Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Regulog BirA - Enterobacteriales

Properties
Regulator type: Transcription factor
Regulator family: BirA
Regulation mode: repressor
Biological process: Biotin biosynthesis
Effector: Biotin
Phylum: Proteobacteria/gamma
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 27 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Escherichia coli str. K-12 substr. MG1655 6 3
Salmonella typhimurium LT2 5 2
Citrobacter koseri ATCC BAA-895 5 2
Klebsiella pneumoniae subsp. pneumoniae MGH 78578 6 3
Enterobacter sp. 638 5 2
Erwinia amylovora ATCC 49946 5 2
Yersinia pestis KIM 6 3
Serratia proteamaculans 568 5 2
Erwinia carotovora subsp. atroseptica SCRI1043 5 2
Edwardsiella tarda EIB202 6 2
Proteus mirabilis HI4320 5 2
Photorhabdus luminescens subsp. laumondii TTO1 5 2
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
bioB
*
Escherichia coli str. K-12 substr. MG1655

Site:
position = -79
score = 9.43903
sequence = TTGTAAACC-(16)-GGTTTACAA

Gene: b0775: Biotin synthase (EC 2.8.1.6)
*
Salmonella typhimurium LT2

Site:
position = -79
score = 9.08123
sequence = TTGTAAACC-(16)-GGTTTACGA

Gene: STM0794: Biotin synthase (EC 2.8.1.6)
*
Citrobacter koseri ATCC BAA-895

Site:
position = -79
score = 9.08123
sequence = TTGTAAACC-(16)-GGTTTACGA

Gene: CKO_02353: Biotin synthase (EC 2.8.1.6)
*
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Site:
position = -230
score = 9.43903
sequence = TTGTAAACC-(16)-GGTTTACAA

Gene: KPN_00800: Biotin synthase (EC 2.8.1.6)
*
Enterobacter sp. 638

Site:
position = -79
score = 8.66221
sequence = TTGTAAACC-(16)-GGTTTACCA

Gene: Ent638_1266: Biotin synthase (EC 2.8.1.6)
*
Erwinia amylovora ATCC 49946

Site:
position = -80
score = 9.03293
sequence = TTGTAAACC-(15)-AGTTTACAA

Gene: EAM_1210: Biotin synthase (EC 2.8.1.6)
*
Yersinia pestis KIM

Site:
position = -89
score = 9.01262
sequence = TTGTAAACC-(16)-GGTTGACAG

Gene: y3031: Biotin synthase (EC 2.8.1.6)
*
Serratia proteamaculans 568

Site:
position = -88
score = 9.01262
sequence = TTGTAAACC-(16)-GGTTgACAg

Gene: Spro_1311: Biotin synthase (EC 2.8.1.6)
*
Erwinia carotovora subsp. atroseptica SCRI1043

Site:
position = -86
score = 8.65482
sequence = TCGTAAACC-(16)-GGTTGACAG

Gene: ECA2825: Biotin synthase (EC 2.8.1.6)
*
Edwardsiella tarda EIB202

Site:
position = -94
score = 8.79814
sequence = CTGTAAACC-(16)-GGTTGACAT

Gene: ETAE_2554: Biotin synthase (EC 2.8.1.6)
*
Proteus mirabilis HI4320

Site:
position = -85
score = 8.39204
sequence = ATGTAAACC-(16)-AGTTGACAT

Gene: PMI0603: Biotin synthase (EC 2.8.1.6)
*
Photorhabdus luminescens subsp. laumondii TTO1

Site:
position = -86
score = 8.44034
sequence = ACGTAAACC-(15)-GGTTGACAG

Gene: plu1485: Biotin synthase (EC 2.8.1.6)
Biotin synthase (EC 2.8.1.6)
bioF
 
Escherichia coli str. K-12 substr. MG1655

Gene: b0776: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Salmonella typhimurium LT2

Gene: STM0795: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Citrobacter koseri ATCC BAA-895

Gene: CKO_02352: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Gene: KPN_00801: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Enterobacter sp. 638

Gene: Ent638_1267: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Erwinia amylovora ATCC 49946

Gene: EAM_1211: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Yersinia pestis KIM

Gene: y3030: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Serratia proteamaculans 568

Gene: Spro_1312: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Erwinia carotovora subsp. atroseptica SCRI1043

Gene: ECA2824: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 2
Edwardsiella tarda EIB202

Gene: ETAE_2553: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)

Gene: ETAE_2552: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Proteus mirabilis HI4320

Gene: PMI0604: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
 
Photorhabdus luminescens subsp. laumondii TTO1

Gene: plu1486: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
8-amino-7-oxononanoate synthase (EC 2.3.1.47)
bioC
 
Escherichia coli str. K-12 substr. MG1655

Gene: b0777: Biotin synthesis protein bioC
 
Salmonella typhimurium LT2

Gene: STM0796: Biotin synthesis protein bioC
 
Citrobacter koseri ATCC BAA-895

Gene: CKO_02351: Biotin synthesis protein bioC
 
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Gene: KPN_00802: Biotin synthesis protein bioC
 
Enterobacter sp. 638

Gene: Ent638_1268: Biotin synthesis protein bioC
 
Erwinia amylovora ATCC 49946

Gene: EAM_1212: Biotin synthesis protein bioC
 
Yersinia pestis KIM

Gene: y3029: Biotin synthesis protein bioC
 
Serratia proteamaculans 568

Gene: Spro_1313: Biotin synthesis protein bioC
 
Erwinia carotovora subsp. atroseptica SCRI1043

Gene: ECA2823: Biotin synthesis protein bioC
 
Edwardsiella tarda EIB202

Gene: ETAE_2551: Biotin synthesis protein bioC
 
Proteus mirabilis HI4320

Gene: PMI0605: Biotin synthesis protein bioC
 
Photorhabdus luminescens subsp. laumondii TTO1

Gene: plu1487: Biotin synthesis protein bioC
Biotin synthesis protein bioC
bioD
 
Escherichia coli str. K-12 substr. MG1655

Gene: b0778: Dethiobiotin synthetase (EC 6.3.3.3)
 
Salmonella typhimurium LT2

Gene: STM0797: Dethiobiotin synthetase (EC 6.3.3.3)
 
Citrobacter koseri ATCC BAA-895

Gene: CKO_02350: Dethiobiotin synthetase (EC 6.3.3.3)
 
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Gene: KPN_00803: Dethiobiotin synthetase (EC 6.3.3.3)
 
Enterobacter sp. 638

Gene: Ent638_1269: Dethiobiotin synthetase (EC 6.3.3.3)
 
Erwinia amylovora ATCC 49946

Gene: EAM_1213: Dethiobiotin synthetase (EC 6.3.3.3)
 
Yersinia pestis KIM

Gene: y3028: Dethiobiotin synthetase (EC 6.3.3.3)
 
Serratia proteamaculans 568

Gene: Spro_1314: Dethiobiotin synthetase (EC 6.3.3.3)
 
Erwinia carotovora subsp. atroseptica SCRI1043

Gene: ECA2822: Dethiobiotin synthetase (EC 6.3.3.3)
 
Edwardsiella tarda EIB202

Gene: ETAE_2550: Dethiobiotin synthetase (EC 6.3.3.3)
 
Proteus mirabilis HI4320

Gene: PMI0606: Dethiobiotin synthetase (EC 6.3.3.3)
 
Photorhabdus luminescens subsp. laumondii TTO1

Gene: plu1488: Dethiobiotin synthetase (EC 6.3.3.3)
Dethiobiotin synthetase (EC 6.3.3.3)
 
CRON 2.
bioA
*
Escherichia coli str. K-12 substr. MG1655

Site:
position = -41
score = 9.43903
sequence = TTGTAAACC-(16)-GGTTTACAA

Gene: b0774: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Salmonella typhimurium LT2

Site:
position = -41
score = 9.08123
sequence = TCGTAAACC-(16)-GGTTTACAA

Gene: STM0793: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Citrobacter koseri ATCC BAA-895

Site:
position = -41
score = 9.08123
sequence = TCGTAAACC-(16)-GGTTTACAA

Gene: CKO_02354: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Site:
position = -41
score = 9.43903
sequence = TTGTAAACC-(16)-GGTTTACAA

Gene: KPN_00799: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Enterobacter sp. 638

Site:
position = -22
score = 8.66221
sequence = TgGTAAACC-(16)-GGTTTACAA

Gene: Ent638_1265: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Erwinia amylovora ATCC 49946

Site:
position = -41
score = 9.03293
sequence = TTGTAAACT-(15)-GGTTTACAA

Gene: EAM_1209: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Yersinia pestis KIM

Site:
position = -43
score = 9.01262
sequence = CTGTCAACC-(16)-GGTTTACAA

Gene: y3032: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Serratia proteamaculans 568

Site:
position = -17
score = 9.01262
sequence = cTGTcAACC-(16)-GGTTTACAA

Gene: Spro_1310: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Erwinia carotovora subsp. atroseptica SCRI1043

Site:
position = -43
score = 8.65482
sequence = CTGTCAACC-(16)-GGTTTACGA

Gene: ECA2826: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Edwardsiella tarda EIB202

Site:
position = -141
score = 8.79814
sequence = ATGTCAACC-(16)-GGTTTACAG

Gene: ETAE_2555: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Proteus mirabilis HI4320

Site:
position = -52
score = 8.39204
sequence = ATGTCAACT-(16)-GGTTTACAT

Gene: PMI0602: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Photorhabdus luminescens subsp. laumondii TTO1

Site:
position = -41
score = 8.44034
sequence = CTGTCAACC-(15)-GGTTTACGT

Gene: plu1484: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
CRON 3.
yigM
*
Escherichia coli str. K-12 substr. MG1655

Site:
position = -81
score = 6.05737
sequence = TCGTAATCG-(14)-AGTTGTCAA

Gene: b3827: Predicted biotin transporter YigM
 
Salmonella typhimurium LT2

Gene: STM3963: Predicted biotin transporter YigM
 
Citrobacter koseri ATCC BAA-895

Gene: CKO_00168: Predicted biotin transporter YigM
*
Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Site:
position = -82
score = 4.95947
sequence = TTGACGACT-(15)-AGTCGTCAA

Gene: KPN_04323: Predicted biotin transporter YigM
 
Enterobacter sp. 638

Gene: Ent638_3969: Predicted biotin transporter YigM
 
Erwinia amylovora ATCC 49946
*
Yersinia pestis KIM

Site:
position = -109
score = 5.60431
sequence = TTATCAACA-(15)-ATTTTAAAA

Gene: y0440: Predicted biotin transporter YigM
 
Serratia proteamaculans 568

Gene: Spro_0240: Predicted biotin transporter YigM
 
Erwinia carotovora subsp. atroseptica SCRI1043

Gene: ECA0179: Predicted biotin transporter YigM
 
Edwardsiella tarda EIB202

Gene: ETAE_0141: Predicted biotin transporter YigM
 
Proteus mirabilis HI4320

Gene: PMI3527: Predicted biotin transporter YigM
 
Photorhabdus luminescens subsp. laumondii TTO1
Predicted biotin transporter YigM
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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