Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog MtaR - Streptococcaceae

Properties
Regulator type: Transcription factor
Regulator family: LysR
Regulation mode: repressor
Biological process: Methionine metabolism
Effector: Homocysteine
Phylum: Firmicutes
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 72 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Lactococcus lactis subsp. cremoris SK11
Lactococcus lactis subsp. lactis Il1403
Streptococcus agalactiae 2603V/R 6 2
Streptococcus dysgalactiae subsp. equisimilis GGS_124 5 2
Streptococcus equi subsp. zooepidemicus MGCS10565 4 1
Streptococcus gallolyticus UCN34 14 7
Streptococcus gordonii str. Challis substr. CH1 11 7
Streptococcus mitis B6 14 6
Streptococcus mutans UA159 15 7
Streptococcus pneumoniae TIGR4 15 7
Streptococcus pyogenes M1 GAS 3 1
Streptococcus sanguinis SK36 8 6
Streptococcus suis 05ZYH33 8 5
Streptococcus thermophilus CNRZ1066 18 7
Streptococcus uberis 0140J 9 3
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
fhs
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_1007: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
 
Lactococcus lactis subsp. lactis Il1403

Gene: L159505: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
 
Streptococcus agalactiae 2603V/R

Gene: SAG1055: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Gene: SDEG_1033: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
 
Streptococcus equi subsp. zooepidemicus MGCS10565

Gene: Sez_0945: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1115: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
*
Streptococcus gordonii str. Challis substr. CH1

Site:
position = -42
score = 4.7769
sequence = TTTTGTTATAATCTATA

Gene: SGO_1210: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
*
Streptococcus mitis B6

Site:
position = -157
score = 6.35878
sequence = TATAGTTTCAAACTATA

Gene: smi_1192: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
 
Streptococcus mutans UA159

Gene: SMU.1073: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
*
Streptococcus pneumoniae TIGR4

Site:
position = -156
score = 6.35878
sequence = TATAGTTTCAAACTATA

Gene: SP_1229: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
 
Streptococcus pyogenes M1 GAS

Gene: SPy1213: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
 
Streptococcus sanguinis SK36

Gene: SSA_1200: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
 
Streptococcus suis 05ZYH33

Gene: SSU05_0690: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
 
Streptococcus thermophilus CNRZ1066

Gene: str0791: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
*
Streptococcus uberis 0140J

Site:
position = -129
score = 4.59488
sequence = TAAAGATATACACTATA

Gene: SUB0942: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
Formate--tetrahydrofolate ligase (EC 6.3.4.3)
 
CRON 2.
folD
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_0921: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
Lactococcus lactis subsp. lactis Il1403

Gene: L76582: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
Streptococcus agalactiae 2603V/R

Gene: SAG0494: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Gene: SDEG_1488: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
Streptococcus equi subsp. zooepidemicus MGCS10565

Gene: Sez_0614: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
Streptococcus gallolyticus UCN34

Gene: GALLO_0622: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_0690: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
*
Streptococcus mitis B6

Site:
position = -35
score = 6.15603
sequence = TATAGTTTGAAACTATA

Gene: smi_0869: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
*
Streptococcus mutans UA159

Site:
position = -93
score = 4.62839
sequence = TATAATATTTAAATATA

Gene: SMU.572: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
*
Streptococcus pneumoniae TIGR4

Site:
position = -98
score = 6.26
sequence = TATAGTTTAAAGCTATA

Gene: SP_0825: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
Streptococcus pyogenes M1 GAS

Gene: SPy1502: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
Streptococcus sanguinis SK36

Gene: SSA_0671: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
Streptococcus suis 05ZYH33

Gene: SSU05_0497: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
Streptococcus thermophilus CNRZ1066

Gene: str0611: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
Streptococcus uberis 0140J

Gene: SUB1277: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
 
CRON 3.
metK
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_2161: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Lactococcus lactis subsp. lactis Il1403

Gene: L153408: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Streptococcus agalactiae 2603V/R

Gene: SAG0831: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Gene: SDEG_1371: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Streptococcus equi subsp. zooepidemicus MGCS10565

Gene: Sez_0680: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Streptococcus gallolyticus UCN34

Gene: GALLO_0769: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Streptococcus gordonii str. Challis substr. CH1

Site:
position = -158
score = 5.79099
sequence = TATAGTTTATGTCTATA

Gene: SGO_0987: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Streptococcus mitis B6

Gene: smi_1400: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Streptococcus mutans UA159

Gene: SMU.1573: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Streptococcus pneumoniae TIGR4

Gene: SP_0762: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Streptococcus pyogenes M1 GAS

Gene: SPy1359: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Streptococcus sanguinis SK36

Site:
position = -157
score = 6.25439
sequence = TATAGTTTTAATCTATA

Gene: SSA_1495: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Streptococcus suis 05ZYH33

Gene: SSU05_1621: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Streptococcus thermophilus CNRZ1066

Gene: str1172: S-adenosylmethionine synthetase (EC 2.5.1.6)
 
Streptococcus uberis 0140J

Gene: SUB1211: S-adenosylmethionine synthetase (EC 2.5.1.6)
S-adenosylmethionine synthetase (EC 2.5.1.6)
 
CRON 4.
mmuP
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus agalactiae 2603V/R

Gene: SAG1306: Predicted S-methylmethionine permease
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
*
Streptococcus gallolyticus UCN34

Site:
position = -94
score = 5.04541
sequence = TATAGTTTTTAACTAAT

Gene: GALLO_1253: Predicted S-methylmethionine permease
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6
 
Streptococcus mutans UA159

Gene: SMU.951: Predicted S-methylmethionine permease
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
*2
Streptococcus suis 05ZYH33

Site:
position = -97
score = 5.59363
sequence = CATAGTTTGAAGCTATA

Gene: SSU05_2026: Predicted S-methylmethionine permease

Gene: SSU05_2025: Predicted S-methylmethionine permease
 
Streptococcus thermophilus CNRZ1066

Gene: str0583: Predicted S-methylmethionine permease
 
Streptococcus uberis 0140J
Predicted S-methylmethionine permease
mmuM
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus agalactiae 2603V/R

Gene: SAG1305: Homocysteine S-methyltransferase (EC 2.1.1.10)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1252: Homocysteine S-methyltransferase (EC 2.1.1.10)
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6
 
Streptococcus mutans UA159

Gene: SMU.952: Homocysteine S-methyltransferase (EC 2.1.1.10)
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36

Gene: SSA_1096: Homocysteine S-methyltransferase (EC 2.1.1.10)
 
Streptococcus suis 05ZYH33

Gene: SSU05_2024: Homocysteine S-methyltransferase (EC 2.1.1.10)
 
Streptococcus thermophilus CNRZ1066

Gene: str0584: Homocysteine S-methyltransferase (EC 2.1.1.10)
 
Streptococcus uberis 0140J
Homocysteine S-methyltransferase (EC 2.1.1.10)
 
CRON 5.
COG1912
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus agalactiae 2603V/R
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1836: Conserved hypothetical protein
*
Streptococcus gordonii str. Challis substr. CH1

Site:
position = -30
score = 4.45684
sequence = TAAAGTTCAGGACTATA

Gene: SGO_0468: Conserved hypothetical protein
*
Streptococcus mitis B6

Site:
position = -91
score = 4.6208
sequence = TATAAGGTAAAACTATA

Gene: smi_1812: Conserved hypothetical protein
*
Streptococcus mutans UA159

Site:
position = -110
score = 5.44518
sequence = TATAGGTAATAACTATA

Gene: SMU.1936c: Conserved hypothetical protein
*
Streptococcus pneumoniae TIGR4

Site:
position = -64
score = 4.6208
sequence = TATAAGGTAAAACTATA

Gene: SP_0481: Conserved hypothetical protein
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36

Gene: SSA_0591: Conserved hypothetical protein
 
Streptococcus suis 05ZYH33
*
Streptococcus thermophilus CNRZ1066

Site:
position = -100
score = 4.51555
sequence = CATAGCCAAAGGCTATA

Gene: str0304: Conserved hypothetical protein
*
Streptococcus uberis 0140J

Site:
position = -106
score = 6.28427
sequence = TATAGTTTTAGACTATA

Gene: SUB0314: Conserved hypothetical protein
Conserved hypothetical protein
mtsA
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_0367: Substrate-specific component MtsA of methionine-regulated ECF transporter
 
Lactococcus lactis subsp. lactis Il1403

Gene: L123147: Substrate-specific component MtsA of methionine-regulated ECF transporter
 
Streptococcus agalactiae 2603V/R

Gene: SAG1634: Substrate-specific component MtsA of methionine-regulated ECF transporter
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1835: Substrate-specific component MtsA of methionine-regulated ECF transporter
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_0469: Substrate-specific component MtsA of methionine-regulated ECF transporter
 
Streptococcus mitis B6

Gene: smi_1811: Substrate-specific component MtsA of methionine-regulated ECF transporter
 
Streptococcus mutans UA159

Gene: SMU.1935c: Substrate-specific component MtsA of methionine-regulated ECF transporter
 
Streptococcus pneumoniae TIGR4

Gene: SP_0482: Substrate-specific component MtsA of methionine-regulated ECF transporter
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36

Gene: SSA_0592: Substrate-specific component MtsA of methionine-regulated ECF transporter
 
Streptococcus suis 05ZYH33
 
Streptococcus thermophilus CNRZ1066

Gene: str0306: Substrate-specific component MtsA of methionine-regulated ECF transporter
 
Streptococcus uberis 0140J

Gene: SUB0313: Substrate-specific component MtsA of methionine-regulated ECF transporter
Substrate-specific component MtsA of methionine-regulated ECF transporter
mtsB
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_0368: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
 
Lactococcus lactis subsp. lactis Il1403

Gene: L123777: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
 
Streptococcus agalactiae 2603V/R

Gene: SAG1633: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1834: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_0488: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
 
Streptococcus mitis B6

Gene: smi_1810: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
 
Streptococcus mutans UA159

Gene: SMU.1934c: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
 
Streptococcus pneumoniae TIGR4

Gene: SP_0483: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36

Gene: SSA_0602: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
 
Streptococcus suis 05ZYH33

Gene: SSU05_0409: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
 
Streptococcus thermophilus CNRZ1066

Gene: str0308: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
 
Streptococcus uberis 0140J

Gene: SUB0312: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
mtsC
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_0369: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
Lactococcus lactis subsp. lactis Il1403

Gene: L125503: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
Streptococcus agalactiae 2603V/R

Gene: SAG1632: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1833: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_0489: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
Streptococcus mitis B6

Gene: smi_1809: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
Streptococcus mutans UA159

Gene: SMU.1933c: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
Streptococcus pneumoniae TIGR4

Gene: SP_0484: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36

Gene: SSA_0603: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
Streptococcus suis 05ZYH33

Gene: SSU05_0410: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
Streptococcus thermophilus CNRZ1066

Gene: str0310: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
Streptococcus uberis 0140J

Gene: SUB0311: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
 
CRON 6.
metE2
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus agalactiae 2603V/R
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
*
Streptococcus gallolyticus UCN34

Site:
position = -98
score = 5.9453
sequence = TATAGTTTGTAACTATA

Gene: GALLO_0804: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
*
Streptococcus gordonii str. Challis substr. CH1

Site:
position = -152
score = 6.29145
sequence = TATAGTTATAAACTATA

Gene: SGO_0747: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
 
Streptococcus mitis B6
*
Streptococcus mutans UA159

Site:
position = -100
score = 6.48238
sequence = TATAGTTTAAAACTATA

Gene: SMU.1487: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS
*
Streptococcus sanguinis SK36

Site:
position = -83
score = 5.22779
sequence = AATAGTTTTCGGCTATA

Gene: SSA_0917: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
*
Streptococcus suis 05ZYH33

Site:
position = -102
score = 5.81111
sequence = TATAGTTTTTAACTATG

Gene: SSU05_1320: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
*2
Streptococcus thermophilus CNRZ1066

Site:
position = -257
score = 5.86158
sequence = TATAGTCTAAAACTATA

Gene: str0905: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)

Gene: str0904: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
 
Streptococcus uberis 0140J
Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
COG1878
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus agalactiae 2603V/R
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1176: Metal-dependent hydrolase (EC 3.-.-.-)
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_0748: Metal-dependent hydrolase (EC 3.-.-.-)
 
Streptococcus mitis B6
 
Streptococcus mutans UA159

Gene: SMU.1172c: Metal-dependent hydrolase (EC 3.-.-.-)
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS
*
Streptococcus sanguinis SK36

Site:
position = -178
score = 6.01876
sequence = TATAGCTTCAAACTATA

Gene: SSA_1535: Metal-dependent hydrolase (EC 3.-.-.-)
*
Streptococcus suis 05ZYH33

Site:
position = -67
score = 5.41503
sequence = TATAGTTAAAAGCAATA

Gene: SSU05_0510: Metal-dependent hydrolase (EC 3.-.-.-)
*
Streptococcus thermophilus CNRZ1066

Site:
position = -140
score = 5.91998
sequence = TATAGCTTAAAGCTATA

Gene: str0334: Metal-dependent hydrolase (EC 3.-.-.-)
 
Streptococcus uberis 0140J
Metal-dependent hydrolase (EC 3.-.-.-)
metY
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus agalactiae 2603V/R
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
*
Streptococcus gallolyticus UCN34

Site:
position = -105
score = 6.48238
sequence = TATAGTTTAAAACTATA

Gene: GALLO_1177: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6

Gene: smi_1010: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)
*
Streptococcus mutans UA159

Site:
position = -66
score = 6.27166
sequence = TATAGTTTATAACTATA

Gene: SMU.1173: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36

Gene: SSA_0855: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)
*
Streptococcus suis 05ZYH33

Site:
position = -95
score = 5.85031
sequence = TATAGTTGTTAACTATA

Gene: SSU05_1033: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)
 
Streptococcus thermophilus CNRZ1066

Gene: str0987: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)
 
Streptococcus uberis 0140J
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)
 
CRON 7.
metA
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403

Gene: L0101: Homoserine O-succinyltransferase (EC 2.3.1.46)
 
Streptococcus agalactiae 2603V/R
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
*
Streptococcus gallolyticus UCN34

Site:
position = -105
score = 5.92415
sequence = TATAGCTAAAAACTATA

Site:
position = -71
score = 5.40125
sequence = TATAATTGAAAACTATA

Gene: GALLO_0824: Homoserine O-succinyltransferase (EC 2.3.1.46)
*
Streptococcus gordonii str. Challis substr. CH1

Site:
position = -63
score = 5.40125
sequence = TATAATTGAAAACTATA

Site:
position = -97
score = 5.57098
sequence = CATAGTTTCAGGCTATA

Gene: SGO_1002: Homoserine O-succinyltransferase (EC 2.3.1.46)
 
Streptococcus mitis B6

Gene: smi_1566: Homoserine O-succinyltransferase (EC 2.3.1.46)
*
Streptococcus mutans UA159

Site:
position = -68
score = 5.19052
sequence = TATATTTGATAACTATA

Site:
position = -102
score = 5.28228
sequence = TATAGTTGGAACCTATA

Gene: SMU.1466: Homoserine O-succinyltransferase (EC 2.3.1.46)
*
Streptococcus pneumoniae TIGR4

Site:
position = -109
score = 5.40125
sequence = TATAATTGAAAACTATA

Gene: SP_1576: Homoserine O-succinyltransferase (EC 2.3.1.46)
 
Streptococcus pyogenes M1 GAS
*
Streptococcus sanguinis SK36

Site:
position = -145
score = 5.80803
sequence = CATAGTTTCTAACTATA

Site:
position = -111
score = 5.40125
sequence = TATAATTGAAAACTATA

Gene: SSA_1420: Homoserine O-succinyltransferase (EC 2.3.1.46)
 
Streptococcus suis 05ZYH33

Gene: SSU05_1306: Homoserine O-succinyltransferase (EC 2.3.1.46)
*
Streptococcus thermophilus CNRZ1066

Site:
position = -103
score = 5.62748
sequence = TATAGTTTAAAGTTATA

Gene: str1222: Homoserine O-succinyltransferase (EC 2.3.1.46)
 
Streptococcus uberis 0140J
Homoserine O-succinyltransferase (EC 2.3.1.46)
 
CRON 8.
metE
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_1368: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
Lactococcus lactis subsp. lactis Il1403

Gene: L0100: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Streptococcus agalactiae 2603V/R

Site:
position = -132
score = 6.48238
sequence = TATAGTTTAAAACTATA

Gene: SAG2049: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
*
Streptococcus gallolyticus UCN34

Site:
position = -139
score = 5.92415
sequence = TATAGCTAAAAACTATA

Site:
position = -36
score = 5.22886
sequence = TATAGTTTAAAACTAAT

Site:
position = -170
score = 6.26417
sequence = TATAGTTAAAAACTATA

Gene: GALLO_1316: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Streptococcus gordonii str. Challis substr. CH1

Site:
position = -180
score = 5.44103
sequence = TATAGTTTTTGATTATA

Site:
position = -97
score = 5.85116
sequence = TATAGTTTTTGGCTATA

Gene: SGO_0310: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Streptococcus mitis B6

Site:
position = -99
score = 6.35878
sequence = TATAGTTTCAAACTATA

Gene: smi_1600: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Streptococcus mutans UA159

Site:
position = -186
score = 5.56445
sequence = TATAGATGAAAACTATA

Site:
position = -155
score = 6.14236
sequence = TATAGCTTAAAACTATA

Gene: SMU.873: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Streptococcus pneumoniae TIGR4

Site:
position = -99
score = 6.35878
sequence = TATAGTTTCAAACTATA

Gene: SP_0585: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
Streptococcus pyogenes M1 GAS
*
Streptococcus sanguinis SK36

Site:
position = -97
score = 6.28427
sequence = TATAGTTTTAGACTATA

Site:
position = -180
score = 4.75038
sequence = CATAATTTCTACCTATA

Gene: SSA_0416: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Streptococcus suis 05ZYH33

Site:
position = -99
score = 4.78846
sequence = TATAGTCAAAAGTTATA

Site:
position = -235
score = 5.19956
sequence = CATAGATAAAATCTATA

Gene: SSU05_1774: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
*
Streptococcus thermophilus CNRZ1066

Site:
position = -130
score = 5.85833
sequence = TATAGTTATTAGCTATA

Site:
position = -58
score = 6.48238
sequence = TATAGTTTAAAACTATA

Gene: str0785: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
 
Streptococcus uberis 0140J
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
metF
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_1367: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Lactococcus lactis subsp. lactis Il1403

Gene: L0099: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Streptococcus agalactiae 2603V/R
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gallolyticus UCN34
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_0311: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Streptococcus mitis B6

Gene: smi_1599: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Streptococcus mutans UA159
 
Streptococcus pneumoniae TIGR4

Gene: SP_0586: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36

Gene: SSA_0417: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Streptococcus suis 05ZYH33

Gene: SSU05_1775: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Streptococcus thermophilus CNRZ1066

Gene: str0786: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
 
Streptococcus uberis 0140J
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
metH
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus agalactiae 2603V/R

Gene: SAG2048: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1315: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus mitis B6
 
Streptococcus mutans UA159

Gene: SMU.874: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain
 
Streptococcus pneumoniae TIGR4
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus suis 05ZYH33
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus uberis 0140J
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain
 
CRON 9.
metQ
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
*
Streptococcus agalactiae 2603V/R

Site:
position = -99
score = 6.48238
sequence = TATAGTTTAAAACTATA

Gene: SAG1641: Methionine ABC transporter, substrate-binding protein
*2
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Site:
position = -100
score = 6.29893
sequence = TATAGTTTTTAACTATA

Gene: SDEG_0382: Methionine ABC transporter, substrate-binding protein

Site:
position = -102
score = 6.50966
sequence = TATAGTTTTAAACTATA

Gene: SDEG_0383: Methionine ABC transporter, substrate-binding protein
*
Streptococcus equi subsp. zooepidemicus MGCS10565

Site:
position = -103
score = 5.71342
sequence = TATAGCTAATAACTATA

Gene: Sez_1679: Methionine ABC transporter, substrate-binding protein
*
Streptococcus gallolyticus UCN34

Site:
position = -102
score = 6.50966
sequence = TATAGTTTTAAACTATA

Gene: GALLO_1844: Methionine ABC transporter, substrate-binding protein
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_0458: Methionine ABC transporter, substrate-binding protein
*
Streptococcus mitis B6

Site:
position = -99
score = 6.16964
sequence = TATAGCTTTAAACTATA

Gene: smi_1944: Methionine ABC transporter, substrate-binding protein
*
Streptococcus mutans UA159

Site:
position = -100
score = 6.07655
sequence = TATAGTTTTTAGCTATA

Gene: SMU.1941: Methionine ABC transporter, substrate-binding protein
*
Streptococcus pneumoniae TIGR4

Site:
position = -99
score = 6.50966
sequence = TATAGTTTTAAACTATA

Gene: SP_0149: Methionine ABC transporter, substrate-binding protein
*
Streptococcus pyogenes M1 GAS

Site:
position = -103
score = 5.99457
sequence = TATAGTTTAAAACTATG

Gene: SPy0319: Methionine ABC transporter, substrate-binding protein
 
Streptococcus sanguinis SK36

Gene: SSA_0375: Methionine ABC transporter, substrate-binding protein
 
Streptococcus suis 05ZYH33

Gene: SSU05_1771: Methionine ABC transporter, substrate-binding protein
*
Streptococcus thermophilus CNRZ1066

Site:
position = -103
score = 6.26417
sequence = TATAGTTAAAAACTATA

Gene: str0297: Methionine ABC transporter, substrate-binding protein
*
Streptococcus uberis 0140J

Site:
position = -101
score = 6.28727
sequence = TATAGTTTTAAGCTATA

Gene: SUB0366: Methionine ABC transporter, substrate-binding protein
Methionine ABC transporter, substrate-binding protein
hmrB
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus agalactiae 2603V/R

Gene: SAG1640: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Gene: SDEG_0384: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
 
Streptococcus equi subsp. zooepidemicus MGCS10565

Gene: Sez_1678: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1843: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_0459: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
 
Streptococcus mitis B6

Gene: smi_1943: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
 
Streptococcus mutans UA159

Gene: SMU.1940c: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
 
Streptococcus pneumoniae TIGR4

Gene: SP_0150: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus suis 05ZYH33

Gene: SSU05_1770: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
 3
Streptococcus thermophilus CNRZ1066

Gene: str0300: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)

Gene: str0298: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)

Gene: str0299: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
 
Streptococcus uberis 0140J

Gene: SUB0367: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
metN
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_0365: Methionine ABC transporter, ATP-binding protein
 
Lactococcus lactis subsp. lactis Il1403

Gene: L121289: Methionine ABC transporter, ATP-binding protein
 
Streptococcus agalactiae 2603V/R

Gene: SAG1639: Methionine ABC transporter, ATP-binding protein
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Gene: SDEG_0385: Methionine ABC transporter, ATP-binding protein
 
Streptococcus equi subsp. zooepidemicus MGCS10565

Gene: Sez_1677: Methionine ABC transporter, ATP-binding protein
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1842: Methionine ABC transporter, ATP-binding protein
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_0460: Methionine ABC transporter, ATP-binding protein
 
Streptococcus mitis B6

Gene: smi_1942: Methionine ABC transporter, ATP-binding protein
 
Streptococcus mutans UA159

Gene: SMU.1939c: Methionine ABC transporter, ATP-binding protein
 
Streptococcus pneumoniae TIGR4

Gene: SP_0151: Methionine ABC transporter, ATP-binding protein
 
Streptococcus pyogenes M1 GAS

Gene: SPy0320: Methionine ABC transporter, ATP-binding protein
 
Streptococcus sanguinis SK36

Gene: SSA_0376: Methionine ABC transporter, ATP-binding protein
 
Streptococcus suis 05ZYH33

Gene: SSU05_1769: Methionine ABC transporter, ATP-binding protein
 
Streptococcus thermophilus CNRZ1066

Gene: str0301: Methionine ABC transporter, ATP-binding protein
 
Streptococcus uberis 0140J

Gene: SUB0368: Methionine ABC transporter, ATP-binding protein
Methionine ABC transporter, ATP-binding protein
metP
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_0366: Methionine ABC transporter, permease protein
 
Lactococcus lactis subsp. lactis Il1403

Gene: L122401: Methionine ABC transporter, permease protein
 
Streptococcus agalactiae 2603V/R

Gene: SAG1638: Methionine ABC transporter, permease protein
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Gene: SDEG_0386: Methionine ABC transporter, permease protein
 
Streptococcus equi subsp. zooepidemicus MGCS10565

Gene: Sez_1676: Methionine ABC transporter, permease protein
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1841: Methionine ABC transporter, permease protein
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_0461: Methionine ABC transporter, permease protein
 
Streptococcus mitis B6

Gene: smi_1941: Methionine ABC transporter, permease protein
 
Streptococcus mutans UA159

Gene: SMU.1938c: Methionine ABC transporter, permease protein
 
Streptococcus pneumoniae TIGR4

Gene: SP_0152: Methionine ABC transporter, permease protein
 
Streptococcus pyogenes M1 GAS

Gene: SPy0321: Methionine ABC transporter, permease protein
 
Streptococcus sanguinis SK36

Gene: SSA_0377: Methionine ABC transporter, permease protein
 
Streptococcus suis 05ZYH33

Gene: SSU05_1768: Methionine ABC transporter, permease protein
 
Streptococcus thermophilus CNRZ1066

Gene: str0302: Methionine ABC transporter, permease protein
 
Streptococcus uberis 0140J

Gene: SUB0369: Methionine ABC transporter, permease protein
Methionine ABC transporter, permease protein
 
CRON 10.
metB
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403

Gene: L0102: Cystathionine gamma-synthase (EC 2.5.1.48)
 
Streptococcus agalactiae 2603V/R
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
*
Streptococcus gallolyticus UCN34

Site:
position = -140
score = 5.24128
sequence = TATAGTTTTTACTTATA

Gene: GALLO_1768: Cystathionine gamma-synthase (EC 2.5.1.48)
*
Streptococcus gordonii str. Challis substr. CH1

Site:
position = -101
score = 6.13339
sequence = TATAGTTTCAGACTATA

Gene: SGO_1636: Cystathionine gamma-synthase (EC 2.5.1.48)
*
Streptococcus mitis B6

Site:
position = -93
score = 6.15603
sequence = TATAGTTTGAAACTATA

Gene: smi_1508: Cystathionine gamma-synthase (EC 2.5.1.48)
 
Streptococcus mutans UA159

Gene: SMU.1675: Cystathionine gamma-synthase (EC 2.5.1.48)
*
Streptococcus pneumoniae TIGR4

Site:
position = -93
score = 6.15603
sequence = TATAGTTTGAAACTATA

Gene: SP_1525: Cystathionine gamma-synthase (EC 2.5.1.48)
 
Streptococcus pyogenes M1 GAS
*
Streptococcus sanguinis SK36

Site:
position = -44
score = 6.35878
sequence = TATAGTTTCAAACTATA

Gene: SSA_1737: Cystathionine gamma-synthase (EC 2.5.1.48)
 
Streptococcus suis 05ZYH33

Gene: SSU05_1562: Cystathionine gamma-synthase (EC 2.5.1.48)
*
Streptococcus thermophilus CNRZ1066

Site:
position = -130
score = 5.88594
sequence = TATAGTAATAAACTATA

Gene: str0352: Cystathionine gamma-synthase (EC 2.5.1.48)
 
Streptococcus uberis 0140J
Cystathionine gamma-synthase (EC 2.5.1.48)
csd
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_2187: Cysteine desulfurase (EC 2.8.1.7)
 
Lactococcus lactis subsp. lactis Il1403

Gene: L177593: Cysteine desulfurase (EC 2.8.1.7)
 
Streptococcus agalactiae 2603V/R

Gene: SAG1587: Cysteine desulfurase (EC 2.8.1.7)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1767: Cysteine desulfurase (EC 2.8.1.7)
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_1635: Cysteine desulfurase (EC 2.8.1.7)
 
Streptococcus mitis B6

Gene: smi_1507: Cysteine desulfurase (EC 2.8.1.7)
 
Streptococcus mutans UA159

Gene: SMU.1674: Cysteine desulfurase (EC 2.8.1.7)
 
Streptococcus pneumoniae TIGR4

Gene: SP_1524: Cysteine desulfurase (EC 2.8.1.7)
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36

Gene: SSA_1736: Cysteine desulfurase (EC 2.8.1.7)
 
Streptococcus suis 05ZYH33

Gene: SSU05_1561: Cysteine desulfurase (EC 2.8.1.7)
 
Streptococcus thermophilus CNRZ1066

Gene: str0353: Cysteine desulfurase (EC 2.8.1.7)
 
Streptococcus uberis 0140J

Gene: SUB0427: Cysteine desulfurase (EC 2.8.1.7)
Cysteine desulfurase (EC 2.8.1.7)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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