Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog LexA - Frankineae/Propionibacterineae/Pseudonocardiaceae

Properties
Regulator type: Transcription factor
Regulator family: LexA
Regulation mode: repressor
Biological process: SOS response
Effector: DNA damage
Phylum: Actinobacteria
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 68 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Frankia sp. CcI3 12 8
Frankia sp. EAN1pec 13 9
Nakamurella multipartita DSM 44233 9 6
Acidothermus cellulolyticus 11B 8 5
Nocardioides sp. JS614 8 5
Propionibacterium acnes KPA171202 2 1
Actinosynnema mirum DSM 43827 12 8
Saccharomonospora viridis DSM 43017 9 5
Saccharopolyspora erythraea NRRL 2338 6 4
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
ruvC
*
Frankia sp. CcI3

Site:
position = -40
score = 4.52504
sequence = TCGAACGAATGTTCTT

Gene: Francci3_1369: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
*
Frankia sp. EAN1pec

Site:
position = -37
score = 5.3571
sequence = TCGAACGGATGTTCGT

Gene: Franean1_5146: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
*
Nakamurella multipartita DSM 44233

Site:
position = -85
score = 4.04182
sequence = CTGGACAGGTGTTCGC

Gene: Namu_3396: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
*
Acidothermus cellulolyticus 11B

Site:
position = 15
score = 5.52401
sequence = CCGAACATGCGTTCGA

Gene: Acel_1345: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
*
Nocardioides sp. JS614

Site:
position = -31
score = 5.42347
sequence = CCGAACACCTGTTCGG

Gene: Noca_2385: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
 
Propionibacterium acnes KPA171202

Gene: PPA1158: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
*
Actinosynnema mirum DSM 43827

Site:
position = -58
score = 5.00898
sequence = TCGAACTGGTGTTCGC

Gene: Amir_1692: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
*
Saccharomonospora viridis DSM 43017

Site:
position = -33
score = 5.00898
sequence = TCGAACTGGTGTTCGC

Gene: Svir_15060: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
*
Saccharopolyspora erythraea NRRL 2338

Site:
position = -37
score = 5.05181
sequence = TCGAACGCGTGTTCAG

Gene: SACE_2021: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
ruvA
 
Frankia sp. CcI3

Gene: Francci3_1370: Holliday junction DNA helicase RuvA
 
Frankia sp. EAN1pec

Gene: Franean1_5145: Holliday junction DNA helicase RuvA
 
Nakamurella multipartita DSM 44233

Gene: Namu_3395: Holliday junction DNA helicase RuvA
 
Acidothermus cellulolyticus 11B

Gene: Acel_1344: Holliday junction DNA helicase RuvA
 
Nocardioides sp. JS614

Gene: Noca_2386: Holliday junction DNA helicase RuvA
 
Propionibacterium acnes KPA171202

Gene: PPA1159: Holliday junction DNA helicase RuvA
 
Actinosynnema mirum DSM 43827

Gene: Amir_1691: Holliday junction DNA helicase RuvA
 
Saccharomonospora viridis DSM 43017

Gene: Svir_15070: Holliday junction DNA helicase RuvA
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_2022: Holliday junction DNA helicase RuvA
Holliday junction DNA helicase RuvA
ruvB
 
Frankia sp. CcI3

Gene: Francci3_1371: Holliday junction DNA helicase RuvB
 
Frankia sp. EAN1pec

Gene: Franean1_5144: Holliday junction DNA helicase RuvB
 
Nakamurella multipartita DSM 44233

Gene: Namu_3394: Holliday junction DNA helicase RuvB
 
Acidothermus cellulolyticus 11B

Gene: Acel_1343: Holliday junction DNA helicase RuvB
 
Nocardioides sp. JS614

Gene: Noca_2387: Holliday junction DNA helicase RuvB
 
Propionibacterium acnes KPA171202

Gene: PPA1160: Holliday junction DNA helicase RuvB
 
Actinosynnema mirum DSM 43827

Gene: Amir_1690: Holliday junction DNA helicase RuvB
 
Saccharomonospora viridis DSM 43017

Gene: Svir_15080: Holliday junction DNA helicase RuvB
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_2023: Holliday junction DNA helicase RuvB
Holliday junction DNA helicase RuvB
 
CRON 2.
lexA
*
Frankia sp. CcI3

Site:
position = -198
score = 5.38324
sequence = TCGAACAGACGTTTGA

Site:
position = -251
score = 5.25263
sequence = TCGAACGCGTGGTCGA

Site:
position = -267
score = 5.00596
sequence = TCGAACCTTCGTTCGA

Gene: Francci3_3510: SOS-response repressor and protease LexA (EC 3.4.21.88)
*
Frankia sp. EAN1pec

Site:
position = -298
score = 4.90907
sequence = TCGAACGCCTGAGCGA

Site:
position = -244
score = 5.38324
sequence = TCGAACAGACGTTTGA

Gene: Franean1_1232: SOS-response repressor and protease LexA (EC 3.4.21.88)
*
Nakamurella multipartita DSM 44233

Site:
position = -202
score = 5.08489
sequence = TCGAACGGACGTTCTA

Site:
position = -186
score = 4.43881
sequence = TCGAACGTCTGCACGA

Site:
position = -123
score = 5.49247
sequence = TCGAACGGGTGTTTGA

Gene: Namu_3979: SOS-response repressor and protease LexA (EC 3.4.21.88)
*
Acidothermus cellulolyticus 11B

Site:
position = -106
score = 5.12966
sequence = TCGAACTGGTGTTTGA

Site:
position = -161
score = 5.28686
sequence = TCGAACGGGTGTACGA

Site:
position = -177
score = 5.89309
sequence = TCGAACACGCGTTCGA

Gene: Acel_1479: SOS-response repressor and protease LexA (EC 3.4.21.88)
*
Nocardioides sp. JS614

Site:
position = -47
score = 5.57628
sequence = TCGAACAGGTGTTTGA

Gene: Noca_3817: SOS-response repressor and protease LexA (EC 3.4.21.88)
 
Propionibacterium acnes KPA171202
*2
Actinosynnema mirum DSM 43827

Site:
position = -157
score = 3.75798
sequence = ACGACCTCGTGCTCGA

Gene: Amir_3974: SOS-response repressor and protease LexA (EC 3.4.21.88)

Site:
position = -184
score = 5.575
sequence = TCGAACAACCGTTCGA

Site:
position = -168
score = 5.28722
sequence = TCGAACGCCCGTGCGA

Site:
position = -103
score = 5.57628
sequence = TCGAACAGGTGTTTGA

Gene: Amir_1434: SOS-response repressor and protease LexA (EC 3.4.21.88)
*
Saccharomonospora viridis DSM 43017

Site:
position = -102
score = 5.13261
sequence = TCGAACAAACGTTTGA

Site:
position = -165
score = 5.37103
sequence = TCGAACACCCGTGCGA

Gene: Svir_27590: SOS-response repressor and protease LexA (EC 3.4.21.88)
*2
Saccharopolyspora erythraea NRRL 2338

Site:
position = -98
score = 5.57628
sequence = TCGAACAGGTGTTTGA

Site:
position = -164
score = 4.80198
sequence = TCGAACCTGCGTGCGA

Site:
position = -180
score = 5.09884
sequence = TCGAATGGATGTTCGA

Gene: SACE_1760: SOS-response repressor and protease LexA (EC 3.4.21.88)

Gene: SACE_2836: SOS-response repressor and protease LexA (EC 3.4.21.88)
SOS-response repressor and protease LexA (EC 3.4.21.88)
 
CRON 3.
recA
*
Frankia sp. CcI3

Site:
position = -139
score = 5.39083
sequence = TCGAACGCATGTTCGT

Gene: Francci3_3525: Recombinase A
*2
Frankia sp. EAN1pec

Site:
position = -138
score = 5.49028
sequence = TCGAACGGATGTTCGG

Gene: Franean1_1219: Recombinase A

Site:
position = -142
score = 5.23965
sequence = TCGAACGAATGTTCGG

Gene: Franean1_6708: Recombinase A
*
Nakamurella multipartita DSM 44233

Site:
position = -132
score = 4.97764
sequence = TCGAACAGGTGTACGT

Site:
position = -284
score = 3.92661
sequence = TCGATCAGGCGCTGGA

Gene: Namu_3994: Recombinase A
*
Acidothermus cellulolyticus 11B

Site:
position = -142
score = 5.57408
sequence = TCGAACATCTGTTCGG

Gene: Acel_1492: Recombinase A
*
Nocardioides sp. JS614

Site:
position = -151
score = 5.68332
sequence = TCGAACAGGTGTTCGG

Gene: Noca_2341: Recombinase A
 
Propionibacterium acnes KPA171202

Gene: PPA1012: Recombinase A
*
Actinosynnema mirum DSM 43827

Site:
position = -151
score = 5.68332
sequence = TCGAACACCTGTTCGG

Site:
position = -264
score = 4.22706
sequence = CCGACCAGGCGTTGGA

Gene: Amir_1419: Recombinase A
*
Saccharomonospora viridis DSM 43017

Site:
position = -168
score = 5.68332
sequence = TCGAACAGGTGTTCGG

Gene: Svir_27820: Recombinase A
*
Saccharopolyspora erythraea NRRL 2338

Site:
position = -143
score = 5.46634
sequence = TCGAACACCCGTTCGT

Gene: SACE_1736: Recombinase A
Recombinase A
recX
 
Frankia sp. CcI3

Gene: Francci3_3524: Regulatory protein RecX
 
Frankia sp. EAN1pec

Gene: Franean1_1220: Regulatory protein RecX
 
Nakamurella multipartita DSM 44233

Gene: Namu_3993: Regulatory protein RecX
 
Acidothermus cellulolyticus 11B

Gene: Acel_1491: Regulatory protein RecX
 
Nocardioides sp. JS614

Gene: Noca_2342: Regulatory protein RecX
 
Propionibacterium acnes KPA171202

Gene: PPA1013: Regulatory protein RecX
 
Actinosynnema mirum DSM 43827

Gene: Amir_1420: Regulatory protein RecX
 
Saccharomonospora viridis DSM 43017

Gene: Svir_27810: Regulatory protein RecX
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_1737: Regulatory protein RecX
Regulatory protein RecX
 
CRON 4.
uvrA
 
Frankia sp. CcI3

Gene: Francci3_1631: Excinuclease ABC, subunit A
*
Frankia sp. EAN1pec

Site:
position = -227
score = 5.44239
sequence = TCGAACGCGCGTTTGA

Gene: Franean1_2057: Excinuclease ABC, subunit A
 
Nakamurella multipartita DSM 44233

Gene: Namu_2992: Excinuclease ABC, subunit A
 
Acidothermus cellulolyticus 11B

Gene: Acel_1109: Excinuclease ABC, subunit A
*
Nocardioides sp. JS614

Site:
position = -42
score = 5.55014
sequence = ACGAACACCTGTTCGA

Gene: Noca_2524: Excinuclease ABC, subunit A
 
Propionibacterium acnes KPA171202

Gene: PPA0807: Excinuclease ABC, subunit A
*
Actinosynnema mirum DSM 43827

Site:
position = -38
score = 5.60781
sequence = TCGAACATGTGTTCGG

Gene: Amir_5483: Excinuclease ABC, subunit A
 
Saccharomonospora viridis DSM 43017

Gene: Svir_25750: Excinuclease ABC, subunit A
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_5314: Excinuclease ABC, subunit A
Excinuclease ABC, subunit A
 
CRON 5.
PF02720
*
Frankia sp. CcI3

Site:
position = -197
score = 4.96735
sequence = CCGAACACATGGTCGA

Site:
position = 28
score = 5.60781
sequence = TCGAACACATGTTCGG

Gene: Francci3_0067: HNH endonuclease
*2
Frankia sp. EAN1pec

Gene: Franean1_4861: HNH endonuclease

Site:
position = -75
score = 3.72378
sequence = CCGTTCGGGTGTTCTG

Gene: Franean1_3452: HNH endonuclease
*
Nakamurella multipartita DSM 44233

Site:
position = -49
score = 3.95802
sequence = GTGGACACCCGTTCGG

Gene: Namu_3157: HNH endonuclease
 
Acidothermus cellulolyticus 11B
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
HNH endonuclease
 
CRON 6.
dnaB
*
Frankia sp. CcI3

Site:
position = -50
score = 5.28159
sequence = ACGAACATACGTTCGA

Gene: Francci3_4518: Replicative DNA helicase (EC 3.6.1.-)
*
Frankia sp. EAN1pec

Site:
position = -137
score = 5.75842
sequence = TCGAACATATGTTCGA

Gene: Franean1_7308: Replicative DNA helicase (EC 3.6.1.-)
*
Nakamurella multipartita DSM 44233

Site:
position = -98
score = 4.45388
sequence = CAGAACACATGTCCGA

Gene: Namu_5363: Replicative DNA helicase (EC 3.6.1.-)
 
Acidothermus cellulolyticus 11B

Gene: Acel_2083: Replicative DNA helicase (EC 3.6.1.-)
 
Nocardioides sp. JS614

Gene: Noca_4657: Replicative DNA helicase (EC 3.6.1.-)
 
Propionibacterium acnes KPA171202

Gene: PPA2244: Replicative DNA helicase (EC 3.6.1.-)
 
Actinosynnema mirum DSM 43827

Gene: Amir_7043: Replicative DNA helicase (EC 3.6.1.-)
*
Saccharomonospora viridis DSM 43017

Site:
position = -44
score = 5.85936
sequence = TCGAACAGGCGTTCGA

Gene: Svir_39470: Replicative DNA helicase (EC 3.6.1.-)
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_7347: Replicative DNA helicase (EC 3.6.1.-)
Replicative DNA helicase (EC 3.6.1.-)
 
CRON 7.
dprA
*
Frankia sp. CcI3

Site:
position = -268
score = 4.12562
sequence = CCGAGCGGGCATTCGA

Gene: Francci3_3584: DNA protecting protein DprA
*
Frankia sp. EAN1pec

Site:
position = -154
score = 4.05011
sequence = CCGACCGTGCCTTCGA

Gene: Franean1_1158: DNA protecting protein DprA
 
Nakamurella multipartita DSM 44233

Gene: Namu_3121: DNA protecting protein DprA
*
Acidothermus cellulolyticus 11B

Site:
position = -46
score = 4.27636
sequence = GCGAACACGTGGACGA

Site:
position = -151
score = 4.32766
sequence = TCGAACGCGCCTTGGA

Gene: Acel_1548: DNA protecting protein DprA
 
Nocardioides sp. JS614

Gene: Noca_3246: DNA protecting protein DprA
 
Propionibacterium acnes KPA171202

Gene: PPA1429: DNA protecting protein DprA
*
Actinosynnema mirum DSM 43827

Site:
position = -26
score = 5.75013
sequence = TCGAACAGACGTTCGA

Site:
position = -87
score = 4.18541
sequence = TCGACCACCCGGTCGT

Gene: Amir_5585: DNA protecting protein DprA
 
Saccharomonospora viridis DSM 43017

Gene: Svir_09850: DNA protecting protein DprA
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_6043: DNA protecting protein DprA
DNA protecting protein DprA
xerC
 
Frankia sp. CcI3

Gene: Francci3_3583: Site-specific DNA-tyrosine recombinase, XerC
 
Frankia sp. EAN1pec

Gene: Franean1_1159: Site-specific DNA-tyrosine recombinase, XerC
 
Nakamurella multipartita DSM 44233

Gene: Namu_3115: Site-specific DNA-tyrosine recombinase, XerC
 
Acidothermus cellulolyticus 11B

Gene: Acel_1547: Site-specific DNA-tyrosine recombinase, XerC
 
Nocardioides sp. JS614

Gene: Noca_3245: Site-specific DNA-tyrosine recombinase, XerC
 
Propionibacterium acnes KPA171202

Gene: PPA1522: Site-specific DNA-tyrosine recombinase, XerC
 
Actinosynnema mirum DSM 43827

Gene: Amir_5914: Site-specific DNA-tyrosine recombinase, XerC
 
Saccharomonospora viridis DSM 43017

Gene: Svir_09860: Site-specific DNA-tyrosine recombinase, XerC
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_6041: Site-specific DNA-tyrosine recombinase, XerC
Site-specific DNA-tyrosine recombinase, XerC
 
CRON 8.
PPA1757
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Acidothermus cellulolyticus 11B
 
Nocardioides sp. JS614
*
Propionibacterium acnes KPA171202

Site:
position = -83
score = 3.97338
sequence = TCGATCGTGGGATCGT

Gene: PPA1757: Hypothetical protein
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
Hypothetical protein
uvrD
*
Frankia sp. CcI3

Site:
position = -22
score = 4.86901
sequence = TCGAACGTACGATCGG

Gene: Francci3_0647: ATP-dependent DNA helicase II
*
Frankia sp. EAN1pec

Site:
position = -22
score = 5.12886
sequence = TCGAACGTACGATCGA

Gene: Franean1_5987: ATP-dependent DNA helicase II
*
Nakamurella multipartita DSM 44233

Site:
position = -77
score = 5.22136
sequence = CCGAACAGGTGATCGA

Gene: Namu_1258: ATP-dependent DNA helicase II
*
Acidothermus cellulolyticus 11B

Site:
position = 29
score = 3.6491
sequence = CCGGCCACGTGATCGT

Gene: Acel_0375: ATP-dependent DNA helicase II
*
Nocardioides sp. JS614

Site:
position = -289
score = 4.29323
sequence = CCGACAACCTGTTCGA

Gene: Noca_3593: ATP-dependent DNA helicase II
 
Propionibacterium acnes KPA171202

Gene: PPA1756: ATP-dependent DNA helicase II
 
Actinosynnema mirum DSM 43827

Gene: Amir_6513: ATP-dependent DNA helicase II
 
Saccharomonospora viridis DSM 43017

Gene: Svir_04890: ATP-dependent DNA helicase II
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_6681: ATP-dependent DNA helicase II
ATP-dependent DNA helicase II
 
CRON 9.
gyrB
 
Frankia sp. CcI3

Gene: Francci3_1761: Topoisomerase IV, subunit B (EC 5.99.1.-)
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Acidothermus cellulolyticus 11B

Gene: Acel_1427: Topoisomerase IV, subunit B (EC 5.99.1.-)
 
Nocardioides sp. JS614

Gene: Noca_2958: Topoisomerase IV, subunit B (EC 5.99.1.-)
 
Propionibacterium acnes KPA171202

Gene: PPA1042: Topoisomerase IV, subunit B (EC 5.99.1.-)
*
Actinosynnema mirum DSM 43827

Site:
position = -100
score = 5.5262
sequence = TCGAACGCGTGTTTGA

Gene: Amir_2280: Topoisomerase IV, subunit B (EC 5.99.1.-)
*
Saccharomonospora viridis DSM 43017

Site:
position = -24
score = 4.62435
sequence = TCGAACAGTTGACCGA

Gene: Svir_08220: Topoisomerase IV, subunit B (EC 5.99.1.-)
 
Saccharopolyspora erythraea NRRL 2338
Topoisomerase IV, subunit B (EC 5.99.1.-)
gyrA
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Acidothermus cellulolyticus 11B

Gene: Acel_1422: Topoisomerase IV, subunit A (EC 5.99.1.-)
 
Nocardioides sp. JS614

Gene: Noca_2949: Topoisomerase IV, subunit A (EC 5.99.1.-)
 
Propionibacterium acnes KPA171202

Gene: PPA1045: Topoisomerase IV, subunit A (EC 5.99.1.-)
 
Actinosynnema mirum DSM 43827

Gene: Amir_2281: Topoisomerase IV, subunit A (EC 5.99.1.-)
 
Saccharomonospora viridis DSM 43017

Gene: Svir_08230: Topoisomerase IV, subunit A (EC 5.99.1.-)
 
Saccharopolyspora erythraea NRRL 2338
Topoisomerase IV, subunit A (EC 5.99.1.-)
 
CRON 10.
hsdR
*
Frankia sp. CcI3

Site:
position = -233
score = 3.73751
sequence = GAGAACGGCAGTACGA

Gene: Francci3_0194: Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Acidothermus cellulolyticus 11B
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
*
Actinosynnema mirum DSM 43827

Site:
position = 16
score = 4.09539
sequence = ACGAATCCGCGTTCGG

Gene: Amir_0958: Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)
 
Saccharomonospora viridis DSM 43017
*
Saccharopolyspora erythraea NRRL 2338

Site:
position = -177
score = 4.08266
sequence = AGGAACAGGCGGTCGA

Gene: SACE_0868: Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)
Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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