Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for HrcA transcription factor

General statistics
Genomes 329
TF regulogs 37
TF regulons 300
TF binding sites 869

HrcA belongs to the HrcA family and acts as a repressor of heat shock response genes. The activity of HrcA is regulated by the chaperonine GroE that is sequestered by denatured proteins upon heat shock. HrcA regulation was experimentally analyzed in different species from the Proteobacteria, Firmicutes, Actinobacteria and Chlamydia phyla. We used a comparative genomics approach to reconstruct transcriptional regulons controlled by HrcA orthologs in multiple lineages of Bacteria.

Phylum Regulog TF regulons (studied genomes) TFBSs Logo
Actinobacteria HrcA - Bifidobacteriaceae 10 (10) 39
Actinobacteria HrcA - Corynebacteriaceae 8 (8) 25
Actinobacteria HrcA - Frankineae/Propionibacterineae/Pseudonocardiaceae 9 (9) 47
Actinobacteria HrcA - Micrococcineae 13 (14) 66
Actinobacteria HrcA - Mycobacteriaceae 9 (9) 40
Actinobacteria HrcA - Nocardiaceae 4 (4) 19
Actinobacteria HrcA - Streptomycetaceae 4 (4) 24
Chlamydiae HrcA - Chlamydiales 7 (7) 14
Chlorobi HrcA - Chlorobiales 10 (11) 11
Chloroflexi HrcA - Chloroflexia 5 (5) 16
Cyanobacteria HrcA - Cyanobacteria 14 (14) 29
Deinococcus-Thermus HrcA - Deinococcus-Thermus 2 (5) 4
Firmicutes HrcA - Bacillales 11 (11) 26
Firmicutes HrcA - Clostridia-1 8 (8) 20
Firmicutes HrcA - Clostridia-2 3 (3) 8
Firmicutes HrcA - Clostridia-3 14 (14) 81
Firmicutes HrcA - Lactobacillaceae 14 (15) 69
Firmicutes HrcA - Listeriaceae 4 (4) 8
Firmicutes HrcA - Staphylococcaceae 7 (7) 14
Firmicutes HrcA - Streptococcaceae 15 (15) 49
Firmicutes HrcA - Thermoanaerobacterales 7 (7) 15
Proteobacteria/alpha HrcA - Caulobacterales 4 (4) 4
Proteobacteria/alpha HrcA - Rhizobiales 15 (15) 38
Proteobacteria/alpha HrcA - Rhodobacterales 15 (15) 15
Proteobacteria/alpha HrcA - Rhodospirillales 9 (9) 9
Proteobacteria/alpha HrcA - Sphingomonadales 7 (7) 7
Proteobacteria/beta HrcA - Alcaligenaceae 3 (3) 6
Proteobacteria/beta HrcA - Burkholderia 8 (8) 16
Proteobacteria/beta HrcA - Comamonadaceae 11 (11) 22
Proteobacteria/beta HrcA - Ralstonia 6 (6) 12
Proteobacteria/beta HrcA - Various betaproteobacteria 11 (12) 22
Proteobacteria/delta HrcA - Desulfovibrionales 6 (10) 7
Proteobacteria/delta HrcA - Desulfuromonadales 9 (9) 29
Proteobacteria/gamma HrcA - Alteromonadales 2 (9) 2
Proteobacteria/gamma HrcA - Oceanospirillales/Alteromonadales 1 (12) 2
Proteobacteria/gamma HrcA - Xanthomonadales 4 (4) 4
Thermotogae HrcA - Thermotogales 11 (11) 50