Collection of regulogs for PhrR transcription factor
TF binding sites
Transcription factor PhrR from the MerR protein family binds vitamin B12 as a cofactor and regulates genes in response to blue light. PhrR regulators identified in Proteobacteria by comparative genomes are homologous to the light-inducible LitR repressors from Firmicutes and Thermus spp that are composed of an N-terminal DNA-binding domain from the MerR family and a C-terminal B12-binding domain. The identified novel group of LitR-related transcriptional regulators that control phr genes in gamma-proteobacteria was termed PhrR (for a Phr regulator). The comparative analysis of the reconstructed regulons revealed considerable variability in the regulon content between the analyzed lineages of gamma-proteobacteria.