Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog BirA - Streptococcaceae

Properties
Regulator type: Transcription factor
Regulator family: BirA
Regulation mode: repressor
Biological process: Biotin biosynthesis
Effector: Biotin
Phylum: Firmicutes
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 29 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Lactococcus lactis subsp. cremoris SK11 6 2
Lactococcus lactis subsp. lactis Il1403 5 2
Streptococcus agalactiae 2603V/R 7 3
Streptococcus dysgalactiae subsp. equisimilis GGS_124 6 3
Streptococcus equi subsp. zooepidemicus MGCS10565 5 2
Streptococcus gallolyticus UCN34 6 3
Streptococcus gordonii str. Challis substr. CH1 1 1
Streptococcus mitis B6 1 1
Streptococcus mutans UA159 1 1
Streptococcus pneumoniae TIGR4 1 1
Streptococcus pyogenes M1 GAS 4 2
Streptococcus sanguinis SK36 1 1
Streptococcus suis 05ZYH33 1 1
Streptococcus thermophilus CNRZ1066 2 2
Streptococcus uberis 0140J 2 1
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
SAG0465
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
*
Streptococcus agalactiae 2603V/R

Site:
position = -79
score = 7.98278
sequence = ATTGTAAAC-(16)-GTTAACAAT

Gene: SAG0465: putative thioesterase
*
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Site:
position = -32
score = 7.95649
sequence = AAAGTTAAC-(16)-GGTGACAAT

Gene: SDEG_0560: putative thioesterase
*
Streptococcus equi subsp. zooepidemicus MGCS10565

Site:
position = -32
score = 7.8237
sequence = AAAGTTAAC-(16)-GGTTACAAT

Gene: Sez_1400: putative thioesterase
 
Streptococcus gallolyticus UCN34
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6
 
Streptococcus mutans UA159
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus suis 05ZYH33
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus uberis 0140J
putative thioesterase
yhfS
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_1956: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Lactococcus lactis subsp. lactis Il1403

Gene: L25946: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Streptococcus agalactiae 2603V/R

Gene: SAG0466: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Gene: SDEG_0561: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Streptococcus equi subsp. zooepidemicus MGCS10565

Gene: Sez_1399: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Streptococcus gallolyticus UCN34
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6
 
Streptococcus mutans UA159
 
Streptococcus pneumoniae TIGR4
*
Streptococcus pyogenes M1 GAS

Site:
position = -269
score = 6.46373
sequence = AAAGTCACC-(16)-GGTTACAGT

Gene: SPy0524: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)
 
Streptococcus sanguinis SK36
 
Streptococcus suis 05ZYH33
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus uberis 0140J
Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)
yhfT
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_1955: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
*
Lactococcus lactis subsp. lactis Il1403

Site:
position = -79
score = 7.41687
sequence = ACAGTAACC-(16)-GTTAACTGT

Gene: L24742: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 
Streptococcus agalactiae 2603V/R

Gene: SAG0467: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Gene: SDEG_0562: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 
Streptococcus equi subsp. zooepidemicus MGCS10565

Gene: Sez_1398: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 
Streptococcus gallolyticus UCN34
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6
 
Streptococcus mutans UA159
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS

Gene: SPy0526: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 
Streptococcus sanguinis SK36
 
Streptococcus suis 05ZYH33
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus uberis 0140J
Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
LACR_2462
*
Lactococcus lactis subsp. cremoris SK11

Site:
position = -136
score = 7.22946
sequence = ATAGTAACC-(16)-GTTAACTGC

Gene: LACR_1954: Transposase
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus agalactiae 2603V/R
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gallolyticus UCN34
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6
 
Streptococcus mutans UA159
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus suis 05ZYH33
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus uberis 0140J
Transposase
 
CRON 2.
bioY
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_0357: Substrate-specific component BioY of biotin ECF transporter
 
Lactococcus lactis subsp. lactis Il1403

Gene: L1011: Substrate-specific component BioY of biotin ECF transporter
 
Streptococcus agalactiae 2603V/R
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
*
Streptococcus gallolyticus UCN34

Site:
position = -52
score = 8.66198
sequence = TTAGTTAAC-(16)-GTTAACTAA

Gene: GALLO_1527: Substrate-specific component BioY of biotin ECF transporter
*2
Streptococcus gordonii str. Challis substr. CH1

Site:
position = -35
score = 8.55306
sequence = ATAGTTACC-(16)-GTTTACTAT

Gene: SGO_0746: Substrate-specific component BioY of biotin ECF transporter

Gene: SGO_1070: Substrate-specific component BioY of biotin ECF transporter
*
Streptococcus mitis B6

Site:
position = -87
score = 8.34502
sequence = TTTGTTACC-(16)-GTTGACAAT

Site:
position = -35
score = 8.17947
sequence = ATAGTTACT-(16)-GTTAACTAT

Gene: smi_0834: Substrate-specific component BioY of biotin ECF transporter
 
Streptococcus mutans UA159
*
Streptococcus pneumoniae TIGR4

Site:
position = -35
score = 8.17947
sequence = ATAGTTACT-(16)-GTTAACTAT

Site:
position = -87
score = 7.39502
sequence = TTTGTTACC-(16)-GTTGACATC

Gene: SP_0783: Substrate-specific component BioY of biotin ECF transporter
 
Streptococcus pyogenes M1 GAS
*
Streptococcus sanguinis SK36

Site:
position = -36
score = 8.55306
sequence = ATAGTTACC-(16)-GTTTACTAT

Gene: SSA_1536: Substrate-specific component BioY of biotin ECF transporter
*
Streptococcus suis 05ZYH33

Site:
position = -33
score = 7.79421
sequence = TTTGTTAAC-(16)-GATAACAAA

Gene: SSU05_0509: Substrate-specific component BioY of biotin ECF transporter
*2
Streptococcus thermophilus CNRZ1066

Site:
position = -35
score = 7.84135
sequence = TAAGTTAAC-(16)-GTTAACTCA

Site:
position = -89
score = 8.66198
sequence = TTAGTTAAC-(16)-GTTGACTAA

Gene: str0674: Substrate-specific component BioY of biotin ECF transporter

Site:
position = -171
score = 7.90485
sequence = AAAGTTAAC-(16)-GTTAACATA

Gene: str1308: Substrate-specific component BioY of biotin ECF transporter
 
Streptococcus uberis 0140J
Substrate-specific component BioY of biotin ECF transporter
 
CRON 3.
bioB
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
*
Streptococcus agalactiae 2603V/R

Site:
position = -78
score = 8.35637
sequence = ATTGTTAAC-(16)-GTTTACAAT

Gene: SAG0464: Biotin synthase (EC 2.8.1.6)
*
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Site:
position = -50
score = 7.45011
sequence = AAAGTAAAC-(16)-GGTAACAAT

Gene: SDEG_0379: Biotin synthase (EC 2.8.1.6)
 
Streptococcus equi subsp. zooepidemicus MGCS10565
*
Streptococcus gallolyticus UCN34

Site:
position = -51
score = 7.98339
sequence = ACAGTTAAC-(16)-GTTAACTGT

Gene: GALLO_1916: Biotin synthase (EC 2.8.1.6)
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6
 
Streptococcus mutans UA159
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus suis 05ZYH33
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus uberis 0140J
Biotin synthase (EC 2.8.1.6)
bioD
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus agalactiae 2603V/R
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1915: Dethiobiotin synthetase (EC 6.3.3.3)
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6
 
Streptococcus mutans UA159
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus suis 05ZYH33
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus uberis 0140J
Dethiobiotin synthetase (EC 6.3.3.3)
bioY2
*
Lactococcus lactis subsp. cremoris SK11

Site:
position = -98
score = 7.39609
sequence = GCAGTTAAC-(16)-GGTTACTAT

Gene: LACR_1953: Substrate-specific component BioY of biotin ECF transporter
*
Lactococcus lactis subsp. lactis Il1403

Site:
position = -99
score = 7.43287
sequence = ACAGTTAAC-(16)-GGTTACTGT

Gene: L24031: Substrate-specific component BioY of biotin ECF transporter
 2
Streptococcus agalactiae 2603V/R

Gene: SAG0398: Substrate-specific component BioY of biotin ECF transporter

Gene: SAG0463: Substrate-specific component BioY of biotin ECF transporter
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Gene: SDEG_1996: Substrate-specific component BioY of biotin ECF transporter
 
Streptococcus equi subsp. zooepidemicus MGCS10565

Gene: Sez_0192: Substrate-specific component BioY of biotin ECF transporter
 2
Streptococcus gallolyticus UCN34

Gene: GALLO_1914: Substrate-specific component BioY of biotin ECF transporter

Gene: GALLO_2101: Substrate-specific component BioY of biotin ECF transporter
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6
*
Streptococcus mutans UA159

Site:
position = -48
score = 8.74599
sequence = ATAGTTAAC-(16)-GTTAACTAA

Gene: SMU.1827: Substrate-specific component BioY of biotin ECF transporter
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS

Gene: SPy0207: Substrate-specific component BioY of biotin ECF transporter
 
Streptococcus sanguinis SK36
 
Streptococcus suis 05ZYH33
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus uberis 0140J

Gene: SUB1709: Substrate-specific component BioY of biotin ECF transporter
Substrate-specific component BioY of biotin ECF transporter
birA
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_1952: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Lactococcus lactis subsp. lactis Il1403

Gene: L0191: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus agalactiae 2603V/R

Gene: SAG0830: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Gene: SDEG_1373: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus equi subsp. zooepidemicus MGCS10565

Gene: Sez_0678: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus gallolyticus UCN34

Gene: GALLO_0768: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_0903: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus mitis B6

Gene: smi_0511: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus mutans UA159

Gene: SMU.1578: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus pneumoniae TIGR4

Gene: SP_1900: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus pyogenes M1 GAS

Gene: SPy1362: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus sanguinis SK36

Gene: SSA_0999: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus suis 05ZYH33

Gene: SSU05_1625: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus thermophilus CNRZ1066

Gene: str1173: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
 
Streptococcus uberis 0140J

Gene: SUB1213: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
yemC
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_1951: Zinc finger protein
 
Lactococcus lactis subsp. lactis Il1403

Gene: L200067: Zinc finger protein
*
Streptococcus agalactiae 2603V/R

Site:
position = -72
score = 8.40516
sequence = TTTGTTAAC-(15)-GTTGACAAT

Gene: SAG0397: Zinc finger protein
*
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Site:
position = -73
score = 8.66535
sequence = ATAGTTACC-(16)-GTTGACAAA

Gene: SDEG_1997: Zinc finger protein
*
Streptococcus equi subsp. zooepidemicus MGCS10565

Site:
position = -74
score = 8.07496
sequence = TTAGTAACC-(16)-GTTGACAAA

Gene: Sez_0191: Zinc finger protein
*
Streptococcus gallolyticus UCN34

Site:
position = -69
score = 8.20667
sequence = AGAGTTAAC-(16)-GTTGACTAA

Gene: GALLO_2102: Zinc finger protein
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6
 
Streptococcus mutans UA159
 
Streptococcus pneumoniae TIGR4

Gene: SP_1428: Zinc finger protein
*
Streptococcus pyogenes M1 GAS

Site:
position = -73
score = 8.37211
sequence = ACAGTTACC-(16)-GTTGACAAA

Gene: SPy0205: Zinc finger protein
 
Streptococcus sanguinis SK36

Gene: SSA_1540: Zinc finger protein
 
Streptococcus suis 05ZYH33
 
Streptococcus thermophilus CNRZ1066

Gene: str0673: Zinc finger protein
*
Streptococcus uberis 0140J

Site:
position = -61
score = 7.87566
sequence = TTTGTTACC-(16)-GTTGACACA

Gene: SUB1710: Zinc finger protein
Zinc finger protein
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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