Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog LexA - Streptomycetaceae

Properties
Regulator type: Transcription factor
Regulator family: LexA
Regulation mode: repressor
Biological process: SOS response
Effector: DNA damage
Phylum: Actinobacteria
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 26 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Streptomyces avermitilis MA-4680 8 6
Streptomyces coelicolor A3(2) 10 8
Streptomyces griseus subsp. griseus NBRC 13350 6 5
Streptomyces scabiei 87.22 7 5
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
uvrA
*
Streptomyces avermitilis MA-4680

Site:
position = -166
score = 4.81317
sequence = TCGAATGCGCGTGCTA

Gene: SAV_6286: Excinuclease ABC, subunit A
*
Streptomyces coelicolor A3(2)

Site:
position = -164
score = 4.75442
sequence = TCGAATGCACGTGCTA

Gene: SCO1958: Excinuclease ABC, subunit A
*2
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_704: Excinuclease ABC, subunit A

Site:
position = -117
score = 4.75442
sequence = TCGAATGTGCGTGCTA

Gene: SGR_5564: Excinuclease ABC, subunit A
*
Streptomyces scabiei 87.22

Site:
position = -166
score = 4.75442
sequence = TCGAATGCACGTGCTA

Gene: SCAB_69561: Excinuclease ABC, subunit A
Excinuclease ABC, subunit A
 
CRON 2.
gyrB
*
Streptomyces avermitilis MA-4680

Site:
position = -151
score = 4.66519
sequence = TCGAACGCTCGTACGA

Gene: SAV_2442: Topoisomerase IV, subunit B (EC 5.99.1.-)
*
Streptomyces coelicolor A3(2)

Site:
position = -152
score = 4.85869
sequence = TCGAACAGGCATGCGA

Gene: SCO5822: Topoisomerase IV, subunit B (EC 5.99.1.-)
*2
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_908: Topoisomerase IV, subunit B (EC 5.99.1.-)

Site:
position = -163
score = 4.79995
sequence = TCGAACATCCATGCGA

Gene: SGR_1698: Topoisomerase IV, subunit B (EC 5.99.1.-)
*
Streptomyces scabiei 87.22

Site:
position = -153
score = 5.11227
sequence = TCGAACGCGTATGCGA

Gene: SCAB_24391: Topoisomerase IV, subunit B (EC 5.99.1.-)
Topoisomerase IV, subunit B (EC 5.99.1.-)
 
CRON 3.
lexA
*
Streptomyces avermitilis MA-4680

Site:
position = -75
score = 4.78391
sequence = TCGAACGTGTGTTTGG

Gene: SAV_2463: SOS-response repressor and protease LexA (EC 3.4.21.88)
*
Streptomyces coelicolor A3(2)

Site:
position = -150
score = 4.78391
sequence = TCGAACGTGTGTTTGG

Gene: SCO5803: SOS-response repressor and protease LexA (EC 3.4.21.88)
*
Streptomyces griseus subsp. griseus NBRC 13350

Site:
position = -77
score = 4.78391
sequence = TCGAACGTGTGTTTGG

Gene: SGR_1717: SOS-response repressor and protease LexA (EC 3.4.21.88)
*
Streptomyces scabiei 87.22

Site:
position = -76
score = 4.78391
sequence = TCGAACGTGTGTTTGG

Gene: SCAB_24651: SOS-response repressor and protease LexA (EC 3.4.21.88)
SOS-response repressor and protease LexA (EC 3.4.21.88)
 
CRON 4.
dnaE2
*
Streptomyces avermitilis MA-4680

Site:
position = -106
score = 3.9318
sequence = TCGTACAGCAGTTCGA

Site:
position = -62
score = 4.60268
sequence = TTGAACAGATGTTCGA

Gene: SAV_6555: DNA polymerase III alpha subunit (EC 2.7.7.7)
*
Streptomyces coelicolor A3(2)

Site:
position = -116
score = 5.05353
sequence = TCGCACACACATTCGA

Site:
position = -72
score = 3.86015
sequence = GGGAACAGACGTTCGA

Gene: SCO1739: DNA polymerase III alpha subunit (EC 2.7.7.7)
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_6691: DNA polymerase III alpha subunit (EC 2.7.7.7)
*
Streptomyces scabiei 87.22

Site:
position = -114
score = 4.12663
sequence = TCGTACAGAAGTTCGA

Gene: SCAB_72281: DNA polymerase III alpha subunit (EC 2.7.7.7)
DNA polymerase III alpha subunit (EC 2.7.7.7)
dinP
 
Streptomyces avermitilis MA-4680

Gene: SAV_6556: DNA polymerase IV (EC 2.7.7.7)
*3
Streptomyces coelicolor A3(2)

Site:
position = -27
score = 4.44117
sequence = TCGAATTCCTGTTCGA

Gene: SCP1.321 (deprecated): DNA polymerase IV (EC 2.7.7.7)

Gene: SCO1738: DNA polymerase IV (EC 2.7.7.7)

Site:
position = -27
score = 4.44117
sequence = TCGAATTCCTGTTCGA

Gene: SCP1.33c (deprecated): DNA polymerase IV (EC 2.7.7.7)
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_6692: DNA polymerase IV (EC 2.7.7.7)
 
Streptomyces scabiei 87.22

Gene: SCAB_72291: DNA polymerase IV (EC 2.7.7.7)
DNA polymerase IV (EC 2.7.7.7)
 
CRON 5.
alkB
*
Streptomyces avermitilis MA-4680

Site:
position = -37
score = 4.12499
sequence = TAGAACAGATCTTCGA

Gene: SAV_1131: DNA repair system specific for alkylated DNA
*
Streptomyces coelicolor A3(2)

Site:
position = -36
score = 4.17568
sequence = TAGAACAGACTTTCGA

Gene: SCO7302: DNA repair system specific for alkylated DNA
*
Streptomyces griseus subsp. griseus NBRC 13350

Site:
position = -35
score = 4.68379
sequence = TCGCACACATGCTCGA

Gene: SGR_1536: DNA repair system specific for alkylated DNA
 
Streptomyces scabiei 87.22

Gene: SCAB_85711: DNA repair system specific for alkylated DNA
DNA repair system specific for alkylated DNA
 
CRON 6.
recA
*
Streptomyces avermitilis MA-4680

Site:
position = -178
score = 3.96004
sequence = TCGAACATCCATTCTT

Gene: SAV_2492: Recombinase A
*
Streptomyces coelicolor A3(2)

Site:
position = -178
score = 3.96004
sequence = TCGAACATCCATTCTT

Gene: SCO5769: Recombinase A
*
Streptomyces griseus subsp. griseus NBRC 13350

Site:
position = -154
score = 4.29513
sequence = TCGAACATCCATTCTG

Gene: SGR_1745: Recombinase A
*
Streptomyces scabiei 87.22

Site:
position = -178
score = 3.96004
sequence = TCGAACATCCATTCTT

Gene: SCAB_24951: Recombinase A
Recombinase A
recX
 
Streptomyces avermitilis MA-4680

Gene: SAV_2491: Regulatory protein RecX
 
Streptomyces coelicolor A3(2)

Gene: SCO5770: Regulatory protein RecX
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_1744: Regulatory protein RecX
 
Streptomyces scabiei 87.22

Gene: SCAB_24941: Regulatory protein RecX
Regulatory protein RecX
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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