Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs in Corynebacteriaceae taxonomic group

General statistics
Genomes 8
TF regulogs 59
TF regulons 262
TF binding sites 1647
RNA regulogs 13
RNA regulons 56
RNA sites 80

This collection involves all regulons that were tentatively predicted by applying integrative comparative genomic approach to a single taxonomic group of closely-related genomes. To infer the regulons operated by transcription factors (TFs), we combined the identification of TF binding sites and cross-genome comparison of regulons with the analysis of the genomic and functional context of candidate target genes. To infer the regulons operated by regulatory RNAs such as riboswitches, we identified candidate RNA regulatory elements using HMM profiles and further analyzed their genomic and functional context.

Studied genomes and reconstructed regulon statistics
TF RNA Total
Genomes Regulons Sites Regulons Sites Regulons Sites
Corynebacterium amycolatum SK46 25 138 8 10 33 148
Corynebacterium aurimucosum ATCC 700975 34 175 5 6 39 181
Corynebacterium diphtheriae NCTC 13129 28 172 8 11 36 183
Corynebacterium efficiens YS-314 48 284 8 12 56 296
Corynebacterium glutamicum ATCC 13032 57 438 9 16 66 454
Corynebacterium jeikeium K411 25 163 5 6 30 169
Corynebacterium kroppenstedtii DSM 44385 21 124 8 12 29 136
Corynebacterium urealyticum DSM 7109 24 153 5 7 29 160
Genomic distribution of regulons
Family Type Regulator Function
ArgR TF ArgR
2 ArgR

Corynebacterium glutamicum ATCC 13032
2 ArgR

Corynebacterium efficiens YS-314
1 ArgR

Corynebacterium diphtheriae NCTC 13129
1 ArgR

Corynebacterium aurimucosum ATCC 700975
1 ArgR

Corynebacterium jeikeium K411
1 ArgR

Corynebacterium urealyticum DSM 7109
1 ArgR

Corynebacterium amycolatum SK46
1 ArgR

Corynebacterium kroppenstedtii DSM 44385
Arginine biosynthesis
ArsR TF ArsR
4 ArsR

Corynebacterium glutamicum ATCC 13032
2 ArsR

Corynebacterium efficiens YS-314
2 ArsR

Corynebacterium aurimucosum ATCC 700975
2 ArsR

Corynebacterium jeikeium K411
2 ArsR

Corynebacterium urealyticum DSM 7109
Arsenic resistance
TF CadR
1 CadR

Corynebacterium glutamicum ATCC 13032
1 CadR

Corynebacterium efficiens YS-314
1 CadR

Corynebacterium aurimucosum ATCC 700975
1 CadR

Corynebacterium jeikeium K411
1 CadR

Corynebacterium urealyticum DSM 7109
1 CadR

Corynebacterium amycolatum SK46
1 CadR

Corynebacterium kroppenstedtii DSM 44385
Cadmium resistance
TF Cg1831
2 Cg1831

Corynebacterium glutamicum ATCC 13032
2 Cg1831

Corynebacterium efficiens YS-314
Iron homeostasis
TF SufR
1 SufR

Corynebacterium glutamicum ATCC 13032
1 SufR

Corynebacterium efficiens YS-314
1 SufR

Corynebacterium diphtheriae NCTC 13129
1 SufR

Corynebacterium aurimucosum ATCC 700975
1 SufR

Corynebacterium jeikeium K411
1 SufR

Corynebacterium urealyticum DSM 7109
1 SufR

Corynebacterium amycolatum SK46
1 SufR

Corynebacterium kroppenstedtii DSM 44385
Iron-sulfur cluster biogenesis
TF SutR
1 SutR

Corynebacterium glutamicum ATCC 13032
1 SutR

Corynebacterium efficiens YS-314
Sulfur metabolism
TF Znr
1 Znr

Corynebacterium glutamicum ATCC 13032
1 Znr

Corynebacterium efficiens YS-314
1 Znr

Corynebacterium diphtheriae NCTC 13129
1 Znr

Corynebacterium aurimucosum ATCC 700975
Zinc homeostasis
CRP TF GlxR
114 GlxR

Corynebacterium glutamicum ATCC 13032
77 GlxR

Corynebacterium efficiens YS-314
44 GlxR

Corynebacterium diphtheriae NCTC 13129
52 GlxR

Corynebacterium aurimucosum ATCC 700975
47 GlxR

Corynebacterium jeikeium K411
49 GlxR

Corynebacterium urealyticum DSM 7109
38 GlxR

Corynebacterium amycolatum SK46
47 GlxR

Corynebacterium kroppenstedtii DSM 44385
Energy metabolism; Carbohydrate metabolism
CitB TF CitB
3 CitB

Corynebacterium glutamicum ATCC 13032
2 CitB

Corynebacterium efficiens YS-314
Citrate utilization
CsoR TF CsoR
2 CsoR

Corynebacterium glutamicum ATCC 13032
1 CsoR

Corynebacterium efficiens YS-314
1 CsoR

Corynebacterium aurimucosum ATCC 700975
2 CsoR

Corynebacterium jeikeium K411
1 CsoR

Corynebacterium amycolatum SK46
2 CsoR

Corynebacterium kroppenstedtii DSM 44385
Copper resistance
DeoR TF FruR
2 FruR

Corynebacterium glutamicum ATCC 13032
2 FruR

Corynebacterium efficiens YS-314
Fructose utilization
DtxR TF DtxR
36 DtxR

Corynebacterium glutamicum ATCC 13032
9 DtxR

Corynebacterium efficiens YS-314
26 DtxR

Corynebacterium diphtheriae NCTC 13129
13 DtxR

Corynebacterium aurimucosum ATCC 700975
14 DtxR

Corynebacterium jeikeium K411
11 DtxR

Corynebacterium urealyticum DSM 7109
8 DtxR

Corynebacterium amycolatum SK46
5 DtxR

Corynebacterium kroppenstedtii DSM 44385
Iron homeostasis
TF MntR
1 MntR

Corynebacterium glutamicum ATCC 13032
1 MntR

Corynebacterium efficiens YS-314
2 MntR

Corynebacterium diphtheriae NCTC 13129
2 MntR

Corynebacterium aurimucosum ATCC 700975
3 MntR

Corynebacterium jeikeium K411
1 MntR

Corynebacterium urealyticum DSM 7109
1 MntR

Corynebacterium amycolatum SK46
3 MntR

Corynebacterium kroppenstedtii DSM 44385
Manganese homeostasis
FUR TF Zur
7 Zur

Corynebacterium glutamicum ATCC 13032
1 Zur

Corynebacterium efficiens YS-314
6 Zur

Corynebacterium diphtheriae NCTC 13129
4 Zur

Corynebacterium aurimucosum ATCC 700975
3 Zur

Corynebacterium jeikeium K411
4 Zur

Corynebacterium urealyticum DSM 7109
3 Zur

Corynebacterium amycolatum SK46
2 Zur

Corynebacterium kroppenstedtii DSM 44385
Zinc homeostasis
GntR/MocR TF PdxR
1 PdxR

Corynebacterium glutamicum ATCC 13032
1 PdxR

Corynebacterium diphtheriae NCTC 13129
1 PdxR

Corynebacterium aurimucosum ATCC 700975
Pyridoxine biosynthesis
GntR/Others TF Cg1143
3 Cg1143

Corynebacterium glutamicum ATCC 13032
2 Cg1143

Corynebacterium efficiens YS-314
2 Cg1143

Corynebacterium aurimucosum ATCC 700975
2 Cg1143

Corynebacterium jeikeium K411
2 Cg1143

Corynebacterium urealyticum DSM 7109
2 Cg1143

Corynebacterium amycolatum SK46
TF Cg2544
2 Cg2544

Corynebacterium glutamicum ATCC 13032
2 Cg2544

Corynebacterium efficiens YS-314
TF Cg3261
1 Cg3261

Corynebacterium glutamicum ATCC 13032
1 Cg3261

Corynebacterium efficiens YS-314
1 Cg3261

Corynebacterium diphtheriae NCTC 13129
1 Cg3261

Corynebacterium aurimucosum ATCC 700975
1 Cg3261

Corynebacterium jeikeium K411
2 Cg3261

Corynebacterium urealyticum DSM 7109
1 Cg3261

Corynebacterium amycolatum SK46
Multidrug resistance; Multidrug efflux
TF GntR
7 GntR

Corynebacterium glutamicum ATCC 13032
5 GntR

Corynebacterium efficiens YS-314
1 GntR

Corynebacterium aurimucosum ATCC 700975
Gluconate utilization
TF IolR
6 IolR

Corynebacterium glutamicum ATCC 13032
Inositol utilization
TF LldR
4 LldR

Corynebacterium glutamicum ATCC 13032
3 LldR

Corynebacterium efficiens YS-314
3 LldR

Corynebacterium diphtheriae NCTC 13129
Lactate utilization
TF NanR
3 NanR

Corynebacterium glutamicum ATCC 13032
4 NanR

Corynebacterium diphtheriae NCTC 13129
2 NanR

Corynebacterium aurimucosum ATCC 700975
4 NanR

Corynebacterium kroppenstedtii DSM 44385
Sialic acid utilization
HrcA TF HrcA
2 HrcA

Corynebacterium glutamicum ATCC 13032
2 HrcA

Corynebacterium efficiens YS-314
2 HrcA

Corynebacterium diphtheriae NCTC 13129
2 HrcA

Corynebacterium aurimucosum ATCC 700975
2 HrcA

Corynebacterium jeikeium K411
2 HrcA

Corynebacterium urealyticum DSM 7109
2 HrcA

Corynebacterium amycolatum SK46
2 HrcA

Corynebacterium kroppenstedtii DSM 44385
Heat shock response
HxlR TF QorR
2 QorR

Corynebacterium glutamicum ATCC 13032
Energy metabolism
IclR TF Cg0646
1 Cg0646

Corynebacterium glutamicum ATCC 13032
1 Cg0646

Corynebacterium efficiens YS-314
TF GenR
3 GenR

Corynebacterium glutamicum ATCC 13032
3 GenR

Corynebacterium efficiens YS-314
3-hydroxybenzoate degradation
TF LtbR
5 LtbR

Corynebacterium glutamicum ATCC 13032
5 LtbR

Corynebacterium efficiens YS-314
5 LtbR

Corynebacterium diphtheriae NCTC 13129
5 LtbR

Corynebacterium aurimucosum ATCC 700975
4 LtbR

Corynebacterium jeikeium K411
4 LtbR

Corynebacterium urealyticum DSM 7109
2 LtbR

Corynebacterium amycolatum SK46
3 LtbR

Corynebacterium kroppenstedtii DSM 44385
Tryptophan biosynthesis; Leucine biosynthesis
TF PcaR
4 PcaR

Corynebacterium glutamicum ATCC 13032
4 PcaR

Corynebacterium efficiens YS-314
Protocatechuate degradation
LacI TF Cg2314
2 Cg2314

Corynebacterium glutamicum ATCC 13032
Sugar utilization
TF IolR2
2 IolR2

Corynebacterium glutamicum ATCC 13032
Inositol utilization
TF RbsR
3 RbsR

Corynebacterium glutamicum ATCC 13032
2 RbsR

Corynebacterium efficiens YS-314
1 RbsR

Corynebacterium diphtheriae NCTC 13129
Ribose utilization
TF UriR
2 UriR

Corynebacterium glutamicum ATCC 13032
1 UriR

Corynebacterium efficiens YS-314
Pyrimidine utilization; Uridine utilization
LexA TF LexA
30 LexA

Corynebacterium glutamicum ATCC 13032
16 LexA

Corynebacterium efficiens YS-314
9 LexA

Corynebacterium diphtheriae NCTC 13129
8 LexA

Corynebacterium aurimucosum ATCC 700975
8 LexA

Corynebacterium jeikeium K411
7 LexA

Corynebacterium urealyticum DSM 7109
11 LexA

Corynebacterium amycolatum SK46
7 LexA

Corynebacterium kroppenstedtii DSM 44385
SOS response
LuxR TF BenR
3 BenR

Corynebacterium glutamicum ATCC 13032
3 BenR

Corynebacterium efficiens YS-314
Benzoate degradation
TF PcaO
1 PcaO

Corynebacterium glutamicum ATCC 13032
1 PcaO

Corynebacterium efficiens YS-314
Protocatechuate degradation
LysR TF Cg3239
2 Cg3239

Corynebacterium glutamicum ATCC 13032
2 Cg3239

Corynebacterium efficiens YS-314
2 Cg3239

Corynebacterium aurimucosum ATCC 700975
2 Cg3239

Corynebacterium jeikeium K411
Metabolite transport
TF LysG
2 LysG

Corynebacterium glutamicum ATCC 13032
2 LysG

Corynebacterium efficiens YS-314
2 LysG

Corynebacterium diphtheriae NCTC 13129
2 LysG

Corynebacterium aurimucosum ATCC 700975
Amino acid efflux
TF QsuR
2 QsuR

Corynebacterium glutamicum ATCC 13032
2 QsuR

Corynebacterium efficiens YS-314
Aromatic amino acid metabolism
MarR TF Cg1211
2 Cg1211

Corynebacterium glutamicum ATCC 13032
2 Cg1211

Corynebacterium efficiens YS-314
2 Cg1211

Corynebacterium amycolatum SK46
Metabolite transport
TF RosR
10 RosR

Corynebacterium glutamicum ATCC 13032
8 RosR

Corynebacterium efficiens YS-314
4 RosR

Corynebacterium diphtheriae NCTC 13129
5 RosR

Corynebacterium aurimucosum ATCC 700975
3 RosR

Corynebacterium jeikeium K411
4 RosR

Corynebacterium urealyticum DSM 7109
3 RosR

Corynebacterium amycolatum SK46
4 RosR

Corynebacterium kroppenstedtii DSM 44385
Peroxide stress response
MerR TF HspR
2 HspR

Corynebacterium glutamicum ATCC 13032
2 HspR

Corynebacterium efficiens YS-314
3 HspR

Corynebacterium diphtheriae NCTC 13129
2 HspR

Corynebacterium aurimucosum ATCC 700975
3 HspR

Corynebacterium jeikeium K411
2 HspR

Corynebacterium urealyticum DSM 7109
2 HspR

Corynebacterium amycolatum SK46
2 HspR

Corynebacterium kroppenstedtii DSM 44385
Heat shock response
NrdR TF NrdR
1 NrdR

Corynebacterium glutamicum ATCC 13032
2 NrdR

Corynebacterium efficiens YS-314
2 NrdR

Corynebacterium diphtheriae NCTC 13129
1 NrdR

Corynebacterium aurimucosum ATCC 700975
1 NrdR

Corynebacterium jeikeium K411
2 NrdR

Corynebacterium urealyticum DSM 7109
1 NrdR

Corynebacterium amycolatum SK46
1 NrdR

Corynebacterium kroppenstedtii DSM 44385
Deoxyribonucleotide biosynthesis
NrtR TF NrtR
1 NrtR

Corynebacterium glutamicum ATCC 13032
1 NrtR

Corynebacterium efficiens YS-314
1 NrtR

Corynebacterium diphtheriae NCTC 13129
1 NrtR

Corynebacterium urealyticum DSM 7109
NAD biosynthesis
PadR TF Cg0979
1 Cg0979

Corynebacterium glutamicum ATCC 13032
1 Cg0979

Corynebacterium efficiens YS-314
1 Cg0979

Corynebacterium aurimucosum ATCC 700975
Lipoprotein export
TF VanR
2 VanR

Corynebacterium glutamicum ATCC 13032
2 VanR

Corynebacterium efficiens YS-314
Vanillate utilization
ROK TF SsuR
4 SsuR

Corynebacterium glutamicum ATCC 13032
2 SsuR

Corynebacterium amycolatum SK46
Sulfur metabolism
RpiR TF PctR
1 PctR

Corynebacterium glutamicum ATCC 13032
Phosphonate utilization
TetR TF AcnR
1 AcnR

Corynebacterium glutamicum ATCC 13032
1 AcnR

Corynebacterium efficiens YS-314
1 AcnR

Corynebacterium diphtheriae NCTC 13129
1 AcnR

Corynebacterium aurimucosum ATCC 700975
1 AcnR

Corynebacterium jeikeium K411
1 AcnR

Corynebacterium urealyticum DSM 7109
1 AcnR

Corynebacterium amycolatum SK46
1 AcnR

Corynebacterium kroppenstedtii DSM 44385
Tricarboxylic acid cycle
TF AmtR
14 AmtR

Corynebacterium glutamicum ATCC 13032
12 AmtR

Corynebacterium efficiens YS-314
3 AmtR

Corynebacterium diphtheriae NCTC 13129
1 AmtR

Corynebacterium aurimucosum ATCC 700975
Nitrogen metabolism
TF BioQ
3 BioQ

Corynebacterium glutamicum ATCC 13032
3 BioQ

Corynebacterium efficiens YS-314
4 BioQ

Corynebacterium diphtheriae NCTC 13129
2 BioQ

Corynebacterium aurimucosum ATCC 700975
2 BioQ

Corynebacterium jeikeium K411
3 BioQ

Corynebacterium amycolatum SK46
2 BioQ

Corynebacterium kroppenstedtii DSM 44385
Biotin biosynthesis
TF Cg0454
1 Cg0454

Corynebacterium glutamicum ATCC 13032
1 Cg0454

Corynebacterium efficiens YS-314
1 Cg0454

Corynebacterium diphtheriae NCTC 13129
1 Cg0454

Corynebacterium aurimucosum ATCC 700975
1 Cg0454

Corynebacterium jeikeium K411
1 Cg0454

Corynebacterium urealyticum DSM 7109
1 Cg0454

Corynebacterium amycolatum SK46
1 Cg0454

Corynebacterium kroppenstedtii DSM 44385
Multidrug resistance
TF Cg1053
1 Cg1053

Corynebacterium glutamicum ATCC 13032
1 Cg1053

Corynebacterium efficiens YS-314
1 Cg1053

Corynebacterium jeikeium K411
1 Cg1053

Corynebacterium urealyticum DSM 7109
1 Cg1053

Corynebacterium kroppenstedtii DSM 44385
Multidrug resistance
TF FasR
4 FasR

Corynebacterium glutamicum ATCC 13032
2 FasR

Corynebacterium efficiens YS-314
2 FasR

Corynebacterium diphtheriae NCTC 13129
2 FasR

Corynebacterium aurimucosum ATCC 700975
2 FasR

Corynebacterium amycolatum SK46
Fatty acid biosynthesis
TF Jk1423
1 Jk1423

Corynebacterium aurimucosum ATCC 700975
1 Jk1423

Corynebacterium jeikeium K411
1 Jk1423

Corynebacterium urealyticum DSM 7109
TF McbR
25 McbR

Corynebacterium glutamicum ATCC 13032
16 McbR

Corynebacterium efficiens YS-314
9 McbR

Corynebacterium diphtheriae NCTC 13129
15 McbR

Corynebacterium aurimucosum ATCC 700975
14 McbR

Corynebacterium jeikeium K411
13 McbR

Corynebacterium urealyticum DSM 7109
13 McbR

Corynebacterium amycolatum SK46
10 McbR

Corynebacterium kroppenstedtii DSM 44385
Methionine biosynthesis
TF PaaR
7 PaaR

Corynebacterium efficiens YS-314
Phenylacetic acid degradation
TF QacR
1 QacR

Corynebacterium glutamicum ATCC 13032
1 QacR

Corynebacterium diphtheriae NCTC 13129
1 QacR

Corynebacterium aurimucosum ATCC 700975
1 QacR

Corynebacterium urealyticum DSM 7109
1 QacR

Corynebacterium amycolatum SK46
Drug resistance
XRE TF ClgR
7 ClgR

Corynebacterium glutamicum ATCC 13032
6 ClgR

Corynebacterium efficiens YS-314
6 ClgR

Corynebacterium diphtheriae NCTC 13129
5 ClgR

Corynebacterium aurimucosum ATCC 700975
5 ClgR

Corynebacterium jeikeium K411
4 ClgR

Corynebacterium urealyticum DSM 7109
4 ClgR

Corynebacterium amycolatum SK46
2 ClgR

Corynebacterium kroppenstedtii DSM 44385
Proteolysis
[Other] TF GabR
2 GabR

Corynebacterium glutamicum ATCC 13032
5 GabR

Corynebacterium aurimucosum ATCC 700975
Gamma-aminobutyrate utilization
RF00050 RNA FMN
1 FMN

Corynebacterium glutamicum ATCC 13032
1 FMN

Corynebacterium amycolatum SK46
1 FMN

Corynebacterium kroppenstedtii DSM 44385
Riboflavin biosynthesis
RF00059 RNA TPP
5 TPP

Corynebacterium glutamicum ATCC 13032
4 TPP

Corynebacterium efficiens YS-314
3 TPP

Corynebacterium diphtheriae NCTC 13129
2 TPP

Corynebacterium aurimucosum ATCC 700975
1 TPP

Corynebacterium jeikeium K411
3 TPP

Corynebacterium urealyticum DSM 7109
2 TPP

Corynebacterium amycolatum SK46
3 TPP

Corynebacterium kroppenstedtii DSM 44385
Thiamine biosynthesis
RF00080 RNA yybP-ykoY
3 yybP-ykoY

Corynebacterium glutamicum ATCC 13032
1 yybP-ykoY

Corynebacterium efficiens YS-314
1 yybP-ykoY

Corynebacterium diphtheriae NCTC 13129
1 yybP-ykoY

Corynebacterium aurimucosum ATCC 700975
1 yybP-ykoY

Corynebacterium jeikeium K411
1 yybP-ykoY

Corynebacterium urealyticum DSM 7109
1 yybP-ykoY

Corynebacterium amycolatum SK46
1 yybP-ykoY

Corynebacterium kroppenstedtii DSM 44385
RF00114 RNA S15
1 S15

Corynebacterium glutamicum ATCC 13032
1 S15

Corynebacterium efficiens YS-314
1 S15

Corynebacterium diphtheriae NCTC 13129
1 S15

Corynebacterium aurimucosum ATCC 700975
1 S15

Corynebacterium urealyticum DSM 7109
1 S15

Corynebacterium amycolatum SK46
1 S15

Corynebacterium kroppenstedtii DSM 44385
Ribosome biogenesis
RF00162 RNA SAM
1 SAM

Corynebacterium urealyticum DSM 7109
Methionine biosynthesis
RF00174 RNA Cobalamin
1 Cobalamin

Corynebacterium glutamicum ATCC 13032
1 Cobalamin

Corynebacterium diphtheriae NCTC 13129
2 Cobalamin

Corynebacterium amycolatum SK46
2 Cobalamin

Corynebacterium kroppenstedtii DSM 44385
Cobalamin biosynthesis
RF00230 RNA T-box(Ile)
1 T-box(Ile)

Corynebacterium glutamicum ATCC 13032
1 T-box(Ile)

Corynebacterium efficiens YS-314
1 T-box(Ile)

Corynebacterium diphtheriae NCTC 13129
1 T-box(Ile)

Corynebacterium aurimucosum ATCC 700975
1 T-box(Ile)

Corynebacterium jeikeium K411
1 T-box(Ile)

Corynebacterium urealyticum DSM 7109
1 T-box(Ile)

Corynebacterium amycolatum SK46
1 T-box(Ile)

Corynebacterium kroppenstedtii DSM 44385
Amino acid metabolism
RF00379 RNA ydaO-yuaA
2 ydaO-yuaA

Corynebacterium glutamicum ATCC 13032
2 ydaO-yuaA

Corynebacterium efficiens YS-314
1 ydaO-yuaA

Corynebacterium amycolatum SK46
Cell wall metabolism
RF00380 RNA ykoK
1 ykoK

Corynebacterium amycolatum SK46
Magnesium homeostasis
RF00504 RNA Glycine
1 Glycine

Corynebacterium jeikeium K411
1 Glycine

Corynebacterium kroppenstedtii DSM 44385
Glycine metabolism
RF00513 RNA Trp_leader
1 Trp_leader

Corynebacterium efficiens YS-314
2 Trp_leader

Corynebacterium diphtheriae NCTC 13129
Tryptophan biosynthesis
RF00515 RNA PyrR
1 PyrR

Corynebacterium glutamicum ATCC 13032
1 PyrR

Corynebacterium efficiens YS-314
1 PyrR

Corynebacterium diphtheriae NCTC 13129
1 PyrR

Corynebacterium aurimucosum ATCC 700975
1 PyrR

Corynebacterium jeikeium K411
1 PyrR

Corynebacterium kroppenstedtii DSM 44385
Pyrimidine metabolism
RF00557 RNA L10_leader
1 L10_leader

Corynebacterium glutamicum ATCC 13032
1 L10_leader

Corynebacterium efficiens YS-314
1 L10_leader

Corynebacterium diphtheriae NCTC 13129
Ribosome biogenesis