Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog HypR - Rhodobacterales

Properties
Regulator type: Transcription factor
Regulator family: GntR/Others
Regulation mode: activator (repressor)
Biological process: Proline and 4-hydrohyproline utilization
Effector: 4-hydroxyproline
Phylum: Proteobacteria/alpha
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 10 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Rhodobacter sphaeroides 2.4.1
Paracoccus denitrificans PD1222 15 4
Jannaschia sp. CCS1
Rhodobacterales bacterium HTCC2654
Oceanicola granulosus HTCC2516 5 4
Loktanella vestfoldensis SKA53
Oceanicola batsensis HTCC2597
Roseovarius nubinhibens ISM 4 1
Roseovarius sp. 217
Sulfitobacter sp. EE-36
Silicibacter TM1040
Silicibacter pomeroyi DSS-3
Roseobacter sp. MED193
Hyphomonas neptunium ATCC 15444
Oceanicaulis alexandrii HTCC2633
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
hypH
 
Rhodobacter sphaeroides 2.4.1

Gene: RSP_3656: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
*2
Paracoccus denitrificans PD1222

Site:
position = -94
score = 3.99007
sequence = TTTTGCATACATGA

Gene: Pden_4865: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible

Gene: Pden_3264: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597

Gene: OB2597_14386: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
Roseovarius nubinhibens ISM

Gene: ISM_08240: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
Roseovarius sp. 217
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3

Gene: SPOA0260: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
hypM
 
Rhodobacter sphaeroides 2.4.1
*
Paracoccus denitrificans PD1222

Site:
position = -111
score = 3.53292
sequence = TTTTGTATATTAGT

Gene: Pden_4864: Predicted hydroxyproline ABC transporter, substrate-binding protein
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217

Gene: ROS217_16580: Predicted hydroxyproline ABC transporter, substrate-binding protein
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Predicted hydroxyproline ABC transporter, substrate-binding protein
hypN
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222

Gene: Pden_4863: Predicted hydroxyproline ABC transporter, permease protein
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217

Gene: ROS217_16575: Predicted hydroxyproline ABC transporter, permease protein
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Predicted hydroxyproline ABC transporter, permease protein
hypP
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222

Gene: Pden_4862: Predicted hydroxyproline ABC transporter, permease protein
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217

Gene: ROS217_16570: Predicted hydroxyproline ABC transporter, permease protein
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Predicted hydroxyproline ABC transporter, permease protein
hypQ
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222

Gene: Pden_4861: Predicted hydroxyproline ABC transporter, ATP-binding protein
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217

Gene: ROS217_16565: Predicted hydroxyproline ABC transporter, ATP-binding protein
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Predicted hydroxyproline ABC transporter, ATP-binding protein
hypO
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222

Gene: Pden_4860: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516

Gene: OG2516_08202: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217

Gene: ROS217_16535: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040

Gene: TM1040_3200: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Silicibacter pomeroyi DSS-3

Gene: SPOA0262: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Roseobacter sp. MED193

Gene: MED193_09610: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
hypE
 
Rhodobacter sphaeroides 2.4.1
 2
Paracoccus denitrificans PD1222

Gene: Pden_3467: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)

Gene: Pden_4859: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
*
Oceanicola granulosus HTCC2516

Site:
position = -78
score = 4.79247
sequence = CCTTGTCGACAACG

Gene: OG2516_07016: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217

Gene: ROS217_16540: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040

Gene: TM1040_3199: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Silicibacter pomeroyi DSS-3

Gene: SPOA0266: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Roseobacter sp. MED193

Gene: MED193_09620: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
hypA
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222

Gene: Pden_4858: Predicted hydroxyproline TRAP-type transport system, small permease component
 
Jannaschia sp. CCS1

Gene: Jann_1449: Predicted hydroxyproline TRAP-type transport system, small permease component
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM

Gene: ISM_03720: Predicted hydroxyproline TRAP-type transport system, small permease component
 
Roseovarius sp. 217
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040

Gene: TM1040_1590: Predicted hydroxyproline TRAP-type transport system, small permease component
 
Silicibacter pomeroyi DSS-3

Gene: SPO1772: Predicted hydroxyproline TRAP-type transport system, small permease component
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Predicted hydroxyproline TRAP-type transport system, small permease component
hypB
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222

Gene: Pden_4857: Predicted hydroxyproline TRAP-type transport system, large permease component
 
Jannaschia sp. CCS1

Gene: Jann_1450: Predicted hydroxyproline TRAP-type transport system, large permease component
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM

Gene: ISM_03725: Predicted hydroxyproline TRAP-type transport system, large permease component
 
Roseovarius sp. 217
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040

Gene: TM1040_1589: Predicted hydroxyproline TRAP-type transport system, large permease component
 
Silicibacter pomeroyi DSS-3

Gene: SPO1771: Predicted hydroxyproline TRAP-type transport system, large permease component
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Predicted hydroxyproline TRAP-type transport system, large permease component
hypC
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222

Gene: Pden_4856: Predicted hydroxyproline TRAP-type transport system, periplasmic component
 
Jannaschia sp. CCS1

Gene: Jann_1448: Predicted hydroxyproline TRAP-type transport system, periplasmic component
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM

Gene: ISM_03715: Predicted hydroxyproline TRAP-type transport system, periplasmic component
 
Roseovarius sp. 217
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040

Gene: TM1040_1591: Predicted hydroxyproline TRAP-type transport system, periplasmic component
 
Silicibacter pomeroyi DSS-3

Gene: SPO1773: Predicted hydroxyproline TRAP-type transport system, periplasmic component
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Predicted hydroxyproline TRAP-type transport system, periplasmic component
hypS
 
Rhodobacter sphaeroides 2.4.1
*3
Paracoccus denitrificans PD1222

Gene: Pden_4855: Putative L-lactate/Malate dehydrogenase

Site:
position = -53
score = 3.99007
sequence = TCATGTATGCAAAA

Gene: Pden_4866: Putative L-lactate/Malate dehydrogenase

Gene: Pden_0941: Putative L-lactate/Malate dehydrogenase
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
*
Oceanicola granulosus HTCC2516

Site:
position = -96
score = 4.79247
sequence = CGTTGTCGACAAGG

Gene: OG2516_07021: Putative L-lactate/Malate dehydrogenase
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217

Gene: ROS217_16560: Putative L-lactate/Malate dehydrogenase
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040

Gene: TM1040_3323: Putative L-lactate/Malate dehydrogenase
 
Silicibacter pomeroyi DSS-3
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Putative L-lactate/Malate dehydrogenase
hypX
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222

Gene: Pden_4854: Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM
 
Roseovarius sp. 217

Gene: ROS217_16550: Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3

Gene: SPO0606: Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase
hypY
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222

Gene: Pden_1184: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Jannaschia sp. CCS1

Gene: Jann_1529: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516

Gene: OG2516_07011: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM

Gene: ISM_08250: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Roseovarius sp. 217

Gene: ROS217_16530: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040

Gene: TM1040_3201: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Silicibacter pomeroyi DSS-3

Gene: SPO0607: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
hypD
 
Rhodobacter sphaeroides 2.4.1
*
Paracoccus denitrificans PD1222

Site:
position = -88
score = 4.82649
sequence = CTTTGTCGACAAAT

Gene: Pden_4867: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
*
Oceanicola granulosus HTCC2516

Site:
position = -100
score = 4.78023
sequence = TCTTGTCGACAAAC

Gene: OG2516_07031: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM

Gene: ISM_08255: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Roseovarius sp. 217

Gene: ROS217_16545: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040

Gene: TM1040_3198: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Silicibacter pomeroyi DSS-3

Gene: SPOA0267: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Roseobacter sp. MED193

Gene: MED193_09625: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
CRON 2.
COG4664
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
*
Roseovarius nubinhibens ISM

Site:
position = -91
score = 3.19022
sequence = TTGTGTCGACTCAA

Gene: ISM_10311: TRAP-type C4-dicarboxylate transport system, periplasmic component
 
Roseovarius sp. 217
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
TRAP-type C4-dicarboxylate transport system, periplasmic component
COG3090
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM

Gene: ISM_10306: TRAP-type C4-dicarboxylate transport system, small permease component
 
Roseovarius sp. 217
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
TRAP-type C4-dicarboxylate transport system, small permease component
COG4663
 
Rhodobacter sphaeroides 2.4.1
 
Paracoccus denitrificans PD1222
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
 
Oceanicola granulosus HTCC2516
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM

Gene: ISM_10301: TRAP-type C4-dicarboxylate transport system, large permease component
 
Roseovarius sp. 217
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
TRAP-type C4-dicarboxylate transport system, large permease component
hypR
 
Rhodobacter sphaeroides 2.4.1
*
Paracoccus denitrificans PD1222

Site:
position = -41
score = 3.4022
sequence = AGTTGTCGACGTCA

Gene: Pden_4868: Predicted regulator for proline and hydrohyproline utilization, GntR family
 
Jannaschia sp. CCS1
 
Rhodobacterales bacterium HTCC2654
*
Oceanicola granulosus HTCC2516

Site:
position = -25
score = 4.13568
sequence = ACCTGTCGACAACG

Gene: OG2516_07036: Predicted regulator for proline and hydrohyproline utilization, GntR family
 
Loktanella vestfoldensis SKA53
 
Oceanicola batsensis HTCC2597
 
Roseovarius nubinhibens ISM

Gene: ISM_10296: Predicted regulator for proline and hydrohyproline utilization, GntR family
 
Roseovarius sp. 217
 
Sulfitobacter sp. EE-36
 
Silicibacter TM1040
 
Silicibacter pomeroyi DSS-3
 
Roseobacter sp. MED193
 
Hyphomonas neptunium ATCC 15444
 
Oceanicaulis alexandrii HTCC2633
Predicted regulator for proline and hydrohyproline utilization, GntR family
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
Export
Regulated Genes [ Tab delimited format ] DOWNLOAD
Regulatory Sites [ FASTA format ] DOWNLOAD