Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for HutC transcription factor

General statistics
Genomes 168
TF regulogs 18
TF regulons 113
TF binding sites 387

Transcription factor HutC from the GntR protein family regulates the histidine utilization genes in Proteobacteria. It was originally characterized in Klebsiella aerogenes and Pseudomonas putida as a repressor of the hut catabolic genes. cis-Urocanic acid, the first intermediate of the hut pathway, is an inducer that interacts with HutC, causing a conformational change that dissociates the repressor from the promoter sequences. After dissociation, transcription of the hut genes is derepressed.

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Proteobacteria/alpha HutC - Caulobacterales 4 (4) 10
Proteobacteria/alpha HutC - Rhizobiales 10 (15) 42
Proteobacteria/alpha HutC - Rhodobacterales 10 (15) 29
Proteobacteria/alpha HutC - Rhodospirillales 5 (9) 16
Proteobacteria/alpha HutC - Sphingomonadales 2 (7) 5
Proteobacteria/beta HutC - Burkholderia 8 (8) 46
Proteobacteria/beta HutC - Comamonadaceae 7 (11) 24
Proteobacteria/beta HutC - Ralstonia 6 (6) 22
Proteobacteria/beta HutC - Various betaproteobacteria 1 (12) 2
Proteobacteria/gamma HutC - Alteromonadales 8 (9) 25
Proteobacteria/gamma HutC - Enterobacteriales 8 (12) 27
Proteobacteria/gamma HutC - Moraxellaceae 2 (4) 7
Proteobacteria/gamma HutC - Oceanospirillales/Alteromonadales 3 (12) 11
Proteobacteria/gamma HutC - Pseudomonadaceae 6 (8) 22
Proteobacteria/gamma HutC - Psychromonadaceae/Aeromonadales 4 (6) 10
Proteobacteria/gamma HutC - Shewanellaceae 16 (16) 63
Proteobacteria/gamma HutC - Vibrionales 10 (10) 20
Proteobacteria/gamma HutC - Xanthomonadales 3 (4) 6