Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog Rex - Clostridia-2

Properties
Regulator type: Transcription factor
Regulator family: Rex
Regulation mode: repressor
Biological process: Energy metabolism
Effector: NADH
Phylum: Firmicutes
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 34 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Clostridium bartlettii DSM 16795 19 9
Clostridium difficile 630 23 9
Clostridium hiranonis DSM 13275 6 4
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
grdE
 
Clostridium bartlettii DSM 16795
*
Clostridium difficile 630

Site:
position = -264
score = 5.46615
sequence = TTGATAAATTATTAACAT

Site:
position = -187
score = 4.53735
sequence = TTGTTAAAAAAATAATTT

Gene: CD2354: Glycine reductase component B beta subunit (EC 1.21.4.2) / Glycine reductase component B alpha subunit (EC 1.21.4.2)
 
Clostridium hiranonis DSM 13275
Glycine reductase component B beta subunit (EC 1.21.4.2) / Glycine reductase component B alpha subunit (EC 1.21.4.2)
 
CRON 2.
glcA
*
Clostridium bartlettii DSM 16795

Site:
position = -119
score = 5.17027
sequence = ATGTTAATAAATAAACAA

Site:
position = -138
score = 4.26725
sequence = TTTTTATTAATTTAAAAT

Gene: CLOBAR_02282: Glycolate permease
 
Clostridium difficile 630
 
Clostridium hiranonis DSM 13275
Glycolate permease
PF09861
 
Clostridium bartlettii DSM 16795

Gene: CLOBAR_02281: Protein of unknown function DUF2088
*
Clostridium difficile 630

Site:
position = -113
score = 4.04182
sequence = TTGTTATAAAATAAATTA

Gene: CD1170: Protein of unknown function DUF2088
 
Clostridium hiranonis DSM 13275
Protein of unknown function DUF2088
etfB
 2
Clostridium bartlettii DSM 16795

Gene: CLOBAR_02279: Electron transfer flavoprotein beta-subunit

Gene: CLOBAR_02280: Electron transfer flavoprotein beta-subunit
 
Clostridium difficile 630

Gene: CD1171: Electron transfer flavoprotein beta-subunit
 
Clostridium hiranonis DSM 13275
Electron transfer flavoprotein beta-subunit
etfA
 
Clostridium bartlettii DSM 16795

Gene: CLOBAR_02278: Electron transfer flavoprotein alpha-subunit
 
Clostridium difficile 630

Gene: CD1172: Electron transfer flavoprotein alpha-subunit
 
Clostridium hiranonis DSM 13275
Electron transfer flavoprotein alpha-subunit
glcD
 
Clostridium bartlettii DSM 16795

Gene: CLOBAR_02277: Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing
 
Clostridium difficile 630

Gene: CD1173: Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing
 
Clostridium hiranonis DSM 13275
Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing
 
CRON 3.
rex
*2
Clostridium bartlettii DSM 16795

Site:
position = -37
score = 3.98978
sequence = TTGTTATGAAAATATTAA

Site:
position = -99
score = 4.10187
sequence = TTGGTATAATATAATCAA

Gene: CLOBAR_00711: Redox-sensitive transcriptional regulator Rex

Site:
position = -156
score = 4.34683
sequence = ATAATATATTATTAACTA

Gene: CLOBAR_01830: Redox-sensitive transcriptional regulator Rex
*
Clostridium difficile 630

Site:
position = -96
score = 4.5729
sequence = TTGATATAATATAATCAA

Gene: CD0171: Redox-sensitive transcriptional regulator Rex
*
Clostridium hiranonis DSM 13275

Site:
position = -55
score = 4.33113
sequence = ATGTTATATAATAAACCA

Site:
position = -101
score = 4.01189
sequence = TTGATATAATATATTCAA

Gene: CLOHIR_00042: Redox-sensitive transcriptional regulator Rex
Redox-sensitive transcriptional regulator Rex
 
CRON 4.
bcd2
 
Clostridium bartlettii DSM 16795
*
Clostridium difficile 630

Site:
position = -193
score = 5.04578
sequence = TTGATTTTAAATTAACAA

Gene: CD1054: Butyryl-CoA dehydrogenase (EC 1.3.99.2)
 
Clostridium hiranonis DSM 13275
Butyryl-CoA dehydrogenase (EC 1.3.99.2)
etfB2
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630

Gene: CD1055: Electron transfer flavoprotein, beta subunit
 
Clostridium hiranonis DSM 13275
Electron transfer flavoprotein, beta subunit
etfA2
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630

Gene: CD1056: Electron transfer flavoprotein, alpha subunit
 
Clostridium hiranonis DSM 13275
Electron transfer flavoprotein, alpha subunit
crt2
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630

Gene: CD1057: 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)
 
Clostridium hiranonis DSM 13275
3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)
hbd
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630

Gene: CD1058: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)
 
Clostridium hiranonis DSM 13275
3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)
thlA1
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630

Gene: CD1059: Acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Clostridium hiranonis DSM 13275
Acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
CRON 5.
fprA
 
Clostridium bartlettii DSM 16795
*
Clostridium difficile 630

Site:
position = -63
score = 5.39866
sequence = TTGTTTAAAATATAACAA

Gene: CD1623: H(2)O-forming NADH oxidase (EC 1.6.3.-)
 
Clostridium hiranonis DSM 13275
H(2)O-forming NADH oxidase (EC 1.6.3.-)
 
CRON 6.
CD2344
 
Clostridium bartlettii DSM 16795
*
Clostridium difficile 630

Site:
position = -190
score = 4.56384
sequence = TTGTTAATTAAATCATAA

Site:
position = -129
score = 5.40604
sequence = ATGTTAATTTAATAACAA

Site:
position = -66
score = 5.21897
sequence = TTGTTAATTTAATAACGA

Gene: CD2344: putative transport protein
 
Clostridium hiranonis DSM 13275
putative transport protein
cat1
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630

Gene: CD2343: Succinyl-CoA:coenzyme A transferase (EC 2.8.3.-)
 
Clostridium hiranonis DSM 13275
Succinyl-CoA:coenzyme A transferase (EC 2.8.3.-)
sucD
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630

Gene: CD2342: Succinate-semialdehyde dehydrogenase, CoA-dependent
 
Clostridium hiranonis DSM 13275
Succinate-semialdehyde dehydrogenase, CoA-dependent
abfD
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630

Gene: CD2341: 4-hydroxybutanoyl-CoA dehydratase (EC 4.2.1.-)
 
Clostridium hiranonis DSM 13275
4-hydroxybutanoyl-CoA dehydratase (EC 4.2.1.-)
CD2340
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630

Gene: CD2340: hypothetical protein
 
Clostridium hiranonis DSM 13275
hypothetical protein
abfT
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630

Gene: CD2339: 4-hydroxybutyrate:acetyl-CoA CoA transferase (EC 2.3.1.-)
 
Clostridium hiranonis DSM 13275
4-hydroxybutyrate:acetyl-CoA CoA transferase (EC 2.3.1.-)
4hbd
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630

Gene: CD2338: NAD-dependent 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61)
 
Clostridium hiranonis DSM 13275
NAD-dependent 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61)
 
CRON 7.
nadA
*
Clostridium bartlettii DSM 16795

Site:
position = -113
score = 4.68854
sequence = AAATTAAAAATTTAACTA

Gene: CLOBAR_00531: Quinolinate synthetase (EC 4.1.99.-)
 
Clostridium difficile 630

Gene: CD2372: Quinolinate synthetase (EC 4.1.99.-)
*
Clostridium hiranonis DSM 13275

Site:
position = -210
score = 5.53742
sequence = ATGATAAAAAAATAACAA

Site:
position = -38
score = 5.40536
sequence = TAGATAAAAAAATAACAA

Gene: CLOHIR_00157: Quinolinate synthetase (EC 4.1.99.-)
Quinolinate synthetase (EC 4.1.99.-)
nadB
 
Clostridium bartlettii DSM 16795

Gene: CLOBAR_00532: L-aspartate oxidase (EC 1.4.3.16)
 
Clostridium difficile 630

Gene: CD2371: L-aspartate oxidase (EC 1.4.3.16)
 
Clostridium hiranonis DSM 13275

Gene: CLOHIR_00158: L-aspartate oxidase (EC 1.4.3.16)
L-aspartate oxidase (EC 1.4.3.16)
nadC
 
Clostridium bartlettii DSM 16795

Gene: CLOBAR_00533: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)
 
Clostridium difficile 630

Gene: CD2370: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)
 
Clostridium hiranonis DSM 13275

Gene: CLOHIR_00159: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)
Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)
 
CRON 8.
hydC
*2
Clostridium bartlettii DSM 16795

Site:
position = -125
score = 4.40824
sequence = TATTTAAATTTTTAAAAA

Site:
position = -169
score = 4.8771
sequence = ATGTTAAAAAAGTATCAT

Gene: CLOBAR_00902: NAD-reducing Fe-hydrogenase, subunit HydC (EC 1.12.7.2)

Site:
position = -128
score = 4.69586
sequence = TAGATAATTAAATAAAAA

Gene: CLOBAR_00255: NAD-reducing Fe-hydrogenase, subunit HydC (EC 1.12.7.2)
 
Clostridium difficile 630
 
Clostridium hiranonis DSM 13275
NAD-reducing Fe-hydrogenase, subunit HydC (EC 1.12.7.2)
hydB
 2
Clostridium bartlettii DSM 16795

Gene: CLOBAR_00256: NAD-reducing Fe-hydrogenase, subunit HydB (EC 1.12.7.2)

Gene: CLOBAR_00901: NAD-reducing Fe-hydrogenase, subunit HydB (EC 1.12.7.2)
 
Clostridium difficile 630
 
Clostridium hiranonis DSM 13275
NAD-reducing Fe-hydrogenase, subunit HydB (EC 1.12.7.2)
hydA
 
Clostridium bartlettii DSM 16795

Gene: CLOBAR_00900: NAD-reducing Fe-hydrogenase, subunit HydA (EC 1.12.7.2)
 
Clostridium difficile 630
 
Clostridium hiranonis DSM 13275
NAD-reducing Fe-hydrogenase, subunit HydA (EC 1.12.7.2)
 
CRON 9.
phf1
 
Clostridium bartlettii DSM 16795
 
Clostridium difficile 630
*
Clostridium hiranonis DSM 13275

Site:
position = -107
score = 4.81147
sequence = ATGTTAAAAATATAAAGA

Site:
position = -87
score = 5.08872
sequence = TTGATAAAAAAATGACAA

Gene: CLOHIR_00139: Fe-hydrogenase (EC 1.12.7.2)
Fe-hydrogenase (EC 1.12.7.2)
 
CRON 10.
CD2707
*
Clostridium bartlettii DSM 16795

Site:
position = -91
score = 4.90725
sequence = ACGTTAAGAATTTAACAA

Gene: CLOBAR_02221: Transport protein, MFS family
*
Clostridium difficile 630

Site:
position = -34
score = 5.74236
sequence = ATGTTAATAAATTAACAA

Gene: CD2707: Transport protein, MFS family
 
Clostridium hiranonis DSM 13275

Gene: CLOHIR_00106: Transport protein, MFS family
Transport protein, MFS family
 
CRON 11.
adhE
*
Clostridium bartlettii DSM 16795

Site:
position = -130
score = 5.26195
sequence = ATGTTAAACAAATAACAA

Site:
position = -106
score = 4.77526
sequence = AGGTTAATAATATAACAT

Site:
position = -188
score = 5.53742
sequence = ATGATAAAAAAATAACAA

Gene: CLOBAR_00502: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)
*2
Clostridium difficile 630

Gene: CD0334: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)

Site:
position = -146
score = 5.09002
sequence = ATGTTAAAAAAATAACTT

Site:
position = -103
score = 5.56157
sequence = ATGTTAATAAATTAACAT

Gene: CD2966: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)
*
Clostridium hiranonis DSM 13275

Site:
position = -209
score = 5.27221
sequence = ATGATAAAAAAATATCAA

Gene: CLOHIR_00687: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)
Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)
 
CRON 12.
lldD
*
Clostridium bartlettii DSM 16795

Site:
position = -94
score = 5.49793
sequence = ATGTTAAAAAAATAACAT

Gene: CLOBAR_01995: L-lactate dehydrogenase
 
Clostridium difficile 630
 
Clostridium hiranonis DSM 13275
L-lactate dehydrogenase
 
CRON 13.
noxE
 
Clostridium bartlettii DSM 16795

Gene: CLOBAR_01035: NADH oxidase (EC 1.6.99.3)
*
Clostridium difficile 630

Site:
position = -112
score = 5.23654
sequence = ATGTTAAATAAATAACTA

Gene: CD2540: NADH oxidase (EC 1.6.99.3)
 
Clostridium hiranonis DSM 13275
NADH oxidase (EC 1.6.99.3)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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