Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog IolR - Streptomycetaceae

Properties
Regulator type: Transcription factor
Regulator family: GntR/Others
Regulation mode:
Biological process: Inositol utilization
Effector:
Phylum: Actinobacteria
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 35 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Streptomyces avermitilis MA-4680 24 7
Streptomyces coelicolor A3(2) 24 10
Streptomyces griseus subsp. griseus NBRC 13350 11 5
Streptomyces scabiei 87.22 13 6
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
iolTA2
*
Streptomyces avermitilis MA-4680

Site:
position = -75
score = 3.01748
sequence = CCGATGTCCGGATGCACG

Gene: SAV_1983: Inositol ABC transport system, sugar-binding protein
*
Streptomyces coelicolor A3(2)

Site:
position = -153
score = 4.92093
sequence = GCAATGTCCGGACAATGT

Gene: SCO6257: Inositol ABC transport system, sugar-binding protein
*
Streptomyces griseus subsp. griseus NBRC 13350

Site:
position = -192
score = 3.5129
sequence = GGTAGGTCCGGACACCTG

Gene: SGR_1275: Inositol ABC transport system, sugar-binding protein
 
Streptomyces scabiei 87.22
Inositol ABC transport system, sugar-binding protein
iolTB2
 
Streptomyces avermitilis MA-4680

Gene: SAV_1982: Inositol ABC transport system, permease protein
 
Streptomyces coelicolor A3(2)

Gene: SCO6258: Inositol ABC transport system, permease protein
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_1274: Inositol ABC transport system, permease protein
 
Streptomyces scabiei 87.22
Inositol ABC transport system, permease protein
iolTC2
 
Streptomyces avermitilis MA-4680

Gene: SAV_1981: Inositol ABC transport system, ATP-binding protein
 
Streptomyces coelicolor A3(2)

Gene: SCO6259: Inositol ABC transport system, ATP-binding protein
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_1273: Inositol ABC transport system, ATP-binding protein
 
Streptomyces scabiei 87.22
Inositol ABC transport system, ATP-binding protein
 
CRON 2.
iolG3
 
Streptomyces avermitilis MA-4680

Gene: SAV_7155: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)
*
Streptomyces coelicolor A3(2)

Site:
position = -103
score = 4.60126
sequence = TCTTTGTCCTGTCAAAAG

Gene: SCO6988: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)
 
Streptomyces griseus subsp. griseus NBRC 13350
 
Streptomyces scabiei 87.22

Gene: SCAB_19091: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)
Myo-inositol 2-dehydrogenase (EC 1.1.1.18)
 
CRON 3.
iolC
*2
Streptomyces avermitilis MA-4680

Site:
position = -78
score = 4.84431
sequence = CGAATGTCTGGACAAAAC

Gene: SAV_5338: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)

Site:
position = -147
score = 4.52018
sequence = ACTTTGTTAAGACATCAT

Site:
position = -115
score = 5.0903
sequence = CGAATGTCCGTACAAACT

Gene: SAV_7150: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)
*
Streptomyces coelicolor A3(2)

Site:
position = -123
score = 4.80425
sequence = ACTTTGTCAAGACATCAT

Site:
position = -91
score = 4.55373
sequence = CGAATGTAAGTACAAAGT

Gene: SCO6978: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)
*
Streptomyces griseus subsp. griseus NBRC 13350

Site:
position = -82
score = 5.3403
sequence = CGAATGTCCGGACAAAAT

Gene: SGR_4834: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)
*
Streptomyces scabiei 87.22

Site:
position = -79
score = 5.10975
sequence = CGAATGTCTGGACAAAGT

Gene: SCAB_58891: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)
5-keto-2-deoxygluconokinase (EC 2.7.1.92)
iolJ
 2
Streptomyces avermitilis MA-4680

Gene: SAV_5339: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)

Gene: SAV_7149: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
 
Streptomyces coelicolor A3(2)

Gene: SCO6977: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_4835: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
 
Streptomyces scabiei 87.22

Gene: SCAB_58901: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
iolB
 2
Streptomyces avermitilis MA-4680

Gene: SAV_5340: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)

Gene: SAV_7148: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)
 
Streptomyces coelicolor A3(2)

Gene: SCO6976: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_4836: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)
 
Streptomyces scabiei 87.22

Gene: SCAB_58911: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)
5-deoxy-glucuronate isomerase (EC 5.3.1.-)
iolD
 2
Streptomyces avermitilis MA-4680

Gene: SAV_5341: Epi-inositol hydrolase (EC 3.7.1.-)

Gene: SAV_7147: Epi-inositol hydrolase (EC 3.7.1.-)
*2
Streptomyces coelicolor A3(2)

Gene: SCO6975: Epi-inositol hydrolase (EC 3.7.1.-)

Site:
position = -86
score = 5.09772
sequence = CGAATGTCCGGACAAAAC

Gene: SCO2727: Epi-inositol hydrolase (EC 3.7.1.-)
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_4837: Epi-inositol hydrolase (EC 3.7.1.-)
 
Streptomyces scabiei 87.22

Gene: SCAB_58921: Epi-inositol hydrolase (EC 3.7.1.-)
Epi-inositol hydrolase (EC 3.7.1.-)
iolA
 
Streptomyces avermitilis MA-4680

Gene: SAV_5342: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
 
Streptomyces coelicolor A3(2)

Gene: SCO2726: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_4838: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
 
Streptomyces scabiei 87.22

Gene: SCAB_58931: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
iolR
 
Streptomyces avermitilis MA-4680

Gene: SAV_7146: Inositol utilization transcriptional regulator, GntR family
*2
Streptomyces coelicolor A3(2)

Gene: SCO6974: Inositol utilization transcriptional regulator, GntR family

Site:
position = -91
score = 5.40241
sequence = CGTATGTCCGGACAATCG

Gene: SCO6256: Inositol utilization transcriptional regulator, GntR family
*
Streptomyces griseus subsp. griseus NBRC 13350

Site:
position = -33
score = 5.06766
sequence = GCTTTGTCCGGACAAGCG

Site:
position = -93
score = 5.31526
sequence = CGTTTGTCCTGACAAATG

Gene: SGR_1276: Inositol utilization transcriptional regulator, GntR family
*
Streptomyces scabiei 87.22

Site:
position = -65
score = 4.66944
sequence = CTCATGTCAGGACAATGC

Gene: SCAB_19081: Inositol utilization transcriptional regulator, GntR family
Inositol utilization transcriptional regulator, GntR family
 
CRON 4.
iolE
*
Streptomyces avermitilis MA-4680

Site:
position = -72
score = 4.84431
sequence = GTTTTGTCCAGACATTCG

Gene: SAV_5337: Inosose dehydratase (EC 4.2.1.44)
 
Streptomyces coelicolor A3(2)
*
Streptomyces griseus subsp. griseus NBRC 13350

Site:
position = -64
score = 5.3403
sequence = ATTTTGTCCGGACATTCG

Gene: SGR_4833: Inosose dehydratase (EC 4.2.1.44)
*
Streptomyces scabiei 87.22

Site:
position = -63
score = 5.10975
sequence = ACTTTGTCCAGACATTCG

Gene: SCAB_58881: Inosose dehydratase (EC 4.2.1.44)
Inosose dehydratase (EC 4.2.1.44)
 
CRON 5.
iolG
*
Streptomyces avermitilis MA-4680

Site:
position = -55
score = 5.09215
sequence = CGGTTGTCCGGACAAACC

Gene: SAV_1985: Inositol 2-dehydrogenase (EC 1.1.1.18 )
*
Streptomyces coelicolor A3(2)

Site:
position = -55
score = 5.40241
sequence = CGATTGTCCGGACATACG

Gene: SCO6255: Inositol 2-dehydrogenase (EC 1.1.1.18 )
*
Streptomyces griseus subsp. griseus NBRC 13350

Site:
position = -116
score = 5.06766
sequence = CGCTTGTCCGGACAAAGC

Site:
position = -56
score = 5.31526
sequence = CATTTGTCAGGACAAACG

Gene: SGR_1277: Inositol 2-dehydrogenase (EC 1.1.1.18 )
*
Streptomyces scabiei 87.22

Site:
position = -56
score = 4.98966
sequence = CGGTTGTCCGGACAAAGC

Gene: SCAB_18231: Inositol 2-dehydrogenase (EC 1.1.1.18 )
Inositol 2-dehydrogenase (EC 1.1.1.18 )
 
CRON 6.
iolR1
*
Streptomyces avermitilis MA-4680

Site:
position = -79
score = 5.09215
sequence = GGTTTGTCCGGACAACCG

Gene: SAV_1984: Inositol utilization transcriptional regulator, GntR family
 
Streptomyces coelicolor A3(2)
 
Streptomyces griseus subsp. griseus NBRC 13350
*
Streptomyces scabiei 87.22

Site:
position = -91
score = 4.98966
sequence = GCTTTGTCCGGACAACCG

Gene: SCAB_18221: Inositol utilization transcriptional regulator, GntR family
Inositol utilization transcriptional regulator, GntR family
iolTA
 
Streptomyces avermitilis MA-4680

Gene: SAV_1983: Inositol ABC transport system sugar-binding protein
*
Streptomyces coelicolor A3(2)

Site:
position = -153
score = 4.92093
sequence = GCAATGTCCGGACAATGT

Gene: SCO6257: Inositol ABC transport system sugar-binding protein
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_1275: Inositol ABC transport system sugar-binding protein
 
Streptomyces scabiei 87.22
Inositol ABC transport system sugar-binding protein
iolTB
 
Streptomyces avermitilis MA-4680

Gene: SAV_1982: Inositol ABC transport system permease protein
 
Streptomyces coelicolor A3(2)

Gene: SCO6258: Inositol ABC transport system permease protein
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_1274: Inositol ABC transport system permease protein
 
Streptomyces scabiei 87.22
Inositol ABC transport system permease protein
iolTC
 
Streptomyces avermitilis MA-4680

Gene: SAV_1981: Inositol ABC transport system ATP-binding protein
 
Streptomyces coelicolor A3(2)

Gene: SCO6259: Inositol ABC transport system ATP-binding protein
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_1273: Inositol ABC transport system ATP-binding protein
 
Streptomyces scabiei 87.22
Inositol ABC transport system ATP-binding protein
SCO6259
 
Streptomyces avermitilis MA-4680

Gene: SAV_1980: Putative sugar kinase
 
Streptomyces coelicolor A3(2)

Gene: SCO6260: Putative sugar kinase
 
Streptomyces griseus subsp. griseus NBRC 13350

Gene: SGR_1272: Putative sugar kinase
 
Streptomyces scabiei 87.22

Gene: SCAB_18211: Putative sugar kinase
Putative sugar kinase
 
CRON 7.
SCO6985
 
Streptomyces avermitilis MA-4680

Gene: SAV_7190: Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin
*
Streptomyces coelicolor A3(2)

Site:
position = -57
score = 4.94892
sequence = CGTTTGTCAGGACAAGAA

Gene: SCO6985: Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin
 
Streptomyces griseus subsp. griseus NBRC 13350
 
Streptomyces scabiei 87.22

Gene: SCAB_79031: Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin
Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin
iolG2
 
Streptomyces avermitilis MA-4680

Gene: SAV_7188: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)
 
Streptomyces coelicolor A3(2)

Gene: SCO6984: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)
 
Streptomyces griseus subsp. griseus NBRC 13350
 
Streptomyces scabiei 87.22

Gene: SCAB_16031: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)
Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)
 
CRON 8.
iolR2
 
Streptomyces avermitilis MA-4680

Gene: SAV_7191: Transcriptional regulator for inositol utilization, LacI family
*
Streptomyces coelicolor A3(2)

Site:
position = -90
score = 4.94892
sequence = TTCTTGTCCTGACAAACG

Gene: SCO6986: Transcriptional regulator for inositol utilization, LacI family
 
Streptomyces griseus subsp. griseus NBRC 13350
 
Streptomyces scabiei 87.22

Gene: SCAB_16011: Transcriptional regulator for inositol utilization, LacI family
Transcriptional regulator for inositol utilization, LacI family
 
CRON 9.
iolTA2
*
Streptomyces avermitilis MA-4680

Site:
position = -178
score = 4.52018
sequence = ATGATGTCTTAACAAAGT

Site:
position = -210
score = 5.0903
sequence = AGTTTGTACGGACATTCG

Gene: SAV_7151: Inositol ABC transport system sugar-binding protein
*
Streptomyces coelicolor A3(2)

Site:
position = -148
score = 4.80425
sequence = ATGATGTCTTGACAAAGT

Site:
position = -180
score = 4.55373
sequence = ACTTTGTACTTACATTCG

Gene: SCO6979: Inositol ABC transport system sugar-binding protein
 
Streptomyces griseus subsp. griseus NBRC 13350
*
Streptomyces scabiei 87.22

Site:
position = -216
score = 4.70485
sequence = ATAATGTCTTAACAAAGT

Site:
position = -248
score = 4.56508
sequence = GCTTTGTACTGACATCCT

Gene: SCAB_19051: Inositol ABC transport system sugar-binding protein
Inositol ABC transport system sugar-binding protein
iolTB2
 
Streptomyces avermitilis MA-4680

Gene: SAV_7152: Inositol ABC transport system permease protein
 
Streptomyces coelicolor A3(2)

Gene: SCO6980: Inositol ABC transport system permease protein
 
Streptomyces griseus subsp. griseus NBRC 13350
 
Streptomyces scabiei 87.22

Gene: SCAB_19041: Inositol ABC transport system permease protein
Inositol ABC transport system permease protein
iolTC2
 
Streptomyces avermitilis MA-4680

Gene: SAV_7153: Inositol ABC transport system ATP-binding protein
 
Streptomyces coelicolor A3(2)

Gene: SCO6981: Inositol ABC transport system ATP-binding protein
 
Streptomyces griseus subsp. griseus NBRC 13350
 
Streptomyces scabiei 87.22

Gene: SCAB_19031: Inositol ABC transport system ATP-binding protein
Inositol ABC transport system ATP-binding protein
iolE2
 
Streptomyces avermitilis MA-4680

Gene: SAV_7154: Inosose dehydratase (EC 4.2.1.44)
 
Streptomyces coelicolor A3(2)

Gene: SCO6982: Inosose dehydratase (EC 4.2.1.44)
 
Streptomyces griseus subsp. griseus NBRC 13350
 
Streptomyces scabiei 87.22
Inosose dehydratase (EC 4.2.1.44)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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