Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog TPP - Streptococcaceae

Properties
Regulator type: RNA regulatory element
Name: TPP
RFAM: RF00059
Regulation mode:
Biological process: Thiamine biosynthesis
Effector: Thiamine pyrophosphate
Phylum: Firmicutes
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Streptococcus pneumoniae TIGR4 15 4
Streptococcus equi subsp. zooepidemicus MGCS10565 1 1
Streptococcus gordonii str. Challis substr. CH1 4 1
Streptococcus thermophilus CNRZ1066 1 1
Streptococcus mutans UA159 1 1
Streptococcus pyogenes M1 GAS 1 1
Streptococcus sanguinis SK36 3 1
Streptococcus agalactiae 2603V/R 9 2
Streptococcus uberis 0140J 1 1
Lactococcus lactis subsp. cremoris SK11 4 2
Lactococcus lactis subsp. lactis Il1403 4 2
Streptococcus suis 05ZYH33 5 2
Streptococcus dysgalactiae subsp. equisimilis GGS_124 1 1
Streptococcus gallolyticus UCN34 8 2
Streptococcus mitis B6 4 1
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
thiT
 
Streptococcus pneumoniae TIGR4
*
Streptococcus equi subsp. zooepidemicus MGCS10565

Site:
position = -144
score = 71.89
sequence = AATTATCACAAAGGA...

Gene: Sez_0708: Substrate-specific component ThiT of thiamin ECF transporter
 
Streptococcus gordonii str. Challis substr. CH1
*
Streptococcus thermophilus CNRZ1066

Site:
position = -197
score = 59.23
sequence = AGAGTCACAAGAGGA...

Gene: str1571: Substrate-specific component ThiT of thiamin ECF transporter
*
Streptococcus mutans UA159

Site:
position = -111
score = 77.59
sequence = TAAATATCACAAGGA...

Gene: SMU.706c: Substrate-specific component ThiT of thiamin ECF transporter
*
Streptococcus pyogenes M1 GAS

Site:
position = -142
score = 70.23
sequence = ATATTTCACAAAGGA...

Gene: SPy0600: Substrate-specific component ThiT of thiamin ECF transporter
 
Streptococcus sanguinis SK36
*
Streptococcus agalactiae 2603V/R

Site:
position = -157
score = 58.74
sequence = TAAATACACAAGGGA...

Gene: SAG0817: Substrate-specific component ThiT of thiamin ECF transporter
*
Streptococcus uberis 0140J

Site:
position = -150
score = 68.62
sequence = ATATTTCACAAAGGA...

Gene: SUB0597: Substrate-specific component ThiT of thiamin ECF transporter
*
Lactococcus lactis subsp. cremoris SK11

Site:
position = -147
score = 55.47
sequence = ATATTTGCACAATGG...

Gene: LACR_0359: Substrate-specific component ThiT of thiamin ECF transporter
*
Lactococcus lactis subsp. lactis Il1403

Site:
position = -120
score = 55.63
sequence = ATATTTGCACAATGG...

Gene: L116212: Substrate-specific component ThiT of thiamin ECF transporter
*
Streptococcus suis 05ZYH33

Site:
position = -155
score = 66.39
sequence = CATATACACAAAGGA...

Gene: SSU05_0523: Substrate-specific component ThiT of thiamin ECF transporter
*
Streptococcus dysgalactiae subsp. equisimilis GGS_124

Site:
position = -112
score = 67.67
sequence = ATGATTCACAAAGGA...

Gene: SDEG_0615: Substrate-specific component ThiT of thiamin ECF transporter
*
Streptococcus gallolyticus UCN34

Site:
position = -174
score = 71.14
sequence = TAGATTCACAAAGGA...

Gene: GALLO_0703: Substrate-specific component ThiT of thiamin ECF transporter
 
Streptococcus mitis B6
Substrate-specific component ThiT of thiamin ECF transporter
 
CRON 2.
thiW
 
Streptococcus pneumoniae TIGR4

Gene: SP_0723: Substrate-specific component ThiW of predicted thiazole ECF transporter
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
*
Streptococcus agalactiae 2603V/R

Site:
position = -244
score = 60.3
sequence = TAGGACATTTGGGGT...

Gene: SAG0835: Substrate-specific component ThiW of predicted thiazole ECF transporter
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus suis 05ZYH33
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
*
Streptococcus gallolyticus UCN34

Site:
position = -267
score = 63.44
sequence = ATAAAGACATTTGGG...

Gene: GALLO_1184: Substrate-specific component ThiW of predicted thiazole ECF transporter
 
Streptococcus mitis B6
Substrate-specific component ThiW of predicted thiazole ECF transporter
ykoE
*
Streptococcus pneumoniae TIGR4

Site:
position = -349
score = 67.67
sequence = AAAGACATTTGGGGT...

Gene: SP_0719: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus agalactiae 2603V/R

Gene: SAG0836: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus suis 05ZYH33
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34
 
Streptococcus mitis B6
Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
ykoD
 
Streptococcus pneumoniae TIGR4

Gene: SP_0720: Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus agalactiae 2603V/R

Gene: SAG0837: Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus suis 05ZYH33
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34
 
Streptococcus mitis B6
Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
ykoC
 
Streptococcus pneumoniae TIGR4

Gene: SP_0721: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus agalactiae 2603V/R

Gene: SAG0838: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus suis 05ZYH33
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34
 
Streptococcus mitis B6
Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
tenA
*2
Streptococcus pneumoniae TIGR4

Site:
position = -302
score = 68.17
sequence = AGAGACATTTGGGGT...

Gene: SP_0716: Thiaminase II (EC 3.5.99.2)

Gene: SP_0722: Thiaminase II (EC 3.5.99.2)
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus agalactiae 2603V/R

Gene: SAG0839: Thiaminase II (EC 3.5.99.2)
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_1950: Thiaminase II (EC 3.5.99.2)
 
Lactococcus lactis subsp. lactis Il1403

Gene: L0228: Thiaminase II (EC 3.5.99.2)
 
Streptococcus suis 05ZYH33
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1181: Thiaminase II (EC 3.5.99.2)
 
Streptococcus mitis B6
Thiaminase II (EC 3.5.99.2)
thiD
*
Streptococcus pneumoniae TIGR4

Site:
position = -183
score = 59.01
sequence = AAACAACCACTAGGG...

Gene: SP_0726: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus agalactiae 2603V/R

Gene: SAG0840: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_1376: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Lactococcus lactis subsp. lactis Il1403

Gene: L0200: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Streptococcus suis 05ZYH33

Gene: SSU05_0733: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1180: Phosphomethylpyrimidine kinase (EC 2.7.4.7)
 
Streptococcus mitis B6
Phosphomethylpyrimidine kinase (EC 2.7.4.7)
thiM
 2
Streptococcus pneumoniae TIGR4

Gene: SP_0717: Hydroxyethylthiazole kinase (EC 2.7.1.50)

Gene: SP_0724: Hydroxyethylthiazole kinase (EC 2.7.1.50)
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus agalactiae 2603V/R

Gene: SAG0841: Hydroxyethylthiazole kinase (EC 2.7.1.50)
 
Streptococcus uberis 0140J
*
Lactococcus lactis subsp. cremoris SK11

Site:
position = -183
score = 52.64
sequence = TCTAATACACAATGG...

Gene: LACR_1377: Hydroxyethylthiazole kinase (EC 2.7.1.50)
*
Lactococcus lactis subsp. lactis Il1403

Site:
position = -184
score = 55.02
sequence = TCAATAACACAATGG...

Gene: L94809: Hydroxyethylthiazole kinase (EC 2.7.1.50)
 
Streptococcus suis 05ZYH33

Gene: SSU05_0734: Hydroxyethylthiazole kinase (EC 2.7.1.50)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1179: Hydroxyethylthiazole kinase (EC 2.7.1.50)
 
Streptococcus mitis B6
Hydroxyethylthiazole kinase (EC 2.7.1.50)
thiE
 2
Streptococcus pneumoniae TIGR4

Gene: SP_0718: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)

Gene: SP_0725: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus agalactiae 2603V/R

Gene: SAG0842: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11

Gene: LACR_1375: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
Lactococcus lactis subsp. lactis Il1403

Gene: L0201: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
Streptococcus suis 05ZYH33

Gene: SSU05_0735: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1178: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
 
Streptococcus mitis B6
Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
GALLO_1183
 
Streptococcus pneumoniae TIGR4
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus agalactiae 2603V/R
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus suis 05ZYH33
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1183: hypothetical protein
 
Streptococcus mitis B6
hypothetical protein
SSU05_0732
 
Streptococcus pneumoniae TIGR4
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus agalactiae 2603V/R
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
*
Streptococcus suis 05ZYH33

Site:
position = -423
score = 68.32
sequence = TAGAACATTTGGGGT...

Gene: SSU05_0732: putative HAD-superfamily hydrolase / phosphatase
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34

Gene: GALLO_1182: putative HAD-superfamily hydrolase / phosphatase
 
Streptococcus mitis B6
putative HAD-superfamily hydrolase / phosphatase
 
CRON 3.
COG0011
*
Streptococcus pneumoniae TIGR4

Site:
position = -174
score = 47.78
sequence = ACATATAATATATGG...

Gene: SP_2199: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family
 
Streptococcus equi subsp. zooepidemicus MGCS10565
*
Streptococcus gordonii str. Challis substr. CH1

Site:
position = -327
score = 51.89
sequence = AATATACATATATGG...

Gene: SGO_2102: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36
 
Streptococcus agalactiae 2603V/R
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus suis 05ZYH33
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34
*
Streptococcus mitis B6

Site:
position = -172
score = 49.96
sequence = CTATATAATATATGG...

Gene: smi_2050: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family
Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family
thiX
 
Streptococcus pneumoniae TIGR4

Gene: SP_2198: Thiamin ABC transporter, transmembrane component
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_2101: Thiamin ABC transporter, transmembrane component
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
*
Streptococcus sanguinis SK36

Site:
position = -216
score = 43.99
sequence = TCCTATATATGGGAG...

Gene: SSA_2353: Thiamin ABC transporter, transmembrane component
 
Streptococcus agalactiae 2603V/R
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus suis 05ZYH33
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34
 
Streptococcus mitis B6

Gene: smi_2049: Thiamin ABC transporter, transmembrane component
Thiamin ABC transporter, transmembrane component
thiY
 
Streptococcus pneumoniae TIGR4

Gene: SP_2197: Thiamin ABC transporter, substrate-binding component
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_2100: Thiamin ABC transporter, substrate-binding component
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36

Gene: SSA_2352: Thiamin ABC transporter, substrate-binding component
 
Streptococcus agalactiae 2603V/R
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus suis 05ZYH33
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34
 
Streptococcus mitis B6

Gene: smi_2048: Thiamin ABC transporter, substrate-binding component
Thiamin ABC transporter, substrate-binding component
thiZ
 
Streptococcus pneumoniae TIGR4

Gene: SP_2196: Thiamin ABC transporter, ATPase component
 
Streptococcus equi subsp. zooepidemicus MGCS10565
 
Streptococcus gordonii str. Challis substr. CH1

Gene: SGO_2099: Thiamin ABC transporter, ATPase component
 
Streptococcus thermophilus CNRZ1066
 
Streptococcus mutans UA159
 
Streptococcus pyogenes M1 GAS
 
Streptococcus sanguinis SK36

Gene: SSA_2351: Thiamin ABC transporter, ATPase component
 
Streptococcus agalactiae 2603V/R
 
Streptococcus uberis 0140J
 
Lactococcus lactis subsp. cremoris SK11
 
Lactococcus lactis subsp. lactis Il1403
 
Streptococcus suis 05ZYH33
 
Streptococcus dysgalactiae subsp. equisimilis GGS_124
 
Streptococcus gallolyticus UCN34
 
Streptococcus mitis B6

Gene: smi_2047: Thiamin ABC transporter, ATPase component
Thiamin ABC transporter, ATPase component
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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