Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog SAM - Staphylococcaceae

Properties
Regulator type: RNA regulatory element
Name: SAM
RFAM: RF00162
Regulation mode:
Biological process: Methionine biosynthesis
Effector: S-adenosylmethionine
Phylum: Firmicutes
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Staphylococcus aureus subsp. aureus N315 6 4
Staphylococcus capitis SK14 6 4
Staphylococcus epidermidis ATCC 12228 6 4
Staphylococcus carnosus subsp. carnosus TM300 14 8
Staphylococcus haemolyticus JCSC1435 8 6
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 9 6
Macrococcus caseolyticus JCSC5402 17 8
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
metK
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -218
score = 79.24
sequence = TCTCTTATCCTGAGT...

Gene: SA1608: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Staphylococcus capitis SK14

Site:
position = -221
score = 80.83
sequence = TCTCTTATCCTGAGT...

Gene: STACA0001_0676: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -219
score = 82.51
sequence = TCTCTTATCCTGAGT...

Gene: SE1458: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -225
score = 70.59
sequence = TCTCTTATCCTGAGT...

Gene: Sca_1389: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -225
score = 79.25
sequence = TCTTATCCTGAGTGG...

Gene: SH1139: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -221
score = 80.18
sequence = TCTTATCCTGAGTGG...

Gene: SSP0976: S-adenosylmethionine synthetase (EC 2.5.1.6)
*
Macrococcus caseolyticus JCSC5402

Site:
position = -201
score = 72.14
sequence = TCTCTTATCCAGAGT...

Gene: MCCL_1498: S-adenosylmethionine synthetase (EC 2.5.1.6)
S-adenosylmethionine synthetase (EC 2.5.1.6)
 
CRON 2.
metT
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -107
score = 76.1
sequence = TCACTTATCTAGAGA...

Gene: SA2117: Methionine transporter MetT
*
Staphylococcus capitis SK14

Site:
position = -291
score = 77.27
sequence = ACTTATCGAGAGAAG...

Gene: STACA0001_1163: Methionine transporter MetT
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -231
score = 78.75
sequence = TAACTTATCAAGAGA...

Gene: SE1902: Methionine transporter MetT
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -82
score = 71.74
sequence = TTGCTTATCAAGAGA...

Gene: Sca_1822: Methionine transporter MetT
 
Staphylococcus haemolyticus JCSC1435

Gene: SH0729: Methionine transporter MetT
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -179
score = 75.05
sequence = ACTTATCAAGAGAAG...

Gene: SSP0578: Methionine transporter MetT
 
Macrococcus caseolyticus JCSC5402
Methionine transporter MetT
 
CRON 3.
metX
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -136
score = 69.39
sequence = TCTTATTGTGAGAAG...

Gene: SA0011: Homoserine O-acetyltransferase (EC 2.3.1.31)
*
Staphylococcus capitis SK14

Site:
position = -167
score = 64.24
sequence = AATCTTATTTCGAGA...

Gene: STACA0001_1363: Homoserine O-acetyltransferase (EC 2.3.1.31)
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -164
score = 68.61
sequence = CCTTATTTTGAGAAG...

Gene: SE0011: Homoserine O-acetyltransferase (EC 2.3.1.31)
 
Staphylococcus carnosus subsp. carnosus TM300
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -171
score = 71.51
sequence = ACTTATTAAGAGAAG...

Gene: SH0011: Homoserine O-acetyltransferase (EC 2.3.1.31)
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -159
score = 60.06
sequence = TCTTATTTCGAGAAG...

Gene: SSP0012: Homoserine O-acetyltransferase (EC 2.3.1.31)
 
Macrococcus caseolyticus JCSC5402
Homoserine O-acetyltransferase (EC 2.3.1.31)
 
CRON 4.
metN
*
Staphylococcus aureus subsp. aureus N315

Site:
position = -191
score = 85.67
sequence = TCTTATCGAGAGTGG...

Gene: SA0769: Methionine ABC transporter ATP-binding protein
*
Staphylococcus capitis SK14

Site:
position = -193
score = 89.61
sequence = ACTCTTATCGAGAGA...

Gene: STACA0001_0218: Methionine ABC transporter ATP-binding protein
*
Staphylococcus epidermidis ATCC 12228

Site:
position = -195
score = 89.56
sequence = TCTTATCGAGAGAGG...

Gene: SE0600: Methionine ABC transporter ATP-binding protein
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -203
score = 89.52
sequence = TCTTATCAAGAGAGG...

Gene: Sca_0455: Methionine ABC transporter ATP-binding protein
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -191
score = 92.73
sequence = ATTCTTATCAAGAGA...

Gene: SH2047: Methionine ABC transporter ATP-binding protein
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -198
score = 84.24
sequence = ACTCTTATCACGAGA...

Gene: SSP1866: Methionine ABC transporter ATP-binding protein
*
Macrococcus caseolyticus JCSC5402

Site:
position = -173
score = 89.62
sequence = TCTTATCAAGAGAGG...

Gene: MCCL_0539: Methionine ABC transporter ATP-binding protein
Methionine ABC transporter ATP-binding protein
metP
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0770: Methionine ABC transporter permease protein
 
Staphylococcus capitis SK14

Gene: STACA0001_0217: Methionine ABC transporter permease protein
 
Staphylococcus epidermidis ATCC 12228

Gene: SE0601: Methionine ABC transporter permease protein
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0456: Methionine ABC transporter permease protein
 
Staphylococcus haemolyticus JCSC1435

Gene: SH2046: Methionine ABC transporter permease protein
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP1865: Methionine ABC transporter permease protein
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0540: Methionine ABC transporter permease protein
Methionine ABC transporter permease protein
metQ
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0771: Methionine ABC transporter substrate-binding protein
 
Staphylococcus capitis SK14

Gene: STACA0001_0216: Methionine ABC transporter substrate-binding protein
 
Staphylococcus epidermidis ATCC 12228

Gene: SE0602: Methionine ABC transporter substrate-binding protein
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0457: Methionine ABC transporter substrate-binding protein
 
Staphylococcus haemolyticus JCSC1435

Gene: SH2045: Methionine ABC transporter substrate-binding protein
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP1864: Methionine ABC transporter substrate-binding protein
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0541: Methionine ABC transporter substrate-binding protein
Methionine ABC transporter substrate-binding protein
 
CRON 5.
SH0402
 
Staphylococcus aureus subsp. aureus N315
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -173
score = 74.05
sequence = TCTTATTAAGAGTGA...

Gene: SH0402: Hypothetical protein
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402
Hypothetical protein
 
CRON 6.
metQ2
 
Staphylococcus aureus subsp. aureus N315
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -209
score = 81.89
sequence = TCTTATCCAGAGCGG...

Gene: Sca_0342: Methionine ABC transporter substrate-binding protein
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -218
score = 88.89
sequence = TCTTATCAAGAGTGG...

Gene: SH0458: Methionine ABC transporter substrate-binding protein
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -195
score = 87.78
sequence = TCTTATCAAGAGTGG...

Gene: SSP0248: Methionine ABC transporter substrate-binding protein
*
Macrococcus caseolyticus JCSC5402

Site:
position = -188
score = 80.01
sequence = TCTTATCCAGAGAGG...

Gene: MCCL_0254: Methionine ABC transporter substrate-binding protein
Methionine ABC transporter substrate-binding protein
SSP0249
 
Staphylococcus aureus subsp. aureus N315
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_0343: Putative dehydrogenase
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP0249: Putative dehydrogenase
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0255: Putative dehydrogenase
Putative dehydrogenase
 
CRON 7.
mtnE
 
Staphylococcus aureus subsp. aureus N315

Gene: SA2347: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)
 
Staphylococcus capitis SK14

Gene: STACA0001_0934: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)
 
Staphylococcus epidermidis ATCC 12228

Gene: SE2122: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -208
score = 73.9
sequence = ACTTATCAAGAGAAG...

Gene: Sca_0010: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)
*
Staphylococcus haemolyticus JCSC1435

Site:
position = -186
score = 72.07
sequence = ACTTATCCAGAGAAG...

Gene: SH0492: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)
*
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Site:
position = -166
score = 76.5
sequence = ACTTATCCAGAGAAG...

Gene: SSP0294: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)
*
Macrococcus caseolyticus JCSC5402

Site:
position = -157
score = 81.74
sequence = TCTTATCCAGAGAAG...

Gene: MCCL_0180: N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)
N-succinyldiaminopimelate aminotransferase (EC 2.6.1.17)
 
CRON 8.
cysD
 
Staphylococcus aureus subsp. aureus N315
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -159
score = 83.14
sequence = ACTTATCCAGAATGG...

Gene: Sca_1003: O-acetylhomoserine (thiol)-lyase (EC 2.5.1.49)
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
*
Macrococcus caseolyticus JCSC5402

Site:
position = -160
score = 91.21
sequence = ATGCTTATCCAGAGT...

Gene: MCCL_0060: O-acetylhomoserine (thiol)-lyase (EC 2.5.1.49)
O-acetylhomoserine (thiol)-lyase (EC 2.5.1.49)
metA
 
Staphylococcus aureus subsp. aureus N315
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_1004: Homoserine O-succinyltransferase (EC 2.3.1.46)
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0059: Homoserine O-succinyltransferase (EC 2.3.1.46)
Homoserine O-succinyltransferase (EC 2.3.1.46)
 
CRON 9.
metN3
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0420: Methionine ABC transporter ATP-binding protein
 
Staphylococcus capitis SK14

Gene: STACA0001_1483: Methionine ABC transporter ATP-binding protein
 
Staphylococcus epidermidis ATCC 12228

Gene: SE2322: Methionine ABC transporter ATP-binding protein
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -226
score = 73.09
sequence = ACTCTTATCCAGAGA...

Gene: Sca_2191: Methionine ABC transporter ATP-binding protein
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
*
Macrococcus caseolyticus JCSC5402

Site:
position = -172
score = 72.86
sequence = TTTTATCAAGAGAGA...

Gene: MCCL_0417: Methionine ABC transporter ATP-binding protein
Methionine ABC transporter ATP-binding protein
metP3
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0421: Methionine ABC transporter permease protein
 
Staphylococcus capitis SK14

Gene: STACA0001_1484: Methionine ABC transporter permease protein
 
Staphylococcus epidermidis ATCC 12228

Gene: SE2321: Methionine ABC transporter permease protein
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_2190: Methionine ABC transporter permease protein
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0418: Methionine ABC transporter permease protein
Methionine ABC transporter permease protein
metQ3
 
Staphylococcus aureus subsp. aureus N315

Gene: SA0422: Methionine ABC transporter substrate-binding protein
 
Staphylococcus capitis SK14

Gene: STACA0001_1485: Methionine ABC transporter substrate-binding protein
 
Staphylococcus epidermidis ATCC 12228

Gene: SE2320: Methionine ABC transporter substrate-binding protein
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_2189: Methionine ABC transporter substrate-binding protein
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0419: Methionine ABC transporter substrate-binding protein
Methionine ABC transporter substrate-binding protein
 
CRON 10.
p20d2
 
Staphylococcus aureus subsp. aureus N315

Gene: SA1935: Predicted peptidase
 
Staphylococcus capitis SK14

Gene: STACA0001_0837: Predicted peptidase
 
Staphylococcus epidermidis ATCC 12228

Gene: SE1731: Predicted peptidase
 
Staphylococcus carnosus subsp. carnosus TM300

Gene: Sca_1636: Predicted peptidase
 
Staphylococcus haemolyticus JCSC1435

Gene: SH0902: Predicted peptidase
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP0752: Predicted peptidase
*
Macrococcus caseolyticus JCSC5402

Site:
position = -166
score = 79.5
sequence = ACACTTATCGAGACG...

Gene: MCCL_1787: Predicted peptidase
Predicted peptidase
SA1934
 
Staphylococcus aureus subsp. aureus N315

Gene: SA1934: Hypothetical protein
 
Staphylococcus capitis SK14

Gene: STACA0001_0836: Hypothetical protein
 
Staphylococcus epidermidis ATCC 12228

Gene: SE1730: Hypothetical protein
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435

Gene: SH0903: Hypothetical protein
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP0753: Hypothetical protein
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_1786: Hypothetical protein
Hypothetical protein
 
CRON 11.
mmuP
 
Staphylococcus aureus subsp. aureus N315
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP2173: Probable S-methylmethionine permease
*
Macrococcus caseolyticus JCSC5402

Site:
position = -150
score = 77.92
sequence = ACTTATACAGAGAGA...

Gene: MCCL_0329: Probable S-methylmethionine permease
Probable S-methylmethionine permease
metE
 
Staphylococcus aureus subsp. aureus N315
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305

Gene: SSP2172: Homocysteine S-methyltransferase (EC 2.1.1.10)
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0330: Homocysteine S-methyltransferase (EC 2.1.1.10)
Homocysteine S-methyltransferase (EC 2.1.1.10)
MCCL_0331
 
Staphylococcus aureus subsp. aureus N315
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
 
Staphylococcus carnosus subsp. carnosus TM300
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0331: Hypothetical protein
Hypothetical protein
 
CRON 12.
Sca_0068
 
Staphylococcus aureus subsp. aureus N315
 
Staphylococcus capitis SK14
 
Staphylococcus epidermidis ATCC 12228
*
Staphylococcus carnosus subsp. carnosus TM300

Site:
position = -488
score = 76.07
sequence = TCTTATTAAGAGTGA...

Gene: Sca_0068: Putative lipoprotein
 
Staphylococcus haemolyticus JCSC1435
 
Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
 
Macrococcus caseolyticus JCSC5402

Gene: MCCL_0531: Putative lipoprotein
Putative lipoprotein
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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