Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog IolR - Frankineae/Propionibacterineae/Pseudonocardiaceae

Properties
Regulator type: Transcription factor
Regulator family: GntR/Others
Regulation mode:
Biological process: Inositol utilization
Effector:
Phylum: Actinobacteria
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 30 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Actinosynnema mirum DSM 43827
Saccharomonospora viridis DSM 43017
Saccharopolyspora erythraea NRRL 2338 19 7
Acidothermus cellulolyticus 11B 18 4
Frankia sp. CcI3
Frankia sp. EAN1pec
Nakamurella multipartita DSM 44233 15 7
Nocardioides sp. JS614
Propionibacterium acnes KPA171202 13 8
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
iolG4
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
 
Acidothermus cellulolyticus 11B
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
*
Nakamurella multipartita DSM 44233

Site:
position = -74
score = 4.85802
sequence = AGTTTGTCTTGACAAGTG

Gene: Namu_1848: Inositol 2-dehydrogenase
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Inositol 2-dehydrogenase
 
CRON 2.
iolY
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
 
Acidothermus cellulolyticus 11B
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
*
Nakamurella multipartita DSM 44233

Site:
position = -60
score = 4.6402
sequence = ATGATGTCAGGACATTTG

Gene: Namu_5196: Inositol 2-dehydrogenase
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Inositol 2-dehydrogenase
 
CRON 3.
iolR2
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
 
Acidothermus cellulolyticus 11B
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
*
Nakamurella multipartita DSM 44233

Site:
position = -121
score = 5.31475
sequence = AGCTTGTCCTGACAAAGT

Gene: Namu_3354: Transcriptional regulator for inositol utilization, LacI family
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Transcriptional regulator for inositol utilization, LacI family
 
CRON 4.
iolR
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
*
Saccharopolyspora erythraea NRRL 2338

Site:
position = -97
score = 3.81628
sequence = AATACGTTCTGTCAAAGT

Gene: SACE_4660: Inositol utilization transcriptional regulator, GntR family
 
Acidothermus cellulolyticus 11B
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Nocardioides sp. JS614
*
Propionibacterium acnes KPA171202

Site:
position = -159
score = 4.2298
sequence = CATATGTCAATACAATTG

Gene: PPA0455: Inositol utilization transcriptional regulator, GntR family
Inositol utilization transcriptional regulator, GntR family
 
CRON 5.
tal
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
 
Acidothermus cellulolyticus 11B
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Nocardioides sp. JS614

Gene: Noca_1175: Transaldolase (EC 2.2.1.2)
*
Propionibacterium acnes KPA171202

Site:
position = -87
score = 4.40722
sequence = TATTTGACAGGACAAATT

Gene: PPA0454: Transaldolase (EC 2.2.1.2)
Transaldolase (EC 2.2.1.2)
 
CRON 6.
iolR3
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
*
Saccharopolyspora erythraea NRRL 2338

Site:
position = -119
score = 5.42223
sequence = AGTTTGTCCGGACATGCT

Gene: SACE_5191: Inositol utilization transcriptional regulator, GntR family
*
Acidothermus cellulolyticus 11B

Site:
position = -99
score = 4.71605
sequence = ATTTTGTAAAGACATTCT

Gene: Acel_1804: Inositol utilization transcriptional regulator, GntR family
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
*
Nakamurella multipartita DSM 44233

Site:
position = -79
score = 4.20949
sequence = ACTTTGATAGGACATATA

Gene: Namu_4543: Inositol utilization transcriptional regulator, GntR family
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Inositol utilization transcriptional regulator, GntR family
 
CRON 7.
iolG
 
Actinosynnema mirum DSM 43827

Gene: Amir_6853: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)
 
Saccharomonospora viridis DSM 43017
 2
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_4657: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)

Gene: SACE_5193: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)
*2
Acidothermus cellulolyticus 11B

Gene: Acel_1809: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)

Site:
position = -87
score = 3.77544
sequence = ACAAAGTCTTGACATGGC

Site:
position = -98
score = 4.22231
sequence = AAGATGTTATTACAAAGT

Gene: Acel_1805: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233

Gene: Namu_4534: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)
 
Nocardioides sp. JS614
*2
Propionibacterium acnes KPA171202

Site:
position = -57
score = 4.07375
sequence = TATATGTCCTGTCAAATA

Site:
position = 7
score = 4.07533
sequence = GCTTTGTGCTAACATTAG

Gene: PPA0469: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)

Site:
position = -65
score = 4.46119
sequence = TTTTTGACAGGACAAATG

Gene: PPA0466: Myo-inositol 2-dehydrogenase (EC 1.1.1.18)
Myo-inositol 2-dehydrogenase (EC 1.1.1.18)
iolTA
 
Actinosynnema mirum DSM 43827

Gene: Amir_6851: Inositol ABC transport system sugar-binding protein
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
 
Acidothermus cellulolyticus 11B

Gene: Acel_1806: Inositol ABC transport system sugar-binding protein
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
*
Nakamurella multipartita DSM 44233

Site:
position = -348
score = 5.08361
sequence = AGAATGTCAGAACAAAGT

Gene: Namu_4537: Inositol ABC transport system sugar-binding protein
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Inositol ABC transport system sugar-binding protein
iolTB
 
Actinosynnema mirum DSM 43827

Gene: Amir_6850: Inositol ABC transport system permease protein
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
 
Acidothermus cellulolyticus 11B

Gene: Acel_1807: Inositol ABC transport system permease protein
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233

Gene: Namu_4536: Inositol ABC transport system permease protein
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Inositol ABC transport system permease protein
iolTC
 
Actinosynnema mirum DSM 43827

Gene: Amir_6849: Inositol ABC transport system ATP-binding protein
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
 
Acidothermus cellulolyticus 11B

Gene: Acel_1808: Inositol ABC transport system ATP-binding protein
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233

Gene: Namu_4535: Inositol ABC transport system ATP-binding protein
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Inositol ABC transport system ATP-binding protein
iolH
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 2
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_2905: putative sugar-phosphate epimerase/isomerase IolH

Gene: SACE_4656: putative sugar-phosphate epimerase/isomerase IolH
 
Acidothermus cellulolyticus 11B

Gene: Acel_1810: putative sugar-phosphate epimerase/isomerase IolH
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
putative sugar-phosphate epimerase/isomerase IolH
iolG3
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
*
Saccharopolyspora erythraea NRRL 2338

Site:
position = -200
score = 4.91509
sequence = GCTATGTCTTGACATACG

Gene: SACE_2908: Myo-inositol 2-dehydrogenase 2 (EC 1.1.1.18)
 
Acidothermus cellulolyticus 11B

Gene: Acel_1811: Myo-inositol 2-dehydrogenase 2 (EC 1.1.1.18)
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Nocardioides sp. JS614
*
Propionibacterium acnes KPA171202

Site:
position = -100
score = 4.52279
sequence = TCCTTGACAGGACAAACT

Gene: PPA0463: Myo-inositol 2-dehydrogenase 2 (EC 1.1.1.18)
Myo-inositol 2-dehydrogenase 2 (EC 1.1.1.18)
iolE
 
Actinosynnema mirum DSM 43827

Gene: Amir_6852: Inosose dehydratase (EC 4.2.1.44)
 
Saccharomonospora viridis DSM 43017
*3
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_2907: Inosose dehydratase (EC 4.2.1.44)

Site:
position = -124
score = 3.81628
sequence = ACTTTGACAGAACGTATT

Gene: SACE_4659: Inosose dehydratase (EC 4.2.1.44)

Site:
position = -164
score = 4.91037
sequence = AGTATGTCAGGACCAAGT

Gene: SACE_5192: Inosose dehydratase (EC 4.2.1.44)
*2
Acidothermus cellulolyticus 11B

Gene: Acel_1812: Inosose dehydratase (EC 4.2.1.44)

Site:
position = -27
score = 4.21339
sequence = ATATTGTCAGGTCTAACT

Gene: Acel_1816: Inosose dehydratase (EC 4.2.1.44)
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233

Gene: Namu_3352: Inosose dehydratase (EC 4.2.1.44)
 
Nocardioides sp. JS614
*2
Propionibacterium acnes KPA171202

Site:
position = -77
score = 4.07375
sequence = TATTTGACAGGACATATA

Site:
position = -141
score = 4.07533
sequence = CTAATGTTAGCACAAAGC

Gene: PPA0468: Inosose dehydratase (EC 4.2.1.44)

Gene: PPA0464: Inosose dehydratase (EC 4.2.1.44)
Inosose dehydratase (EC 4.2.1.44)
SACE_2906
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_2906: hypothetical protein
 
Acidothermus cellulolyticus 11B
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
hypothetical protein
iolT
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 2
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_2904: Myo-inositol transporter, MFS family

Gene: SACE_4658: Myo-inositol transporter, MFS family
 
Acidothermus cellulolyticus 11B
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Myo-inositol transporter, MFS family
iolC
 
Actinosynnema mirum DSM 43827

Gene: Amir_6848: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)
 
Saccharomonospora viridis DSM 43017
*
Saccharopolyspora erythraea NRRL 2338

Site:
position = -90
score = 5.42223
sequence = AGCATGTCCGGACAAACT

Gene: SACE_5189: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)
*
Acidothermus cellulolyticus 11B

Site:
position = -83
score = 4.71605
sequence = AGAATGTCTTTACAAAAT

Gene: Acel_1803: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
*
Nakamurella multipartita DSM 44233

Site:
position = -143
score = 4.20949
sequence = TATATGTCCTATCAAAGT

Gene: Namu_4542: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)
 
Nocardioides sp. JS614
*
Propionibacterium acnes KPA171202

Site:
position = -73
score = 4.2298
sequence = CAATTGTATTGACATATG

Gene: PPA0456: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)
5-keto-2-deoxygluconokinase (EC 2.7.1.92)
iolJ
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_5188: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
 
Acidothermus cellulolyticus 11B

Gene: Acel_1802: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233

Gene: Namu_4541: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202

Gene: PPA0457: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)
iolB
 
Actinosynnema mirum DSM 43827

Gene: Amir_6847: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_5187: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)
 
Acidothermus cellulolyticus 11B

Gene: Acel_1801: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233

Gene: Namu_4540: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202

Gene: PPA0458: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)
5-deoxy-glucuronate isomerase (EC 5.3.1.-)
iolD
 
Actinosynnema mirum DSM 43827

Gene: Amir_6846: Epi-inositol hydrolase (EC 3.7.1.-)
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_5186: Epi-inositol hydrolase (EC 3.7.1.-)
 
Acidothermus cellulolyticus 11B

Gene: Acel_1800: Epi-inositol hydrolase (EC 3.7.1.-)
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233

Gene: Namu_4539: Epi-inositol hydrolase (EC 3.7.1.-)
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202

Gene: PPA0459: Epi-inositol hydrolase (EC 3.7.1.-)
Epi-inositol hydrolase (EC 3.7.1.-)
iolA
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338

Gene: SACE_5185: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
 
Acidothermus cellulolyticus 11B

Gene: Acel_1799: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233

Gene: Namu_4538: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
 
Nocardioides sp. JS614
*
Propionibacterium acnes KPA171202

Site:
position = -101
score = 4.26004
sequence = TATTTGTTAGTACAAATT

Site:
position = -253
score = 3.79356
sequence = AACATGTTAGCACAATTG

Gene: PPA0461: Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)
Acel_1815
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
 
Acidothermus cellulolyticus 11B

Gene: Acel_1815: Oxidoreductase, short chain dehydrogenase/reductase family
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Oxidoreductase, short chain dehydrogenase/reductase family
iolG2
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
 
Acidothermus cellulolyticus 11B

Gene: Acel_1814: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
*
Nakamurella multipartita DSM 44233

Site:
position = -57
score = 5.31475
sequence = ACTTTGTCAGGACAAGCT

Gene: Namu_3353: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)
Acel_1813
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
 
Acidothermus cellulolyticus 11B

Gene: Acel_1813: Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin
iolR1
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
 
Saccharopolyspora erythraea NRRL 2338
 
Acidothermus cellulolyticus 11B
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202

Gene: PPA0462: Inositol utilization transcriptional regulator, GntR family
Inositol utilization transcriptional regulator, GntR family
 
CRON 8.
yadN
 
Actinosynnema mirum DSM 43827
 
Saccharomonospora viridis DSM 43017
*
Saccharopolyspora erythraea NRRL 2338

Site:
position = -113
score = 4.66865
sequence = CTAATGTACGGACATATT

Gene: SACE_4661: Probable tautomerase (EC 5.3.2.-)
 
Acidothermus cellulolyticus 11B
 
Frankia sp. CcI3
 
Frankia sp. EAN1pec
 
Nakamurella multipartita DSM 44233
 
Nocardioides sp. JS614
 
Propionibacterium acnes KPA171202
Probable tautomerase (EC 5.3.2.-)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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