Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for NikR transcription factor family

General statistics
TF regulogs 13
TF regulons 44
TF binding sites 72

NikR transcription factors are involved in the control of nickel homeostasis including nickel uptake, storage, and usage genes [21666253]. NikR repressor was originally experimentally characterized in E. coli, where it negatively controls expression of the nickel uptake transporter. NikR protein binds to its DNA operator in the presence of nickel ions [15287729]. In Helicobacter pylori, nickel response is controlled by a NikR ortholog that co-regulates a larger set of genes involved in nickel homeostasis (Ni-dependent enzymes, Ni transporter), at that, depending on the target gene NikR acts as an activator or a repressor [20863122, 21666253]. more

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Chlorobiales NikR - Chlorobiales 5 (11) 5
Firmicutes NikR - Thermoanaerobacterales 3 (7) 3
Proteobacteria/alpha NikR - Rhizobiales 4 (15) 11
Proteobacteria/alpha NikR - Rhodobacterales 2 (15) 2
Proteobacteria/alpha NikR - Rhodospirillales 1 (9) 2
Proteobacteria/beta NikR - Burkholderia 1 (8) 2
Proteobacteria/beta NikR - Comamonadaceae 2 (11) 3
Proteobacteria/beta NikR - Various betaproteobacteria 2 (12) 2
Proteobacteria/delta NikR - Desulfovibrionales 8 (10) 16
Proteobacteria/delta NikR - Desulfuromonadales 6 (9) 7
Proteobacteria/gamma NikR - Enterobacteriales 6 (12) 9
Proteobacteria/gamma NikR - Pseudomonadaceae 1 (8) 2
Proteobacteria/gamma NikR - Shewanellaceae 3 (16) 8