Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog GalR - Lactobacillaceae

Properties
Regulator type: Transcription factor
Regulator family: LacI
Regulation mode: repressor
Biological process: Galactosides utilization; Galactose utilization
Effector: Galactose
Phylum: Firmicutes
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 30 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Lactobacillus acidophilus NCFM
Lactobacillus brevis ATCC 367 7 3
Lactobacillus casei ATCC 334 5 1
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
Lactobacillus fermentum IFO 3956 2 1
Lactobacillus helveticus DPC 4571
Lactobacillus johnsonii NCC 533
Lactobacillus plantarum WCFS1 8 3
Lactobacillus reuteri JCM 1112 7 4
Lactobacillus rhamnosus GG 5 1
Lactobacillus sakei subsp. sakei 23K 7 3
Lactobacillus salivarius subsp. salivarius UCC118 5 3
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 4 1
Oenococcus oeni PSU-1 7 1
Pediococcus pentosaceus ATCC 25745 8 5
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
lacL
 
Lactobacillus acidophilus NCFM

Gene: LBA1467: Beta-galactosidase large subunit (EC 3.2.1.23)
 
Lactobacillus brevis ATCC 367

Gene: LVIS_2259: Beta-galactosidase large subunit (EC 3.2.1.23)
 
Lactobacillus casei ATCC 334
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365

Gene: LBUL_1114: Beta-galactosidase large subunit (EC 3.2.1.23) / Beta-galactosidase small subunit (EC 3.2.1.23)
*
Lactobacillus fermentum IFO 3956

Site:
position = -91
score = 5.51933
sequence = TAATATTTACTAAACTTTT

Gene: LAF_0247: Beta-galactosidase large subunit (EC 3.2.1.23)
 
Lactobacillus helveticus DPC 4571

Gene: lhv_1549: Beta-galactosidase large subunit (EC 3.2.1.23)
 
Lactobacillus johnsonii NCC 533

Gene: LJ0855: Beta-galactosidase large subunit (EC 3.2.1.23)
*
Lactobacillus plantarum WCFS1

Site:
position = -266
score = 5.86403
sequence = ATAGTTTTACTAAAATTTT

Gene: lp_3483: Beta-galactosidase large subunit (EC 3.2.1.23)
*
Lactobacillus reuteri JCM 1112

Site:
position = -95
score = 4.8753
sequence = AAAATTTACGTAAATTTTA

Gene: LAR_0276: Beta-galactosidase large subunit (EC 3.2.1.23)
 
Lactobacillus rhamnosus GG
 
Lactobacillus sakei subsp. sakei 23K

Gene: LSA1711: Beta-galactosidase large subunit (EC 3.2.1.23)
*
Lactobacillus salivarius subsp. salivarius UCC118

Site:
position = -86
score = 5.49169
sequence = AATATTTTAGTAAAAAGTA

Gene: LSL_0376: Beta-galactosidase large subunit (EC 3.2.1.23) / Beta-galactosidase small subunit (EC 3.2.1.23)
 
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
 
Oenococcus oeni PSU-1
*
Pediococcus pentosaceus ATCC 25745

Site:
position = -266
score = 6.17867
sequence = ATAATTTTACTAAAATTTT

Site:
position = -94
score = 5.13391
sequence = AAATTTTAACTAAAACAAC

Gene: PEPE_0205: Beta-galactosidase large subunit (EC 3.2.1.23)
Beta-galactosidase large subunit (EC 3.2.1.23)
lacM
 
Lactobacillus acidophilus NCFM

Gene: LBA1468: Beta-galactosidase small subunit (EC 3.2.1.23)
 
Lactobacillus brevis ATCC 367

Gene: LVIS_2258: Beta-galactosidase small subunit (EC 3.2.1.23)
 
Lactobacillus casei ATCC 334
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
 
Lactobacillus fermentum IFO 3956

Gene: LAF_0248: Beta-galactosidase small subunit (EC 3.2.1.23)
 
Lactobacillus helveticus DPC 4571

Gene: lhv_1550: Beta-galactosidase small subunit (EC 3.2.1.23)
 
Lactobacillus johnsonii NCC 533

Gene: LJ0854: Beta-galactosidase small subunit (EC 3.2.1.23)
 
Lactobacillus plantarum WCFS1

Gene: lp_3484: Beta-galactosidase small subunit (EC 3.2.1.23)
 
Lactobacillus reuteri JCM 1112

Gene: LAR_0277: Beta-galactosidase small subunit (EC 3.2.1.23)
 
Lactobacillus rhamnosus GG
 
Lactobacillus sakei subsp. sakei 23K

Gene: LSA1710: Beta-galactosidase small subunit (EC 3.2.1.23)
 
Lactobacillus salivarius subsp. salivarius UCC118
 
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
 
Oenococcus oeni PSU-1
 
Pediococcus pentosaceus ATCC 25745

Gene: PEPE_0204: Beta-galactosidase small subunit (EC 3.2.1.23)
Beta-galactosidase small subunit (EC 3.2.1.23)
 
CRON 2.
OEOE_0356
 
Lactobacillus acidophilus NCFM
 
Lactobacillus brevis ATCC 367
 
Lactobacillus casei ATCC 334
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
 
Lactobacillus fermentum IFO 3956
 
Lactobacillus helveticus DPC 4571
 
Lactobacillus johnsonii NCC 533
 
Lactobacillus plantarum WCFS1
 
Lactobacillus reuteri JCM 1112
 
Lactobacillus rhamnosus GG
 
Lactobacillus sakei subsp. sakei 23K
 
Lactobacillus salivarius subsp. salivarius UCC118
 
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
*
Oenococcus oeni PSU-1

Site:
position = -231
score = 5.50887
sequence = AATATTTTAGTAAAGATTT

Gene: OEOE_0307: Transposase, IS30 family
 
Pediococcus pentosaceus ATCC 25745
Transposase, IS30 family
LVIS_1906
 
Lactobacillus acidophilus NCFM
*
Lactobacillus brevis ATCC 367

Site:
position = -222
score = 5.08976
sequence = ATTGATTTACTAAATTTTT

Gene: LVIS_1906: Conserved hypothetical protein
 
Lactobacillus casei ATCC 334
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
 
Lactobacillus fermentum IFO 3956
 
Lactobacillus helveticus DPC 4571
 
Lactobacillus johnsonii NCC 533
 
Lactobacillus plantarum WCFS1
 
Lactobacillus reuteri JCM 1112
 
Lactobacillus rhamnosus GG
*
Lactobacillus sakei subsp. sakei 23K

Site:
position = -111
score = 5.51027
sequence = AAAAGTTTAGTAAAATGAA

Gene: LSA0184: Conserved hypothetical protein
 
Lactobacillus salivarius subsp. salivarius UCC118
 
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
 
Oenococcus oeni PSU-1

Gene: OEOE_0306: Conserved hypothetical protein
 
Pediococcus pentosaceus ATCC 25745
Conserved hypothetical protein
lacS
 
Lactobacillus acidophilus NCFM
 
Lactobacillus brevis ATCC 367

Gene: LVIS_1905: Lactose and galactose permease, GPH translocator family
 
Lactobacillus casei ATCC 334
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
 
Lactobacillus fermentum IFO 3956
 
Lactobacillus helveticus DPC 4571
 
Lactobacillus johnsonii NCC 533
 
Lactobacillus plantarum WCFS1
 
Lactobacillus reuteri JCM 1112
 
Lactobacillus rhamnosus GG
 
Lactobacillus sakei subsp. sakei 23K

Gene: LSA0185: Lactose and galactose permease, GPH translocator family
 
Lactobacillus salivarius subsp. salivarius UCC118
 
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
 
Oenococcus oeni PSU-1

Gene: OEOE_0305: Lactose and galactose permease, GPH translocator family
 
Pediococcus pentosaceus ATCC 25745
Lactose and galactose permease, GPH translocator family
galK
 
Lactobacillus acidophilus NCFM

Gene: LBA1459: Galactokinase (EC 2.7.1.6)
*
Lactobacillus brevis ATCC 367

Site:
position = -38
score = 5.86403
sequence = AAAACTTTACTAAAAATTT

Gene: LVIS_1904: Galactokinase (EC 2.7.1.6)
*
Lactobacillus casei ATCC 334

Site:
position = -79
score = 5.80407
sequence = TTATTTTTAGTAAAATAAA

Gene: LSEI_0664: Galactokinase (EC 2.7.1.6)
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
 
Lactobacillus fermentum IFO 3956

Gene: LAF_1792: Galactokinase (EC 2.7.1.6)
 
Lactobacillus helveticus DPC 4571
 
Lactobacillus johnsonii NCC 533
*
Lactobacillus plantarum WCFS1

Site:
position = -36
score = 5.95267
sequence = AAAATTTTAGTAAAACTAT

Gene: lp_3482: Galactokinase (EC 2.7.1.6)
*
Lactobacillus reuteri JCM 1112

Site:
position = -53
score = 4.90499
sequence = TTGTATTTAGTAAAAGTTT

Gene: LAR_1662: Galactokinase (EC 2.7.1.6)
*
Lactobacillus rhamnosus GG

Site:
position = -78
score = 5.85359
sequence = TTAATTTTAGTAAAATAAA

Gene: LGG_00653: Galactokinase (EC 2.7.1.6)
*
Lactobacillus sakei subsp. sakei 23K

Site:
position = -45
score = 5.46075
sequence = AAATGTTTAGTAAAATGAA

Gene: LSA0764: Galactokinase (EC 2.7.1.6)
*
Lactobacillus salivarius subsp. salivarius UCC118

Site:
position = -101
score = 5.78437
sequence = ATATTTTTAGTAAATTTTA

Site:
position = -79
score = 5.46075
sequence = AAAAGTTTACTAAAAAGTA

Gene: LSL_0381: Galactokinase (EC 2.7.1.6)
 2
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293

Gene: LEUM_0883: Galactokinase (EC 2.7.1.6)

Gene: LEUM_0883: Galactokinase (EC 2.7.1.6)
 
Oenococcus oeni PSU-1

Gene: OEOE_0304: Galactokinase (EC 2.7.1.6)
*
Pediococcus pentosaceus ATCC 25745

Site:
position = -33
score = 6.26731
sequence = AAAATTTTAGTAAAATTAT

Site:
position = -193
score = 5.17056
sequence = AAAATTTAACCAAAATTAA

Gene: PEPE_0206: Galactokinase (EC 2.7.1.6)
Galactokinase (EC 2.7.1.6)
galT
 
Lactobacillus acidophilus NCFM

Gene: LBA1458: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
 
Lactobacillus brevis ATCC 367

Gene: LVIS_1902: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
 
Lactobacillus casei ATCC 334

Gene: LSEI_0666: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
 
Lactobacillus fermentum IFO 3956

Gene: LAF_1791: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
 
Lactobacillus helveticus DPC 4571
 
Lactobacillus johnsonii NCC 533
 
Lactobacillus plantarum WCFS1

Gene: lp_3480: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
 
Lactobacillus reuteri JCM 1112

Gene: LAR_1661: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
 
Lactobacillus rhamnosus GG

Gene: LGG_00655: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
 
Lactobacillus sakei subsp. sakei 23K

Gene: LSA0766: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
 
Lactobacillus salivarius subsp. salivarius UCC118

Gene: LSL_0383: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
 2
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293

Gene: LEUM_0884: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)

Gene: LEUM_0884: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
 
Oenococcus oeni PSU-1

Gene: OEOE_0303: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
 
Pediococcus pentosaceus ATCC 25745

Gene: PEPE_0208: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
galR
 
Lactobacillus acidophilus NCFM
 
Lactobacillus brevis ATCC 367

Gene: LVIS_1901: Galactose utilization transcriptional regulator GalR, LacI family
 
Lactobacillus casei ATCC 334

Gene: LSEI_0667: Galactose utilization transcriptional regulator GalR, LacI family
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
 
Lactobacillus fermentum IFO 3956

Gene: LAF_1790: Galactose utilization transcriptional regulator GalR, LacI family
 
Lactobacillus helveticus DPC 4571
 
Lactobacillus johnsonii NCC 533
 2
Lactobacillus plantarum WCFS1

Gene: lp_3488: Galactose utilization transcriptional regulator GalR, LacI family

Gene: lp_3479: Galactose utilization transcriptional regulator GalR, LacI family
*2
Lactobacillus reuteri JCM 1112

Gene: LAR_1660: Galactose utilization transcriptional regulator GalR, LacI family

Site:
position = -54
score = 5.54939
sequence = AAACGTTTACTAAAAATAT

Gene: LAR_0856: Galactose utilization transcriptional regulator GalR, LacI family
 
Lactobacillus rhamnosus GG

Gene: LGG_00656: Galactose utilization transcriptional regulator GalR, LacI family
*
Lactobacillus sakei subsp. sakei 23K

Site:
position = -101
score = 5.40378
sequence = AAACATTTACTAAAAAATC

Gene: LSA0763: Galactose utilization transcriptional regulator GalR, LacI family
*
Lactobacillus salivarius subsp. salivarius UCC118

Site:
position = -89
score = 5.90543
sequence = TAAAATTTACTAAAAATAT

Gene: LSL_0380: Galactose utilization transcriptional regulator GalR, LacI family
*
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293

Site:
position = -106
score = 5.11966
sequence = TACTTTTTAGTAAATATTT

Gene: LEUM_0881: Galactose utilization transcriptional regulator GalR, LacI family
 
Oenococcus oeni PSU-1

Gene: OEOE_0302: Galactose utilization transcriptional regulator GalR, LacI family
*
Pediococcus pentosaceus ATCC 25745

Site:
position = -177
score = 5.1775
sequence = CAAAATTTTGTAAAAATAT

Gene: PEPE_0201: Galactose utilization transcriptional regulator GalR, LacI family
Galactose utilization transcriptional regulator GalR, LacI family
galM
 
Lactobacillus acidophilus NCFM

Gene: LBA1457: Aldose 1-epimerase (EC 5.1.3.3)
*
Lactobacillus brevis ATCC 367

Site:
position = -84
score = 5.29823
sequence = CGAATTTTAGTAAAAAATT

Gene: LVIS_1908: Aldose 1-epimerase (EC 5.1.3.3)
 
Lactobacillus casei ATCC 334

Gene: LSEI_0668: Aldose 1-epimerase (EC 5.1.3.3)
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
 
Lactobacillus fermentum IFO 3956
 
Lactobacillus helveticus DPC 4571
 
Lactobacillus johnsonii NCC 533
 
Lactobacillus plantarum WCFS1

Gene: lp_3487: Aldose 1-epimerase (EC 5.1.3.3)
 
Lactobacillus reuteri JCM 1112
 
Lactobacillus rhamnosus GG

Gene: LGG_00657: Aldose 1-epimerase (EC 5.1.3.3)
 
Lactobacillus sakei subsp. sakei 23K

Gene: LSA0767: Aldose 1-epimerase (EC 5.1.3.3)
 
Lactobacillus salivarius subsp. salivarius UCC118
 
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
 
Oenococcus oeni PSU-1

Gene: OEOE_0301: Aldose 1-epimerase (EC 5.1.3.3)
*
Pediococcus pentosaceus ATCC 25745

Site:
position = -89
score = 5.42754
sequence = TTATTTTAACTAAAATATT

Gene: PEPE_0202: Aldose 1-epimerase (EC 5.1.3.3)
Aldose 1-epimerase (EC 5.1.3.3)
galE
 
Lactobacillus acidophilus NCFM
 
Lactobacillus brevis ATCC 367

Gene: LVIS_1903: UDP-glucose 4-epimerase (EC 5.1.3.2)
 
Lactobacillus casei ATCC 334

Gene: LSEI_0665: UDP-glucose 4-epimerase (EC 5.1.3.2)
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
 
Lactobacillus fermentum IFO 3956
 
Lactobacillus helveticus DPC 4571
 
Lactobacillus johnsonii NCC 533
 
Lactobacillus plantarum WCFS1

Gene: lp_3481: UDP-glucose 4-epimerase (EC 5.1.3.2)
 
Lactobacillus reuteri JCM 1112
 
Lactobacillus rhamnosus GG

Gene: LGG_00654: UDP-glucose 4-epimerase (EC 5.1.3.2)
 2
Lactobacillus sakei subsp. sakei 23K

Gene: LSA1280: UDP-glucose 4-epimerase (EC 5.1.3.2)

Gene: LSA0765: UDP-glucose 4-epimerase (EC 5.1.3.2)
 
Lactobacillus salivarius subsp. salivarius UCC118

Gene: LSL_0382: UDP-glucose 4-epimerase (EC 5.1.3.2)
 
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
 
Oenococcus oeni PSU-1
 
Pediococcus pentosaceus ATCC 25745

Gene: PEPE_0207: UDP-glucose 4-epimerase (EC 5.1.3.2)
UDP-glucose 4-epimerase (EC 5.1.3.2)
melA
 
Lactobacillus acidophilus NCFM
 
Lactobacillus brevis ATCC 367
 
Lactobacillus casei ATCC 334
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
 
Lactobacillus fermentum IFO 3956
 
Lactobacillus helveticus DPC 4571
 
Lactobacillus johnsonii NCC 533
 
Lactobacillus plantarum WCFS1

Gene: lp_3485: Alpha-galactosidase (EC 3.2.1.22)
*
Lactobacillus reuteri JCM 1112

Site:
position = -128
score = 5.42842
sequence = ATATTTTTAGTAAACGTTT

Gene: LAR_0857: Alpha-galactosidase (EC 3.2.1.22)
 
Lactobacillus rhamnosus GG
 
Lactobacillus sakei subsp. sakei 23K
 
Lactobacillus salivarius subsp. salivarius UCC118
 
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293

Gene: LEUM_0882: Alpha-galactosidase (EC 3.2.1.22)
 
Oenococcus oeni PSU-1
 
Pediococcus pentosaceus ATCC 25745
Alpha-galactosidase (EC 3.2.1.22)
lacS2
 
Lactobacillus acidophilus NCFM
 
Lactobacillus brevis ATCC 367
 
Lactobacillus casei ATCC 334
 
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
 
Lactobacillus fermentum IFO 3956
 
Lactobacillus helveticus DPC 4571
 
Lactobacillus johnsonii NCC 533
*
Lactobacillus plantarum WCFS1

Site:
position = -88
score = 5.70467
sequence = CAAATTTTACTAAAAATCA

Gene: lp_3486: Lactose and galactose permease, GPH translocator family
 
Lactobacillus reuteri JCM 1112
 
Lactobacillus rhamnosus GG
 
Lactobacillus sakei subsp. sakei 23K
 
Lactobacillus salivarius subsp. salivarius UCC118
 
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
 
Oenococcus oeni PSU-1
*
Pediococcus pentosaceus ATCC 25745

Site:
position = -108
score = 5.13166
sequence = ACTAATTTACTAAAATAAT

Site:
position = -85
score = 5.58529
sequence = CAAATTTTACTAAAAAACA

Gene: PEPE_0203: Lactose and galactose permease, GPH translocator family
Lactose and galactose permease, GPH translocator family
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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