Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for BirA transcription factor

General statistics
Genomes 208
TF regulogs 22
TF regulons 179
TF binding sites 360

The transcription repressor BirA protein was experimentally analyzed in Escherichia coli. BirA is a bifunctional protein that acts as a repressor of biotin biosynthesis genes and as an enzyme, biotin-protein ligase, that charges the biotin-dependent enzymes with the co-factor. The BirA repressor binds to the promoter regions of the regulated genes in the presence of the biotinyl-5'-adenylate. We used a comparative genomics approach to reconstruct transcriptional regulons controlled by BirA orthologs in different lineages of Proteobacteria and Firmicutes. The reconstructed BirA regulons include multiple genes involved in the biotin metabolism and transport [12368242].

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Chlorobiales BirA - Chlorobiales 10 (11) 10
Deinococcus-Thermus BirA - Deinococcus-Thermus 2 (5) 3
Firmicutes BirA - Bacillales 11 (11) 36
Firmicutes BirA - Clostridia-1 7 (8) 19
Firmicutes BirA - Clostridia-2 3 (3) 5
Firmicutes BirA - Clostridia-3 14 (14) 25
Firmicutes BirA - Lactobacillaceae 7 (15) 10
Firmicutes BirA - Listeriaceae 3 (4) 3
Firmicutes BirA - Staphylococcaceae 7 (7) 21
Firmicutes BirA - Streptococcaceae 15 (15) 29
Firmicutes BirA - Thermoanaerobacterales 6 (7) 11
Proteobacteria/Gamma BirA - Pseudomonadaceae 8 (8) 15
Proteobacteria/delta BirA - Desulfovibrionales 3 (10) 6
Proteobacteria/delta BirA - Desulfuromonadales 8 (9) 15
Proteobacteria/gamma BirA - Alteromonadales 9 (9) 17
Proteobacteria/gamma BirA - Enterobacteriales 12 (12) 27
Proteobacteria/gamma BirA - Oceanospirillales/Alteromonadales 11 (12) 26
Proteobacteria/gamma BirA - Psychromonadaceae/Aeromonadales 6 (6) 12
Proteobacteria/gamma BirA - Shewanellaceae 16 (16) 32
Proteobacteria/gamma BirA - Various betaproteobacteria 8 (12) 13
Proteobacteria/gamma BirA - Vibrionales 10 (10) 20
Proteobacteria/gamma BirA - Xanthomonadales 3 (4) 5