Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog Cobalamin - Mycobacteriaceae

Properties
Regulator type: RNA regulatory element
Name: Cobalamin
RFAM: RF00174
Regulation mode:
Biological process: Cobalamin biosynthesis
Effector: Adenosylcobalamin
Phylum: Actinobacteria
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Mycobacterium tuberculosis H37Rv 4 2
Mycobacterium leprae TN 2 2
Mycobacterium marinum M 5 3
Mycobacterium avium 104 5 3
Mycobacterium sp. JLS 3 1
Mycobacterium vanbaalenii PYR-1 3 1
Mycobacterium flavescens PYR-GCK 6 2
Mycobacterium smegmatis str. MC2 155 12 5
Mycobacterium abscessus ATCC 19977 4 2
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
btuC3
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK
 
Mycobacterium smegmatis str. MC2 155
*
Mycobacterium abscessus ATCC 19977

Site:
position = -325
score = 98.07
sequence = ATAGTTTTGGCGCCG...

Gene: MAB_0549c: Vitamin B12 ABC transporter, permease component
Vitamin B12 ABC transporter, permease component
btuD3
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK
 
Mycobacterium smegmatis str. MC2 155
 
Mycobacterium abscessus ATCC 19977

Gene: MAB_0548c: Vitamin B12 ABC transporter, ATPase component
Vitamin B12 ABC transporter, ATPase component
btuF3
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK
 
Mycobacterium smegmatis str. MC2 155
 
Mycobacterium abscessus ATCC 19977

Gene: MAB_0547c: Vitamin B12 ABC transporter, B12-binding component
Vitamin B12 ABC transporter, B12-binding component
 
CRON 2.
metE
*
Mycobacterium tuberculosis H37Rv

Site:
position = -305
score = 68.17
sequence = GAGAGGGAACCTGGT...

Gene: Rv1133c: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Mycobacterium leprae TN

Site:
position = -392
score = 80.07
sequence = TAACCTGAATGATGC...

Gene: ML0961: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Mycobacterium marinum M

Site:
position = -306
score = 77.35
sequence = AAGAGGGAATCCGGT...

Gene: MMAR_4328: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Mycobacterium avium 104

Site:
position = -378
score = 65.61
sequence = CATCGAGCGAAGCAA...

Gene: MAV_1262: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK
*
Mycobacterium smegmatis str. MC2 155

Site:
position = -287
score = 75.54
sequence = AGTTCCGTGTGCTGT...

Gene: MSMEG_6638: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Mycobacterium abscessus ATCC 19977

Site:
position = -350
score = 85.74
sequence = GCCGTTGTCAGCATC...

Gene: MAB_4623c: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
CRON 3.
cbtG
*
Mycobacterium tuberculosis H37Rv

Site:
position = -336
score = 81.37
sequence = CGCTCAACGTGCAAA...

Gene: Rv0256c: Predicted cobalt transporter
*
Mycobacterium leprae TN

Site:
position = -298
score = 90.94
sequence = TGTACTATATGCGAC...

Gene: ML1828: Predicted cobalt transporter
*
Mycobacterium marinum M

Site:
position = -433
score = 72.15
sequence = GTTGTCGGCATCAAG...

Gene: MMAR_2944: Predicted cobalt transporter
*
Mycobacterium avium 104

Site:
position = -307
score = 77.49
sequence = ATGTCACCCGTAAGG...

Gene: MAV_1329: Predicted cobalt transporter
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK
 
Mycobacterium smegmatis str. MC2 155
 
Mycobacterium abscessus ATCC 19977
Predicted cobalt transporter
cbiP
 
Mycobacterium tuberculosis H37Rv

Gene: Rv0255c: Cobyric acid synthase
 
Mycobacterium leprae TN
 
Mycobacterium marinum M

Gene: MMAR_3838: Cobyric acid synthase
 
Mycobacterium avium 104

Gene: MAV_3720: Cobyric acid synthase
 
Mycobacterium sp. JLS

Gene: Mjls_2034: Cobyric acid synthase
 
Mycobacterium vanbaalenii PYR-1

Gene: Mvan_0377: Cobyric acid synthase
 
Mycobacterium flavescens PYR-GCK

Gene: Mflv_0360: Cobyric acid synthase
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_2588: Cobyric acid synthase
 
Mycobacterium abscessus ATCC 19977

Gene: MAB_3163c: Cobyric acid synthase
Cobyric acid synthase
cobU
 
Mycobacterium tuberculosis H37Rv

Gene: Rv0254c: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
Mycobacterium leprae TN
 
Mycobacterium marinum M

Gene: MMAR_3251: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
Mycobacterium avium 104

Gene: MAV_2284: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
Mycobacterium sp. JLS

Gene: Mjls_3315: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
Mycobacterium vanbaalenii PYR-1

Gene: Mvan_0379: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
Mycobacterium flavescens PYR-GCK

Gene: Mflv_0355: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_4274: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
Mycobacterium abscessus ATCC 19977

Gene: MAB_1954c: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
CRON 4.
btuF
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
*
Mycobacterium flavescens PYR-GCK

Site:
position = -170
score = 75.39
sequence = GGAAGCCGGTGTGAA...

Gene: Mflv_3882: Vitamin B12 ABC transporter, B12-binding component
*
Mycobacterium smegmatis str. MC2 155

Site:
position = -177
score = 46.41
sequence = CGTGCGGTATGACAC...

Gene: MSMEG_6064: Vitamin B12 ABC transporter, B12-binding component
 
Mycobacterium abscessus ATCC 19977
Vitamin B12 ABC transporter, B12-binding component
btuC
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK

Gene: Mflv_3883: Vitamin B12 ABC transporter, permease component
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_6063: Vitamin B12 ABC transporter, permease component
 
Mycobacterium abscessus ATCC 19977
Vitamin B12 ABC transporter, permease component
btuD
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK

Gene: Mflv_3884: Vitamin B12 ABC transporter, ATPase component
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_6062: Vitamin B12 ABC transporter, ATPase component
 
Mycobacterium abscessus ATCC 19977
Vitamin B12 ABC transporter, ATPase component
 
CRON 5.
btuF2
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK
*2
Mycobacterium smegmatis str. MC2 155

Site:
position = -130
score = 38.51
sequence = CAGGGGAATCCGGTG...

Gene: MSMEG_4561: Vitamin B12 ABC transporter, B12-binding component

Gene: MSMEG_4560: Vitamin B12 ABC transporter, B12-binding component
 
Mycobacterium abscessus ATCC 19977
Vitamin B12 ABC transporter, B12-binding component
btuC2
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_4559: Vitamin B12 ABC transporter, permease component
 
Mycobacterium abscessus ATCC 19977
Vitamin B12 ABC transporter, permease component
btuD2
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_4557: Vitamin B12 ABC transporter, ATPase component
 
Mycobacterium abscessus ATCC 19977
Vitamin B12 ABC transporter, ATPase component
 
CRON 6.
MSMEG_6649
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M
 
Mycobacterium avium 104
 
Mycobacterium sp. JLS
 
Mycobacterium vanbaalenii PYR-1
 
Mycobacterium flavescens PYR-GCK
*
Mycobacterium smegmatis str. MC2 155

Site:
position = -292
score = 74.16
sequence = TAGGAAGCCGGTGTG...

Gene: MSMEG_6649: Hypothetical protein
 
Mycobacterium abscessus ATCC 19977
Hypothetical protein
 
CRON 7.
Mjls_5141
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
*
Mycobacterium marinum M

Site:
position = -147
score = 24.64
sequence = GTTTACACTGGCCGG...

Gene: MMAR_5098: Hypothetical protein
*
Mycobacterium avium 104

Site:
position = -100
score = 19.63
sequence = GAATTTGGTGAAACT...

Gene: MAV_0557: Hypothetical protein
*
Mycobacterium sp. JLS

Site:
position = -101
score = 25.1
sequence = AGGAATCTGGTGAGA...

Gene: Mjls_5141: Hypothetical protein
*
Mycobacterium vanbaalenii PYR-1

Site:
position = -101
score = 22.15
sequence = CGGAATCTGGTGAGA...

Gene: Mvan_5356: Hypothetical protein
*
Mycobacterium flavescens PYR-GCK

Site:
position = -136
score = 26.61
sequence = TTGGCTTACGATGCT...

Gene: Mflv_1431: Hypothetical protein
*
Mycobacterium smegmatis str. MC2 155

Site:
position = -105
score = 25.06
sequence = CGGAATCTGGTGAGA...

Gene: MSMEG_6090: Hypothetical protein
 
Mycobacterium abscessus ATCC 19977
Hypothetical protein
cbtA
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M

Gene: MMAR_5097: Predicted cobalt transporter CbtA
 
Mycobacterium avium 104

Gene: MAV_0558: Predicted cobalt transporter CbtA
 
Mycobacterium sp. JLS

Gene: Mjls_5140: Predicted cobalt transporter CbtA
 
Mycobacterium vanbaalenii PYR-1

Gene: Mvan_5355: Predicted cobalt transporter CbtA
 
Mycobacterium flavescens PYR-GCK

Gene: Mflv_1432: Predicted cobalt transporter CbtA
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_6089: Predicted cobalt transporter CbtA
 
Mycobacterium abscessus ATCC 19977
Predicted cobalt transporter CbtA
phoE
 
Mycobacterium tuberculosis H37Rv
 
Mycobacterium leprae TN
 
Mycobacterium marinum M

Gene: MMAR_5096: Probable phosphoglycerate mutase
 
Mycobacterium avium 104

Gene: MAV_0559: Probable phosphoglycerate mutase
 
Mycobacterium sp. JLS

Gene: Mjls_5139: Probable phosphoglycerate mutase
 
Mycobacterium vanbaalenii PYR-1

Gene: Mvan_5354: Probable phosphoglycerate mutase
 
Mycobacterium flavescens PYR-GCK

Gene: Mflv_1433: Probable phosphoglycerate mutase
 
Mycobacterium smegmatis str. MC2 155

Gene: MSMEG_6088: Probable phosphoglycerate mutase
 
Mycobacterium abscessus ATCC 19977
Probable phosphoglycerate mutase
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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