Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog MetJ - Pasteurellales

Properties
Regulator type: Transcription factor
Regulator family: MetJ
Regulation mode: repressor
Biological process: Methionine metabolism; Methionine biosynthesis
Effector: S-adenosylmethionine
Phylum: Proteobacteria/Gamma
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 50 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Haemophilus influenzae Rd KW20 5 5
Aggregatibacter aphrophilus NJ8700 6 4
Pasteurella multocida subsp. multocida str. Pm70 8 6
Mannheimia succiniciproducens MBEL55E 7 5
Actinobacillus succinogenes 130Z 6 4
Haemophilus somnus 2336 7 5
Actinobacillus pleuropneumoniae serovar 7 str. AP76 6 3
Haemophilus ducreyi 35000HP 4 2
Haemophilus parasuis SH0165 8 5
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
metB
 
Haemophilus influenzae Rd KW20

Gene: HI0086: Cystathionine gamma-synthase (EC 2.5.1.48)
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_1400: Cystathionine gamma-synthase (EC 2.5.1.48)
*
Pasteurella multocida subsp. multocida str. Pm70

Site:
position = -61
score = 6.69574
sequence = AGACATCT-(0)-AGATAGCT

Gene: PM0995: Cystathionine gamma-synthase (EC 2.5.1.48)
*
Mannheimia succiniciproducens MBEL55E

Site:
position = -121
score = 6.0394
sequence = AGAAATTA-(0)-AGATGTTT

Gene: MS1627: Cystathionine gamma-synthase (EC 2.5.1.48)
 
Actinobacillus succinogenes 130Z

Gene: Asuc_1846: Cystathionine gamma-synthase (EC 2.5.1.48)
 
Haemophilus somnus 2336

Gene: HSM_0277: Cystathionine gamma-synthase (EC 2.5.1.48)
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_0723: Cystathionine gamma-synthase (EC 2.5.1.48)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165

Gene: HAPS_2273: Cystathionine gamma-synthase (EC 2.5.1.48)
Cystathionine gamma-synthase (EC 2.5.1.48)
 
CRON 2.
metK
*
Haemophilus influenzae Rd KW20

Site:
position = -50
score = 6.67509
sequence = AGCCGTCT-(0)-ATACGTCA

Gene: HI1172: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_2370: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1027: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Mannheimia succiniciproducens MBEL55E

Site:
position = -46
score = 6.18043
sequence = AGCCGTCC-(0)-ATACGTCC

Gene: MS0669: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Actinobacillus succinogenes 130Z

Site:
position = -38
score = 6.80421
sequence = GGCCGTCT-(0)-AAACGGCT

Gene: Asuc_0835: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Haemophilus somnus 2336

Site:
position = -66
score = 6.93657
sequence = AGCCGTCT-(0)-AGACGTTA

Site:
position = -58
score = 6.45841
sequence = AGACGTTA-(0)-AAACATCT

Gene: HSM_0387: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_1138: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Haemophilus ducreyi 35000HP

Site:
position = -162
score = 6.24015
sequence = AGACGTCT-(0)-AGATGTAC

Gene: HD0569: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Haemophilus parasuis SH0165

Site:
position = -161
score = 5.8083
sequence = AGCCATCT-(0)-AGACGGAA

Gene: HAPS_0500: S-adenosylmethionine synthetase (EC 2.5.1.6)
S-adenosylmethionine synthetase (EC 2.5.1.6)
 
CRON 3.
metN
*
Haemophilus influenzae Rd KW20

Site:
position = -61
score = 7.34702
sequence = AGCAATCT-(0)-AGACATCT

Gene: HI0621: Methionine ABC transporter ATP-binding protein
*
Aggregatibacter aphrophilus NJ8700

Site:
position = -65
score = 6.82024
sequence = GGCATTCT-(0)-AGACGTCT

Gene: NT05HA_2130: Methionine ABC transporter ATP-binding protein
*
Pasteurella multocida subsp. multocida str. Pm70

Site:
position = -62
score = 7.28636
sequence = GGAAATCT-(0)-AGACGTCT

Gene: PM1728: Methionine ABC transporter ATP-binding protein
*
Mannheimia succiniciproducens MBEL55E

Site:
position = -68
score = 7.32491
sequence = AAACGTCT-(0)-AGACATCT

Gene: MS0434: Methionine ABC transporter ATP-binding protein
*
Actinobacillus succinogenes 130Z

Site:
position = -51
score = 7.13012
sequence = AGCCATAT-(0)-AGCCGTCT

Gene: Asuc_0032: Methionine ABC transporter ATP-binding protein
*
Haemophilus somnus 2336

Site:
position = -61
score = 7.8321
sequence = AGCAATCT-(0)-AGACGTCT

Gene: HSM_0571: Methionine ABC transporter ATP-binding protein
*
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Site:
position = -62
score = 7.8321
sequence = AGCAATCT-(0)-AGACGTCT

Gene: APP7_0972: Methionine ABC transporter ATP-binding protein
*
Haemophilus ducreyi 35000HP

Site:
position = -56
score = 7.40479
sequence = AGCATTCT-(0)-AGACGTCT

Gene: HD1098: Methionine ABC transporter ATP-binding protein
*
Haemophilus parasuis SH0165

Site:
position = -61
score = 7.8321
sequence = AGCAATCT-(0)-AGACGTCT

Gene: HAPS_0448: Methionine ABC transporter ATP-binding protein
Methionine ABC transporter ATP-binding protein
metI
 
Haemophilus influenzae Rd KW20
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_2129: Methionine ABC transporter permease protein
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1729 (deprecated): Methionine ABC transporter permease protein
 
Mannheimia succiniciproducens MBEL55E

Gene: MS0433: Methionine ABC transporter permease protein
 
Actinobacillus succinogenes 130Z

Gene: Asuc_0033: Methionine ABC transporter permease protein
 
Haemophilus somnus 2336

Gene: HSM_0570: Methionine ABC transporter permease protein
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_0971: Methionine ABC transporter permease protein
 
Haemophilus ducreyi 35000HP

Gene: HD1099: Methionine ABC transporter permease protein
 
Haemophilus parasuis SH0165

Gene: HAPS_0447: Methionine ABC transporter permease protein
Methionine ABC transporter permease protein
metQ
 
Haemophilus influenzae Rd KW20

Gene: HI0620: Methionine ABC transporter substrate-binding protein
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_2128: Methionine ABC transporter substrate-binding protein
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1730: Methionine ABC transporter substrate-binding protein
 
Mannheimia succiniciproducens MBEL55E

Gene: MS0432: Methionine ABC transporter substrate-binding protein
 
Actinobacillus succinogenes 130Z

Gene: Asuc_0034: Methionine ABC transporter substrate-binding protein
 
Haemophilus somnus 2336

Gene: HSM_0569: Methionine ABC transporter substrate-binding protein
 2
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_0970: Methionine ABC transporter substrate-binding protein

Gene: APP7_0969: Methionine ABC transporter substrate-binding protein
 
Haemophilus ducreyi 35000HP

Gene: HD1100: Methionine ABC transporter substrate-binding protein
 2
Haemophilus parasuis SH0165

Gene: HAPS_0446: Methionine ABC transporter substrate-binding protein

Gene: HAPS_0445: Methionine ABC transporter substrate-binding protein
Methionine ABC transporter substrate-binding protein
 
CRON 4.
metE
*
Haemophilus influenzae Rd KW20

Site:
position = -52
score = 7.86939
sequence = AGACGTTT-(0)-AGCCGTCT

Gene: HI1702: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
*
Aggregatibacter aphrophilus NJ8700

Site:
position = -46
score = 7.86939
sequence = AGACGTTT-(0)-AGCCGTCT

Gene: NT05HA_0341: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
*
Pasteurella multocida subsp. multocida str. Pm70

Site:
position = -56
score = 7.86939
sequence = AGACGTTT-(0)-AGCCGTCT

Gene: PM0420: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
 
Mannheimia succiniciproducens MBEL55E
 
Actinobacillus succinogenes 130Z
*
Haemophilus somnus 2336

Site:
position = -52
score = 8.28113
sequence = AGACGTTT-(0)-AGACGTCT

Gene: HSM_1293: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_1214: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
 
Haemophilus ducreyi 35000HP
*
Haemophilus parasuis SH0165

Site:
position = -64
score = 7.59565
sequence = AGCCATTT-(0)-AGACGGCT

Site:
position = -56
score = 7.31677
sequence = AGACGGCT-(0)-AAACGTCT

Gene: HAPS_1354: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
 
CRON 5.
metX
*
Haemophilus influenzae Rd KW20

Site:
position = -87
score = 7.76856
sequence = AGCCGTTT-(0)-AGACGGCT

Gene: HI1263: Homoserine O-acetyltransferase (EC 2.3.1.31)
*
Aggregatibacter aphrophilus NJ8700

Site:
position = -163
score = 7.86746
sequence = AGATGTTT-(0)-AGACGTCT

Gene: NT05HA_0899: Homoserine O-acetyltransferase (EC 2.3.1.31)
*
Pasteurella multocida subsp. multocida str. Pm70

Site:
position = -70
score = 7.16165
sequence = AGATGTTT-(0)-AGACGTCC

Gene: PM0866: Homoserine O-acetyltransferase (EC 2.3.1.31)
*
Mannheimia succiniciproducens MBEL55E

Site:
position = -94
score = 8.24232
sequence = AGCCGTTT-(0)-AGACGTCT

Gene: MS0924: Homoserine O-acetyltransferase (EC 2.3.1.31)
*
Actinobacillus succinogenes 130Z

Site:
position = -100
score = 8.24232
sequence = AGCCGTTT-(0)-AGACGTCT

Gene: Asuc_1733: Homoserine O-acetyltransferase (EC 2.3.1.31)
*
Haemophilus somnus 2336

Site:
position = -119
score = 6.39054
sequence = GGCTGTCT-(0)-AGATGTTT

Site:
position = -111
score = 6.21414
sequence = AGATGTTT-(0)-GGATGGCT

Gene: HSM_1561: Homoserine O-acetyltransferase (EC 2.3.1.31)
*
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Site:
position = -147
score = 7.04368
sequence = AGAACTCT-(0)-AGACGTTT

Site:
position = -74
score = 7.49184
sequence = AGGCGTTT-(0)-AGACGTCT

Site:
position = -139
score = 7.80737
sequence = AGACGTTT-(0)-AGACGGCT

Gene: APP7_0516: Homoserine O-acetyltransferase (EC 2.3.1.31)
 
Haemophilus ducreyi 35000HP
*
Haemophilus parasuis SH0165

Site:
position = -107
score = 7.80737
sequence = AGACGTTT-(0)-AGATGTCT

Site:
position = -123
score = 6.5112
sequence = AGCCATTT-(0)-AAAAATCT

Gene: HAPS_0134: Homoserine O-acetyltransferase (EC 2.3.1.31)
Homoserine O-acetyltransferase (EC 2.3.1.31)
 
CRON 6.
metJ
*
Haemophilus influenzae Rd KW20

Site:
position = -83
score = 6.01034
sequence = AGCCGTCT-(0)-AGATTGTT

Site:
position = -91
score = 7.02742
sequence = GGAAGTTT-(0)-AGCCGTCT

Gene: HI0294: S-adenosylmethionine-responsive transcriptional repressor MetJ
*
Aggregatibacter aphrophilus NJ8700

Site:
position = -85
score = 5.72379
sequence = AGCAGTCT-(0)-TCACGGCT

Site:
position = -93
score = 6.78595
sequence = AGAAATCT-(0)-AGCAGTCT

Gene: NT05HA_1785: S-adenosylmethionine-responsive transcriptional repressor MetJ
*
Pasteurella multocida subsp. multocida str. Pm70

Site:
position = -97
score = 5.56007
sequence = GGATATCT-(0)-AGCAATCT

Site:
position = -89
score = 6.50624
sequence = AGCAATCT-(0)-TAACGTCT

Gene: PM1290: S-adenosylmethionine-responsive transcriptional repressor MetJ
*
Mannheimia succiniciproducens MBEL55E

Site:
position = -26
score = 6.19755
sequence = AGCAGTCT-(0)-TCACGTCT

Site:
position = -34
score = 5.82751
sequence = ACCTGTTT-(0)-AGCAGTCT

Gene: MS1966: S-adenosylmethionine-responsive transcriptional repressor MetJ
*
Actinobacillus succinogenes 130Z

Site:
position = -80
score = 5.33846
sequence = GGCAGTCC-(0)-ATACGTCC

Gene: Asuc_0407: S-adenosylmethionine-responsive transcriptional repressor MetJ
*
Haemophilus somnus 2336

Site:
position = -83
score = 7.00263
sequence = AGCTATCT-(0)-AGAAGTCT

Site:
position = -75
score = 5.79173
sequence = AGAAGTCT-(0)-AGATTGTT

Gene: HSM_0768: S-adenosylmethionine-responsive transcriptional repressor MetJ
*
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Site:
position = -82
score = 7.1651
sequence = AGAAATCT-(0)-AGACGTCC

Gene: APP7_2006: S-adenosylmethionine-responsive transcriptional repressor MetJ
 
Haemophilus ducreyi 35000HP

Gene: HD0675: S-adenosylmethionine-responsive transcriptional repressor MetJ
 
Haemophilus parasuis SH0165

Gene: HAPS_2077: S-adenosylmethionine-responsive transcriptional repressor MetJ
S-adenosylmethionine-responsive transcriptional repressor MetJ
 
CRON 7.
metF
 
Haemophilus influenzae Rd KW20

Gene: HI1444: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_0300: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
*
Pasteurella multocida subsp. multocida str. Pm70

Site:
position = -43
score = 7.05679
sequence = AGCCATAT-(0)-AGACATCT

Gene: PM0235: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Mannheimia succiniciproducens MBEL55E

Gene: MS0787: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Actinobacillus succinogenes 130Z
 
Haemophilus somnus 2336

Gene: HSM_1047: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_0912: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Haemophilus ducreyi 35000HP
*
Haemophilus parasuis SH0165

Site:
position = -86
score = 7.6896
sequence = AGCCATCT-(0)-AAACGTCT

Gene: HAPS_2275: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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