Collection of regulogs for SiaR transcription factor
TF binding sites
Transcription factor SiaR from the RpiR protein family regulates the sialic acid utilization genes in Gammaproteobacteria. The SiaR regulon and its DNA-binding motif were discovered by application of the comparative genomic approach and was then experimentally validated in Haemophilus influenzae . SiaR is a non-orthologous replacement for the GntR-family NanR regulator of silaic acid utilization in E.coli. Physiological and biochemical studies indicated that glucosamine-6-phosphate, is an inducer which interacts with SiaR, provoking its dissociation from DNA.