Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for FnrN/FixK transcription factor

General statistics
Genomes 50
TF regulogs 5
TF regulons 43
TF binding sites 343

Transcription factors FixK and FnrN are members of Crp family. In nitrogen-fixing Alphaproteobacteria, these homologous regulators activate expression of genes for adaptation to microaerobic conditions. Activation of genes is required for utilization of molecular oxygen and protection of oxygen-sensitive nitrogenase. Binding motifs for FnrN and FixK are undistinguisible. The main difference between FixK and FnrN is that FnrN can directly sence the presence of molecular oxygen by iron-sulfur cluster. FixK lacks such iron-sulfur cluster (and thus it is always on) however the fixK expression is activated by the oxygen-sensitive regulatory system FixL-FixJ . more

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Proteobacteria/Alpha FnrN/FixK/AadR - Rhizobiales 14 (15) 192
Proteobacteria/alpha FixK - Caulobacterales 4 (4) 25
Proteobacteria/alpha FnrN - Rhodobacterales 12 (15) 85
Proteobacteria/alpha FnrN - Rhodospirillales 8 (9) 18
Proteobacteria/alpha FnrN - Sphingomonadales 5 (7) 23