Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog BirA - Various betaproteobacteria

Properties
Regulator type: Transcription factor
Regulator family: BirA
Regulation mode: repressor
Biological process: Biotin biosynthesis
Effector: Biotin
Phylum: Proteobacteria/gamma
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 13 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Azoarcus sp. EbN1
Thauera sp. MZ1T
Dechloromonas aromatica RCB
Nitrosomonas europaea ATCC 19718 5 1
Nitrosospira multiformis ATCC 25196 6 2
Thiobacillus denitrificans 6 2
Chromobacterium violaceum ATCC 12472 7 2
Neisseria meningitidis MC58
Laribacter hongkongensis HLHK9 3 2
Methylobacillus flagellatus KT 5 1
Methylotenera mobilis JLW8 6 2
Methylophilales bacterium HTCC2181 5 1
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
bioB
 
Azoarcus sp. EbN1

Gene: ebA1066: Biotin synthase (EC 2.8.1.6)
 
Thauera sp. MZ1T

Gene: Tmz1t_1536: Biotin synthase (EC 2.8.1.6)
 
Dechloromonas aromatica RCB

Gene: Daro_0618: Biotin synthase (EC 2.8.1.6)
*
Nitrosomonas europaea ATCC 19718

Site:
position = -96
score = 7.57847
sequence = CTGTTTAAT-(14)-AATTGACAA

Gene: NE2300: Biotin synthase (EC 2.8.1.6)
*
Nitrosospira multiformis ATCC 25196

Site:
position = -164
score = 7.16729
sequence = TAGTTCAAA-(14)-AATTGACAA

Gene: Nmul_A1129: Biotin synthase (EC 2.8.1.6)
*
Thiobacillus denitrificans

Site:
position = -583
score = 7.58393
sequence = ATGTTCAAT-(15)-ATTTGACAG

Gene: Tbd_0319: Biotin synthase (EC 2.8.1.6)
*
Chromobacterium violaceum ATCC 12472

Site:
position = -132
score = 7.97831
sequence = TTGTCAATT-(14)-GTTTGACAG

Gene: CV4381: Biotin synthase (EC 2.8.1.6)
 2
Neisseria meningitidis MC58

Gene: NMB1184: Biotin synthase (EC 2.8.1.6)

Gene: NMB1146: Biotin synthase (EC 2.8.1.6)
*
Laribacter hongkongensis HLHK9

Site:
position = -900
score = 6.99832
sequence = CTGTTTATA-(14)-GTTTGACAG

Gene: LHK_00097: Biotin synthase (EC 2.8.1.6)
*
Methylobacillus flagellatus KT

Site:
position = -469
score = 6.72128
sequence = ATGTAAATG-(15)-GCTTGACAA

Gene: Mfla_2164: Biotin synthase (EC 2.8.1.6)
*
Methylotenera mobilis JLW8

Site:
position = -118
score = 7.30061
sequence = TTGTTCAAA-(15)-TGTTGACAA

Gene: Mmol_0572: Biotin synthase (EC 2.8.1.6)
*
Methylophilales bacterium HTCC2181

Site:
position = -81
score = 7.02877
sequence = TTGTTAAAA-(14)-GCTTAACCA

Gene: MB2181_06030: Biotin synthase (EC 2.8.1.6)
Biotin synthase (EC 2.8.1.6)
bioF
 
Azoarcus sp. EbN1

Gene: ebA6018: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB

Gene: Daro_2897: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Nitrosomonas europaea ATCC 19718

Gene: NE2299: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Nitrosospira multiformis ATCC 25196

Gene: Nmul_A1130: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Thiobacillus denitrificans

Gene: Tbd_0320: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Chromobacterium violaceum ATCC 12472

Gene: CV4380: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Neisseria meningitidis MC58

Gene: NMB0472: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Laribacter hongkongensis HLHK9

Gene: LHK_00098: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Methylobacillus flagellatus KT

Gene: Mfla_2163: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Methylotenera mobilis JLW8

Gene: Mmol_0573: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Methylophilales bacterium HTCC2181

Gene: MB2181_06025: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
8-amino-7-oxononanoate synthase (EC 2.3.1.47)
CV4379
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV4379: Sensory box/GGDEF family protein
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Sensory box/GGDEF family protein
CV3478
 
Azoarcus sp. EbN1
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB
 
Nitrosomonas europaea ATCC 19718
 
Nitrosospira multiformis ATCC 25196
 
Thiobacillus denitrificans
 
Chromobacterium violaceum ATCC 12472

Gene: CV4378: Phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17)
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9
 
Methylobacillus flagellatus KT
 
Methylotenera mobilis JLW8
 
Methylophilales bacterium HTCC2181
Phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17)
bioH
 
Azoarcus sp. EbN1

Gene: ebA6017: Biotin synthesis protein bioH
 
Thauera sp. MZ1T

Gene: Tmz1t_1979: Biotin synthesis protein bioH
 
Dechloromonas aromatica RCB

Gene: Daro_2898: Biotin synthesis protein bioH
 
Nitrosomonas europaea ATCC 19718

Gene: NE2298: Biotin synthesis protein bioH
 
Nitrosospira multiformis ATCC 25196

Gene: Nmul_A1131: Biotin synthesis protein bioH
 
Thiobacillus denitrificans

Gene: Tbd_0321: Biotin synthesis protein bioH
 
Chromobacterium violaceum ATCC 12472

Gene: CV4377: Biotin synthesis protein bioH
 
Neisseria meningitidis MC58

Gene: NMB0270: Biotin synthesis protein bioH
 
Laribacter hongkongensis HLHK9

Gene: LHK_03115: Biotin synthesis protein bioH
 
Methylobacillus flagellatus KT

Gene: Mfla_2162: Biotin synthesis protein bioH
 
Methylotenera mobilis JLW8

Gene: Mmol_0574: Biotin synthesis protein bioH
 
Methylophilales bacterium HTCC2181

Gene: MB2181_06020: Biotin synthesis protein bioH
Biotin synthesis protein bioH
bioC
 
Azoarcus sp. EbN1

Gene: ebA6013: Biotin synthesis protein bioC
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB

Gene: Daro_2899: Biotin synthesis protein bioC
 
Nitrosomonas europaea ATCC 19718

Gene: NE2297: Biotin synthesis protein bioC
 
Nitrosospira multiformis ATCC 25196

Gene: Nmul_A1132: Biotin synthesis protein bioC
 
Thiobacillus denitrificans

Gene: Tbd_0322: Biotin synthesis protein bioC
 
Chromobacterium violaceum ATCC 12472

Gene: CV4376: Biotin synthesis protein bioC
 
Neisseria meningitidis MC58

Gene: NMB0474: Biotin synthesis protein bioC
 
Laribacter hongkongensis HLHK9

Gene: LHK_03114: Biotin synthesis protein bioC
 
Methylobacillus flagellatus KT

Gene: Mfla_2161: Biotin synthesis protein bioC
 
Methylotenera mobilis JLW8

Gene: Mmol_0575: Biotin synthesis protein bioC
 
Methylophilales bacterium HTCC2181

Gene: MB2181_06015: Biotin synthesis protein bioC
Biotin synthesis protein bioC
bioD
 
Azoarcus sp. EbN1

Gene: ebA6011: Dethiobiotin synthetase (EC 6.3.3.3)
 
Thauera sp. MZ1T
 
Dechloromonas aromatica RCB

Gene: Daro_2900: Dethiobiotin synthetase (EC 6.3.3.3)
 
Nitrosomonas europaea ATCC 19718

Gene: NE2296: Dethiobiotin synthetase (EC 6.3.3.3)
 
Nitrosospira multiformis ATCC 25196

Gene: Nmul_A1133: Dethiobiotin synthetase (EC 6.3.3.3)
 
Thiobacillus denitrificans

Gene: Tbd_0323: Dethiobiotin synthetase (EC 6.3.3.3)
 
Chromobacterium violaceum ATCC 12472

Gene: CV0598: Dethiobiotin synthetase (EC 6.3.3.3)
 
Neisseria meningitidis MC58
 
Laribacter hongkongensis HLHK9

Gene: LHK_00168: Dethiobiotin synthetase (EC 6.3.3.3)
 
Methylobacillus flagellatus KT

Gene: Mfla_2160: Dethiobiotin synthetase (EC 6.3.3.3)
 
Methylotenera mobilis JLW8

Gene: Mmol_0576: Dethiobiotin synthetase (EC 6.3.3.3)
 
Methylophilales bacterium HTCC2181

Gene: MB2181_06010: Dethiobiotin synthetase (EC 6.3.3.3)
Dethiobiotin synthetase (EC 6.3.3.3)
 
CRON 2.
COG1040
 
Azoarcus sp. EbN1

Gene: ebA1065: Competence protein F homolog, phosphoribosyltransferase domain; protein YhgH required for utilization of DNA as sole source of carbon and energy
 
Thauera sp. MZ1T

Gene: Tmz1t_1537: Competence protein F homolog, phosphoribosyltransferase domain; protein YhgH required for utilization of DNA as sole source of carbon and energy
 
Dechloromonas aromatica RCB

Gene: Daro_0617: Competence protein F homolog, phosphoribosyltransferase domain; protein YhgH required for utilization of DNA as sole source of carbon and energy
 
Nitrosomonas europaea ATCC 19718
*
Nitrosospira multiformis ATCC 25196

Site:
position = 3
score = 7.16729
sequence = TTGTCAATT-(14)-TTTGAACTA

Gene: Nmul_A1128: Competence protein F homolog, phosphoribosyltransferase domain; protein YhgH required for utilization of DNA as sole source of carbon and energy
*
Thiobacillus denitrificans

Site:
position = -25
score = 7.58393
sequence = CTGTCAAAT-(15)-ATTGAACAT

Gene: Tbd_0317: Competence protein F homolog, phosphoribosyltransferase domain; protein YhgH required for utilization of DNA as sole source of carbon and energy
*
Chromobacterium violaceum ATCC 12472

Site:
position = -39
score = 7.97831
sequence = CTGTCAAAC-(14)-AATTGACAA

Gene: CV4382: Competence protein F homolog, phosphoribosyltransferase domain; protein YhgH required for utilization of DNA as sole source of carbon and energy
 
Neisseria meningitidis MC58

Gene: NMB0269: Competence protein F homolog, phosphoribosyltransferase domain; protein YhgH required for utilization of DNA as sole source of carbon and energy
*
Laribacter hongkongensis HLHK9

Site:
position = 12
score = 6.99832
sequence = CTGTCAAAC-(14)-TATAAACAG

Gene: LHK_00099: Competence protein F homolog, phosphoribosyltransferase domain; protein YhgH required for utilization of DNA as sole source of carbon and energy
 
Methylobacillus flagellatus KT

Gene: Mfla_2181: Competence protein F homolog, phosphoribosyltransferase domain; protein YhgH required for utilization of DNA as sole source of carbon and energy
*
Methylotenera mobilis JLW8

Site:
position = 17
score = 7.30061
sequence = TTGTCAACA-(15)-TTTGAACAA

Gene: Mmol_0571: Competence protein F homolog, phosphoribosyltransferase domain; protein YhgH required for utilization of DNA as sole source of carbon and energy
 
Methylophilales bacterium HTCC2181
Competence protein F homolog, phosphoribosyltransferase domain; protein YhgH required for utilization of DNA as sole source of carbon and energy
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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