Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for MetR transcription factor

General statistics
Genomes 141
TF regulogs 15
TF regulons 120
TF binding sites 583

Transcription factor MetR from the LysR protein family regulates the methionine metabolism in Proteobacteria. It was characterized in E. coli, Salmonella and Vibrio spp. as an activator of the methionine biosynthesis (metE, metH, metF) and other (glyA) genes, and a repressor of the metR gene [1943695]. Physiological and biochemical studies indicated that homocysteine, an itermediate in the biosynthesis of methionine, binds to MetR and enhances the activity of some MetR-activated promoters [1943695]. The comparative genomic approach was used to reconstruct orthologous MetR regulons in Gamma- and Beta-proteobacteria, and in the Rhodobacterales.

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Proteobacteria/Alpha MetR - Rhodobacterales 13 (15) 30
Proteobacteria/Beta MetR - Alcaligenaceae 3 (3) 13
Proteobacteria/Beta MetR - Burkholderia 7 (8) 18
Proteobacteria/Beta MetR - Ralstonia 6 (6) 12
Proteobacteria/Gamma MetR - Alteromonadales 4 (9) 15
Proteobacteria/Gamma MetR - Enterobacteriales 12 (12) 140
Proteobacteria/Gamma MetR - Oceanospirillales/Alteromonadales 12 (12) 46
Proteobacteria/Gamma MetR - Pasteurellales 8 (9) 40
Proteobacteria/Gamma MetR - Pseudomonadaceae 8 (8) 44
Proteobacteria/Gamma MetR - Psychromonadaceae/Aeromonadales 5 (6) 13
Proteobacteria/Gamma MetR - Shewanellaceae 16 (16) 117
Proteobacteria/Gamma MetR - Vibrionales 10 (10) 57
Proteobacteria/beta MetR - Comamonadaceae 5 (11) 13
Proteobacteria/beta MetR - Various betaproteobacteria 8 (12) 19
Proteobacteria/gamma MetR - Xanthomonadales 3 (4) 6