Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for BirA transcription factor family

General statistics
TF regulogs 22
TF regulons 179
TF binding sites 360

BirA repressors control transcription of the biotin biosynthesis operon, and in the same time BirA proteins act as a biotin-protein ligase. Biotin is an essential coenzyme required for central cellular metabolism and its biosynthesis is tightly controlled [20142036, 12368242]. Transcription of the biotin operon in E.coli is derepressed under biotin starvation conditions, when BirA repressors remain largely monomeric and bio operator is unoccupied. When all available acceptor proteins are biotinylated, BirA bind its target DNA operator as a dimer and thus negatively regulate transcription of the biotin operon [20142036]. more

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Chlorobiales BirA - Chlorobiales 10 (11) 10
Deinococcus-Thermus BirA - Deinococcus-Thermus 2 (5) 3
Firmicutes BirA - Bacillales 11 (11) 36
Firmicutes BirA - Clostridia-1 7 (8) 19
Firmicutes BirA - Clostridia-2 3 (3) 5
Firmicutes BirA - Clostridia-3 14 (14) 25
Firmicutes BirA - Lactobacillaceae 7 (15) 10
Firmicutes BirA - Listeriaceae 3 (4) 3
Firmicutes BirA - Staphylococcaceae 7 (7) 21
Firmicutes BirA - Streptococcaceae 15 (15) 29
Firmicutes BirA - Thermoanaerobacterales 6 (7) 11
Proteobacteria/Gamma BirA - Pseudomonadaceae 8 (8) 15
Proteobacteria/delta BirA - Desulfovibrionales 3 (10) 6
Proteobacteria/delta BirA - Desulfuromonadales 8 (9) 15
Proteobacteria/gamma BirA - Alteromonadales 9 (9) 17
Proteobacteria/gamma BirA - Enterobacteriales 12 (12) 27
Proteobacteria/gamma BirA - Oceanospirillales/Alteromonadales 11 (12) 26
Proteobacteria/gamma BirA - Psychromonadaceae/Aeromonadales 6 (6) 12
Proteobacteria/gamma BirA - Shewanellaceae 16 (16) 32
Proteobacteria/gamma BirA - Various betaproteobacteria 8 (12) 13
Proteobacteria/gamma BirA - Vibrionales 10 (10) 20
Proteobacteria/gamma BirA - Xanthomonadales 3 (4) 5