Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog Cobalamin - Deinococcus-Thermus

Properties
Regulator type: RNA regulatory element
Name: Cobalamin
RFAM: RF00174
Regulation mode:
Biological process: Cobalamin biosynthesis
Effector: Adenosylcobalamin
Phylum: Deinococcus-Thermus
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Deinococcus radiodurans R1 10 2
Deinococcus geothermalis DSM 11300 24 2
Deinococcus deserti VCD115 20 2
Thermus thermophilus HB27 24 3
Thermus aquaticus Y51MC23 18 3
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
btuF
*
Deinococcus radiodurans R1

Site:
position = -84
score = 17.62
sequence = GGGAAAGTCCGGTTT...

Gene: DR2588: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Deinococcus geothermalis DSM 11300

Site:
position = -244
score = 21.57
sequence = GGGAAAGACCGGTGA...

Gene: Dgeo_0025: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Deinococcus deserti VCD115

Site:
position = -274
score = 25.48
sequence = GGAAGCAGGTGAAGA...

Gene: Deide_02140: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Thermus thermophilus HB27

Site:
position = -291
score = 60.52
sequence = CCAGGTCCCGTAGCC...

Gene: TTC0390: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Thermus aquaticus Y51MC23

Site:
position = -291
score = 55.74
sequence = CAGGTCCCGTTTGCC...

Gene: TaqDRAFT_5534: Vitamin B12 ABC transporter, B12-binding component BtuF
Vitamin B12 ABC transporter, B12-binding component BtuF
btuC
 
Deinococcus radiodurans R1

Gene: DR2589: Vitamin B12 ABC transporter, permease component
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_0024: Vitamin B12 ABC transporter, permease component
 
Deinococcus deserti VCD115

Gene: Deide_02150: Vitamin B12 ABC transporter, permease component
 
Thermus thermophilus HB27

Gene: TTC0391: Vitamin B12 ABC transporter, permease component
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5535: Vitamin B12 ABC transporter, permease component
Vitamin B12 ABC transporter, permease component
btuD
 
Deinococcus radiodurans R1

Gene: DR2590: Vitamin B12 ABC transporter, ATP-binding component
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_0023: Vitamin B12 ABC transporter, ATP-binding component
 
Deinococcus deserti VCD115

Gene: Deide_02160: Vitamin B12 ABC transporter, ATP-binding component
 
Thermus thermophilus HB27

Gene: TTC0392: Vitamin B12 ABC transporter, ATP-binding component
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5536: Vitamin B12 ABC transporter, ATP-binding component
Vitamin B12 ABC transporter, ATP-binding component
COG3411
 
Deinococcus radiodurans R1

Gene: DR2591: Thioredoxin domain protein
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_0022: Thioredoxin domain protein
 
Deinococcus deserti VCD115

Gene: Deide_02170: Thioredoxin domain protein
 
Thermus thermophilus HB27

Gene: TTC0393: Thioredoxin domain protein
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5537: Thioredoxin domain protein
Thioredoxin domain protein
 
CRON 2.
achX
 
Deinococcus radiodurans R1

Gene: DRB0106: Acyl-CoA hydrolase (EC 3.1.2.20)
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_1772: Acyl-CoA hydrolase (EC 3.1.2.20)
 
Deinococcus deserti VCD115
*
Thermus thermophilus HB27

Site:
position = -240
score = 35.57
sequence = GGAAGTCCGGTGAAA...

Gene: TTP0160: Acyl-CoA hydrolase (EC 3.1.2.20)
*
Thermus aquaticus Y51MC23

Site:
position = -260
score = 37.4
sequence = GGAAGTCCGGTGCAA...

Gene: TaqDRAFT_3194: Acyl-CoA hydrolase (EC 3.1.2.20)
Acyl-CoA hydrolase (EC 3.1.2.20)
nrdB
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27

Gene: TTP0161: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_3195: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
nrdA
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27

Gene: TTP0162: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_3196: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
 
CRON 3.
btuF
*
Deinococcus radiodurans R1

Site:
position = -100
score = 13.78
sequence = GGGGAAGCCCGGTGA...

Gene: DRB0007: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Deinococcus geothermalis DSM 11300

Site:
position = -259
score = 35.03
sequence = CCGGCTTCTGCTATC...

Gene: Dgeo_2363: Vitamin B12 ABC transporter, B12-binding component BtuF
*
Deinococcus deserti VCD115

Site:
position = -242
score = 41.15
sequence = GGAAGTCCGGTGAGA...

Gene: Deide_2p01550: Vitamin B12 ABC transporter, B12-binding component BtuF
 
Thermus thermophilus HB27
 
Thermus aquaticus Y51MC23
Vitamin B12 ABC transporter, B12-binding component BtuF
btuR
 
Deinococcus radiodurans R1

Gene: DRB0008: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2362: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
 
Deinococcus deserti VCD115

Gene: Deide_2p01560: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
 
Thermus thermophilus HB27

Gene: TTP0002: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_3284: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
cbiE
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2361: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
 
Deinococcus deserti VCD115

Gene: Deide_2p01570: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
 
Thermus thermophilus HB27
 
Thermus aquaticus Y51MC23
Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
cbiXC
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2360: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
 
Deinococcus deserti VCD115

Gene: Deide_2p01580: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
 
Thermus thermophilus HB27
 
Thermus aquaticus Y51MC23
Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) / Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
cbiD
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2359: Cobalt-precorrin-6 synthase, anaerobic
 
Deinococcus deserti VCD115

Gene: Deide_2p01590: Cobalt-precorrin-6 synthase, anaerobic
 
Thermus thermophilus HB27

Gene: TTP0008: Cobalt-precorrin-6 synthase, anaerobic
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5284: Cobalt-precorrin-6 synthase, anaerobic
Cobalt-precorrin-6 synthase, anaerobic
cbiL
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2358: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
 
Deinococcus deserti VCD115

Gene: Deide_2p01600: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
 
Thermus thermophilus HB27

Gene: TTP0011: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5281: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
cbiF
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2357: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
 
Deinococcus deserti VCD115

Gene: Deide_2p01610: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
 
Thermus thermophilus HB27

Gene: TTP0012: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5280: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
cbiG
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2356: Cobalamin biosynthesis protein CbiG
 
Deinococcus deserti VCD115

Gene: Deide_2p01620: Cobalamin biosynthesis protein CbiG
 
Thermus thermophilus HB27

Gene: TTP0014: Cobalamin biosynthesis protein CbiG
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5278: Cobalamin biosynthesis protein CbiG
Cobalamin biosynthesis protein CbiG
cbiHJ
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2355: Cobalt-precorrin-3b C17-methyltransferase / Cobalt-precorrin-6x reductase (EC 1.3.1.54)
 
Deinococcus deserti VCD115

Gene: Deide_2p01630: Cobalt-precorrin-3b C17-methyltransferase / Cobalt-precorrin-6x reductase (EC 1.3.1.54)
 
Thermus thermophilus HB27
 
Thermus aquaticus Y51MC23
Cobalt-precorrin-3b C17-methyltransferase / Cobalt-precorrin-6x reductase (EC 1.3.1.54)
cobW
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2354: Cobalamin synthesis protein
 
Deinococcus deserti VCD115

Gene: Deide_2p01640: Cobalamin synthesis protein
 
Thermus thermophilus HB27
 
Thermus aquaticus Y51MC23
Cobalamin synthesis protein
hoxN
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2353: HoxN/HupN/NixA family cobalt transporter
 
Deinococcus deserti VCD115

Gene: Deide_2p01650: HoxN/HupN/NixA family cobalt transporter
*
Thermus thermophilus HB27

Site:
position = -209
score = 45.89
sequence = AGGGGGAAGACCGGT...

Gene: TTP0007: HoxN/HupN/NixA family cobalt transporter
*
Thermus aquaticus Y51MC23

Site:
position = -204
score = 42.11
sequence = AAAGGGGGAAGACCG...

Gene: TaqDRAFT_5285: HoxN/HupN/NixA family cobalt transporter
HoxN/HupN/NixA family cobalt transporter
cobN
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2352: Cobaltochelatase, CobN subunit
 
Deinococcus deserti VCD115

Gene: Deide_2p01670: Cobaltochelatase, CobN subunit
 
Thermus thermophilus HB27
 
Thermus aquaticus Y51MC23
Cobaltochelatase, CobN subunit
Dgeo_2351
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2351: Methyltransferase type 11
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27
 
Thermus aquaticus Y51MC23
Methyltransferase type 11
chlID
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2350: Cobalt chelatase, ChlI subunit / Cobalt chelatase, ChlD subunit
 
Deinococcus deserti VCD115

Gene: Deide_2p01680: Cobalt chelatase, ChlI subunit / Cobalt chelatase, ChlD subunit
 
Thermus thermophilus HB27
 
Thermus aquaticus Y51MC23
Cobalt chelatase, ChlI subunit / Cobalt chelatase, ChlD subunit
cbiA
 
Deinococcus radiodurans R1

Gene: DRB0009: Cobyrinic acid a,c-diamide synthase
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2349: Cobyrinic acid a,c-diamide synthase
 
Deinococcus deserti VCD115

Gene: Deide_2p01690: Cobyrinic acid a,c-diamide synthase
 
Thermus thermophilus HB27

Gene: TTP0001: Cobyrinic acid a,c-diamide synthase
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_3286: Cobyrinic acid a,c-diamide synthase
Cobyrinic acid a,c-diamide synthase
cbiB
 
Deinococcus radiodurans R1

Gene: DRB0010: Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2348: Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)
 
Deinococcus deserti VCD115

Gene: Deide_2p01700: Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)
 
Thermus thermophilus HB27

Gene: TTP0019: Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_3278: Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)
Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)
cobD
 
Deinococcus radiodurans R1

Gene: DRB0011: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2875: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27

Gene: TTP0022: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_3274: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
cbiP
 
Deinococcus radiodurans R1

Gene: DRB0012: Cobyric acid synthase
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2874: Cobyric acid synthase
 
Deinococcus deserti VCD115

Gene: Deide_2p01820: Cobyric acid synthase
 
Thermus thermophilus HB27

Gene: TTP0023: Cobyric acid synthase / Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_3272: Cobyric acid synthase / Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
Cobyric acid synthase
cobU
 
Deinococcus radiodurans R1

Gene: DRA0020: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2873: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
Deinococcus deserti VCD115

Gene: Deide_2p01830: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
 
Thermus thermophilus HB27
 
Thermus aquaticus Y51MC23
Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
cobT
 
Deinococcus radiodurans R1

Gene: DRA0240: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
 
Deinococcus geothermalis DSM 11300

Gene: Dgeo_2872: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
 
Deinococcus deserti VCD115

Gene: Deide_2p01840: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
 
Thermus thermophilus HB27
 
Thermus aquaticus Y51MC23
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
cbiC
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27

Gene: TTP0009: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5283: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
cbiET
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27

Gene: TTP0010: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5282: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
cbiH
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27

Gene: TTP0013: Cobalt-precorrin-3b C17-methyltransferase
 2
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5279: Cobalt-precorrin-3b C17-methyltransferase

Gene: TaqDRAFT_5224: Cobalt-precorrin-3b C17-methyltransferase
Cobalt-precorrin-3b C17-methyltransferase
cbiX
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27

Gene: TTP0015: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5277: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)
Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)
DUF3209
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27

Gene: TTP0016: Hypothetical protein implicated in coenzyme B12 biosynthesis
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5276: Hypothetical protein implicated in coenzyme B12 biosynthesis
Hypothetical protein implicated in coenzyme B12 biosynthesis
cobA
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27

Gene: TTP0017: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
 
Thermus aquaticus Y51MC23

Gene: TaqDRAFT_5275: Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
Uroporphyrinogen-III methyltransferase (EC 2.1.1.107)
bluB
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300
 
Deinococcus deserti VCD115

Gene: Deide_2p01660: Cob(II)yrinic acid a,c-diamide reductase
 
Thermus thermophilus HB27

Gene: TTP0018: Cob(II)yrinic acid a,c-diamide reductase
 
Thermus aquaticus Y51MC23
Cob(II)yrinic acid a,c-diamide reductase
TTP0020
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27

Gene: TTP0020: HEPN domain-containing nucleotidyltransferase
 
Thermus aquaticus Y51MC23
HEPN domain-containing nucleotidyltransferase
TTP0021
 
Deinococcus radiodurans R1
 
Deinococcus geothermalis DSM 11300
 
Deinococcus deserti VCD115
 
Thermus thermophilus HB27

Gene: TTP0021: Nucleotidyltransferase
 
Thermus aquaticus Y51MC23
Nucleotidyltransferase
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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