensis KOD1 5 3
Thermococcus onnurineus NA1 5 2
Thermococcus sibiricus MM 739 10 3
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
cytX
 
Pyrococcus abyssi GE5

Gene: PAB1643: Hydroxymethylpyrimidine transporter CytX
 
Pyrococcus furiosus DSM 3638

Gene: PF1336: Hydroxymethylpyrimidine transporter CytX
 
Pyrococcus horikoshii OT3

Gene: PH1159: Hydroxymethylpyrimidine transporter CytX
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1
*
Thermococcus sibiricus MM 739

Site:
position = -70
score = 5.05112
sequence = ATAACTTGGTTTT

Gene: TSIB_0467: Hydroxymethylpyrimidine transporter CytX
Hydroxymethylpyrimidine transporter CytX
tenA1
*
Pyrococcus abyssi GE5

Site:
position = -70
score = 5.05112
sequence = ATAACCAAGTTTT

Gene: PAB1641: Thiaminase II (EC 3.5.99.2)
*
Pyrococcus furiosus DSM 3638

Site:
position = -68
score = 5.05112
sequence = ATAACTTGGTTTT

Gene: PF1338: Thiaminase II (EC 3.5.99.2)
*
Pyrococcus horikoshii OT3

Site:
position = -214
score = 4.60795
sequence = AAACCTCAGTTTT

Site:
position = -61
score = 4.67474
sequence = ATAACAAGGTTAT

Gene: PH1161: Thiaminase II (EC 3.5.99.2)
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739

Gene: TSIB_0466: Thiaminase II (EC 3.5.99.2)
Thiaminase II (EC 3.5.99.2)
thiM
 
Pyrococcus abyssi GE5

Gene: PAB2432: Hydroxyethylthiazole kinase (EC 2.7.1.50)
 
Pyrococcus furiosus DSM 3638

Gene: PF1335: Hydroxyethylthiazole kinase (EC 2.7.1.50)
 
Pyrococcus horikoshii OT3

Gene: PH1157: Hydroxyethylthiazole kinase (EC 2.7.1.50)
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739

Gene: TSIB_0465: Hydroxyethylthiazole kinase (EC 2.7.1.50)
Hydroxyethylthiazole kinase (EC 2.7.1.50)
thiE
 
Pyrococcus abyssi GE5

Gene: PAB1645: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
Pyrococcus furiosus DSM 3638

Gene: PF1334: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
Pyrococcus horikoshii OT3

Gene: PH1156: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739

Gene: TSIB_0464: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
thiW
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638
 
Pyrococcus horikoshii OT3
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739

Gene: TSIB_0463: Thiazole transporter ThiW
Thiazole transporter ThiW
thiDN
 
Pyrococcus abyssi GE5

Gene: PAB1646: Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiamin-phosphate synthase ThiN (EC 2.5.1.3)
 
Pyrococcus furiosus DSM 3638

Gene: PF1333: Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiamin-phosphate synthase ThiN (EC 2.5.1.3)
 
Pyrococcus horikoshii OT3

Gene: PH1155: Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiamin-phosphate synthase ThiN (EC 2.5.1.3)
 
Thermococcus gammatolerans EJ3

Gene: TGAM_1271: Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiamin-phosphate synthase ThiN (EC 2.5.1.3)
 
Thermococcus kodakaraensis KOD1

Gene: TK0435: Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiamin-phosphate synthase ThiN (EC 2.5.1.3)
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739

Gene: TSIB_0462: Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiamin-phosphate synthase ThiN (EC 2.5.1.3)
Phosphomethylpyrimidine kinase (EC 2.7.4.7) / Thiamin-phosphate synthase ThiN (EC 2.5.1.3)
tenA2
 
Pyrococcus abyssi GE5

Gene: PAB1642: Thiaminase II (EC 3.5.99.2)
 
Pyrococcus furiosus DSM 3638

Gene: PF1337: Thiaminase II (EC 3.5.99.2)
 
Pyrococcus horikoshii OT3

Gene: PH1160: Thiaminase II (EC 3.5.99.2)
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739
Thiaminase II (EC 3.5.99.2)
thi4
*
Pyrococcus abyssi GE5

Site:
position = -47
score = 5.1769
sequence = ATAACAAAGTTTT

Site:
position = -26
score = 5.55328
sequence = AAAACTAAGTTTT

Gene: PAB0536: Thiazole biosynthetic enzyme Thi4
*
Pyrococcus furiosus DSM 3638

Site:
position = -93
score = 5.22862
sequence = AAAACTTGGTTTT

Site:
position = -48
score = 5.3544
sequence = AAAACAAAGTTTT

Site:
position = -27
score = 5.36989
sequence = AAAACTCAGTTTT

Gene: PF1530: Thiazole biosynthetic enzyme Thi4
*
Pyrococcus horikoshii OT3

Site:
position = -18
score = 4.51375
sequence = AAAATGAAGTTTT

Site:
position = -39
score = 5.1769
sequence = ATAACAAAGTTTT

Gene: PH1357: Thiazole biosynthetic enzyme Thi4
*
Thermococcus gammatolerans EJ3

Site:
position = -45
score = 5.55328
sequence = AAAACTTAGTTTT

Site:
position = -66
score = 5.1769
sequence = ATAACAAAGTTTT

Gene: TGAM_1270: Thiazole biosynthetic enzyme Thi4
*
Thermococcus kodakaraensis KOD1

Site:
position = -45
score = 5.55328
sequence = AAAACTTAGTTTT

Site:
position = -66
score = 5.1769
sequence = ATAACAAAGTTTT

Gene: TK0434: Thiazole biosynthetic enzyme Thi4
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739
Thiazole biosynthetic enzyme Thi4
 
CRON 2.
thiC
*
Pyrococcus abyssi GE5

Site:
position = -38
score = 4.39625
sequence = ATTACTTGGTTTT

Gene: PAB1930: Thiamin biosynthesis protein ThiC
*
Pyrococcus furiosus DSM 3638

Site:
position = -114
score = 5.36989
sequence = AAAACTGAGTTTT

Site:
position = -93
score = 5.3544
sequence = AAAACTTTGTTTT

Site:
position = -48
score = 5.22862
sequence = AAAACCAAGTTTT

Gene: PF1531: Thiamin biosynthesis protein ThiC
 
Pyrococcus horikoshii OT3
*
Thermococcus gammatolerans EJ3

Site:
position = -41
score = 5.1769
sequence = AAAACTTTGTTAT

Site:
position = -62
score = 5.55328
sequence = AAAACTAAGTTTT

Gene: TGAM_1269: Thiamin biosynthesis protein ThiC
*
Thermococcus kodakaraensis KOD1

Site:
position = -63
score = 5.55328
sequence = AAAACTAAGTTTT

Site:
position = -42
score = 5.1769
sequence = AAAACTTTGTTAT

Gene: TK0433: Thiamin biosynthesis protein ThiC
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739
Thiamin biosynthesis protein ThiC
 
CRON 3.
thiB
*
Pyrococcus abyssi GE5

Site:
position = -37
score = 4.11726
sequence = AAAATCTTATTTT

Gene: PAB1835: Thiamin ABC transporter, substrate-binding component
*2
Pyrococcus furiosus DSM 3638

Gene: PF1518: Thiamin ABC transporter, substrate-binding component

Site:
position = -45
score = 4.64749
sequence = AGAACACAGTTTT

Gene: PF1751: Thiamin ABC transporter, substrate-binding component
*
Pyrococcus horikoshii OT3

Site:
position = -42
score = 4.28918
sequence = ATAGCTTGGTTTT

Site:
position = -63
score = 4.89841
sequence = AATACTTAGTTTT

Gene: PH1349: Thiamin ABC transporter, substrate-binding component
*
Thermococcus gammatolerans EJ3

Site:
position = -16
score = 4.46194
sequence = AAAACCGCGTTTT

Gene: TGAM_1706: Thiamin ABC transporter, substrate-binding component
 
Thermococcus kodakaraensis KOD1

Gene: TK0757: Thiamin ABC transporter, substrate-binding component
 
Thermococcus onnurineus NA1

Gene: TON_0963: Thiamin ABC transporter, substrate-binding component
*
Thermococcus sibiricus MM 739

Site:
position = -15
score = 4.91069
sequence = AAAAATTAGTTTT

Site:
position = -36
score = 4.46998
sequence = AGAACAGAGTTAT

Gene: TSIB_0369: Thiamin ABC transporter, substrate-binding component
Thiamin ABC transporter, substrate-binding component
 
CRON 4.
thiP
 
Pyrococcus abyssi GE5

Gene: PAB0543: Thiamin ABC transporter, transmembrane component
 3
Pyrococcus furiosus DSM 3638

Gene: PF1749: Thiamin ABC transporter, transmembrane component

Gene: PF1748: Thiamin ABC transporter, transmembrane component

Gene: PF1520: Thiamin ABC transporter, transmembrane component
 
Pyrococcus horikoshii OT3

Gene: PH1352: Thiamin ABC transporter, transmembrane component
 
Thermococcus gammatolerans EJ3

Gene: TGAM_1704: Thiamin ABC transporter, transmembrane component
 
Thermococcus kodakaraensis KOD1

Gene: TK0159: Thiamin ABC transporter, transmembrane component
*
Thermococcus onnurineus NA1

Site:
position = -17
score = 4.5217
sequence = AAAACCGAGTTGT

Gene: TON_1959: Thiamin ABC transporter, transmembrane component
 
Thermococcus sibiricus MM 739

Gene: TSIB_0367: Thiamin ABC transporter, transmembrane component
Thiamin ABC transporter, transmembrane component
thiQ
 
Pyrococcus abyssi GE5

Gene: PAB0545: Thiamin ABC transporter, ATPase component
 2
Pyrococcus furiosus DSM 3638

Gene: PF1750: Thiamin ABC transporter, ATPase component

Gene: PF1519: Thiamin ABC transporter, ATPase component
 
Pyrococcus horikoshii OT3

Gene: PH1350: Thiamin ABC transporter, ATPase component
 
Thermococcus gammatolerans EJ3

Gene: TGAM_1705: Thiamin ABC transporter, ATPase component
 
Thermococcus kodakaraensis KOD1

Gene: TK0158: Thiamin ABC transporter, ATPase component
 
Thermococcus onnurineus NA1

Gene: TON_1958: Thiamin ABC transporter, ATPase component
 
Thermococcus sibiricus MM 739

Gene: TSIB_0368: Thiamin ABC transporter, ATPase component
Thiamin ABC transporter, ATPase component
 
CRON 5.
thiR
 
Pyrococcus abyssi GE5

Gene: PAB0877: Thiamin-phosphate synthase-like transcriptional regulator ThiR
 
Pyrococcus furiosus DSM 3638

Gene: PF0601: Thiamin-phosphate synthase-like transcriptional regulator ThiR
 
Pyrococcus horikoshii OT3

Gene: PH0716: Thiamin-phosphate synthase-like transcriptional regulator ThiR
 
Thermococcus gammatolerans EJ3

Gene: TGAM_2087: Thiamin-phosphate synthase-like transcriptional regulator ThiR
*
Thermococcus kodakaraensis KOD1

Site:
position = -25
score = 4.20293
sequence = ATAACCTGGTTGT

Gene: TK2197: Thiamin-phosphate synthase-like transcriptional regulator ThiR
*
Thermococcus onnurineus NA1

Site:
position = -24
score = 4.54306
sequence = ATAACCGGGTTTT

Gene: TON_1436: Thiamin-phosphate synthase-like transcriptional regulator ThiR
*
Thermococcus sibiricus MM 739

Site:
position = -37
score = 5.19239
sequence = ATAACTGAGTTTT

Gene: TSIB_0198: Thiamin-phosphate synthase-like transcriptional regulator ThiR
Thiamin-phosphate synthase-like transcriptional regulator ThiR
TON_1435
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638
 
Pyrococcus horikoshii OT3
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1

Gene: TON_1435: hypothetical protein
 
Thermococcus sibiricus MM 739
hypothetical protein
yjbQ
 
Pyrococcus abyssi GE5

Gene: PAB0878: YjbQ (alternate ThiE)
 
Pyrococcus furiosus DSM 3638

Gene: PF0680: YjbQ (alternate ThiE)
 
Pyrococcus horikoshii OT3

Gene: PH0713: YjbQ (alternate ThiE)
 
Thermococcus gammatolerans EJ3

Gene: TGAM_2086: YjbQ (alternate ThiE)
 
Thermococcus kodakaraensis KOD1

Gene: TK2198: YjbQ (alternate ThiE)
 
Thermococcus onnurineus NA1

Gene: TON_1434: YjbQ (alternate ThiE)
 
Thermococcus sibiricus MM 739

Gene: TSIB_0200: YjbQ (alternate ThiE)
YjbQ (alternate ThiE)
TSIB_0199
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638
 
Pyrococcus horikoshii OT3
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739

Gene: TSIB_0199: hypothetical protein
hypothetical protein
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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