Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog His_leader - Pasteurellales

Properties
Regulator type: RNA regulatory element
Name: His_leader
RFAM: RF00514
Regulation mode:
Biological process: Histidine biosynthesis
Effector:
Phylum: Proteobacteria
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Haemophilus influenzae Rd KW20 9 2
Aggregatibacter aphrophilus NJ8700 5 2
Pasteurella multocida subsp. multocida str. Pm70 12 1
Mannheimia succiniciproducens MBEL55E 4 1
Actinobacillus succinogenes 130Z 7 1
Haemophilus somnus 2336
Actinobacillus pleuropneumoniae serovar 7 str. AP76 10 1
Haemophilus ducreyi 35000HP
Haemophilus parasuis SH0165 1 1
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
hisG
*
Haemophilus influenzae Rd KW20

Site:
position = -165
score = 65.21
sequence = CATCATCACCACACC...

Gene: HI0468: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Aggregatibacter aphrophilus NJ8700

Site:
position = -173
score = 61.13
sequence = ACCATCATCACCGTT...

Gene: NT05HA_1777: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Pasteurella multocida subsp. multocida str. Pm70

Site:
position = -163
score = 65.64
sequence = CATCACCATCTACCC...

Gene: PM1195: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Mannheimia succiniciproducens MBEL55E

Site:
position = -181
score = 73.09
sequence = CTCATCACCATCATC...

Gene: MS1893: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Actinobacillus succinogenes 130Z

Site:
position = -166
score = 53.86
sequence = CATCACCGTCATTAT...

Gene: Asuc_0630: ATP phosphoribosyltransferase (EC 2.4.2.17)
 
Haemophilus somnus 2336
*
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Site:
position = -178
score = 47.61
sequence = CATCACCATCATTCA...

Gene: APP7_2106: ATP phosphoribosyltransferase (EC 2.4.2.17)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
ATP phosphoribosyltransferase (EC 2.4.2.17)
PM1196
 
Haemophilus influenzae Rd KW20
 
Aggregatibacter aphrophilus NJ8700
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1196: unknown
 
Mannheimia succiniciproducens MBEL55E
 
Actinobacillus succinogenes 130Z
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
unknown
vatB
 
Haemophilus influenzae Rd KW20
 
Aggregatibacter aphrophilus NJ8700
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1197: VatB
 
Mannheimia succiniciproducens MBEL55E
 
Actinobacillus succinogenes 130Z
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
VatB
hisD
 
Haemophilus influenzae Rd KW20

Gene: HI0469: Histidinol dehydrogenase (EC 1.1.1.23)
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_1776: Histidinol dehydrogenase (EC 1.1.1.23)
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1198: Histidinol dehydrogenase (EC 1.1.1.23)
 
Mannheimia succiniciproducens MBEL55E

Gene: MS1892: Histidinol dehydrogenase (EC 1.1.1.23)
 
Actinobacillus succinogenes 130Z

Gene: Asuc_0631: Histidinol dehydrogenase (EC 1.1.1.23)
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_2107: Histidinol dehydrogenase (EC 1.1.1.23)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
Histidinol dehydrogenase (EC 1.1.1.23)
hisC
 
Haemophilus influenzae Rd KW20

Gene: HI0470: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_1775: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1199: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Mannheimia succiniciproducens MBEL55E

Gene: MS1891: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Actinobacillus succinogenes 130Z

Gene: Asuc_0633: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_2108: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
Histidinol-phosphate aminotransferase (EC 2.6.1.9)
hisB
 
Haemophilus influenzae Rd KW20

Gene: HI0471: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_1774: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1200: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Mannheimia succiniciproducens MBEL55E

Gene: MS1890: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Actinobacillus succinogenes 130Z

Gene: Asuc_0634: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_2110: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
PM1201
 
Haemophilus influenzae Rd KW20
 
Aggregatibacter aphrophilus NJ8700
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1201: unknown
 
Mannheimia succiniciproducens MBEL55E
 
Actinobacillus succinogenes 130Z
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
unknown
hisH
 
Haemophilus influenzae Rd KW20

Gene: HI0472: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_1772: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1202: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Mannheimia succiniciproducens MBEL55E

Gene: MS1885: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 2
Actinobacillus succinogenes 130Z

Gene: Asuc_0636: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)

Gene: Asuc_1766: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_2112: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
hisA
 
Haemophilus influenzae Rd KW20

Gene: HI0473: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_1770: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1203: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Mannheimia succiniciproducens MBEL55E

Gene: MS1883: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Actinobacillus succinogenes 130Z

Gene: Asuc_1768: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_2113: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
hisF
 
Haemophilus influenzae Rd KW20

Gene: HI0474: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_1769: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1204: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Mannheimia succiniciproducens MBEL55E

Gene: MS1882: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Actinobacillus succinogenes 130Z

Gene: Asuc_1769: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_2114: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
PM1205
 
Haemophilus influenzae Rd KW20
 
Aggregatibacter aphrophilus NJ8700
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1205: unknown
 
Mannheimia succiniciproducens MBEL55E
 
Actinobacillus succinogenes 130Z
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
unknown
hisI
 
Haemophilus influenzae Rd KW20

Gene: HI0475: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_1767: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM1206: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Mannheimia succiniciproducens MBEL55E

Gene: MS1881: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Actinobacillus succinogenes 130Z

Gene: Asuc_1770: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_2115: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
NT05HA_1771
 
Haemophilus influenzae Rd KW20
 
Aggregatibacter aphrophilus NJ8700

Gene: NT05HA_1771: Transposase IS200-like protein
 
Pasteurella multocida subsp. multocida str. Pm70
 
Mannheimia succiniciproducens MBEL55E
 
Actinobacillus succinogenes 130Z
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_2109: Transposase IS200-like protein
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
Transposase IS200-like protein
APP7_2111
 
Haemophilus influenzae Rd KW20
 
Aggregatibacter aphrophilus NJ8700
 
Pasteurella multocida subsp. multocida str. Pm70
 
Mannheimia succiniciproducens MBEL55E
 
Actinobacillus succinogenes 130Z
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_2111: hypothetical protein
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
hypothetical protein
Asuc_0632
 
Haemophilus influenzae Rd KW20
 
Aggregatibacter aphrophilus NJ8700
 
Pasteurella multocida subsp. multocida str. Pm70
 
Mannheimia succiniciproducens MBEL55E
 
Actinobacillus succinogenes 130Z

Gene: Asuc_0632: Threonine efflux protein
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
Threonine efflux protein
Asuc_0635
 
Haemophilus influenzae Rd KW20
 
Aggregatibacter aphrophilus NJ8700
 
Pasteurella multocida subsp. multocida str. Pm70
 
Mannheimia succiniciproducens MBEL55E
 
Actinobacillus succinogenes 130Z

Gene: Asuc_0635: hypothetical protein
 
Haemophilus somnus 2336
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76
 
Haemophilus ducreyi 35000HP
 
Haemophilus parasuis SH0165
hypothetical protein
 
CRON 2.
yuiF
*
Haemophilus influenzae Rd KW20

Site:
position = -218
score = 77.43
sequence = CATCATCACCATTCA...

Gene: HI0325: Histidine permease YuiF
*
Aggregatibacter aphrophilus NJ8700

Site:
position = -230
score = 61.07
sequence = CATCACCACCATGTA...

Gene: NT05HA_1368: Histidine permease YuiF
 
Pasteurella multocida subsp. multocida str. Pm70

Gene: PM0989: Histidine permease YuiF
 
Mannheimia succiniciproducens MBEL55E

Gene: MS0701: Histidine permease YuiF
 
Actinobacillus succinogenes 130Z

Gene: Asuc_1810: Histidine permease YuiF
 
Haemophilus somnus 2336

Gene: HSM_1491: Histidine permease YuiF
 
Actinobacillus pleuropneumoniae serovar 7 str. AP76

Gene: APP7_1032: Histidine permease YuiF
 
Haemophilus ducreyi 35000HP

Gene: HD1717: Histidine permease YuiF
*
Haemophilus parasuis SH0165

Site:
position = -195
score = 51.43
sequence = ACCGTCATCACCATT...

Gene: HAPS_0311: Histidine permease YuiF
Histidine permease YuiF
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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