Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for HrcA transcription factor family

General statistics
TF regulogs 37
TF regulons 300
TF binding sites 869

HrcA family of transcription factors includes highly conserved master regulators of heat-shock response genes in bacteria [9987104]. Under non-heat shock conditions HrcA protein interacts with GroEL chaperone and binds CIRCE (controlling inverted repeat of chaperone expression) element and thus represses the target gene expression. Elevated temperature causes HrcA instability and its dissociation from the CIRCE elements, leading to enhanced expression of the heat-shock genes. Under non-heat-shock conditions, the GroES and GroEL chaperones return HrcA to its active conformation. HrcA proteins contain an N-terminal winged HTH DNA binding domain (PF03444) and a characteristic C-terminal domain (PF01628).

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Actinobacteria HrcA - Bifidobacteriaceae 10 (10) 39
Actinobacteria HrcA - Corynebacteriaceae 8 (8) 25
Actinobacteria HrcA - Frankineae/Propionibacterineae/Pseudonocardiaceae 9 (9) 47
Actinobacteria HrcA - Micrococcineae 13 (14) 66
Actinobacteria HrcA - Mycobacteriaceae 9 (9) 40
Actinobacteria HrcA - Nocardiaceae 4 (4) 19
Actinobacteria HrcA - Streptomycetaceae 4 (4) 24
Chlamydiae HrcA - Chlamydiales 7 (7) 14
Chlorobi HrcA - Chlorobiales 10 (11) 11
Chloroflexi HrcA - Chloroflexia 5 (5) 16
Cyanobacteria HrcA - Cyanobacteria 14 (14) 29
Deinococcus-Thermus HrcA - Deinococcus-Thermus 2 (5) 4
Firmicutes HrcA - Bacillales 11 (11) 26
Firmicutes HrcA - Clostridia-1 8 (8) 20
Firmicutes HrcA - Clostridia-2 3 (3) 8
Firmicutes HrcA - Clostridia-3 14 (14) 81
Firmicutes HrcA - Lactobacillaceae 14 (15) 69
Firmicutes HrcA - Listeriaceae 4 (4) 8
Firmicutes HrcA - Staphylococcaceae 7 (7) 14
Firmicutes HrcA - Streptococcaceae 15 (15) 49
Firmicutes HrcA - Thermoanaerobacterales 7 (7) 15
Proteobacteria/alpha HrcA - Caulobacterales 4 (4) 4
Proteobacteria/alpha HrcA - Rhizobiales 15 (15) 38
Proteobacteria/alpha HrcA - Rhodobacterales 15 (15) 15
Proteobacteria/alpha HrcA - Rhodospirillales 9 (9) 9
Proteobacteria/alpha HrcA - Sphingomonadales 7 (7) 7
Proteobacteria/beta HrcA - Alcaligenaceae 3 (3) 6
Proteobacteria/beta HrcA - Burkholderia 8 (8) 16
Proteobacteria/beta HrcA - Comamonadaceae 11 (11) 22
Proteobacteria/beta HrcA - Ralstonia 6 (6) 12
Proteobacteria/beta HrcA - Various betaproteobacteria 11 (12) 22
Proteobacteria/delta HrcA - Desulfovibrionales 6 (10) 7
Proteobacteria/delta HrcA - Desulfuromonadales 9 (9) 29
Proteobacteria/gamma HrcA - Alteromonadales 2 (9) 2
Proteobacteria/gamma HrcA - Oceanospirillales/Alteromonadales 1 (12) 2
Proteobacteria/gamma HrcA - Xanthomonadales 4 (4) 4
Thermotogae HrcA - Thermotogales 11 (11) 50