Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog T-box(Leu) - Clostridiaceae

Properties
Regulator type: RNA regulatory element
Name: T-box
RFAM: RF00230
Regulation mode:
Biological process: Amino acid metabolism
Effector: Leu-tRNA
Phylum: Firmicutes
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Clostridium beijerincki NCIMB 8052 1 1
Clostridium difficile 630 5 2
Clostridium perfringens ATCC 13124 1 1
Clostridium novyi NT 2 2
Clostridium botulinum A str. ATCC 3502 1 1
Clostridium acetobutylicum ATCC 824 2 2
Clostridium tetani E88 1 1
Clostridium phytofermentans ISDg 2 2
Clostridium cellulolyticum H10 6 2
Clostridium kluyveri DSM 555 9 5
Clostridium sp. OhILAs 1 1
Clostridium bartlettii DSM 16795 1 1
Clostridium bolteae ATCC BAA-613 1 1
Clostridium butyricum 5521 3 2
Clostridium hiranonis DSM 13275 1 1
Clostridium leptum DSM 753 1 1
Clostridium nexile DSM 1787 1 1
Clostridium scindens ATCC 35704 1 1
Clostridium sp. L2-50 1 1
Clostridium sp. SS2/1 1 1
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
leuS
*
Clostridium beijerincki NCIMB 8052

Site:
position = -382
score = 106.02
sequence = ATTGTGCGATGAATA...

Gene: Cbei_4590: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium difficile 630

Site:
position = -302
score = 78.6
sequence = TTGAATAGACTAGAG...

Gene: CD2521: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium perfringens ATCC 13124

Site:
position = -297
score = 138.51
sequence = ATTAAAAGCTTTGAT...

Gene: CPF_0657: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium novyi NT

Site:
position = -270
score = 124.94
sequence = TGTTATTGCTTTGAA...

Gene: NT01CX_1372: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium botulinum A str. ATCC 3502

Site:
position = -308
score = 134.44
sequence = ATTAAAGGCTTTGAA...

Gene: CBO0186: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium acetobutylicum ATCC 824

Site:
position = -244
score = 129.12
sequence = TTTAAAAGCTTTGAA...

Gene: CAC0646: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium tetani E88

Site:
position = -218
score = 123.16
sequence = ATGAAAAGCTATGAG...

Gene: CTC00337: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium phytofermentans ISDg

Site:
position = -266
score = 127.58
sequence = AAAAAGTTATGATTA...

Gene: null: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium cellulolyticum H10

Site:
position = -258
score = 104.98
sequence = TTAAAGTTATGAAGC...

Gene: Ccel_3454: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium kluyveri DSM 555

Site:
position = -371
score = 118.75
sequence = ACTTAGCTTTGAAGA...

Gene: CKL_3605: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium sp. OhILAs

Site:
position = -301
score = 104.31
sequence = AAAAGTTGCTGTGAA...

Gene: Clos_2587: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium bartlettii DSM 16795

Site:
position = -299
score = 87.43
sequence = CAAATAAACTAAAGT...

Gene: CLOBAR_01473: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium bolteae ATCC BAA-613

Site:
position = -364
score = 98.06
sequence = TGCAAATACGCAGAT...

Gene: CLOBOL_01934: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium butyricum 5521

Site:
position = -379
score = 122.73
sequence = ATATTAAGCTATGAG...

Gene: CBY_1582: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium hiranonis DSM 13275

Site:
position = -285
score = 92.59
sequence = AGACAGTCTGAAGTA...

Gene: CLOHIR_01984: Leucyl-tRNA synthetase (EC 6.1.1.4)
 
Clostridium leptum DSM 753

Gene: CLOLEP_03285: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium nexile DSM 1787

Site:
position = -419
score = 96.97
sequence = TCAAAAAACATAGAT...

Gene: CLONEX_03143: Leucyl-tRNA synthetase (EC 6.1.1.4)
*
Clostridium scindens ATCC 35704

Site:
position = -198
score = 109.61
sequence = TAGAAACGAAGAAGA...

Gene: CLOSCI_03648: Leucyl-tRNA synthetase (EC 6.1.1.4)
 
Clostridium sp. L2-50

Gene: CLOL250_02927: Leucyl-tRNA synthetase (EC 6.1.1.4)
 
Clostridium sp. SS2/1

Gene: CLOSS21_01939: Leucyl-tRNA synthetase (EC 6.1.1.4)
Leucyl-tRNA synthetase (EC 6.1.1.4)
 
CRON 2.
brnQ1
 
Clostridium beijerincki NCIMB 8052
 
Clostridium difficile 630
 
Clostridium perfringens ATCC 13124
*
Clostridium novyi NT

Site:
position = -381
score = 71.14
sequence = TCAAGACATTGACGG...

Gene: NT01CX_2428: branched-chain amino acid transport system II carrier protein
 
Clostridium botulinum A str. ATCC 3502
 
Clostridium acetobutylicum ATCC 824
 
Clostridium tetani E88
 
Clostridium phytofermentans ISDg
 
Clostridium cellulolyticum H10
 
Clostridium kluyveri DSM 555
 
Clostridium sp. OhILAs
 
Clostridium bartlettii DSM 16795
 
Clostridium bolteae ATCC BAA-613
 
Clostridium butyricum 5521
 
Clostridium hiranonis DSM 13275
 
Clostridium leptum DSM 753
 
Clostridium nexile DSM 1787
 
Clostridium scindens ATCC 35704
 
Clostridium sp. L2-50
 
Clostridium sp. SS2/1
branched-chain amino acid transport system II carrier protein
 
CRON 3.
leuA1
 
Clostridium beijerincki NCIMB 8052

Gene: Cbei_2175: 2-isopropylmalate synthase (EC 2.3.3.13)
 
Clostridium difficile 630
 
Clostridium perfringens ATCC 13124
 
Clostridium novyi NT
 
Clostridium botulinum A str. ATCC 3502
 
Clostridium acetobutylicum ATCC 824
 
Clostridium tetani E88
 
Clostridium phytofermentans ISDg
 
Clostridium cellulolyticum H10
*
Clostridium kluyveri DSM 555

Site:
position = -332
score = 57.43
sequence = TAAAGGATATGAAAA...

Gene: CKL_0047: 2-isopropylmalate synthase (EC 2.3.3.13)
 
Clostridium sp. OhILAs
 
Clostridium bartlettii DSM 16795
 
Clostridium bolteae ATCC BAA-613
 
Clostridium butyricum 5521
 
Clostridium hiranonis DSM 13275
*
Clostridium leptum DSM 753

Site:
position = -281
score = 110.24
sequence = TAAATACGATGAAGA...

Gene: CLOLEP_01755: 2-isopropylmalate synthase (EC 2.3.3.13)
 
Clostridium nexile DSM 1787

Gene: CLONEX_02947: 2-isopropylmalate synthase (EC 2.3.3.13)
 
Clostridium scindens ATCC 35704

Gene: CLOSCI_01346: 2-isopropylmalate synthase (EC 2.3.3.13)
*
Clostridium sp. L2-50

Site:
position = -284
score = 119.05
sequence = ATAATACGATGAAGA...

Gene: CLOL250_00490: 2-isopropylmalate synthase (EC 2.3.3.13)
*
Clostridium sp. SS2/1

Site:
position = -306
score = 142.75
sequence = TTTAAATACAATGAT...

Gene: CLOSS21_00446: 2-isopropylmalate synthase (EC 2.3.3.13)
2-isopropylmalate synthase (EC 2.3.3.13)
 
CRON 4.
ilvB
 
Clostridium beijerincki NCIMB 8052
 
Clostridium difficile 630
 
Clostridium perfringens ATCC 13124
 
Clostridium novyi NT
 
Clostridium botulinum A str. ATCC 3502
 
Clostridium acetobutylicum ATCC 824
 
Clostridium tetani E88
 
Clostridium phytofermentans ISDg
*
Clostridium cellulolyticum H10

Site:
position = -327
score = 86.73
sequence = TATACAGCTTATGAT...

Gene: Ccel_3437: Acetolactate synthase large subunit (EC 2.2.1.6)
*
Clostridium kluyveri DSM 555

Site:
position = -306
score = 102.99
sequence = TATAAAAGCTATGAT...

Gene: CKL_1618: Acetolactate synthase large subunit (EC 2.2.1.6)
 
Clostridium sp. OhILAs
 
Clostridium bartlettii DSM 16795
 
Clostridium bolteae ATCC BAA-613
*
Clostridium butyricum 5521

Site:
position = -461
score = 56.75
sequence = TTACAAGTATGACAA...

Gene: CBY_1194: Acetolactate synthase large subunit (EC 2.2.1.6)
 
Clostridium hiranonis DSM 13275
 
Clostridium leptum DSM 753
 
Clostridium nexile DSM 1787
 
Clostridium scindens ATCC 35704
 
Clostridium sp. L2-50
 
Clostridium sp. SS2/1
Acetolactate synthase large subunit (EC 2.2.1.6)
ilvH
 
Clostridium beijerincki NCIMB 8052
 
Clostridium difficile 630
 
Clostridium perfringens ATCC 13124
 
Clostridium novyi NT
 
Clostridium botulinum A str. ATCC 3502
 
Clostridium acetobutylicum ATCC 824
 
Clostridium tetani E88
 
Clostridium phytofermentans ISDg
 
Clostridium cellulolyticum H10

Gene: Ccel_3436: Acetolactate synthase small subunit (EC 2.2.1.6)
 
Clostridium kluyveri DSM 555

Gene: CKL_1617: Acetolactate synthase small subunit (EC 2.2.1.6)
 
Clostridium sp. OhILAs
 
Clostridium bartlettii DSM 16795
 
Clostridium bolteae ATCC BAA-613
 
Clostridium butyricum 5521
 
Clostridium hiranonis DSM 13275
 
Clostridium leptum DSM 753
 
Clostridium nexile DSM 1787
 
Clostridium scindens ATCC 35704
 
Clostridium sp. L2-50
 
Clostridium sp. SS2/1
Acetolactate synthase small subunit (EC 2.2.1.6)
ilvC
 
Clostridium beijerincki NCIMB 8052
 
Clostridium difficile 630
 
Clostridium perfringens ATCC 13124
 
Clostridium novyi NT
 
Clostridium botulinum A str. ATCC 3502
 
Clostridium acetobutylicum ATCC 824
 
Clostridium tetani E88
 
Clostridium phytofermentans ISDg
 
Clostridium cellulolyticum H10

Gene: Ccel_3435: Ketol-acid reductoisomerase (EC 1.1.1.86)
*
Clostridium kluyveri DSM 555

Site:
position = -253
score = 104.84
sequence = TAAAAACTGAGACAG...

Gene: CKL_1089: Ketol-acid reductoisomerase (EC 1.1.1.86)
 
Clostridium sp. OhILAs
 
Clostridium bartlettii DSM 16795
 
Clostridium bolteae ATCC BAA-613
 
Clostridium butyricum 5521
 
Clostridium hiranonis DSM 13275
 
Clostridium leptum DSM 753
 
Clostridium nexile DSM 1787
 
Clostridium scindens ATCC 35704
 
Clostridium sp. L2-50
 
Clostridium sp. SS2/1
Ketol-acid reductoisomerase (EC 1.1.1.86)
leuA2
 
Clostridium beijerincki NCIMB 8052
 
Clostridium difficile 630
 
Clostridium perfringens ATCC 13124
 
Clostridium novyi NT
 
Clostridium botulinum A str. ATCC 3502
 
Clostridium acetobutylicum ATCC 824
 
Clostridium tetani E88
*
Clostridium phytofermentans ISDg

Site:
position = -421
score = 109.86
sequence = GAAAAATACTTGGAA...

Gene: Cphy_3171: 2-isopropylmalate synthase (EC 2.3.3.13)
 
Clostridium cellulolyticum H10

Gene: Ccel_3434: 2-isopropylmalate synthase (EC 2.3.3.13)
*
Clostridium kluyveri DSM 555

Site:
position = -244
score = 112.64
sequence = TGTAAAAACTATGAT...

Gene: CKL_2160: 2-isopropylmalate synthase (EC 2.3.3.13)
 
Clostridium sp. OhILAs
 
Clostridium bartlettii DSM 16795
 
Clostridium bolteae ATCC BAA-613
 
Clostridium butyricum 5521
 
Clostridium hiranonis DSM 13275
 
Clostridium leptum DSM 753
 
Clostridium nexile DSM 1787
 
Clostridium scindens ATCC 35704
 
Clostridium sp. L2-50
 
Clostridium sp. SS2/1
2-isopropylmalate synthase (EC 2.3.3.13)
leuA
 
Clostridium beijerincki NCIMB 8052
*
Clostridium difficile 630

Site:
position = -369
score = 116.48
sequence = AAAAAGTGATGAATA...

Gene: CD0989: 2-isopropylmalate synthase (EC 2.3.3.13)
 
Clostridium perfringens ATCC 13124
 
Clostridium novyi NT
 
Clostridium botulinum A str. ATCC 3502
*
Clostridium acetobutylicum ATCC 824

Site:
position = -310
score = 123.39
sequence = ATATTGCTATGAACA...

Gene: CAC0273: 2-isopropylmalate synthase (EC 2.3.3.13)
 
Clostridium tetani E88
 
Clostridium phytofermentans ISDg
 
Clostridium cellulolyticum H10

Gene: Ccel_3433: 2-isopropylmalate synthase (EC 2.3.3.13)
 
Clostridium kluyveri DSM 555
 
Clostridium sp. OhILAs
 
Clostridium bartlettii DSM 16795
 
Clostridium bolteae ATCC BAA-613
 
Clostridium butyricum 5521
 
Clostridium hiranonis DSM 13275
 
Clostridium leptum DSM 753
 
Clostridium nexile DSM 1787
 
Clostridium scindens ATCC 35704
 
Clostridium sp. L2-50
 
Clostridium sp. SS2/1
2-isopropylmalate synthase (EC 2.3.3.13)
leuC
 
Clostridium beijerincki NCIMB 8052
 
Clostridium difficile 630

Gene: CD0990: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
 
Clostridium perfringens ATCC 13124
 
Clostridium novyi NT
 
Clostridium botulinum A str. ATCC 3502
 
Clostridium acetobutylicum ATCC 824
 
Clostridium tetani E88
 
Clostridium phytofermentans ISDg
 
Clostridium cellulolyticum H10
 
Clostridium kluyveri DSM 555

Gene: CKL_2159: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
 
Clostridium sp. OhILAs
 
Clostridium bartlettii DSM 16795
 
Clostridium bolteae ATCC BAA-613
 
Clostridium butyricum 5521
 
Clostridium hiranonis DSM 13275
 
Clostridium leptum DSM 753
 
Clostridium nexile DSM 1787
 
Clostridium scindens ATCC 35704
 
Clostridium sp. L2-50
 
Clostridium sp. SS2/1
3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
leuD
 
Clostridium beijerincki NCIMB 8052
 
Clostridium difficile 630

Gene: CD0991: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
 
Clostridium perfringens ATCC 13124
 
Clostridium novyi NT
 
Clostridium botulinum A str. ATCC 3502
 
Clostridium acetobutylicum ATCC 824
 
Clostridium tetani E88
 
Clostridium phytofermentans ISDg
 
Clostridium cellulolyticum H10
 
Clostridium kluyveri DSM 555

Gene: CKL_2158: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
 
Clostridium sp. OhILAs
 
Clostridium bartlettii DSM 16795
 
Clostridium bolteae ATCC BAA-613
 
Clostridium butyricum 5521
 
Clostridium hiranonis DSM 13275
 
Clostridium leptum DSM 753
 
Clostridium nexile DSM 1787
 
Clostridium scindens ATCC 35704
 
Clostridium sp. L2-50
 
Clostridium sp. SS2/1
3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
leuB
 
Clostridium beijerincki NCIMB 8052
 
Clostridium difficile 630

Gene: CD0992: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
 
Clostridium perfringens ATCC 13124
 
Clostridium novyi NT
 
Clostridium botulinum A str. ATCC 3502
 
Clostridium acetobutylicum ATCC 824
 
Clostridium tetani E88
 
Clostridium phytofermentans ISDg
 
Clostridium cellulolyticum H10
 
Clostridium kluyveri DSM 555

Gene: CKL_2157: 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
 
Clostridium sp. OhILAs
 
Clostridium bartlettii DSM 16795
 
Clostridium bolteae ATCC BAA-613
 
Clostridium butyricum 5521
 
Clostridium hiranonis DSM 13275
 
Clostridium leptum DSM 753
 
Clostridium nexile DSM 1787
 
Clostridium scindens ATCC 35704
 
Clostridium sp. L2-50
 
Clostridium sp. SS2/1
3-isopropylmalate dehydrogenase (EC 1.1.1.85)
ilvH1
 
Clostridium beijerincki NCIMB 8052
 
Clostridium difficile 630
 
Clostridium perfringens ATCC 13124
 
Clostridium novyi NT
 
Clostridium botulinum A str. ATCC 3502
 
Clostridium acetobutylicum ATCC 824
 
Clostridium tetani E88
 
Clostridium phytofermentans ISDg
 
Clostridium cellulolyticum H10
 
Clostridium kluyveri DSM 555
 
Clostridium sp. OhILAs
 
Clostridium bartlettii DSM 16795
 
Clostridium bolteae ATCC BAA-613
 
Clostridium butyricum 5521

Gene: CBY_1195: Acetolactate synthase small subunit (EC 2.2.1.6)
 
Clostridium hiranonis DSM 13275
 
Clostridium leptum DSM 753
 
Clostridium nexile DSM 1787
 
Clostridium scindens ATCC 35704
 
Clostridium sp. L2-50
 
Clostridium sp. SS2/1
Acetolactate synthase small subunit (EC 2.2.1.6)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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