Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog CblR - Thermococcales

Properties
Regulator type: Transcription factor
Regulator family:
Regulation mode:
Biological process: Cobalamin biosynthesis
Effector:
Phylum: Euryarchaeota
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 82 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Pyrococcus abyssi GE5 16 10
Pyrococcus furiosus DSM 3638 22 10
Pyrococcus horikoshii OT3 18 10
Thermococcus gammatolerans EJ3 26 14
Thermococcus kodakaraensis KOD1 20 11
Thermococcus onnurineus NA1 22 13
Thermococcus sibiricus MM 739 8 6
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
meaB
*
Pyrococcus abyssi GE5

Site:
position = -26
score = 5.54965
sequence = TTGGATAAATTCTCCAG

Gene: PAB2398: GTP-dependent assembly of methylmalonyl-CoA mutase
*
Pyrococcus furiosus DSM 3638

Site:
position = -26
score = 5.54965
sequence = TTGGATAATTTCTCCAG

Gene: PF1947: GTP-dependent assembly of methylmalonyl-CoA mutase
*
Pyrococcus horikoshii OT3

Site:
position = -26
score = 5.54965
sequence = TTGGATAATTTCTCCAG

Gene: PH0274: GTP-dependent assembly of methylmalonyl-CoA mutase
*
Thermococcus gammatolerans EJ3

Site:
position = -25
score = 5.54965
sequence = TTGGATAATTTCTCCAG

Gene: TGAM_1930: GTP-dependent assembly of methylmalonyl-CoA mutase
*
Thermococcus kodakaraensis KOD1

Site:
position = -27
score = 4.98773
sequence = CTGGATGATTAATCCAG

Gene: TK0329: GTP-dependent assembly of methylmalonyl-CoA mutase
*
Thermococcus onnurineus NA1

Site:
position = -26
score = 5.41445
sequence = TTGGATAATTTGTCCGA

Gene: TON_1075: GTP-dependent assembly of methylmalonyl-CoA mutase
*
Thermococcus sibiricus MM 739

Site:
position = -17
score = 5.75444
sequence = TTGGATAATTAATCCAA

Gene: TSIB_1401: GTP-dependent assembly of methylmalonyl-CoA mutase
GTP-dependent assembly of methylmalonyl-CoA mutase
mceE
 
Pyrococcus abyssi GE5

Gene: PAB2438: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
 
Pyrococcus furiosus DSM 3638

Gene: PF1948: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
 
Pyrococcus horikoshii OT3

Gene: PH0272: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
 
Thermococcus gammatolerans EJ3

Gene: TGAM_1929: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
 
Thermococcus kodakaraensis KOD1

Gene: TK0330: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
 
Thermococcus onnurineus NA1

Gene: TON_1074: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
 
Thermococcus sibiricus MM 739

Gene: TSIB_1400: Methylmalonyl-CoA epimerase (EC 5.1.99.1)
Methylmalonyl-CoA epimerase (EC 5.1.99.1)
 
CRON 2.
mutB_C
*
Pyrococcus abyssi GE5

Site:
position = -72
score = 5.05534
sequence = TGGGATAATATATCCAT

Gene: PAB2187: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
*
Pyrococcus furiosus DSM 3638

Site:
position = -78
score = 5.14126
sequence = TAGGATAAAATGTCCAA

Gene: PF1946: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
*
Pyrococcus horikoshii OT3

Site:
position = -61
score = 4.94022
sequence = CGGGATAAAATATCCAT

Gene: PH0275: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
*
Thermococcus gammatolerans EJ3

Site:
position = -77
score = 5.09035
sequence = GTGGACAAAAAATCCAA

Gene: TGAM_1931: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
*
Thermococcus kodakaraensis KOD1

Site:
position = -87
score = 5.52924
sequence = CTGGACAAAATATCCAA

Gene: TK0328: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
*
Thermococcus onnurineus NA1

Site:
position = -87
score = 5.52924
sequence = CTGGACAAAATATCCAA

Gene: TON_1076: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
*
Thermococcus sibiricus MM 739

Site:
position = -87
score = 5.65647
sequence = ATGGATAAAATATCCAA

Gene: TSIB_1402: B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
B12 binding domain of Methylmalonyl-CoA mutase (EC 5.4.99.2)
 
CRON 3.
mutB_N
*
Pyrococcus abyssi GE5

Site:
position = -81
score = 5.32731
sequence = TTAGATAATTTATCCAA

Gene: PAB1800: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
*
Pyrococcus furiosus DSM 3638

Site:
position = -83
score = 4.64086
sequence = GTGGATAAAAAAGCCAG

Gene: PF1477: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
*
Pyrococcus horikoshii OT3

Site:
position = -77
score = 4.87505
sequence = TTGAACAAAATGTCCAA

Gene: PH1306: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
*
Thermococcus gammatolerans EJ3

Site:
position = -87
score = 5.34267
sequence = CTGGACTTTTTATCCAA

Gene: TGAM_1685: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
*
Thermococcus kodakaraensis KOD1

Site:
position = -89
score = 5.6419
sequence = ATGGACAATTTATCCAA

Gene: TK1149: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
*
Thermococcus onnurineus NA1

Site:
position = -88
score = 5.52924
sequence = CTGGACAATATATCCAA

Gene: TON_1110: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
*
Thermococcus sibiricus MM 739

Site:
position = -88
score = 5.52924
sequence = CTGGATAAAATGTCCAA

Gene: TSIB_0812: Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
Methylmalonyl-CoA mutase (EC 5.4.99.2), alpha subunit, N-terminal
 
CRON 4.
TON_1664
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638
 
Pyrococcus horikoshii OT3
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
*
Thermococcus onnurineus NA1

Site:
position = -29
score = 5.06159
sequence = GCGGATAAAATATCCAA

Gene: TON_1664: anion transporter
 
Thermococcus sibiricus MM 739
anion transporter
sucD
*
Pyrococcus abyssi GE5

Site:
position = -62
score = 5.6134
sequence = TTGGATATTTAATCCAA

Gene: PAB1230: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
*
Pyrococcus furiosus DSM 3638

Site:
position = -71
score = 5.6134
sequence = TTGGATATTTAATCCAA

Gene: PF0233: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
*
Pyrococcus horikoshii OT3

Site:
position = -63
score = 5.45779
sequence = TTGGATATTTAGTCCAA

Gene: PH1928: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
*
Thermococcus gammatolerans EJ3

Site:
position = -67
score = 5.51298
sequence = ATGGATAAAATATCCAT

Gene: TGAM_0218: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
*
Thermococcus kodakaraensis KOD1

Site:
position = -69
score = 5.18538
sequence = ATGGATATAAAATCCAT

Gene: TK1880: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
 
Thermococcus onnurineus NA1

Gene: TON_1665: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
 
Thermococcus sibiricus MM 739

Gene: TSIB_1965: Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
Archaeal succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
 
CRON 5.
cobS
 
Pyrococcus abyssi GE5

Gene: PAB2320: Cobalamin-5-phosphate synthase
*2
Pyrococcus furiosus DSM 3638

Gene: PF0837: Cobalamin-5-phosphate synthase

Site:
position = -25
score = 5.14933
sequence = TTGGATTAATTAGCCAG

Gene: PF0836: Cobalamin-5-phosphate synthase
 
Pyrococcus horikoshii OT3

Gene: PH0373: Cobalamin-5-phosphate synthase
 
Thermococcus gammatolerans EJ3

Gene: TGAM_0538: Cobalamin-5-phosphate synthase
 
Thermococcus kodakaraensis KOD1

Gene: TK0857: Cobalamin-5-phosphate synthase
 
Thermococcus onnurineus NA1

Gene: TON_0684: Cobalamin-5-phosphate synthase
 
Thermococcus sibiricus MM 739
Cobalamin-5-phosphate synthase
PAB7298
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638

Gene: PF0838: Function Code: 16.1 Conserved Hypothetical
 
Pyrococcus horikoshii OT3
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739
hypothetical protein
PF0839
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638

Gene: PF0839: Function Code: 16.1 Conserved Hypothetical
 
Pyrococcus horikoshii OT3
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739
Function Code: 16.1 Conserved Hypothetical
cobY
 
Pyrococcus abyssi GE5

Gene: PAB2323: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
 2
Pyrococcus furiosus DSM 3638

Gene: PF0841: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)

Gene: PF0840: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
 
Pyrococcus horikoshii OT3

Gene: PH0372: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1

Gene: TK0856: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
 
Thermococcus onnurineus NA1

Gene: TON_0686: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
 
Thermococcus sibiricus MM 739

Gene: TSIB_2027: Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
Adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62)
PF0841.1n
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638

Gene: PF0841.1n: hypothetical protein
 
Pyrococcus horikoshii OT3
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739
hypothetical protein
PAB3017
 
Pyrococcus abyssi GE5

Gene: PAB3017: hypothetical protein
 
Pyrococcus furiosus DSM 3638
 
Pyrococcus horikoshii OT3

Gene: PH0373.1n: hypothetical protein
 
Thermococcus gammatolerans EJ3
*
Thermococcus kodakaraensis KOD1

Site:
position = -42
score = 5.05018
sequence = ATGGATAAAAACTCCAT

Gene: TK0862: hypothetical protein
*
Thermococcus onnurineus NA1

Site:
position = -41
score = 4.6169
sequence = AAGGATAAAACATCCAA

Gene: TON_0681: hypothetical protein
 
Thermococcus sibiricus MM 739
hypothetical protein
PH0375
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638
*
Pyrococcus horikoshii OT3

Site:
position = -41
score = 5.05018
sequence = ATGGATAAAAACTCCAT

Gene: PH0375: conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
 
Thermococcus gammatolerans EJ3
 
Thermococcus kodakaraensis KOD1

Gene: TK0861: conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
 
Thermococcus onnurineus NA1

Gene: TON_0682: conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
 
Thermococcus sibiricus MM 739
conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
TGAM_0541
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638
 
Pyrococcus horikoshii OT3
 
Thermococcus gammatolerans EJ3

Gene: TGAM_0541: hypothetical protein
 
Thermococcus kodakaraensis KOD1

Gene: TK0860: hypothetical protein
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739
hypothetical protein
TGAM_0540
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638
 
Pyrococcus horikoshii OT3
 
Thermococcus gammatolerans EJ3

Gene: TGAM_0540: hypothetical protein
 
Thermococcus kodakaraensis KOD1

Gene: TK0859: hypothetical protein
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739
hypothetical protein
cobZ
*
Pyrococcus abyssi GE5

Site:
position = -48
score = 4.98725
sequence = TTGGATAAAAGCTCCAA

Gene: PAB2319: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
 
Pyrococcus furiosus DSM 3638

Gene: PF0294: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
 
Pyrococcus horikoshii OT3

Gene: PH0374: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
 
Thermococcus gammatolerans EJ3

Gene: TGAM_0539: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
 
Thermococcus kodakaraensis KOD1

Gene: TK0858: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
 
Thermococcus onnurineus NA1

Gene: TON_0683: Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
 
Thermococcus sibiricus MM 739
Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73)
PAB0415
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638

Gene: PF0295: conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
 
Pyrococcus horikoshii OT3
*
Thermococcus gammatolerans EJ3

Site:
position = -41
score = 4.84376
sequence = ATGGATAAAAGCTCCAA

Gene: TGAM_0542: N-type ATP pyrophosphatase, putative
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1
 
Thermococcus sibiricus MM 739
conserved hypothetical protein [Pyrococcus horikoshii]; COG2102: Predicted ATPases of PP-loop superfamily; IPR002761: Domain of unknown function DUF71
cbiB
*
Pyrococcus abyssi GE5

Site:
position = -31
score = 4.98725
sequence = TTGGAGCTTTTATCCAA

Gene: PAB0025: Adenosylcobinamide-phosphate synthase
*
Pyrococcus furiosus DSM 3638

Site:
position = -19
score = 5.06159
sequence = GCGGATAAAATATCCAA

Gene: PF0296: Adenosylcobinamide-phosphate synthase
*
Pyrococcus horikoshii OT3

Site:
position = -23
score = 5.05018
sequence = ATGGAGTTTTTATCCAT

Gene: PH0376: Adenosylcobinamide-phosphate synthase
 
Thermococcus gammatolerans EJ3

Gene: TGAM_0544: Adenosylcobinamide-phosphate synthase
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1

Gene: TON_0679: Adenosylcobinamide-phosphate synthase
 
Thermococcus sibiricus MM 739
Adenosylcobinamide-phosphate synthase
cobD
 
Pyrococcus abyssi GE5

Gene: PAB0026: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
 
Pyrococcus furiosus DSM 3638

Gene: PF0293: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
 
Pyrococcus horikoshii OT3

Gene: PH0377: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
 
Thermococcus gammatolerans EJ3

Gene: TGAM_0545: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
 
Thermococcus kodakaraensis KOD1
 
Thermococcus onnurineus NA1

Gene: TON_0678: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
 
Thermococcus sibiricus MM 739
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
TGAM_0543
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638
 
Pyrococcus horikoshii OT3
*
Thermococcus gammatolerans EJ3

Site:
position = 0
score = 4.84376
sequence = TTGGAGCTTTTATCCAT

Gene: TGAM_0543: Uracil-DNA glycosylase superfamily protein
 
Thermococcus kodakaraensis KOD1
*
Thermococcus onnurineus NA1

Site:
position = -18
score = 4.6169
sequence = TTGGATGTTTTATCCTT

Gene: TON_0680: Uracil-DNA glycosylase superfamily protein
 
Thermococcus sibiricus MM 739
Uracil-DNA glycosylase superfamily protein
btuF
*
Pyrococcus abyssi GE5

Site:
position = -30
score = 4.83212
sequence = CTGGACGAATAATCCAG

Gene: PAB0349: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Pyrococcus furiosus DSM 3638

Site:
position = -29
score = 5.21796
sequence = TTGGATGATTAATCCAA

Site:
position = -72
score = 5.6134
sequence = TTGGATTTTTTATCCAA

Gene: PF1774: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Pyrococcus horikoshii OT3

Site:
position = -74
score = 5.3143
sequence = TTGGACTTTTTATCCAT

Site:
position = -29
score = 5.06235
sequence = TTGGACGAATAATCCAA

Gene: PH1659: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Thermococcus gammatolerans EJ3

Site:
position = -17
score = 5.36859
sequence = CTGGACAATTAATCCAG

Site:
position = -65
score = 4.96684
sequence = TTGGACGTTATATCCAA

Gene: TGAM_0480: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Thermococcus kodakaraensis KOD1

Site:
position = -26
score = 4.99766
sequence = CCGGACAAATAATCCAG

Site:
position = -73
score = 4.61789
sequence = TTGGCCGTTTTATCCAA

Gene: TK0865: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Thermococcus onnurineus NA1

Site:
position = -73
score = 5.01088
sequence = ATGGCCAAAATATCCAA

Site:
position = -26
score = 5.34022
sequence = ATGGACAAATAATCCAG

Gene: TON_0546: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Thermococcus sibiricus MM 739

Site:
position = 56
score = 5.64436
sequence = TTGGACAAAATATCCAA

Gene: TSIB_1577: Vitamin B12 ABC transporter, B12-binding component BtuF
Vitamin B12 ABC transporter, B12-binding component BtuF
 
CRON 6.
nrdD
*
Pyrococcus abyssi GE5

Site:
position = 58
score = 5.47236
sequence = TTGGATTTAATATCCAA

Gene: PAB2337: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
*
Pyrococcus furiosus DSM 3638

Site:
position = -99
score = 5.16649
sequence = ATGGATATTTTAGCCAA

Site:
position = -29
score = 5.64436
sequence = TTGGACAAAATATCCAA

Gene: PF1971: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
*
Pyrococcus horikoshii OT3

Site:
position = -28
score = 5.64436
sequence = TTGGACAAAATATCCAA

Site:
position = -99
score = 5.79996
sequence = TTGGATATTTTATCCAA

Gene: PH0021: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
*
Thermococcus gammatolerans EJ3

Site:
position = -17
score = 5.82589
sequence = TTGGATAATTTATCCAG

Gene: TGAM_0161: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
*
Thermococcus kodakaraensis KOD1

Site:
position = -35
score = 5.82589
sequence = TTGGATAAATTATCCAG

Site:
position = -127
score = 5.941
sequence = TTGGATAATTTATCCAA

Gene: TK2298: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
*
Thermococcus onnurineus NA1

Site:
position = -27
score = 5.82589
sequence = TTGGATAAATTATCCAG

Gene: TON_1870: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
 
Thermococcus sibiricus MM 739
Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG
 
Pyrococcus abyssi GE5

Gene: PAB2338: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
 
Pyrococcus furiosus DSM 3638

Gene: PF1972: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
 
Pyrococcus horikoshii OT3

Gene: PH0020: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
 
Thermococcus gammatolerans EJ3

Gene: TGAM_0160: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
 
Thermococcus kodakaraensis KOD1

Gene: TK2299: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
 
Thermococcus onnurineus NA1

Gene: TON_1871: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
 
Thermococcus sibiricus MM 739
Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
 
CRON 7.
cobT
*
Pyrococcus abyssi GE5

Site:
position = -27
score = 4.98725
sequence = TTGGATAAAACCTCCAA

Gene: PAB2326: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
*
Pyrococcus furiosus DSM 3638

Site:
position = -27
score = 5.32641
sequence = ATGGATAAAAAATCCAT

Gene: PF0303: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
*
Pyrococcus horikoshii OT3

Site:
position = -19
score = 5.04355
sequence = TTGGACAAAATTTCCAT

Gene: PH0034: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
*
Thermococcus gammatolerans EJ3

Site:
position = -27
score = 4.85461
sequence = CTGGATAAAAACTCCAC

Gene: TGAM_0534: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
*
Thermococcus kodakaraensis KOD1

Site:
position = -27
score = 4.97523
sequence = CTGGATAAAAAGTCCAC

Gene: TK0853: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
*
Thermococcus onnurineus NA1

Site:
position = -27
score = 4.84376
sequence = TTGGATAAAACCTCCAT

Gene: TON_0688: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
 
Thermococcus sibiricus MM 739
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
 
CRON 8.
btuC
*
Pyrococcus abyssi GE5

Site:
position = -19
score = 4.99803
sequence = ATGGAATATTTGTCCAA

Gene: PAB1535: Vitamin B12 ABC transporter, permease component BtuC
*
Pyrococcus furiosus DSM 3638

Site:
position = -19
score = 4.65153
sequence = TTGGCATATTTGTCCAA

Gene: PF0503: Vitamin B12 ABC transporter, permease component BtuC
*
Pyrococcus horikoshii OT3

Site:
position = -20
score = 4.4397
sequence = GTGGCATATTTATCCAA

Gene: PH0790: Vitamin B12 ABC transporter, permease component BtuC
*
Thermococcus gammatolerans EJ3

Site:
position = -20
score = 4.95132
sequence = CTGGACAAAAACTCCAG

Gene: TGAM_2054: Vitamin B12 ABC transporter, permease component BtuC
*
Thermococcus kodakaraensis KOD1

Site:
position = -20
score = 5.07195
sequence = CTGGACAAAAAGTCCAG

Gene: TK2209: Vitamin B12 ABC transporter, permease component BtuC
*
Thermococcus onnurineus NA1

Site:
position = -21
score = 4.86394
sequence = GTGGACAAATAATCCAC

Gene: TON_1424: Vitamin B12 ABC transporter, permease component BtuC
*
Thermococcus sibiricus MM 739

Site:
position = -24
score = 5.63932
sequence = TTGGATAAATAATCCAG

Gene: TSIB_1460: Vitamin B12 ABC transporter, permease component BtuC
Vitamin B12 ABC transporter, permease component BtuC
btuD
 
Pyrococcus abyssi GE5

Gene: PAB1536: Vitamin B12 ABC transporter, ATPase component BtuD
 
Pyrococcus furiosus DSM 3638

Gene: PF0502: Vitamin B12 ABC transporter, ATPase component BtuD
 
Pyrococcus horikoshii OT3

Gene: PH0791: Vitamin B12 ABC transporter, ATPase component BtuD
 
Thermococcus gammatolerans EJ3

Gene: TGAM_2053: Vitamin B12 ABC transporter, ATPase component BtuD
 
Thermococcus kodakaraensis KOD1

Gene: TK2208: Vitamin B12 ABC transporter, ATPase component BtuD
 
Thermococcus onnurineus NA1

Gene: TON_1425: Vitamin B12 ABC transporter, ATPase component BtuD
 
Thermococcus sibiricus MM 739

Gene: TSIB_1459: Vitamin B12 ABC transporter, ATPase component BtuD
Vitamin B12 ABC transporter, ATPase component BtuD
 
CRON 9.
nrdJ
 
Pyrococcus abyssi GE5

Gene: PAB1057: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
 
Pyrococcus furiosus DSM 3638

Gene: PF0440: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
 
Pyrococcus horikoshii OT3

Gene: PH0363: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
*
Thermococcus gammatolerans EJ3

Site:
position = -187
score = 5.27096
sequence = ATGGACAAATTATCCGA

Gene: TGAM_0422: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
*
Thermococcus kodakaraensis KOD1

Site:
position = -198
score = 4.99031
sequence = ATGGATAATTCGTCCAG

Gene: TK1736: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
*
Thermococcus onnurineus NA1

Site:
position = -186
score = 5.41445
sequence = TTGGATAATTTGTCCGA

Gene: TON_1816: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
*
Thermococcus sibiricus MM 739

Site:
position = -185
score = 5.42903
sequence = TTGGATAAAATATCCGA

Gene: TSIB_1142: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing
 
CRON 10.
btuR
 
Pyrococcus abyssi GE5

Gene: PAB2289: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
 
Pyrococcus furiosus DSM 3638

Gene: PF2038: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
 
Pyrococcus horikoshii OT3

Gene: PH0075: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
*
Thermococcus gammatolerans EJ3

Site:
position = -27
score = 4.9848
sequence = TTGGAGGATTTATCCAT

Gene: TGAM_0096: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
*
Thermococcus kodakaraensis KOD1

Site:
position = -28
score = 5.11197
sequence = CTGGAGATTATGTCCAA

Gene: TK2130: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
*
Thermococcus onnurineus NA1

Site:
position = -31
score = 4.41015
sequence = CTGGCGATTATATCCAC

Gene: TON_1529: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
 
Thermococcus sibiricus MM 739

Gene: TSIB_0909: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
 
CRON 11.
cbiP
 
Pyrococcus abyssi GE5
 
Pyrococcus furiosus DSM 3638

Gene: PF0301: Cobyrinic acid ac-diamide synthase
 
Pyrococcus horikoshii OT3
*
Thermococcus gammatolerans EJ3

Site:
position = -44
score = 4.85461
sequence = GTGGAGTTTTTATCCAG

Gene: TGAM_0535: Cobyrinic acid ac-diamide synthase
 
Thermococcus kodakaraensis KOD1

Gene: TK0854: Cobyrinic acid ac-diamide synthase
*
Thermococcus onnurineus NA1

Site:
position = -58
score = 4.84376
sequence = ATGGAGGTTTTATCCAA

Gene: TON_0687: Cobyrinic acid ac-diamide synthase
 
Thermococcus sibiricus MM 739
Cobyrinic acid ac-diamide synthase
 
CRON 12.
mmdA
 
Pyrococcus abyssi GE5

Gene: PAB1769: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
 
Pyrococcus furiosus DSM 3638

Gene: PF0671: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
 
Pyrococcus horikoshii OT3

Gene: PH1287: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
*
Thermococcus gammatolerans EJ3

Site:
position = -98
score = 5.05051
sequence = GTGGACAAATTATCCAC

Gene: TGAM_2026: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
 
Thermococcus kodakaraensis KOD1

Gene: TK1622: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
 
Thermococcus onnurineus NA1

Gene: TON_0041: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
 
Thermococcus sibiricus MM 739

Gene: TSIB_1534: Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
Methylmalonyl-CoA decarboxylase, alpha chain (EC 4.1.1.41)
mmdD
 
Pyrococcus abyssi GE5

Gene: PAB1770: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
 
Pyrococcus furiosus DSM 3638

Gene: PF0672: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
 
Pyrococcus horikoshii OT3

Gene: PH1285: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
 
Thermococcus gammatolerans EJ3

Gene: TGAM_2027: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
 
Thermococcus kodakaraensis KOD1

Gene: TK1623: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
 
Thermococcus onnurineus NA1

Gene: TON_0040: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
 
Thermococcus sibiricus MM 739

Gene: TSIB_1535: Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
Methylmalonyl-CoA decarboxylase, gamma chain (EC 4.1.1.41)
mmdC
 
Pyrococcus abyssi GE5

Gene: PAB1771: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
 
Pyrococcus furiosus DSM 3638

Gene: PF0673: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
 
Pyrococcus horikoshii OT3

Gene: PH1284: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
 
Thermococcus gammatolerans EJ3

Gene: TGAM_2028: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
 
Thermococcus kodakaraensis KOD1

Gene: TK1624: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
 
Thermococcus onnurineus NA1

Gene: TON_0039: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
 
Thermococcus sibiricus MM 739

Gene: TSIB_1536: Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
Biotin carboxyl carrier protein of methylmalonyl-CoA decarboxylase
mmdB
 
Pyrococcus abyssi GE5

Gene: PAB1772: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)
 
Pyrococcus furiosus DSM 3638

Gene: PF0674: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)
 
Pyrococcus horikoshii OT3

Gene: PH1283: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)
 
Thermococcus gammatolerans EJ3

Gene: TGAM_2029: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)
 
Thermococcus kodakaraensis KOD1

Gene: TK1625: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)
 
Thermococcus onnurineus NA1

Gene: TON_0038: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)
 
Thermococcus sibiricus MM 739

Gene: TSIB_1537: Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)
Methylmalonyl-CoA decarboxylase, beta chain (EC 4.1.1.41)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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