Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for NrdR transcription factor family

General statistics
TF regulogs 43
TF regulons 363
TF binding sites 1208

NrdR repressor controls expression of genes for deoxyribonucleotide reductases (nrd) of all three types in most lineages of Bacteria [15949864]. Novel DNA-binding motif (NrdR-box) was first discovered by application of the comparative genomic approach, and the NrdR transcription factor (previously known as hypothetical protein YbaD in E. coli) was attributed to the identified NrdR-box motif by correlating their occurrence with the phylogenetic distribution of ortholog families. The DNA-binding motifs of NrdR showed significant conservation across diverse bacterial lineages. The predicted regulatory role of NrdR was confirmed in experiments conducted in E. more

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Actinobacteria NrdR - Bifidobacteriaceae 10 (10) 31
Actinobacteria NrdR - Corynebacteriaceae 8 (8) 26
Actinobacteria NrdR - Frankineae/Propionibacterineae/Pseudonocardiaceae 9 (9) 17
Actinobacteria NrdR - Micrococcineae 14 (14) 44
Actinobacteria NrdR - Mycobacteriaceae 9 (9) 43
Actinobacteria NrdR - Nocardiaceae 4 (4) 10
Actinobacteria NrdR - Streptomycetaceae 4 (4) 16
Chlamydiae NrdR - Chlamydiales 7 (7) 14
Chloroflexi NrdR - Chloroflexia 5 (5) 8
Cyanobacteria NrdR - Cyanobacteria 5 (14) 8
Deinococcus-Thermus NrdR - Deinococcus-Thermus 3 (5) 5
Firmicutes NrdR - Bacillales 11 (11) 27
Firmicutes NrdR - Clostridia-1 8 (8) 31
Firmicutes NrdR - Clostridia-2 3 (3) 12
Firmicutes NrdR - Clostridia-3 14 (14) 49
Firmicutes NrdR - Lactobacillaceae 13 (15) 81
Firmicutes NrdR - Listeriaceae 4 (4) 17
Firmicutes NrdR - Staphylococcaceae 7 (7) 30
Firmicutes NrdR - Streptococcaceae 15 (15) 63
Firmicutes NrdR - Thermoanaerobacterales 6 (7) 18
Planctomycetes NrdR - Planctomycetes 4 (5) 14
Proteobacteria/Beta NrdR - Alcaligenaceae 3 (3) 6
Proteobacteria/alpha NrdR - Caulobacterales 4 (4) 21
Proteobacteria/alpha NrdR - Rhizobiales 15 (15) 39
Proteobacteria/alpha NrdR - Rhodobacterales 15 (15) 17
Proteobacteria/alpha NrdR - Rhodospirillales 9 (9) 21
Proteobacteria/alpha NrdR - Sphingomonadales 7 (7) 17
Proteobacteria/beta NrdR - Burkholderia 8 (8) 20
Proteobacteria/beta NrdR - Comamonadaceae 11 (11) 28
Proteobacteria/beta NrdR - Ralstonia 6 (6) 18
Proteobacteria/beta NrdR - Various betaproteobacteria 12 (12) 20
Proteobacteria/delta NrdR - Desulfuromonadales 9 (9) 21
Proteobacteria/gamma NrdR - Alteromonadales 9 (9) 24
Proteobacteria/gamma NrdR - Enterobacteriales 12 (12) 70
Proteobacteria/gamma NrdR - Moraxellaceae 4 (4) 8
Proteobacteria/gamma NrdR - Oceanospirillales/Alteromonadales 12 (12) 39
Proteobacteria/gamma NrdR - Pasteurellales 9 (9) 41
Proteobacteria/gamma NrdR - Pseudomonadaceae 8 (8) 35
Proteobacteria/gamma NrdR - Psychromonadaceae/Aeromonadales 6 (6) 26
Proteobacteria/gamma NrdR - Shewanellaceae 16 (16) 64
Proteobacteria/gamma NrdR - Vibrionales 10 (10) 40
Proteobacteria/gamma NrdR - Xanthomonadales 4 (4) 9
Thermotogae NrdR - Thermotogales 11 (11) 60