Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for HexR transcription factor

General statistics
Genomes 110
TF regulogs 13
TF regulons 95
TF binding sites 897

HexR transcriptional factor from the RpiR family has been implicated in regulation of glucose metabolism genes in Pseudomonas putida. We used a comparative genomics approach to reconstruct transcriptional regulons controlled by HexR orthologs in Proteobacteria [21849503]. HexR regulates various genes from the central carbohydrate metabolism. The predicted in Shewanella oneidensis HexR regulon was experimentally validated by using in vitro and in vivo approaches. Binding of 2-keto-3-deoxy-6-phosphogluconate to HexR destroys the DNA-regulator complex formation. HexR has a dual mode of action on various target promoters - repression of genes involved in catabolic pathways and activation of gluconeogenic genes.

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Proteobacteria/beta HexR - Burkholderia 8 (8) 38
Proteobacteria/beta HexR - Comamonadaceae 9 (11) 28
Proteobacteria/beta HexR - Ralstonia 6 (6) 24
Proteobacteria/beta HexR - Various betaproteobacteria 2 (12) 13
Proteobacteria/gamma HexR - Alteromonadales 5 (9) 38
Proteobacteria/gamma HexR - Enterobacteriales 11 (12) 45
Proteobacteria/gamma HexR - Oceanospirillales/Alteromonadales 3 (12) 40
Proteobacteria/gamma HexR2 - Oceanospirillales/Alteromonadales 3 (12) 12
Proteobacteria/gamma HexR - Pseudomonadaceae 8 (8) 44
Proteobacteria/gamma HexR1 - Pseudomonadaceae 8 (8) 30
Proteobacteria/gamma HexR - Psychromonadaceae/Aeromonadales 6 (6) 79
Proteobacteria/gamma HexR - Shewanellaceae 16 (16) 316
Proteobacteria/gamma HexR - Vibrionales 10 (10) 190