Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog HexR - Pseudomonadaceae

Properties
Regulator type: Transcription factor
Regulator family: RpiR
Regulation mode: repressor (activator)
Biological process: Central carbohydrate metabolism
Effector: 2-keto-3-deoxy-6-phosphogluconate
Phylum: Proteobacteria/gamma
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 44 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Azotobacter vinelandii AvOP 12 5
Pseudomonas aeruginosa PAO1 9 4
Pseudomonas entomophila L48 9 4
Pseudomonas fluorescens Pf-5 9 4
Pseudomonas mendocina ymp 9 5
Pseudomonas putida KT2440 9 4
Pseudomonas stutzeri A1501 12 4
Pseudomonas syringae pv. tomato str. DC3000 9 4
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
zwf
*3
Azotobacter vinelandii AvOP

Site:
position = -84
score = 6.94492
sequence = TTGTTTT-(4)-ACAACAT

Gene: Avin_17630: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)

Site:
position = -84
score = 5.52106
sequence = ATGTaGT-(6)-ACgcaAT

Gene: Avin_27260: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)

Gene: Avin_16620: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
*
Pseudomonas aeruginosa PAO1

Site:
position = -81
score = 7.76461
sequence = ATGTTGT-(6)-ACTACAT

Gene: PA3183: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
*
Pseudomonas entomophila L48

Site:
position = -85
score = 7.76461
sequence = ATGTTGT-(7)-ACTACAT

Gene: PSEEN4405: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
*
Pseudomonas fluorescens Pf-5

Site:
position = -85
score = 7.76461
sequence = ATGTTGT-(7)-ACTACAT

Gene: PFL_4610: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
*
Pseudomonas mendocina ymp

Site:
position = -85
score = 8.10947
sequence = ATGTTGT-(7)-ACAACAT

Gene: Pmen_3143: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
*
Pseudomonas putida KT2440

Site:
position = -85
score = 7.76461
sequence = ATGTTGT-(7)-ACTACAT

Gene: PP1022: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
*2
Pseudomonas stutzeri A1501

Site:
position = -85
score = 7.76461
sequence = ATGTTGT-(7)-ACTACAT

Gene: PST_3497: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)

Gene: PST_2329: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
*
Pseudomonas syringae pv. tomato str. DC3000

Site:
position = -85
score = 7.76461
sequence = ATGTTGT-(7)-ACTACAT

Gene: PSPTO1300: Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)
eda
 3
Azotobacter vinelandii AvOP

Gene: Avin_27250: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)

Gene: Avin_15720: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)

Gene: Avin_27250: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 
Pseudomonas aeruginosa PAO1

Gene: PA3181: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 
Pseudomonas entomophila L48

Gene: PSEEN4403: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 
Pseudomonas fluorescens Pf-5

Gene: PFL_4608: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 
Pseudomonas mendocina ymp

Gene: Pmen_3141: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 
Pseudomonas putida KT2440

Gene: PP1024: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 2
Pseudomonas stutzeri A1501

Gene: PST_3495: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)

Gene: PST_2327: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
 
Pseudomonas syringae pv. tomato str. DC3000

Gene: PSPTO1302: 4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) / 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)
pykA
 
Azotobacter vinelandii AvOP

Gene: Avin_27240: Pyruvate kinase
 
Pseudomonas aeruginosa PAO1
 
Pseudomonas entomophila L48
 
Pseudomonas fluorescens Pf-5
 
Pseudomonas mendocina ymp
 
Pseudomonas putida KT2440
 
Pseudomonas stutzeri A1501
 
Pseudomonas syringae pv. tomato str. DC3000
Pyruvate kinase
Avin_45750
 
Azotobacter vinelandii AvOP

Gene: Avin_27230: hypothetical protein
 
Pseudomonas aeruginosa PAO1
 
Pseudomonas entomophila L48
 
Pseudomonas fluorescens Pf-5
 
Pseudomonas mendocina ymp
 
Pseudomonas putida KT2440
 
Pseudomonas stutzeri A1501
 
Pseudomonas syringae pv. tomato str. DC3000
hypothetical protein
eno
 
Azotobacter vinelandii AvOP

Gene: Avin_27220: Enolase
 
Pseudomonas aeruginosa PAO1
 
Pseudomonas entomophila L48
 
Pseudomonas fluorescens Pf-5
 
Pseudomonas mendocina ymp
 
Pseudomonas putida KT2440
 
Pseudomonas stutzeri A1501
 
Pseudomonas syringae pv. tomato str. DC3000
Enolase
gapN
 2
Azotobacter vinelandii AvOP

Gene: Avin_27210: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)

Gene: Avin_45780: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)
 
Pseudomonas aeruginosa PAO1

Gene: PA2323: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)
 
Pseudomonas entomophila L48

Gene: PSEEN2956: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)
 
Pseudomonas fluorescens Pf-5
 
Pseudomonas mendocina ymp
 
Pseudomonas putida KT2440

Gene: PP3443: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)
 
Pseudomonas stutzeri A1501

Gene: PST_3494: NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)
 
Pseudomonas syringae pv. tomato str. DC3000
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.9)
pgl
*2
Azotobacter vinelandii AvOP

Gene: Avin_17640: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type

Site:
position = -127
score = 7.03484
sequence = TCGTAGT-(6)-ACAACAT

Gene: Avin_15710: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Pseudomonas aeruginosa PAO1

Gene: PA3182: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Pseudomonas entomophila L48

Gene: PSEEN4404: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Pseudomonas fluorescens Pf-5

Gene: PFL_4609: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Pseudomonas mendocina ymp

Gene: Pmen_3142: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Pseudomonas putida KT2440

Gene: PP1023: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 2
Pseudomonas stutzeri A1501

Gene: PST_2328: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type

Gene: PST_3496: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
 
Pseudomonas syringae pv. tomato str. DC3000

Gene: PSPTO1301: 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type
PST_3493
 
Azotobacter vinelandii AvOP
 
Pseudomonas aeruginosa PAO1
 
Pseudomonas entomophila L48
 
Pseudomonas fluorescens Pf-5
 
Pseudomonas mendocina ymp
 
Pseudomonas putida KT2440
 
Pseudomonas stutzeri A1501

Gene: PST_3493: Aldo/keto reductase
 
Pseudomonas syringae pv. tomato str. DC3000
Aldo/keto reductase
 
CRON 2.
hexR
*2
Azotobacter vinelandii AvOP

Site:
position = -66
score = 7.03484
sequence = ATGTTGT-(6)-ACtACga

Gene: Avin_15700: Central carbohydrate metabolism transcription regulator HexR, RpiR family

Site:
position = -111
score = 5.52106
sequence = ATtgcGT-(6)-ACtACAT

Gene: Avin_27270: Central carbohydrate metabolism transcription regulator HexR, RpiR family
*
Pseudomonas aeruginosa PAO1

Site:
position = -125
score = 7.76461
sequence = ATGTAGT-(6)-ACAACAT

Gene: PA3184: Central carbohydrate metabolism transcription regulator HexR, RpiR family
*
Pseudomonas entomophila L48

Site:
position = -138
score = 7.76461
sequence = ATGTAGT-(7)-ACAACAT

Gene: PSEEN4406: Central carbohydrate metabolism transcription regulator HexR, RpiR family
*
Pseudomonas fluorescens Pf-5

Site:
position = -239
score = 7.76461
sequence = ATGTAGT-(7)-ACAACAT

Gene: PFL_4611: Central carbohydrate metabolism transcription regulator HexR, RpiR family
*
Pseudomonas mendocina ymp

Site:
position = -138
score = 8.10947
sequence = ATGTTGT-(7)-ACAACAT

Gene: Pmen_3144: Central carbohydrate metabolism transcription regulator HexR, RpiR family
*
Pseudomonas putida KT2440

Site:
position = -138
score = 7.76461
sequence = ATGTAGT-(7)-ACAACAT

Gene: PP_1021: Central carbohydrate metabolism transcription regulator HexR, RpiR family
*
Pseudomonas stutzeri A1501

Site:
position = -178
score = 7.76461
sequence = ATGTAGT-(7)-ACAACAT

Gene: PST_3498: Central carbohydrate metabolism transcription regulator HexR, RpiR family
*
Pseudomonas syringae pv. tomato str. DC3000

Site:
position = -154
score = 7.76461
sequence = ATGTAGT-(7)-ACAACAT

Gene: PSPTO1299: Central carbohydrate metabolism transcription regulator HexR, RpiR family
Central carbohydrate metabolism transcription regulator HexR, RpiR family
 
CRON 3.
edd
 2
Azotobacter vinelandii AvOP

Gene: Avin_15680: Phosphogluconate dehydratase (EC 4.2.1.12)

Gene: Avin_27280: Phosphogluconate dehydratase (EC 4.2.1.12)
*
Pseudomonas aeruginosa PAO1

Site:
position = -43
score = 7.91839
sequence = ATGTTGT-(4)-ACAACAA

Gene: PA3194: Phosphogluconate dehydratase (EC 4.2.1.12)
*
Pseudomonas entomophila L48

Site:
position = -141
score = 7.03565
sequence = ATTTTGT-(8)-ACAACGA

Site:
position = -204
score = 7.51083
sequence = TTGTTGT-(7)-ACAAGAT

Gene: PSEEN4417: Phosphogluconate dehydratase (EC 4.2.1.12)
*
Pseudomonas fluorescens Pf-5

Site:
position = -138
score = 7.03565
sequence = ATtTTGT-(7)-ACAACga

Site:
position = -201
score = 7.51083
sequence = TTGTTGT-(7)-ACAAGAT

Gene: PFL_4622: Phosphogluconate dehydratase (EC 4.2.1.12)
*
Pseudomonas mendocina ymp

Site:
position = -50
score = 6.46186
sequence = ATtTTGT-(7)-ACAAaca

Site:
position = -111
score = 7.51083
sequence = TTGTTGT-(7)-ACAAGAT

Gene: Pmen_1312: Phosphogluconate dehydratase (EC 4.2.1.12)
*
Pseudomonas putida KT2440

Site:
position = -142
score = 7.03565
sequence = ATtTTGT-(8)-ACAACga

Site:
position = -203
score = 7.51083
sequence = TTGTTGT-(7)-ACAAGAT

Gene: PP1010: Phosphogluconate dehydratase (EC 4.2.1.12)
*2
Pseudomonas stutzeri A1501

Site:
position = -38
score = 6.80592
sequence = tgGTTGT-(6)-ACAAaAT

Gene: PST_2444: Phosphogluconate dehydratase (EC 4.2.1.12)

Site:
position = -31
score = 6.58015
sequence = TTGTTAT-(4)-ACTACAA

Gene: PST_3500: Phosphogluconate dehydratase (EC 4.2.1.12)
*
Pseudomonas syringae pv. tomato str. DC3000

Site:
position = -140
score = 6.90724
sequence = ATtTTGT-(7)-ACAACta

Site:
position = -201
score = 7.51083
sequence = TTGTTGT-(7)-ACAAGAT

Gene: PSPTO1288: Phosphogluconate dehydratase (EC 4.2.1.12)
Phosphogluconate dehydratase (EC 4.2.1.12)
glk
 2
Azotobacter vinelandii AvOP

Gene: Avin_04130: Glucokinase (EC 2.7.1.2)

Gene: Avin_15690: Glucokinase (EC 2.7.1.2)
 
Pseudomonas aeruginosa PAO1

Gene: PA3193: Glucokinase (EC 2.7.1.2)
 
Pseudomonas entomophila L48

Gene: PSEEN4416: Glucokinase (EC 2.7.1.2)
 
Pseudomonas fluorescens Pf-5

Gene: PFL_4621: Glucokinase (EC 2.7.1.2)
*
Pseudomonas mendocina ymp

Site:
position = -193
score = 7.72731
sequence = TTGTTGT-(8)-ACAACAA

Gene: Pmen_1147: Glucokinase (EC 2.7.1.2)
 
Pseudomonas putida KT2440

Gene: PP1011: Glucokinase (EC 2.7.1.2)
 2
Pseudomonas stutzeri A1501

Gene: PST_2443: Glucokinase (EC 2.7.1.2)

Gene: PST_3499: Glucokinase (EC 2.7.1.2)
 
Pseudomonas syringae pv. tomato str. DC3000

Gene: PSPTO1289: Glucokinase (EC 2.7.1.2)
Glucokinase (EC 2.7.1.2)
gltR
 
Azotobacter vinelandii AvOP
 
Pseudomonas aeruginosa PAO1

Gene: PA3192: DNA-binding response regulator GltR, controls specific porins for the entry of glucose
 
Pseudomonas entomophila L48

Gene: PSEEN4415: DNA-binding response regulator GltR, controls specific porins for the entry of glucose
 
Pseudomonas fluorescens Pf-5

Gene: PFL_4620: DNA-binding response regulator GltR, controls specific porins for the entry of glucose
 
Pseudomonas mendocina ymp

Gene: Pmen_1148: DNA-binding response regulator GltR, controls specific porins for the entry of glucose
 
Pseudomonas putida KT2440

Gene: PP1012: DNA-binding response regulator GltR, controls specific porins for the entry of glucose
 
Pseudomonas stutzeri A1501

Gene: PST_2442: DNA-binding response regulator GltR, controls specific porins for the entry of glucose
 
Pseudomonas syringae pv. tomato str. DC3000

Gene: PSPTO1290: DNA-binding response regulator GltR, controls specific porins for the entry of glucose
DNA-binding response regulator GltR, controls specific porins for the entry of glucose
gltS
 
Azotobacter vinelandii AvOP
 
Pseudomonas aeruginosa PAO1

Gene: PA3191: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster
 
Pseudomonas entomophila L48

Gene: PSEEN4414: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster
 
Pseudomonas fluorescens Pf-5

Gene: PFL_4619: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster
 
Pseudomonas mendocina ymp

Gene: Pmen_1149: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster
 
Pseudomonas putida KT2440

Gene: PP1013: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster
 
Pseudomonas stutzeri A1501

Gene: PST_2441: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster
 
Pseudomonas syringae pv. tomato str. DC3000

Gene: PSPTO1291: Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster
Integral membrane sensor signal transduction histidine kinase (EC 2.7.13.3), glucose catabolism cluster
 
CRON 4.
gapA
 
Azotobacter vinelandii AvOP
*
Pseudomonas aeruginosa PAO1

Site:
position = -104
score = 7.91839
sequence = TTGTTGT-(4)-ACAACAT

Gene: PA3195: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
*
Pseudomonas entomophila L48

Site:
position = -146
score = 7.03565
sequence = TCGTTGT-(8)-ACAAAAT

Site:
position = -83
score = 7.51083
sequence = ATCTTGT-(7)-ACAACAA

Gene: PSEEN4418: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
*
Pseudomonas fluorescens Pf-5

Site:
position = -105
score = 7.03565
sequence = TCGTTGT-(7)-ACAAAAT

Site:
position = -43
score = 7.51083
sequence = ATCTTGT-(7)-ACAACAA

Gene: PFL_4623: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
*
Pseudomonas mendocina ymp

Site:
position = -97
score = 6.256
sequence = TTGTATT-(4)-ACAAAAT

Site:
position = -38
score = 7.51083
sequence = ATCTTGT-(7)-ACAACAA

Gene: Pmen_1311: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
*
Pseudomonas putida KT2440

Site:
position = -145
score = 7.03565
sequence = TCGTTGT-(8)-ACAAAAT

Site:
position = -82
score = 7.51083
sequence = ATCTTGT-(7)-ACAACAA

Gene: PP1009: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
 
Pseudomonas stutzeri A1501
*
Pseudomonas syringae pv. tomato str. DC3000

Site:
position = -98
score = 6.25077
sequence = TTGTAGA-(4)-ACAAAAT

Site:
position = -39
score = 7.51083
sequence = ATCTTGT-(7)-ACAACAA

Gene: PSPTO1287: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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