Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog NrdR - Various betaproteobacteria

Properties
Regulator type: Transcription factor
Regulator family: NrdR
Regulation mode: repressor
Biological process: Deoxyribonucleotide biosynthesis
Effector: Deoxyribonucleotides
Phylum: Proteobacteria/beta
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 20 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Azoarcus sp. EbN1 1 1
Thauera sp. MZ1T 1 1
Dechloromonas aromatica RCB 1 1
Nitrosomonas europaea ATCC 19718 2 1
Nitrosospira multiformis ATCC 25196 2 1
Thiobacillus denitrificans 2 1
Chromobacterium violaceum ATCC 12472 7 3
Neisseria meningitidis MC58 5 1
Laribacter hongkongensis HLHK9 6 3
Methylobacillus flagellatus KT 5 2
Methylotenera mobilis JLW8 4 2
Methylophilales bacterium HTCC2181 1 1
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
nrdA
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
*
Neisseria meningitidis MC58

Site:
position = -72
score = 4.10309
sequence = ATCCACTATATTGTCT

Gene: NMB1291: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
 
Laribacter hongkongensis HLHK9
*
Methylobacillus flagellatus KT

Site:
position = -376
score = 5.29873
sequence = GAACAATATATAGTGT

Gene: Mfla_1223: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
NMB1290
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58

Gene: NMB1290: C-5 cytosine-specific DNA-methylase
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
C-5 cytosine-specific DNA-methylase
NMB1289
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58

Gene: NMB1289: type II restriction enzyme, putative
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
type II restriction enzyme, putative
nrdB
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58

Gene: NMB1288: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT

Gene: Mfla_1224: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
yfaE
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58

Gene: NMB1287: Ferredoxin
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT

Gene: Mfla_1225: Ferredoxin
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Ferredoxin
 
CRON 2.
nrdD
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
*
Chromobacterium violaceum ATCC 12472

Site:
position = -162
score = 4.4603
sequence = GCACAATATATTGATC

Gene: CV2412: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
 
Neisseria meningitidis MC58
*
Laribacter hongkongensis HLHK9

Site:
position = -80
score = 5.56687
sequence = ACACAACATCTTGTGT

Gene: LHK_02258: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV2413: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9

Gene: LHK_02259: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)
 
CRON 3.
nrdJa
*
Azoarcus sp. EbN1

Site:
position = -140
score = 4.83809
sequence = CTACTACATATAGTAC

Gene: ebA4850: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
*
Thauera sp. MZ1T

Site:
position = -149
score = 4.89862
sequence = CTACTACATGTAGTGC

Gene: Tmz1t_1360: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
*
Dechloromonas aromatica RCB

Site:
position = -75
score = 4.80233
sequence = GCACTATATCTAGTAG

Gene: Daro_0964: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans

Gene: Tbd_0058: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
*
Chromobacterium violaceum ATCC 12472

Site:
position = -121
score = 4.56469
sequence = ACACAACAACTTGCGT

Site:
position = -88
score = 5.328
sequence = TAACAACATATAGTGT

Gene: CV1446: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
 
Neisseria meningitidis MC58
*
Laribacter hongkongensis HLHK9

Site:
position = -158
score = 5.34018
sequence = AAACAACATCTAGTGT

Gene: LHK_01596: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
*
Methylobacillus flagellatus KT

Site:
position = -95
score = 5.06584
sequence = TCACTATATGTTGTGG

Gene: Mfla_2541: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
*
Methylotenera mobilis JLW8

Site:
position = -148
score = 5.55372
sequence = ACACAATATATAGTGG

Gene: Mmol_0049: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
*
Methylophilales bacterium HTCC2181

Site:
position = -82
score = 5.44506
sequence = TCACAACATATTGTGG

Gene: MB2181_01310: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
nrdJb
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT

Gene: Mfla_2542: Ribonucleotide reductase of class II (coenzyme B12-dependent), alpha subunit (EC 1.17.4.1)
 
Methylotenera mobilis JLW8

Gene: Mmol_0050: Ribonucleotide reductase of class II (coenzyme B12-dependent), alpha subunit (EC 1.17.4.1)
 
Methylophilales bacterium HTCC2181
Ribonucleotide reductase of class II (coenzyme B12-dependent), alpha subunit (EC 1.17.4.1)
 
CRON 4.
nrdA
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
*
Nitrosomonas europaea ATCC 19718

Site:
position = -116
score = 5.70196
sequence = ACACAATATATTGTGT

Gene: NE2423: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
*
Nitrosospira multiformis ATCC 25196

Site:
position = -112
score = 4.8583
sequence = CTACTATATATAGTAG

Gene: Nmul_A2468: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
*
Thiobacillus denitrificans

Site:
position = -88
score = 4.63574
sequence = CCACAAGATGTTGTGA

Gene: Tbd_1976: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
*
Chromobacterium violaceum ATCC 12472

Site:
position = -283
score = 5.18318
sequence = CTACAACATCTAGTGC

Site:
position = -50
score = 4.54922
sequence = ACGGTATATATTGTGT

Gene: CV2287: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
 
Neisseria meningitidis MC58
*
Laribacter hongkongensis HLHK9

Site:
position = -69
score = 5.45724
sequence = ACACAACATCTTGTGC

Gene: LHK_01803: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
 
Methylobacillus flagellatus KT
*
Methylotenera mobilis JLW8

Site:
position = -442
score = 4.90239
sequence = TATCAATATATTGTGT

Gene: Mmol_1920: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
 
Methylophilales bacterium HTCC2181
Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
CV2286
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV2286: hypothetical protein
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
hypothetical protein
CV2285
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV2285: hypothetical protein
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
hypothetical protein
nrdB
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718

Gene: NE2422: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
 
Nitrosospira multiformis ATCC 25196

Gene: Nmul_A2469: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
 
Thiobacillus denitrificans

Gene: Tbd_1975: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
 
Chromobacterium violaceum ATCC 12472

Gene: CV2284: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9

Gene: LHK_01801: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8

Gene: Mmol_1921: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
 
Methylophilales bacterium HTCC2181
Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
CV3202
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9

Gene: LHK_01802: hypothetical protein
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
hypothetical protein
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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