Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for Irr transcription factor

General statistics
Genomes 39
TF regulogs 3
TF regulons 32
TF binding sites 172

Transcription factor Irr controls iron homeostasis in alpha-porteobacteria. This regulator from the Fur protein family was shown to interact with heme and thus it senses the physiological consequence of the iron availability rather than its concentration per se. Irr was originally identified in Bradyrhizobium japonicum as a repressor of the heme biosynthesis genes. Later on it was shown to act as an activator of multiple iron uptake genes. Comparative genomic analysis identified DNA binding motifs of Irr and reconstructed the Irr regulons in 5 taxonomic groups of alpha-proteobacteria [17173478]. more

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Proteobacteria/alpha Irr - Rhizobiales 15 (15) 122
Proteobacteria/alpha Irr - Rhodobacterales 12 (15) 37
Proteobacteria/alpha Irr - Rhodospirillales 5 (9) 13