Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for NrtR transcription factor

General statistics
Genomes 263
TF regulogs 26
TF regulons 97
TF binding sites 224

Transcription factor NrtR negatively controls metabolic pathways of NAD biosynthesis, salvage and recycling [18276643]. The NrtR regulon and its DNA-binding motif were discovered by application of the comparative genomic approach to the NAD biosynthetic genes in Cyanobacteria. Then NrtR regulons were reconstructed by the same approach in diverse taxonomic groups of bacteria that have an ortholog of the NrtR regulator. The DNA-binding motifs of NrtR showed significant variability between microbial lineages, although the common consensus could be traced for all of them. Regulators of the NrtR family are composed of an N-terminal Nudix-like effector domain, which is similar to the ADP-ribose pyrophosphatases from the Nudix family, and a C-terminal DNA-binding HTH-like domain. more

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Actinobacteria NrtR - Bifidobacteriaceae 8 (10) 8
Actinobacteria NrtR - Corynebacteriaceae 4 (8) 6
Actinobacteria NrtR - Frankineae/Propionibacterineae/Pseudonocardiaceae 2 (9) 6
Actinobacteria NrtR - Micrococcineae 7 (14) 13
Actinobacteria NrtR - Mycobacteriaceae 9 (9) 18
Actinobacteria NrtR - Nocardiaceae 1 (4) 2
Actinobacteria NrtR - Streptomycetaceae 4 (4) 19
Bacteroidetes NrtR - Flavobacteria 2 (19) 3
Bacteroidetes NrtR - Sphingobacteria 2 (8) 4
Chloroflexi NrtR - Chloroflexia 5 (5) 27
Cyanobacteria NrtR - Cyanobacteria 8 (14) 17
Cyanobacteria NrtR2 - Cyanobacteria 2 (14) 5
Firmicutes NrtR - Clostridia-1 2 (8) 6
Firmicutes NrtR - Lactobacillaceae 8 (15) 8
Firmicutes NrtR - Streptococcaceae 5 (15) 7
Proteobacteria/alpha NrtR - Rhizobiales 2 (15) 8
Proteobacteria/alpha NrtR - Rhodobacterales 1 (15) 2
Proteobacteria/beta NrtR - Comamonadaceae 4 (11) 12
Proteobacteria/beta NrtR - Various betaproteobacteria 2 (12) 6
Proteobacteria/gamma NrtR - Enterobacteriales 1 (12) 6
Proteobacteria/gamma NrtR - Moraxellaceae 2 (4) 3
Proteobacteria/gamma NrtR - Oceanospirillales/Alteromonadales 2 (12) 7
Proteobacteria/gamma NrtR - Pseudomonadaceae 4 (8) 10
Proteobacteria/gamma NrtR - Psychromonadaceae/Aeromonadales 3 (6) 6
Proteobacteria/gamma NrtR - Shewanellaceae 3 (16) 6
Proteobacteria/gamma NrtR - Vibrionales 4 (10) 9