Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog His_leader - Enterobacteriales

Properties
Regulator type: RNA regulatory element
Name: His_leader
RFAM: RF00514
Regulation mode:
Biological process: Histidine biosynthesis
Effector:
Phylum: Proteobacteria
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Escherichia coli str. K-12 substr. MG1655 8 1
Salmonella typhimurium LT2 8 1
Citrobacter koseri ATCC BAA-895 8 1
Klebsiella pneumoniae subsp. pneumoniae MGH 78578 8 1
Enterobacter sp. 638 8 1
Erwinia amylovora ATCC 49946 8 1
Yersinia pestis KIM 5 1
Serratia proteamaculans 568 8 1
Erwinia carotovora subsp. atroseptica SCRI1043 8 1
Edwardsiella tarda EIB202 8 1
Proteus mirabilis HI4320 8 1
Photorhabdus luminescens subsp. laumondii TTO1 7 1
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
hisG
*
Escherichia coli str. K-12 substr. MG1655

Site:
position = -169
score = 129.5
sequence = CATCATCACCATCAT...

Gene: b2019: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Salmonella typhimurium LT2

Site:
position = -170
score = 130.58
sequence = CATCATCACCATCAT...

Gene: STM2071: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Citrobacter koseri ATCC BAA-895

Site:
position = -82
score = 126.57
sequence = ACCATCATCACCATC...

Gene: CKO_00766: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Site:
position = -169
score = 116.27
sequence = CATCATCACCATCAT...

Gene: KPN_02475: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Enterobacter sp. 638

Site:
position = -168
score = 128.47
sequence = CATCATCACCATCAT...

Gene: Ent638_2631: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Erwinia amylovora ATCC 49946

Site:
position = -191
score = 110.36
sequence = CATCACCACCATCAC...

Gene: EAM_2141: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Yersinia pestis KIM

Site:
position = -306
score = 112.8
sequence = CATCACCACCATCAT...

Gene: y2620: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Serratia proteamaculans 568

Site:
position = -198
score = 110.96
sequence = ACCATCATCACCATC...

Gene: Spro_1616: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Erwinia carotovora subsp. atroseptica SCRI1043

Site:
position = -170
score = 103.35
sequence = CATCATCACCATCAT...

Gene: ECA2582: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Edwardsiella tarda EIB202

Site:
position = -187
score = 106.18
sequence = CATCATCACCATCAT...

Gene: ETAE_2275: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Proteus mirabilis HI4320

Site:
position = -177
score = 101.68
sequence = ACCATCATCACCATC...

Gene: PMI0665: ATP phosphoribosyltransferase (EC 2.4.2.17)
*
Photorhabdus luminescens subsp. laumondii TTO1

Site:
position = -139
score = 97.4
sequence = ATTACCACCATCATC...

Gene: plu1570: ATP phosphoribosyltransferase (EC 2.4.2.17)
ATP phosphoribosyltransferase (EC 2.4.2.17)
hisD
 
Escherichia coli str. K-12 substr. MG1655

Gene: b2020: Histidinol dehydrogenase (EC 1.1.1.23)
 
Salmonella typhimurium LT2

Gene: STM2072: Histidinol dehydrogenase (EC 1.1.1.23)
 
Citrobacter koseri ATCC BAA-895

Gene: CKO_00765: Histidinol dehydrogenase (EC 1.1.1.23)
 
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Gene: KPN_02476: Histidinol dehydrogenase (EC 1.1.1.23)
 
Enterobacter sp. 638

Gene: Ent638_2632: Histidinol dehydrogenase (EC 1.1.1.23)
 
Erwinia amylovora ATCC 49946

Gene: EAM_2142: Histidinol dehydrogenase (EC 1.1.1.23)
 
Yersinia pestis KIM

Gene: y2621: Histidinol dehydrogenase (EC 1.1.1.23)
 
Serratia proteamaculans 568

Gene: Spro_1615: Histidinol dehydrogenase (EC 1.1.1.23)
 
Erwinia carotovora subsp. atroseptica SCRI1043

Gene: ECA2583: Histidinol dehydrogenase (EC 1.1.1.23)
 
Edwardsiella tarda EIB202

Gene: ETAE_2276: Histidinol dehydrogenase (EC 1.1.1.23)
 
Proteus mirabilis HI4320

Gene: PMI0664: Histidinol dehydrogenase (EC 1.1.1.23)
 
Photorhabdus luminescens subsp. laumondii TTO1

Gene: plu1569: Histidinol dehydrogenase (EC 1.1.1.23) / Histidinol-phosphate aminotransferase (EC 2.6.1.9)
Histidinol dehydrogenase (EC 1.1.1.23)
hisC
 
Escherichia coli str. K-12 substr. MG1655

Gene: b2021: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Salmonella typhimurium LT2

Gene: STM2073: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Citrobacter koseri ATCC BAA-895

Gene: CKO_00764: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Gene: KPN_02477: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Enterobacter sp. 638

Gene: Ent638_2633: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Erwinia amylovora ATCC 49946

Gene: EAM_2143: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Yersinia pestis KIM

Gene: y2622: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Serratia proteamaculans 568

Gene: Spro_1614: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Erwinia carotovora subsp. atroseptica SCRI1043

Gene: ECA2584: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Edwardsiella tarda EIB202

Gene: ETAE_2277: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Proteus mirabilis HI4320

Gene: PMI0663: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
 
Photorhabdus luminescens subsp. laumondii TTO1
Histidinol-phosphate aminotransferase (EC 2.6.1.9)
hisB
 
Escherichia coli str. K-12 substr. MG1655

Gene: b2022: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Salmonella typhimurium LT2

Gene: STM2074: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Citrobacter koseri ATCC BAA-895

Gene: CKO_00763: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Gene: KPN_02478: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Enterobacter sp. 638

Gene: Ent638_2634: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Erwinia amylovora ATCC 49946

Gene: EAM_2144: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Yersinia pestis KIM

Gene: y2623: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Serratia proteamaculans 568

Gene: Spro_1613: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Erwinia carotovora subsp. atroseptica SCRI1043

Gene: ECA2585: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Edwardsiella tarda EIB202

Gene: ETAE_2278: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Proteus mirabilis HI4320

Gene: PMI0662: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
 
Photorhabdus luminescens subsp. laumondii TTO1

Gene: plu1568: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
hisH
 
Escherichia coli str. K-12 substr. MG1655

Gene: b2023: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Salmonella typhimurium LT2

Gene: STM2075: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Citrobacter koseri ATCC BAA-895

Gene: CKO_00762: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Gene: KPN_02479: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Enterobacter sp. 638

Gene: Ent638_2635: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Erwinia amylovora ATCC 49946

Gene: EAM_2145: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Yersinia pestis KIM

Gene: y2625: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Serratia proteamaculans 568

Gene: Spro_1612: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Erwinia carotovora subsp. atroseptica SCRI1043

Gene: ECA2586: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Edwardsiella tarda EIB202

Gene: ETAE_2279: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Proteus mirabilis HI4320

Gene: PMI0661: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
 
Photorhabdus luminescens subsp. laumondii TTO1

Gene: plu1567: Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)
hisA
 
Escherichia coli str. K-12 substr. MG1655

Gene: b2024: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Salmonella typhimurium LT2

Gene: STM2076: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Citrobacter koseri ATCC BAA-895

Gene: CKO_00761: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Gene: KPN_02480: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Enterobacter sp. 638

Gene: Ent638_2636: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Erwinia amylovora ATCC 49946

Gene: EAM_2146: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Yersinia pestis KIM

Gene: y2626: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Serratia proteamaculans 568

Gene: Spro_1611: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Erwinia carotovora subsp. atroseptica SCRI1043

Gene: ECA2587: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Edwardsiella tarda EIB202

Gene: ETAE_2280: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Proteus mirabilis HI4320

Gene: PMI0660: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
 
Photorhabdus luminescens subsp. laumondii TTO1

Gene: plu1566: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
hisF
 
Escherichia coli str. K-12 substr. MG1655

Gene: b2025: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Salmonella typhimurium LT2

Gene: STM2077: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Citrobacter koseri ATCC BAA-895

Gene: CKO_00760: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Gene: KPN_02481: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Enterobacter sp. 638

Gene: Ent638_2637: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Erwinia amylovora ATCC 49946

Gene: EAM_2147: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Yersinia pestis KIM

Gene: y2627: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Serratia proteamaculans 568

Gene: Spro_1610: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Erwinia carotovora subsp. atroseptica SCRI1043

Gene: ECA2588: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Edwardsiella tarda EIB202

Gene: ETAE_2281: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Proteus mirabilis HI4320

Gene: PMI0659: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
 
Photorhabdus luminescens subsp. laumondii TTO1

Gene: plu1565: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)
hisI
 
Escherichia coli str. K-12 substr. MG1655

Gene: b2026: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Salmonella typhimurium LT2

Gene: STM2078: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Citrobacter koseri ATCC BAA-895

Gene: CKO_00759: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Gene: KPN_02482: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Enterobacter sp. 638

Gene: Ent638_2638: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Erwinia amylovora ATCC 49946

Gene: EAM_2148: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Yersinia pestis KIM

Gene: y2628: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Serratia proteamaculans 568

Gene: Spro_1609: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Erwinia carotovora subsp. atroseptica SCRI1043

Gene: ECA2589: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Edwardsiella tarda EIB202

Gene: ETAE_2282: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Proteus mirabilis HI4320

Gene: PMI0658: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
 
Photorhabdus luminescens subsp. laumondii TTO1

Gene: plu1564: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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