Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for PurR transcription factor family

General statistics
TF regulogs 4
TF regulons 48
TF binding sites 304

PurR family of transcription factors includes homologous regulators of purine metabolism in Firmicutes [12837784]. Activity of PurR-family repressors is modulated by an effector molecule, 5-phosphoribosyl 1-pyrophosphate (PRPP), which is an essential compound in many purine metabolism reactions [14594850]. When PRPP is abundant, it prevents PurR from binding to DNA sites, relieving expression of target genes. PurR regulators are composed of an N-terminal winged HTH DNA binding domain (PF09182) and a C-terminal phosphoribosyltransferase-like effector binding domain (PF00156).

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Firmicutes PurR - Bacillales 11 (11) 102
Firmicutes PurR - Lactobacillaceae 15 (15) 76
Firmicutes PurR - Staphylococcaceae 7 (7) 26
Firmicutes PurR - Streptococcaceae 15 (15) 100