Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog BioQ - Micrococcineae

Properties
Regulator type: Transcription factor
Regulator family: TetR
Regulation mode: repressor
Biological process: Biotin biosynthesis
Effector: Biotin
Phylum: Actinobacteria
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 17 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Arthrobacter aurescens TC1
Arthrobacter chlorophenolicus A6
Arthrobacter sp. FB24
Beutenbergia cavernae DSM 12333
Brachybacterium faecium DSM 4810
Brevibacterium linens BL2 8 3
Clavibacter michiganensis subsp. michiganensis NCPPB 382 4 2
Janibacter sp. HTCC2649
Jonesia denitrificans DSM 20603
Kocuria rhizophila DC2201 5 2
Kytococcus sedentarius DSM 20547
Leifsonia xyli subsp. xyli str. CTCB07 7 2
Renibacterium salmoninarum ATCC 33209 9 2
Tropheryma whipplei str. Twist
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
bioY
 
Arthrobacter aurescens TC1

Gene: AAur_2114: Substrate-specific component BioY of biotin ECF transporter
 
Arthrobacter chlorophenolicus A6

Gene: Achl_1855: Substrate-specific component BioY of biotin ECF transporter
 
Arthrobacter sp. FB24

Gene: Arth_2113: Substrate-specific component BioY of biotin ECF transporter
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
*
Brevibacterium linens BL2

Site:
position = -21
score = 5.97442
sequence = CCTGAACAGTGTTCAGT

Gene: BlinB01002267: Substrate-specific component BioY of biotin ECF transporter
*
Clavibacter michiganensis subsp. michiganensis NCPPB 382

Site:
position = -65
score = 5.78156
sequence = AGTGAACGCCGTTCAGG

Site:
position = -50
score = 5.45395
sequence = GGTGAACATCGTTCAGG

Gene: CMM_1625: Substrate-specific component BioY of biotin ECF transporter
 
Janibacter sp. HTCC2649

Gene: JNB_15728: Substrate-specific component BioY of biotin ECF transporter
 
Jonesia denitrificans DSM 20603

Gene: Jden_1159: Substrate-specific component BioY of biotin ECF transporter
 
Kocuria rhizophila DC2201

Gene: KRH_12340: Substrate-specific component BioY of biotin ECF transporter
 
Kytococcus sedentarius DSM 20547

Gene: Ksed_01740: Substrate-specific component BioY of biotin ECF transporter
*
Leifsonia xyli subsp. xyli str. CTCB07

Site:
position = -44
score = 5.84457
sequence = AGTGAACGCTGTTCAGG

Site:
position = -29
score = 5.69988
sequence = GGTGAACACCGTTCAGT

Gene: Lxx20880: Substrate-specific component BioY of biotin ECF transporter
*
Renibacterium salmoninarum ATCC 33209

Site:
position = -113
score = 5.48572
sequence = ATTGAACCCTGTTCAAT

Gene: RSal33209_2106: Substrate-specific component BioY of biotin ECF transporter
 
Tropheryma whipplei str. Twist

Gene: TW211: Substrate-specific component BioY of biotin ECF transporter
Substrate-specific component BioY of biotin ECF transporter
yhfT
 
Arthrobacter aurescens TC1
 
Arthrobacter chlorophenolicus A6
 
Arthrobacter sp. FB24
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
 
Brevibacterium linens BL2
 
Clavibacter michiganensis subsp. michiganensis NCPPB 382
 
Janibacter sp. HTCC2649
 
Jonesia denitrificans DSM 20603
 
Kocuria rhizophila DC2201
 
Kytococcus sedentarius DSM 20547
 
Leifsonia xyli subsp. xyli str. CTCB07

Gene: Lxx20870: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 
Renibacterium salmoninarum ATCC 33209
 
Tropheryma whipplei str. Twist
Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
yhfS
 
Arthrobacter aurescens TC1
 
Arthrobacter chlorophenolicus A6
 
Arthrobacter sp. FB24
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
 
Brevibacterium linens BL2
 
Clavibacter michiganensis subsp. michiganensis NCPPB 382
 
Janibacter sp. HTCC2649
 
Jonesia denitrificans DSM 20603
 
Kocuria rhizophila DC2201
 
Kytococcus sedentarius DSM 20547
 
Leifsonia xyli subsp. xyli str. CTCB07

Gene: Lxx20900: acetyl-coA acyltransferase
 
Renibacterium salmoninarum ATCC 33209
 
Tropheryma whipplei str. Twist
acetyl-coA acyltransferase
bioM
 
Arthrobacter aurescens TC1

Gene: AAur_2113: ATPase component BioM of energizing module of biotin ECF transporter
 
Arthrobacter chlorophenolicus A6

Gene: Achl_1854: ATPase component BioM of energizing module of biotin ECF transporter
 
Arthrobacter sp. FB24

Gene: Arth_2112: ATPase component BioM of energizing module of biotin ECF transporter
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
 
Brevibacterium linens BL2

Gene: BlinB01002268: ATPase component BioM of energizing module of biotin ECF transporter
 
Clavibacter michiganensis subsp. michiganensis NCPPB 382

Gene: CMM_1626: ATPase component BioM of energizing module of biotin ECF transporter
 
Janibacter sp. HTCC2649

Gene: JNB_15723: ATPase component BioM of energizing module of biotin ECF transporter
 
Jonesia denitrificans DSM 20603

Gene: Jden_1158: ATPase component BioM of energizing module of biotin ECF transporter
 
Kocuria rhizophila DC2201

Gene: KRH_12330: ATPase component BioM of energizing module of biotin ECF transporter
 
Kytococcus sedentarius DSM 20547

Gene: Ksed_01750: ATPase component BioM of energizing module of biotin ECF transporter
 
Leifsonia xyli subsp. xyli str. CTCB07

Gene: Lxx20910: ATPase component BioM of energizing module of biotin ECF transporter
 
Renibacterium salmoninarum ATCC 33209

Gene: RSal33209_2107: ATPase component BioM of energizing module of biotin ECF transporter
 
Tropheryma whipplei str. Twist
ATPase component BioM of energizing module of biotin ECF transporter
bioN
 
Arthrobacter aurescens TC1

Gene: AAur_2111: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Arthrobacter chlorophenolicus A6

Gene: Achl_1853: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Arthrobacter sp. FB24

Gene: Arth_2111: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
 
Brevibacterium linens BL2

Gene: BlinB01002269: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Clavibacter michiganensis subsp. michiganensis NCPPB 382

Gene: CMM_1627: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Janibacter sp. HTCC2649

Gene: JNB_15718: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Jonesia denitrificans DSM 20603

Gene: Jden_1157: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Kocuria rhizophila DC2201

Gene: KRH_12320: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Kytococcus sedentarius DSM 20547

Gene: Ksed_01760: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Leifsonia xyli subsp. xyli str. CTCB07

Gene: Lxx20920: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Renibacterium salmoninarum ATCC 33209

Gene: RSal33209_2108: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Tropheryma whipplei str. Twist
Transmembrane component BioN of energizing module of biotin ECF transporter
CMM_2958
 
Arthrobacter aurescens TC1
 
Arthrobacter chlorophenolicus A6
 
Arthrobacter sp. FB24
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
 
Brevibacterium linens BL2
 
Clavibacter michiganensis subsp. michiganensis NCPPB 382
 
Janibacter sp. HTCC2649
 
Jonesia denitrificans DSM 20603
 
Kocuria rhizophila DC2201
 
Kytococcus sedentarius DSM 20547
 
Leifsonia xyli subsp. xyli str. CTCB07

Gene: Lxx20930: hypothetical protein
 
Renibacterium salmoninarum ATCC 33209
 
Tropheryma whipplei str. Twist
hypothetical protein
 
CRON 2.
bioB
 
Arthrobacter aurescens TC1

Gene: AAur_1091: Biotin synthase (EC 2.8.1.6)
 
Arthrobacter chlorophenolicus A6

Gene: Achl_0984: Biotin synthase (EC 2.8.1.6)
 
Arthrobacter sp. FB24

Gene: Arth_0875: Biotin synthase (EC 2.8.1.6)
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
*2
Brevibacterium linens BL2

Site:
position = -23
score = 5.90758
sequence = CCTGAACAGTGTTCAAT

Gene: BlinB01003681: Biotin synthase (EC 2.8.1.6)

Site:
position = -68
score = 5.90758
sequence = ATTGAACACTGTTCAGG

Gene: BlinB01003562: Biotin synthase (EC 2.8.1.6)
 
Clavibacter michiganensis subsp. michiganensis NCPPB 382
 
Janibacter sp. HTCC2649
 
Jonesia denitrificans DSM 20603
*
Kocuria rhizophila DC2201

Site:
position = -8
score = 5.63854
sequence = ATTGAACAATGTTCAAG

Site:
position = -26
score = 5.84457
sequence = CCTGAACACCGTTCAAT

Gene: KRH_02440: Biotin synthase (EC 2.8.1.6)
 
Kytococcus sedentarius DSM 20547

Gene: Ksed_26490: Biotin synthase (EC 2.8.1.6)
 
Leifsonia xyli subsp. xyli str. CTCB07
*
Renibacterium salmoninarum ATCC 33209

Site:
position = -8
score = 5.5208
sequence = TTTGAACAGTGTTCAAT

Gene: RSal33209_0557: Biotin synthase (EC 2.8.1.6)
 
Tropheryma whipplei str. Twist
Biotin synthase (EC 2.8.1.6)
bioA
 
Arthrobacter aurescens TC1

Gene: AAur_1089: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
Arthrobacter chlorophenolicus A6
 
Arthrobacter sp. FB24
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
 
Brevibacterium linens BL2

Gene: BlinB01003680: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
Clavibacter michiganensis subsp. michiganensis NCPPB 382
 
Janibacter sp. HTCC2649
 
Jonesia denitrificans DSM 20603
 
Kocuria rhizophila DC2201

Gene: KRH_02450: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
Kytococcus sedentarius DSM 20547
 
Leifsonia xyli subsp. xyli str. CTCB07
 
Renibacterium salmoninarum ATCC 33209

Gene: RSal33209_0558: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
Tropheryma whipplei str. Twist
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
RSal33209_0559
 
Arthrobacter aurescens TC1
 
Arthrobacter chlorophenolicus A6
 
Arthrobacter sp. FB24
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
 
Brevibacterium linens BL2
 
Clavibacter michiganensis subsp. michiganensis NCPPB 382
 
Janibacter sp. HTCC2649
 
Jonesia denitrificans DSM 20603
 
Kocuria rhizophila DC2201
 
Kytococcus sedentarius DSM 20547
 
Leifsonia xyli subsp. xyli str. CTCB07
 
Renibacterium salmoninarum ATCC 33209

Gene: RSal33209_0559: hypothetical membrane protein
 
Tropheryma whipplei str. Twist
hypothetical membrane protein
bioF
 
Arthrobacter aurescens TC1

Gene: AAur_1088: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Arthrobacter chlorophenolicus A6
 
Arthrobacter sp. FB24
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
 
Brevibacterium linens BL2

Gene: BlinB01003679: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Clavibacter michiganensis subsp. michiganensis NCPPB 382
 
Janibacter sp. HTCC2649
 
Jonesia denitrificans DSM 20603
 
Kocuria rhizophila DC2201

Gene: KRH_02460: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Kytococcus sedentarius DSM 20547
 
Leifsonia xyli subsp. xyli str. CTCB07
 2
Renibacterium salmoninarum ATCC 33209

Gene: RSal33209_0560: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)

Gene: RSal33209_0561: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Tropheryma whipplei str. Twist
8-amino-7-oxononanoate synthase (EC 2.3.1.47)
bioD
 
Arthrobacter aurescens TC1

Gene: AAur_1087: Dethiobiotin synthetase (EC 6.3.3.3)
 
Arthrobacter chlorophenolicus A6
 
Arthrobacter sp. FB24
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
 
Brevibacterium linens BL2

Gene: BlinB01003678: Dethiobiotin synthetase (EC 6.3.3.3)
 
Clavibacter michiganensis subsp. michiganensis NCPPB 382
 
Janibacter sp. HTCC2649
 
Jonesia denitrificans DSM 20603
 
Kocuria rhizophila DC2201

Gene: KRH_02470: Dethiobiotin synthetase (EC 6.3.3.3)
 
Kytococcus sedentarius DSM 20547
 
Leifsonia xyli subsp. xyli str. CTCB07
 
Renibacterium salmoninarum ATCC 33209

Gene: RSal33209_0562: Dethiobiotin synthetase (EC 6.3.3.3)
 
Tropheryma whipplei str. Twist
Dethiobiotin synthetase (EC 6.3.3.3)
 
CRON 3.
bioQ
 
Arthrobacter aurescens TC1
 
Arthrobacter chlorophenolicus A6
 
Arthrobacter sp. FB24
 
Beutenbergia cavernae DSM 12333
 
Brachybacterium faecium DSM 4810
 
Brevibacterium linens BL2
*
Clavibacter michiganensis subsp. michiganensis NCPPB 382

Site:
position = -47
score = 5.45395
sequence = CCTGAACGATGTTCACC

Site:
position = -32
score = 5.78156
sequence = CCTGAACGGCGTTCACT

Gene: CMM_1624: Biotin repressor, TetR family
 
Janibacter sp. HTCC2649
 
Jonesia denitrificans DSM 20603
*
Kocuria rhizophila DC2201

Site:
position = -253
score = 5.84457
sequence = ATTGAACGGTGTTCAGG

Site:
position = -271
score = 5.63854
sequence = CTTGAACATTGTTCAAT

Gene: KRH_02430: Biotin repressor, TetR family
 
Kytococcus sedentarius DSM 20547
*
Leifsonia xyli subsp. xyli str. CTCB07

Site:
position = -43
score = 5.69988
sequence = ACTGAACGGTGTTCACC

Site:
position = -28
score = 5.84457
sequence = CCTGAACAGCGTTCACT

Gene: Lxx20890: Biotin repressor, TetR family
 
Renibacterium salmoninarum ATCC 33209
 
Tropheryma whipplei str. Twist
Biotin repressor, TetR family
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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