Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog MetR - Pasteurellales

Properties
Regulator type: Transcription factor
Regulator family: LysR
Regulation mode: repressor (activator)
Biological process: Methionine biosynthesis
Effector: Homocysteine
Phylum: Proteobacteria/Gamma
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 40 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Haemophilus influenzae Rd KW20 5 5
Aggregatibacter aphrophilus NJ8700 4 4
Pasteurella multocida subsp. multocida str. Pm70 4 4
Mannheimia succiniciproducens MBEL55E 5 5
Actinobacillus succinogenes 130Z 2 2
Haemophilus somnus 2336 3 3
Actinobacillus pleuropneumoniae serovar 7 str. AP76 7 7
Haemophilus ducreyi 35000HP
Haemophilus parasuis SH0165 2 2
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
glyA
*
Haemophilus influenzae Rd KW20

Site:
position = -109
score = 5.49937
sequence = ATGAATTAATTTCAT

Gene: HI0889: Serine hydroxymethyltransferase (EC 2.1.2.1)
*
Aggregatibacter aphrophilus NJ8700

Site:
position = -114
score = 4.87918
sequence = GTGAAAATTTTTCAT

Gene: NT05HA_1325: Serine hydroxymethyltransferase (EC 2.1.2.1)
*
Pasteurella multocida subsp. multocida str. Pm70

Site:
position = -119
score = 5.46053
sequence = ATGAATTTTTTTCAT

Gene: PM0225: Serine hydroxymethyltransferase (EC 2.1.2.1)
*
Mannheimia succiniciproducens MBEL55E

Site:
position = -103
score = 4.54964
sequence = CTTAATTAATTTCAT

Gene: MS1295: Serine hydroxymethyltransferase (EC 2.1.2.1)
 
Actinobacillus succinogenes 130Z

Gene: Asuc_1360: Serine hydroxymethyltransferase (EC 2.1.2.1)
*
Haemophilus somnus 2336

Site:
position = -112
score = 5.42558
sequence = ATGAAATTTTTTCAT

Gene: HSM_0382: Serine hydroxymethyltransferase (EC 2.1.2.1)
*
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Site:
position = -153
score = 5.19542
sequence = ATTAATTTTTTTCAT

Gene: APP7_0213: Serine hydroxymethyltransferase (EC 2.1.2.1)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165

Gene: HAPS_0379: Serine hydroxymethyltransferase (EC 2.1.2.1)
Serine hydroxymethyltransferase (EC 2.1.2.1)
 
CRON 2.
metE
*
Haemophilus influenzae Rd KW20

Site:
position = -128
score = 5.23426
sequence = ATGAATTTATTTAAT

Gene: HI1702: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Aggregatibacter aphrophilus NJ8700

Site:
position = -122
score = 5.15658
sequence = ATTAAAATTATTCAT

Gene: NT05HA_0341: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Pasteurella multocida subsp. multocida str. Pm70

Site:
position = -132
score = 5.12163
sequence = ATTAAAAATTTTCAT

Gene: PM0420: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
Mannheimia succiniciproducens MBEL55E
 
Actinobacillus succinogenes 130Z
*
Haemophilus somnus 2336

Site:
position = -129
score = 5.19542
sequence = ATTAATTTTTTTCAT

Gene: HSM_1293: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Site:
position = -131
score = 4.94346
sequence = ATTAATATGTTTCAT

Gene: APP7_1214: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
Haemophilus ducreyi 35000HP
*
Haemophilus parasuis SH0165

Site:
position = -136
score = 5.38674
sequence = ATGAAAAATTTTCAT

Gene: HAPS_1354: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
CRON 3.
metR
*
Haemophilus influenzae Rd KW20

Site:
position = -13
score = 5.19153
sequence = ATGAATATTATTAAT

Site:
position = -82
score = 4.96527
sequence = ATTAATTTTATTAAT

Gene: HI1739: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Aggregatibacter aphrophilus NJ8700

Site:
position = -157
score = 5.15658
sequence = ATGAATAATTTTAAT

Gene: NT05HA_0342: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Pasteurella multocida subsp. multocida str. Pm70

Site:
position = -13
score = 4.94346
sequence = ATGAATCTTTTTAAT

Site:
position = -181
score = 5.12163
sequence = ATGAAAATTTTTAAT

Gene: PM0421: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Mannheimia succiniciproducens MBEL55E

Site:
position = -13
score = 4.51704
sequence = ATGAATTATTCTAAT

Gene: MS0763: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
 
Actinobacillus succinogenes 130Z

Gene: Asuc_1680: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
 
Haemophilus somnus 2336

Gene: HSM_1538: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
*
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Site:
position = -13
score = 4.76989
sequence = ATGAATTATTTACAT

Gene: APP7_1216: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165

Gene: HAPS_2191: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
 
CRON 4.
metE2
 
Haemophilus influenzae Rd KW20
 
Aggregatibacter aphrophilus NJ8700
 
Pasteurella multocida subsp. multocida str. Pm70
*
Mannheimia succiniciproducens MBEL55E

Site:
position = -30
score = 5.07657
sequence = ATAAAATTTATTCAT

Site:
position = -104
score = 4.78233
sequence = ATGAATCCGTTTCAT

Gene: MS0941: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
*
Actinobacillus succinogenes 130Z

Site:
position = -30
score = 4.94346
sequence = ATTAAAACTATTCAT

Site:
position = -105
score = 4.78233
sequence = ATGAATCCGTTTCAT

Gene: Asuc_1191: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
 
Haemophilus somnus 2336
*
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Site:
position = -104
score = 5.49547
sequence = ATGAATATAATTCAT

Site:
position = -139
score = 4.77739
sequence = ATTATTTTTATTCAT

Gene: APP7_0911: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
 
CRON 5.
HI0736
*
Haemophilus influenzae Rd KW20

Site:
position = -55
score = 4.79443
sequence = ATGATTAGATTTCAT

Gene: HI0736: hypothetical sodium-dependent transporter
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_1978: hypothetical sodium-dependent transporter
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM0718: hypothetical sodium-dependent transporter
*
Mannheimia succiniciproducens MBEL55E

Site:
position = -110
score = 5.07657
sequence = ATAAAAATAATTCAT

Gene: MS2382: hypothetical sodium-dependent transporter
 
Actinobacillus succinogenes 130Z

Gene: Asuc_0284: hypothetical sodium-dependent transporter
 
Haemophilus somnus 2336

Gene: HSM_1866: hypothetical sodium-dependent transporter
*
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Site:
position = -70
score = 4.85723
sequence = ATGACATATTTTCAT

Gene: APP7_1441: hypothetical sodium-dependent transporter
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
hypothetical sodium-dependent transporter
 
CRON 6.
metE2-2
 
Haemophilus influenzae Rd KW20
 
Aggregatibacter aphrophilus NJ8700
 
Pasteurella multocida subsp. multocida str. Pm70
 
Mannheimia succiniciproducens MBEL55E
*
Actinobacillus succinogenes 130Z

Site:
position = -128
score = 5.32119
sequence = ATGAATTGAATTCAT

Gene: Asuc_0713: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
 
Haemophilus somnus 2336
*
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Site:
position = -121
score = 5.49937
sequence = ATGAATTAATTTCAT

Gene: APP7_0324: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
 
CRON 7.
metF
*
Haemophilus influenzae Rd KW20

Site:
position = -100
score = 4.73855
sequence = ATTAATAATAATCAT

Gene: HI1444: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
*
Aggregatibacter aphrophilus NJ8700

Site:
position = -106
score = 4.97841
sequence = ATTAATCTTATTCAT

Gene: NT05HA_0300: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
*
Pasteurella multocida subsp. multocida str. Pm70

Site:
position = -109
score = 5.32119
sequence = ATGAATTGAATTCAT

Gene: PM0235: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
*
Mannheimia succiniciproducens MBEL55E

Site:
position = -124
score = 5.26921
sequence = ATTAATTAAATTCAT

Gene: MS0787: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Actinobacillus succinogenes 130Z
*
Haemophilus somnus 2336

Site:
position = -199
score = 4.46704
sequence = ACAAAAAAATTTCAT

Site:
position = -111
score = 5.53431
sequence = ATGAATTTAATTCAT

Gene: HSM_1047: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
*
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Site:
position = -139
score = 5.49547
sequence = ATGAATTATATTCAT

Site:
position = -104
score = 4.77739
sequence = ATGAATAAAAATAAT

Gene: APP7_0912: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Haemophilus ducreyi 35000HP
*
Haemophilus parasuis SH0165

Site:
position = -154
score = 5.15036
sequence = ATAAATTAAATTCAT

Site:
position = -186
score = 4.43702
sequence = TTTAAAAATTTTCAT

Gene: HAPS_2275: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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Regulated Genes [ Tab delimited format ] DOWNLOAD
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