Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog HypR - Rhizobiales

Properties
Regulator type: Transcription factor
Regulator family: GntR/Others
Regulation mode: activator (repressor)
Biological process: Proline and 4-hydrohyproline utilization
Effector: Proline
Phylum: Proteobacteria/alpha
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 18 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Sinorhizobium meliloti 1021 14 5
Rhizobium sp. NGR234
Rhizobium leguminosarum bv. viciae 3841 2 2
Rhizobium etli CFN 42 2 2
Agrobacterium tumefaciens str. C58 (Cereon) 10 4
Mesorhizobium sp. BNC1 2 2
Mesorhizobium loti MAFF303099
Brucella melitensis 16M 1 1
Bartonella quintana str. Toulouse
Rhodopseudomonas palustris CGA009
Bradyrhizobium japonicum USDA 110
Bradyrhizobium sp. BTAi1
Nitrobacter winogradskyi Nb-255
Azorhizobium caulinodans ORS 571
Xanthobacter autotrophicus Py2
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
hypS
*
Sinorhizobium meliloti 1021

Site:
position = -71
score = 3.81704
sequence = GTTTGTATACTCTA

Gene: SMb20261: Putative L-lactate/Malate dehydrogenase
 
Rhizobium sp. NGR234
 
Rhizobium leguminosarum bv. viciae 3841
 
Rhizobium etli CFN 42
*
Agrobacterium tumefaciens str. C58 (Cereon)

Site:
position = -52
score = 3.46455
sequence = CTTTGTATACTTTA

Site:
position = -232
score = 4.18237
sequence = ATGAGTATACAAAA

Site:
position = -41
score = 3.72489
sequence = TTATGTATTCAAAA

Gene: Atu4676: Putative L-lactate/Malate dehydrogenase
 
Mesorhizobium sp. BNC1
 
Mesorhizobium loti MAFF303099
 
Brucella melitensis 16M

Gene: BMEII1005: Putative L-lactate/Malate dehydrogenase
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
Putative L-lactate/Malate dehydrogenase
hypT
 
Sinorhizobium meliloti 1021

Gene: SMb20260: Putative hydroxyproline transporter
 
Rhizobium sp. NGR234

Gene: NGR_b14200: Putative hydroxyproline transporter
 
Rhizobium leguminosarum bv. viciae 3841

Gene: RL1805: Putative hydroxyproline transporter
 
Rhizobium etli CFN 42

Gene: RHE_CH01706: Putative hydroxyproline transporter
 
Agrobacterium tumefaciens str. C58 (Cereon)
 
Mesorhizobium sp. BNC1

Gene: Meso_0754: Putative hydroxyproline transporter
 
Mesorhizobium loti MAFF303099
 
Brucella melitensis 16M
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
Putative hydroxyproline transporter
 
CRON 2.
hypD
*2
Sinorhizobium meliloti 1021

Gene: SMc03259: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted

Site:
position = -108
score = 5.12511
sequence = TTTTGTCGACAAAT

Gene: SMb20259: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Rhizobium sp. NGR234

Gene: NGR_c13110: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
*
Rhizobium leguminosarum bv. viciae 3841

Site:
position = -51
score = 4.56911
sequence = TCTTGTCGACAGTT

Gene: pRL100268: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
*
Rhizobium etli CFN 42

Site:
position = -51
score = 4.56911
sequence = TCTTGTCGACAGTT

Gene: RHE_PC00042: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
*
Agrobacterium tumefaciens str. C58 (Cereon)

Site:
position = -99
score = 5.09177
sequence = TCTTGTCGACAAAT

Gene: Atu4675: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
*
Mesorhizobium sp. BNC1

Site:
position = -71
score = 4.60882
sequence = TTGTGTCGACAAAC

Gene: Meso_2568: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 3
Mesorhizobium loti MAFF303099

Gene: mlr6292: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted

Gene: mll3981: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted

Gene: mll6811: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
*
Brucella melitensis 16M

Site:
position = -89
score = 5.23266
sequence = TCTTGTCGACAAGA

Gene: BMEII1006: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110

Gene: bll4423: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2

Gene: Xaut_2517: 1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
1-pyrroline-4-hydroxy-2-carboxylate deaminase (EC 3.5.4.22) # predicted
 
CRON 3.
hypM
*
Sinorhizobium meliloti 1021

Site:
position = -101
score = 4.50138
sequence = TTTTGTATACTAAT

Gene: SMb20263: Predicted hydroxyproline ABC transporter, substrate-binding protein
 
Rhizobium sp. NGR234
 
Rhizobium leguminosarum bv. viciae 3841
 
Rhizobium etli CFN 42
*
Agrobacterium tumefaciens str. C58 (Cereon)

Site:
position = -100
score = 4.18237
sequence = TTTTGTATACTCAT

Gene: Atu4678: Predicted hydroxyproline ABC transporter, substrate-binding protein
 
Mesorhizobium sp. BNC1
 
Mesorhizobium loti MAFF303099
 
Brucella melitensis 16M
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
Predicted hydroxyproline ABC transporter, substrate-binding protein
hypN
 
Sinorhizobium meliloti 1021

Gene: SMb20264: Predicted hydroxyproline ABC transporter, permease protein
 
Rhizobium sp. NGR234
 
Rhizobium leguminosarum bv. viciae 3841
 
Rhizobium etli CFN 42
 
Agrobacterium tumefaciens str. C58 (Cereon)

Gene: Atu4679: Predicted hydroxyproline ABC transporter, permease protein
 
Mesorhizobium sp. BNC1
 
Mesorhizobium loti MAFF303099
 
Brucella melitensis 16M
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
Predicted hydroxyproline ABC transporter, permease protein
hypP
 
Sinorhizobium meliloti 1021

Gene: SMb20265: Predicted hydroxyproline ABC transporter, permease protein
 
Rhizobium sp. NGR234
 
Rhizobium leguminosarum bv. viciae 3841
 
Rhizobium etli CFN 42
 
Agrobacterium tumefaciens str. C58 (Cereon)

Gene: Atu4680: Predicted hydroxyproline ABC transporter, permease protein
 
Mesorhizobium sp. BNC1
 
Mesorhizobium loti MAFF303099
 
Brucella melitensis 16M
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
Predicted hydroxyproline ABC transporter, permease protein
hypQ
 
Sinorhizobium meliloti 1021

Gene: SMb20266: Predicted hydroxyproline ABC transporter, ATP-binding protein
 
Rhizobium sp. NGR234
 
Rhizobium leguminosarum bv. viciae 3841
 
Rhizobium etli CFN 42
 
Agrobacterium tumefaciens str. C58 (Cereon)

Gene: Atu4681: Predicted hydroxyproline ABC transporter, ATP-binding protein
 
Mesorhizobium sp. BNC1
 
Mesorhizobium loti MAFF303099
 
Brucella melitensis 16M
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
Predicted hydroxyproline ABC transporter, ATP-binding protein
hypO
 
Sinorhizobium meliloti 1021

Gene: SMb20267: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Rhizobium sp. NGR234
 
Rhizobium leguminosarum bv. viciae 3841
 
Rhizobium etli CFN 42
 2
Agrobacterium tumefaciens str. C58 (Cereon)

Gene: Atu3364: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster

Gene: Atu4682: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Mesorhizobium sp. BNC1

Gene: Meso_3322: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Mesorhizobium loti MAFF303099

Gene: mll3980: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Brucella melitensis 16M

Gene: BMEI0256: D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
D-amino acid dehydrogenase (EC 1.4.99.1) family protein in hydroxy-L-proline catabolic cluster
hypE
 
Sinorhizobium meliloti 1021

Gene: SMb20268: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Rhizobium sp. NGR234
 
Rhizobium leguminosarum bv. viciae 3841

Gene: pRL120535: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Rhizobium etli CFN 42

Gene: RHE_PF00391: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Agrobacterium tumefaciens str. C58 (Cereon)

Gene: Atu3953: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Mesorhizobium sp. BNC1
 
Mesorhizobium loti MAFF303099

Gene: mll3979: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Brucella melitensis 16M

Gene: BMEI0257: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8)
hypX
 
Sinorhizobium meliloti 1021

Gene: SMb20269: Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase
 
Rhizobium sp. NGR234
 
Rhizobium leguminosarum bv. viciae 3841
 
Rhizobium etli CFN 42
 
Agrobacterium tumefaciens str. C58 (Cereon)

Gene: Atu4683: Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase
 
Mesorhizobium sp. BNC1
 
Mesorhizobium loti MAFF303099
 
Brucella melitensis 16M
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
Putative citrate/isocitrate isomerase or aconitase ## predicted from clustering to proline racemase
hypY
 
Sinorhizobium meliloti 1021

Gene: SMb20270: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Rhizobium sp. NGR234

Gene: NGR_c20530: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Rhizobium leguminosarum bv. viciae 3841
 
Rhizobium etli CFN 42
 
Agrobacterium tumefaciens str. C58 (Cereon)

Gene: Atu4684: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Mesorhizobium sp. BNC1
 
Mesorhizobium loti MAFF303099

Gene: mlr6810: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Brucella melitensis 16M

Gene: BMEI1586: Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
Proline racemase /4-hydroxyproline epimerase (EC 5.1.1.8), possible pseudogene, inactive
hypZ
 
Sinorhizobium meliloti 1021

Gene: SMb20271: OsmC/Ohr family protein
 
Rhizobium sp. NGR234

Gene: NGR_b08950: OsmC/Ohr family protein
 
Rhizobium leguminosarum bv. viciae 3841
 
Rhizobium etli CFN 42
 
Agrobacterium tumefaciens str. C58 (Cereon)
 
Mesorhizobium sp. BNC1
 
Mesorhizobium loti MAFF303099

Gene: mll0741: OsmC/Ohr family protein
 
Brucella melitensis 16M
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
OsmC/Ohr family protein
 
CRON 4.
hypH
*
Sinorhizobium meliloti 1021

Site:
position = -185
score = 3.81704
sequence = TAGAGTATACAAAC

Gene: SMb20262: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
Rhizobium sp. NGR234
 
Rhizobium leguminosarum bv. viciae 3841

Gene: pRL120235: Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
Rhizobium etli CFN 42
 
Agrobacterium tumefaciens str. C58 (Cereon)
 
Mesorhizobium sp. BNC1
 
Mesorhizobium loti MAFF303099
 
Brucella melitensis 16M
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26) # hydroxy-L-proline-inducible
 
CRON 5.
hypR
*
Sinorhizobium meliloti 1021

Site:
position = -24
score = 5.266
sequence = TTTTGTCGACAAGA

Gene: SMb20258: Predicted regulator for proline and hydrohyproline utilization, GntR family
 
Rhizobium sp. NGR234
*
Rhizobium leguminosarum bv. viciae 3841

Site:
position = -113
score = 4.56911
sequence = AACTGTCGACAAGA

Gene: pRL100269: Predicted regulator for proline and hydrohyproline utilization, GntR family
*
Rhizobium etli CFN 42

Site:
position = -93
score = 4.56911
sequence = AACTGTCGACAAGA

Gene: RHE_PC00043: Predicted regulator for proline and hydrohyproline utilization, GntR family
*
Agrobacterium tumefaciens str. C58 (Cereon)

Site:
position = -25
score = 4.73111
sequence = TTATGTCGACAAGA

Gene: Atu4674: Predicted regulator for proline and hydrohyproline utilization, GntR family
*
Mesorhizobium sp. BNC1

Site:
position = -143
score = 3.41635
sequence = ACGTGTTTACAATC

Gene: Meso_2569: Predicted regulator for proline and hydrohyproline utilization, GntR family
 
Mesorhizobium loti MAFF303099
 
Brucella melitensis 16M

Gene: BMEII1007: Predicted regulator for proline and hydrohyproline utilization, GntR family
 
Bartonella quintana str. Toulouse
 
Rhodopseudomonas palustris CGA009
 
Bradyrhizobium japonicum USDA 110
 
Bradyrhizobium sp. BTAi1
 
Nitrobacter winogradskyi Nb-255
 
Azorhizobium caulinodans ORS 571
 
Xanthobacter autotrophicus Py2
Predicted regulator for proline and hydrohyproline utilization, GntR family
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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