Collection of regulogs for KdgR transcription factor
|TF binding sites
Transcription factor KdgR from the IclR protein family regulates genes involved in utilization of pectin and its derivatives in Gammaproteobacteria. It was originally characterized in Erwinia chrysanthemi as a repressor of the pectin degradation genes, and later it was shown to act as an activator of some genes such as ppsA. Physiological and biochemical studies indicated that an intermediate of pectin catabolism, 2-keto-3-deoxygluconate (KDG), is the main inducing molecule which interacts in vivo and in vitro with KdgR, provoking dissociation of KdgR from its operators. The comparative genomic approach was used to reconstruct orthologous KdgR regulons in the Enterobacteriales, Vibrionales and Pasteurellales lineages of Gammaproteobacteria [11115104, 15528647, 21622752] as well as in Thermotogales.