Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs in Streptococcaceae taxonomic group

General statistics
Genomes 15
TF regulogs 70
TF regulons 595
TF binding sites 3131
RNA regulogs 29
RNA regulons 330
RNA sites 406

This collection involves all regulons that were tentatively predicted by applying integrative comparative genomic approach to a single taxonomic group of closely-related genomes. To infer the regulons operated by transcription factors (TFs), we combined the identification of TF binding sites and cross-genome comparison of regulons with the analysis of the genomic and functional context of candidate target genes. To infer the regulons operated by regulatory RNAs such as riboswitches, we identified candidate RNA regulatory elements using HMM profiles and further analyzed their genomic and functional context.

Studied genomes and reconstructed regulon statistics
TF RNA Total
Genomes Regulons Sites Regulons Sites Regulons Sites
Lactococcus lactis subsp. cremoris SK11 37 159 25 31 62 190
Lactococcus lactis subsp. lactis Il1403 35 173 24 31 59 204
Streptococcus agalactiae 2603V/R 38 222 21 28 59 250
Streptococcus dysgalactiae subsp. equisimilis GGS_124 43 227 22 26 65 253
Streptococcus equi subsp. zooepidemicus MGCS10565 42 195 20 24 62 219
Streptococcus gallolyticus UCN34 41 246 23 29 64 275
Streptococcus gordonii str. Challis substr. CH1 42 233 22 30 64 263
Streptococcus mitis B6 35 201 22 26 57 227
Streptococcus mutans UA159 42 209 23 24 65 233
Streptococcus pneumoniae TIGR4 42 233 21 30 63 263
Streptococcus pyogenes M1 GAS 40 215 21 24 61 239
Streptococcus sanguinis SK36 43 226 23 27 66 253
Streptococcus suis 05ZYH33 43 204 21 28 64 232
Streptococcus thermophilus CNRZ1066 30 169 20 23 50 192
Streptococcus uberis 0140J 42 219 22 25 64 244
Genomic distribution of regulons
Family Type Regulator Function
ArgR TF ArgR
5 ArgR

Streptococcus pyogenes M1 GAS
5 ArgR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
4 ArgR

Streptococcus equi subsp. zooepidemicus MGCS10565
7 ArgR

Streptococcus uberis 0140J
4 ArgR

Streptococcus agalactiae 2603V/R
5 ArgR

Streptococcus mutans UA159
6 ArgR

Streptococcus gallolyticus UCN34
5 ArgR

Streptococcus thermophilus CNRZ1066
7 ArgR

Streptococcus pneumoniae TIGR4
5 ArgR

Streptococcus mitis B6
2 ArgR

Streptococcus sanguinis SK36
5 ArgR

Streptococcus gordonii str. Challis substr. CH1
6 ArgR

Streptococcus suis 05ZYH33
6 ArgR

Lactococcus lactis subsp. cremoris SK11
6 ArgR

Lactococcus lactis subsp. lactis Il1403
Arginine biosynthesis; Arginine degradation
BglG TF CelR
2 CelR

Streptococcus pyogenes M1 GAS
1 CelR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 CelR

Streptococcus equi subsp. zooepidemicus MGCS10565
1 CelR

Streptococcus uberis 0140J
1 CelR

Streptococcus mutans UA159
2 CelR

Streptococcus gallolyticus UCN34
2 CelR

Streptococcus pneumoniae TIGR4
2 CelR

Streptococcus gordonii str. Challis substr. CH1
2 CelR

Streptococcus suis 05ZYH33
Cellobiose utilization
TF GutR
1 GutR

Streptococcus equi subsp. zooepidemicus MGCS10565
1 GutR

Streptococcus uberis 0140J
1 GutR

Streptococcus mutans UA159
Sorbitol utilization
TF MtlR
1 MtlR

Streptococcus uberis 0140J
1 MtlR

Streptococcus mutans UA159
1 MtlR

Streptococcus gallolyticus UCN34
1 MtlR

Streptococcus pneumoniae TIGR4
1 MtlR

Lactococcus lactis subsp. cremoris SK11
1 MtlR

Lactococcus lactis subsp. lactis Il1403
Mannitol utilization
TF SgaR
2 SgaR

Streptococcus pyogenes M1 GAS
2 SgaR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 SgaR

Streptococcus equi subsp. zooepidemicus MGCS10565
2 SgaR

Streptococcus uberis 0140J
2 SgaR

Streptococcus agalactiae 2603V/R
2 SgaR

Streptococcus mutans UA159
1 SgaR

Streptococcus gallolyticus UCN34
1 SgaR

Streptococcus pneumoniae TIGR4
1 SgaR

Streptococcus mitis B6
2 SgaR

Streptococcus sanguinis SK36
2 SgaR

Streptococcus suis 05ZYH33
Ascorbate utilization
TF SgaR2
1 SgaR2

Streptococcus pyogenes M1 GAS
1 SgaR2

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 SgaR2

Streptococcus equi subsp. zooepidemicus MGCS10565
1 SgaR2

Streptococcus uberis 0140J
1 SgaR2

Streptococcus agalactiae 2603V/R
1 SgaR2

Streptococcus pneumoniae TIGR4
1 SgaR2

Streptococcus mitis B6
1 SgaR2

Streptococcus suis 05ZYH33
Ascorbate utilization
BirA TF BirA
2 BirA

Streptococcus pyogenes M1 GAS
3 BirA

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 BirA

Streptococcus equi subsp. zooepidemicus MGCS10565
1 BirA

Streptococcus uberis 0140J
3 BirA

Streptococcus agalactiae 2603V/R
1 BirA

Streptococcus mutans UA159
3 BirA

Streptococcus gallolyticus UCN34
2 BirA

Streptococcus thermophilus CNRZ1066
1 BirA

Streptococcus pneumoniae TIGR4
1 BirA

Streptococcus mitis B6
1 BirA

Streptococcus sanguinis SK36
1 BirA

Streptococcus gordonii str. Challis substr. CH1
1 BirA

Streptococcus suis 05ZYH33
2 BirA

Lactococcus lactis subsp. cremoris SK11
2 BirA

Lactococcus lactis subsp. lactis Il1403
Biotin biosynthesis
CRP TF FlpA
2 FlpA

Lactococcus lactis subsp. cremoris SK11
2 FlpA

Lactococcus lactis subsp. lactis Il1403
Heavy metal resistance
CcpN TF CcpN
1 CcpN

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 CcpN

Streptococcus uberis 0140J
1 CcpN

Streptococcus agalactiae 2603V/R
2 CcpN

Streptococcus sanguinis SK36
2 CcpN

Streptococcus gordonii str. Challis substr. CH1
Gluconeogenesis
CodY TF CodY
8 CodY

Streptococcus pyogenes M1 GAS
12 CodY

Streptococcus dysgalactiae subsp. equisimilis GGS_124
7 CodY

Streptococcus equi subsp. zooepidemicus MGCS10565
17 CodY

Streptococcus uberis 0140J
18 CodY

Streptococcus agalactiae 2603V/R
24 CodY

Streptococcus mutans UA159
28 CodY

Streptococcus gallolyticus UCN34
24 CodY

Streptococcus thermophilus CNRZ1066
20 CodY

Streptococcus pneumoniae TIGR4
22 CodY

Streptococcus mitis B6
21 CodY

Streptococcus sanguinis SK36
21 CodY

Streptococcus gordonii str. Challis substr. CH1
14 CodY

Streptococcus suis 05ZYH33
12 CodY

Lactococcus lactis subsp. cremoris SK11
13 CodY

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
CopY TF CopR
1 CopR

Streptococcus pyogenes M1 GAS
1 CopR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 CopR

Streptococcus equi subsp. zooepidemicus MGCS10565
1 CopR

Streptococcus uberis 0140J
1 CopR

Streptococcus agalactiae 2603V/R
1 CopR

Streptococcus mutans UA159
1 CopR

Streptococcus gallolyticus UCN34
1 CopR

Streptococcus thermophilus CNRZ1066
1 CopR

Streptococcus pneumoniae TIGR4
1 CopR

Streptococcus mitis B6
1 CopR

Streptococcus sanguinis SK36
2 CopR

Streptococcus gordonii str. Challis substr. CH1
1 CopR

Streptococcus suis 05ZYH33
6 CopR

Lactococcus lactis subsp. cremoris SK11
5 CopR

Lactococcus lactis subsp. lactis Il1403
Copper homeostasis
CtsR TF CtsR
5 CtsR

Streptococcus pyogenes M1 GAS
4 CtsR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
5 CtsR

Streptococcus equi subsp. zooepidemicus MGCS10565
4 CtsR

Streptococcus uberis 0140J
5 CtsR

Streptococcus agalactiae 2603V/R
3 CtsR

Streptococcus mutans UA159
5 CtsR

Streptococcus gallolyticus UCN34
5 CtsR

Streptococcus thermophilus CNRZ1066
5 CtsR

Streptococcus pneumoniae TIGR4
5 CtsR

Streptococcus mitis B6
4 CtsR

Streptococcus sanguinis SK36
4 CtsR

Streptococcus gordonii str. Challis substr. CH1
4 CtsR

Streptococcus suis 05ZYH33
5 CtsR

Lactococcus lactis subsp. cremoris SK11
5 CtsR

Lactococcus lactis subsp. lactis Il1403
Heat shock response
DeoR TF FruR
1 FruR

Streptococcus pyogenes M1 GAS
1 FruR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 FruR

Streptococcus equi subsp. zooepidemicus MGCS10565
1 FruR

Streptococcus uberis 0140J
1 FruR

Streptococcus agalactiae 2603V/R
1 FruR

Streptococcus mutans UA159
1 FruR

Streptococcus gallolyticus UCN34
1 FruR

Streptococcus thermophilus CNRZ1066
1 FruR

Streptococcus pneumoniae TIGR4
1 FruR

Streptococcus mitis B6
1 FruR

Streptococcus sanguinis SK36
1 FruR

Streptococcus gordonii str. Challis substr. CH1
1 FruR

Streptococcus suis 05ZYH33
1 FruR

Lactococcus lactis subsp. cremoris SK11
1 FruR

Lactococcus lactis subsp. lactis Il1403
Fructose utilization
TF FucR
2 FucR

Streptococcus pneumoniae TIGR4
Fucose utilization
TF LacR
3 LacR

Streptococcus pyogenes M1 GAS
2 LacR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 LacR

Streptococcus equi subsp. zooepidemicus MGCS10565
4 LacR

Streptococcus uberis 0140J
3 LacR

Streptococcus agalactiae 2603V/R
1 LacR

Streptococcus mutans UA159
4 LacR

Streptococcus gallolyticus UCN34
2 LacR

Streptococcus pneumoniae TIGR4
3 LacR

Streptococcus mitis B6
1 LacR

Streptococcus sanguinis SK36
1 LacR

Streptococcus gordonii str. Challis substr. CH1
1 LacR

Streptococcus suis 05ZYH33
2 LacR

Lactococcus lactis subsp. cremoris SK11
Lactose utilization; Galactose utilization
TF PflR
3 PflR

Streptococcus pyogenes M1 GAS
3 PflR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
3 PflR

Streptococcus equi subsp. zooepidemicus MGCS10565
3 PflR

Streptococcus uberis 0140J
2 PflR

Streptococcus agalactiae 2603V/R
3 PflR

Streptococcus mutans UA159
3 PflR

Streptococcus pneumoniae TIGR4
3 PflR

Streptococcus sanguinis SK36
3 PflR

Streptococcus gordonii str. Challis substr. CH1
2 PflR

Streptococcus suis 05ZYH33
Formate metabolism
DtxR TF MntR
3 MntR

Streptococcus pyogenes M1 GAS
3 MntR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
3 MntR

Streptococcus equi subsp. zooepidemicus MGCS10565
4 MntR

Streptococcus uberis 0140J
4 MntR

Streptococcus agalactiae 2603V/R
1 MntR

Streptococcus mutans UA159
2 MntR

Streptococcus gallolyticus UCN34
2 MntR

Streptococcus pneumoniae TIGR4
3 MntR

Streptococcus mitis B6
1 MntR

Streptococcus sanguinis SK36
1 MntR

Streptococcus gordonii str. Challis substr. CH1
2 MntR

Streptococcus suis 05ZYH33
1 MntR

Lactococcus lactis subsp. cremoris SK11
2 MntR

Lactococcus lactis subsp. lactis Il1403
Manganese homeostasis
FUR TF PerR
6 PerR

Streptococcus pyogenes M1 GAS
7 PerR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
5 PerR

Streptococcus equi subsp. zooepidemicus MGCS10565
6 PerR

Streptococcus uberis 0140J
4 PerR

Streptococcus agalactiae 2603V/R
5 PerR

Streptococcus mutans UA159
4 PerR

Streptococcus gallolyticus UCN34
4 PerR

Streptococcus thermophilus CNRZ1066
6 PerR

Streptococcus sanguinis SK36
4 PerR

Streptococcus gordonii str. Challis substr. CH1
4 PerR

Streptococcus suis 05ZYH33
1 PerR

Lactococcus lactis subsp. cremoris SK11
1 PerR

Lactococcus lactis subsp. lactis Il1403
Iron homeostasis; Manganese homeostasis; Oxidative stress response
GntR/MocR TF PdxR
2 PdxR

Streptococcus pyogenes M1 GAS
2 PdxR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 PdxR

Streptococcus equi subsp. zooepidemicus MGCS10565
2 PdxR

Streptococcus mutans UA159
2 PdxR

Streptococcus gallolyticus UCN34
2 PdxR

Streptococcus sanguinis SK36
2 PdxR

Streptococcus gordonii str. Challis substr. CH1
Pyridoxine biosynthesis
TF SMU640c
2 SMU640c

Streptococcus mutans UA159
GntR/Others TF AgaR
2 AgaR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 AgaR

Streptococcus equi subsp. zooepidemicus MGCS10565
2 AgaR

Streptococcus uberis 0140J
2 AgaR

Streptococcus pneumoniae TIGR4
2 AgaR

Streptococcus mitis B6
2 AgaR

Streptococcus sanguinis SK36
2 AgaR

Streptococcus gordonii str. Challis substr. CH1
2 AgaR

Streptococcus suis 05ZYH33
N-acetylgalactosamine utilization
TF AgaR2
1 AgaR2

Streptococcus pyogenes M1 GAS
1 AgaR2

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 AgaR2

Streptococcus equi subsp. zooepidemicus MGCS10565
1 AgaR2

Streptococcus uberis 0140J
4 AgaR2

Streptococcus suis 05ZYH33
N-acetylgalactosamine utilization
TF BusR
1 BusR

Streptococcus sanguinis SK36
1 BusR

Lactococcus lactis subsp. cremoris SK11
1 BusR

Lactococcus lactis subsp. lactis Il1403
Betaine utilization
TF NagR
3 NagR

Streptococcus pyogenes M1 GAS
3 NagR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
3 NagR

Streptococcus equi subsp. zooepidemicus MGCS10565
3 NagR

Streptococcus uberis 0140J
3 NagR

Streptococcus agalactiae 2603V/R
3 NagR

Streptococcus mutans UA159
3 NagR

Streptococcus gallolyticus UCN34
2 NagR

Streptococcus thermophilus CNRZ1066
3 NagR

Streptococcus pneumoniae TIGR4
3 NagR

Streptococcus mitis B6
3 NagR

Streptococcus sanguinis SK36
3 NagR

Streptococcus gordonii str. Challis substr. CH1
2 NagR

Streptococcus suis 05ZYH33
3 NagR

Lactococcus lactis subsp. cremoris SK11
3 NagR

Lactococcus lactis subsp. lactis Il1403
N-acetylglucosamine utilization
TF SPy1285
3 SPy1285

Streptococcus pyogenes M1 GAS
3 SPy1285

Streptococcus dysgalactiae subsp. equisimilis GGS_124
3 SPy1285

Streptococcus equi subsp. zooepidemicus MGCS10565
3 SPy1285

Streptococcus uberis 0140J
3 SPy1285

Streptococcus agalactiae 2603V/R
3 SPy1285

Streptococcus mutans UA159
3 SPy1285

Streptococcus gallolyticus UCN34
1 SPy1285

Streptococcus thermophilus CNRZ1066
3 SPy1285

Streptococcus pneumoniae TIGR4
2 SPy1285

Streptococcus mitis B6
1 SPy1285

Streptococcus gordonii str. Challis substr. CH1
3 SPy1285

Streptococcus suis 05ZYH33
Transport
TF TreR (RgrA)
2 TreR (RgrA)

Lactococcus lactis subsp. cremoris SK11
2 TreR (RgrA)

Lactococcus lactis subsp. lactis Il1403
Trehalose utilization
TF TreR
2 TreR

Streptococcus pyogenes M1 GAS
2 TreR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 TreR

Streptococcus uberis 0140J
2 TreR

Streptococcus mutans UA159
2 TreR

Streptococcus gallolyticus UCN34
2 TreR

Streptococcus pneumoniae TIGR4
2 TreR

Streptococcus sanguinis SK36
2 TreR

Streptococcus gordonii str. Challis substr. CH1
Trehalose utilization
TF UxuR
2 UxuR

Lactococcus lactis subsp. cremoris SK11
2 UxuR

Lactococcus lactis subsp. lactis Il1403
Glucuronate utilization
HrcA TF HrcA
2 HrcA

Streptococcus pyogenes M1 GAS
3 HrcA

Streptococcus dysgalactiae subsp. equisimilis GGS_124
3 HrcA

Streptococcus equi subsp. zooepidemicus MGCS10565
3 HrcA

Streptococcus uberis 0140J
3 HrcA

Streptococcus agalactiae 2603V/R
2 HrcA

Streptococcus mutans UA159
3 HrcA

Streptococcus gallolyticus UCN34
2 HrcA

Streptococcus thermophilus CNRZ1066
2 HrcA

Streptococcus pneumoniae TIGR4
2 HrcA

Streptococcus mitis B6
2 HrcA

Streptococcus sanguinis SK36
2 HrcA

Streptococcus gordonii str. Challis substr. CH1
2 HrcA

Streptococcus suis 05ZYH33
3 HrcA

Lactococcus lactis subsp. cremoris SK11
3 HrcA

Lactococcus lactis subsp. lactis Il1403
Heat shock response
LacI TF AlsR
2 AlsR

Lactococcus lactis subsp. cremoris SK11
Allose utilization
TF BfrR
1 BfrR

Streptococcus uberis 0140J
1 BfrR

Streptococcus pneumoniae TIGR4
1 BfrR

Streptococcus gordonii str. Challis substr. CH1
1 BfrR

Streptococcus suis 05ZYH33
Fructooligosaccharides utilization
TF CcpA
69 CcpA

Streptococcus pyogenes M1 GAS
68 CcpA

Streptococcus dysgalactiae subsp. equisimilis GGS_124
52 CcpA

Streptococcus equi subsp. zooepidemicus MGCS10565
61 CcpA

Streptococcus uberis 0140J
65 CcpA

Streptococcus agalactiae 2603V/R
48 CcpA

Streptococcus mutans UA159
52 CcpA

Streptococcus gallolyticus UCN34
35 CcpA

Streptococcus thermophilus CNRZ1066
73 CcpA

Streptococcus pneumoniae TIGR4
59 CcpA

Streptococcus mitis B6
66 CcpA

Streptococcus sanguinis SK36
69 CcpA

Streptococcus gordonii str. Challis substr. CH1
67 CcpA

Streptococcus suis 05ZYH33
32 CcpA

Lactococcus lactis subsp. cremoris SK11
31 CcpA

Lactococcus lactis subsp. lactis Il1403
Global catabolite repression
TF CcpB
1 CcpB

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 CcpB

Streptococcus agalactiae 2603V/R
1 CcpB

Streptococcus gallolyticus UCN34
1 CcpB

Lactococcus lactis subsp. cremoris SK11
1 CcpB

Lactococcus lactis subsp. lactis Il1403
Sugar utilization
TF GalR
2 GalR

Streptococcus equi subsp. zooepidemicus MGCS10565
2 GalR

Streptococcus mutans UA159
3 GalR

Streptococcus gallolyticus UCN34
3 GalR

Streptococcus thermophilus CNRZ1066
2 GalR

Streptococcus pneumoniae TIGR4
2 GalR

Streptococcus mitis B6
2 GalR

Streptococcus sanguinis SK36
2 GalR

Streptococcus gordonii str. Challis substr. CH1
2 GalR

Streptococcus suis 05ZYH33
Galactose utilization
TF LACR_0766
2 LACR_0766

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 LACR_0766

Lactococcus lactis subsp. cremoris SK11
Sugar utilization
TF MalR
6 MalR

Streptococcus pyogenes M1 GAS
4 MalR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
6 MalR

Streptococcus equi subsp. zooepidemicus MGCS10565
4 MalR

Streptococcus uberis 0140J
6 MalR

Streptococcus agalactiae 2603V/R
4 MalR

Streptococcus mutans UA159
7 MalR

Streptococcus gallolyticus UCN34
2 MalR

Streptococcus thermophilus CNRZ1066
6 MalR

Streptococcus pneumoniae TIGR4
7 MalR

Streptococcus mitis B6
6 MalR

Streptococcus sanguinis SK36
5 MalR

Streptococcus gordonii str. Challis substr. CH1
4 MalR

Streptococcus suis 05ZYH33
2 MalR

Lactococcus lactis subsp. cremoris SK11
2 MalR

Lactococcus lactis subsp. lactis Il1403
Maltose utilization; Maltodextrin utilization
TF MalR2
1 MalR2

Streptococcus pyogenes M1 GAS
1 MalR2

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 MalR2

Streptococcus equi subsp. zooepidemicus MGCS10565
1 MalR2

Streptococcus gallolyticus UCN34
Maltose utilization; Maltodextrin utilization
TF MdxR
1 MdxR

Streptococcus suis 05ZYH33
Maltose utilization; Maltodextrin utilization
TF NigR
1 NigR

Streptococcus mutans UA159
Nigerose utilization
TF RbsR2
1 RbsR2

Streptococcus pyogenes M1 GAS
1 RbsR2

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 RbsR2

Streptococcus equi subsp. zooepidemicus MGCS10565
1 RbsR2

Streptococcus uberis 0140J
1 RbsR2

Streptococcus agalactiae 2603V/R
1 RbsR2

Lactococcus lactis subsp. cremoris SK11
1 RbsR2

Lactococcus lactis subsp. lactis Il1403
Ribose utilization
TF RegR
3 RegR

Streptococcus pyogenes M1 GAS
2 RegR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 RegR

Streptococcus equi subsp. zooepidemicus MGCS10565
3 RegR

Streptococcus agalactiae 2603V/R
3 RegR

Streptococcus pneumoniae TIGR4
2 RegR

Streptococcus suis 05ZYH33
Hyaluronate utilization
TF SAG1808
1 SAG1808

Streptococcus agalactiae 2603V/R
1 SAG1808

Streptococcus sanguinis SK36
Sugar utilization
TF ScrR
2 ScrR

Streptococcus pyogenes M1 GAS
2 ScrR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 ScrR

Streptococcus equi subsp. zooepidemicus MGCS10565
2 ScrR

Streptococcus uberis 0140J
2 ScrR

Streptococcus agalactiae 2603V/R
2 ScrR

Streptococcus mutans UA159
2 ScrR

Streptococcus gallolyticus UCN34
2 ScrR

Streptococcus thermophilus CNRZ1066
2 ScrR

Streptococcus pneumoniae TIGR4
2 ScrR

Streptococcus mitis B6
2 ScrR

Streptococcus sanguinis SK36
2 ScrR

Streptococcus gordonii str. Challis substr. CH1
2 ScrR

Streptococcus suis 05ZYH33
Sucrose utilization
LysR TF CmbR
2 CmbR

Streptococcus pyogenes M1 GAS
3 CmbR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
4 CmbR

Streptococcus equi subsp. zooepidemicus MGCS10565
4 CmbR

Streptococcus uberis 0140J
4 CmbR

Streptococcus agalactiae 2603V/R
6 CmbR

Streptococcus mutans UA159
9 CmbR

Streptococcus gallolyticus UCN34
10 CmbR

Streptococcus thermophilus CNRZ1066
7 CmbR

Streptococcus pneumoniae TIGR4
6 CmbR

Streptococcus mitis B6
5 CmbR

Streptococcus sanguinis SK36
5 CmbR

Streptococcus gordonii str. Challis substr. CH1
4 CmbR

Streptococcus suis 05ZYH33
5 CmbR

Lactococcus lactis subsp. cremoris SK11
9 CmbR

Lactococcus lactis subsp. lactis Il1403
Cysteine metabolism
TF HomR
4 HomR

Streptococcus mutans UA159
4 HomR

Streptococcus gallolyticus UCN34
2 HomR

Streptococcus thermophilus CNRZ1066
1 HomR

Streptococcus pneumoniae TIGR4
1 HomR

Streptococcus mitis B6
1 HomR

Streptococcus sanguinis SK36
1 HomR

Streptococcus gordonii str. Challis substr. CH1
1 HomR

Streptococcus suis 05ZYH33
1 HomR

Lactococcus lactis subsp. cremoris SK11
2 HomR

Lactococcus lactis subsp. lactis Il1403
Methionine metabolism; Cysteine metabolism
TF MleR
1 MleR

Streptococcus mutans UA159
2 MleR

Streptococcus gallolyticus UCN34
1 MleR

Streptococcus sanguinis SK36
2 MleR

Streptococcus gordonii str. Challis substr. CH1
1 MleR

Lactococcus lactis subsp. cremoris SK11
1 MleR

Lactococcus lactis subsp. lactis Il1403
Malate utilization
TF MtaR
1 MtaR

Streptococcus pyogenes M1 GAS
2 MtaR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 MtaR

Streptococcus equi subsp. zooepidemicus MGCS10565
3 MtaR

Streptococcus uberis 0140J
2 MtaR

Streptococcus agalactiae 2603V/R
7 MtaR

Streptococcus mutans UA159
7 MtaR

Streptococcus gallolyticus UCN34
7 MtaR

Streptococcus thermophilus CNRZ1066
7 MtaR

Streptococcus pneumoniae TIGR4
6 MtaR

Streptococcus mitis B6
6 MtaR

Streptococcus sanguinis SK36
7 MtaR

Streptococcus gordonii str. Challis substr. CH1
5 MtaR

Streptococcus suis 05ZYH33
Methionine metabolism
MarR TF AdcR
7 AdcR

Streptococcus pyogenes M1 GAS
9 AdcR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
10 AdcR

Streptococcus equi subsp. zooepidemicus MGCS10565
5 AdcR

Streptococcus uberis 0140J
9 AdcR

Streptococcus agalactiae 2603V/R
2 AdcR

Streptococcus mutans UA159
3 AdcR

Streptococcus gallolyticus UCN34
2 AdcR

Streptococcus thermophilus CNRZ1066
6 AdcR

Streptococcus pneumoniae TIGR4
4 AdcR

Streptococcus mitis B6
3 AdcR

Streptococcus sanguinis SK36
2 AdcR

Streptococcus gordonii str. Challis substr. CH1
3 AdcR

Streptococcus suis 05ZYH33
1 AdcR

Lactococcus lactis subsp. cremoris SK11
2 AdcR

Lactococcus lactis subsp. lactis Il1403
Zinc homeostasis
TF FabT
3 FabT

Streptococcus pyogenes M1 GAS
3 FabT

Streptococcus dysgalactiae subsp. equisimilis GGS_124
3 FabT

Streptococcus equi subsp. zooepidemicus MGCS10565
3 FabT

Streptococcus uberis 0140J
3 FabT

Streptococcus agalactiae 2603V/R
3 FabT

Streptococcus mutans UA159
3 FabT

Streptococcus gallolyticus UCN34
3 FabT

Streptococcus thermophilus CNRZ1066
3 FabT

Streptococcus pneumoniae TIGR4
3 FabT

Streptococcus mitis B6
3 FabT

Streptococcus sanguinis SK36
3 FabT

Streptococcus gordonii str. Challis substr. CH1
3 FabT

Streptococcus suis 05ZYH33
3 FabT

Lactococcus lactis subsp. cremoris SK11
3 FabT

Lactococcus lactis subsp. lactis Il1403
Fatty acid biosynthesis
TF SAG1910
1 SAG1910

Streptococcus pyogenes M1 GAS
2 SAG1910

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 SAG1910

Streptococcus equi subsp. zooepidemicus MGCS10565
2 SAG1910

Streptococcus uberis 0140J
3 SAG1910

Streptococcus agalactiae 2603V/R
3 SAG1910

Streptococcus mutans UA159
1 SAG1910

Streptococcus gallolyticus UCN34
2 SAG1910

Streptococcus thermophilus CNRZ1066
2 SAG1910

Streptococcus sanguinis SK36
2 SAG1910

Streptococcus gordonii str. Challis substr. CH1
2 SAG1910

Streptococcus suis 05ZYH33
unknown
TF YjdR
1 YjdR

Streptococcus pyogenes M1 GAS
1 YjdR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 YjdR

Streptococcus equi subsp. zooepidemicus MGCS10565
2 YjdR

Streptococcus uberis 0140J
2 YjdR

Streptococcus agalactiae 2603V/R
1 YjdR

Streptococcus mutans UA159
1 YjdR

Streptococcus gallolyticus UCN34
1 YjdR

Streptococcus thermophilus CNRZ1066
1 YjdR

Streptococcus pneumoniae TIGR4
1 YjdR

Streptococcus mitis B6
1 YjdR

Streptococcus sanguinis SK36
1 YjdR

Streptococcus gordonii str. Challis substr. CH1
1 YjdR

Streptococcus suis 05ZYH33
Multidrug resistance
MerR TF GlnR
2 GlnR

Streptococcus pyogenes M1 GAS
2 GlnR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 GlnR

Streptococcus equi subsp. zooepidemicus MGCS10565
3 GlnR

Streptococcus uberis 0140J
3 GlnR

Streptococcus agalactiae 2603V/R
6 GlnR

Streptococcus mutans UA159
7 GlnR

Streptococcus gallolyticus UCN34
7 GlnR

Streptococcus thermophilus CNRZ1066
5 GlnR

Streptococcus pneumoniae TIGR4
4 GlnR

Streptococcus mitis B6
6 GlnR

Streptococcus sanguinis SK36
5 GlnR

Streptococcus gordonii str. Challis substr. CH1
4 GlnR

Streptococcus suis 05ZYH33
3 GlnR

Lactococcus lactis subsp. cremoris SK11
3 GlnR

Lactococcus lactis subsp. lactis Il1403
Nitrogen assimilation
TF NmlR
2 NmlR

Streptococcus uberis 0140J
2 NmlR

Streptococcus agalactiae 2603V/R
2 NmlR

Streptococcus mutans UA159
2 NmlR

Streptococcus gallolyticus UCN34
1 NmlR

Streptococcus pneumoniae TIGR4
1 NmlR

Streptococcus suis 05ZYH33
2 NmlR

Lactococcus lactis subsp. cremoris SK11
2 NmlR

Lactococcus lactis subsp. lactis Il1403
Carbonyl stress response
NiaR TF NiaR
3 NiaR

Streptococcus pyogenes M1 GAS
2 NiaR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 NiaR

Streptococcus equi subsp. zooepidemicus MGCS10565
1 NiaR

Streptococcus uberis 0140J
1 NiaR

Streptococcus agalactiae 2603V/R
2 NiaR

Streptococcus mutans UA159
3 NiaR

Streptococcus gallolyticus UCN34
1 NiaR

Streptococcus thermophilus CNRZ1066
3 NiaR

Streptococcus pneumoniae TIGR4
1 NiaR

Streptococcus mitis B6
1 NiaR

Streptococcus sanguinis SK36
1 NiaR

Streptococcus gordonii str. Challis substr. CH1
1 NiaR

Streptococcus suis 05ZYH33
NAD biosynthesis
NrdR TF NrdR
3 NrdR

Streptococcus pyogenes M1 GAS
3 NrdR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
3 NrdR

Streptococcus equi subsp. zooepidemicus MGCS10565
2 NrdR

Streptococcus uberis 0140J
3 NrdR

Streptococcus agalactiae 2603V/R
2 NrdR

Streptococcus mutans UA159
2 NrdR

Streptococcus gallolyticus UCN34
2 NrdR

Streptococcus thermophilus CNRZ1066
2 NrdR

Streptococcus pneumoniae TIGR4
2 NrdR

Streptococcus mitis B6
2 NrdR

Streptococcus sanguinis SK36
2 NrdR

Streptococcus gordonii str. Challis substr. CH1
2 NrdR

Streptococcus suis 05ZYH33
2 NrdR

Lactococcus lactis subsp. cremoris SK11
2 NrdR

Lactococcus lactis subsp. lactis Il1403
Deoxyribonucleotide biosynthesis
NrtR TF NrtR
1 NrtR

Streptococcus thermophilus CNRZ1066
1 NrtR

Streptococcus mitis B6
1 NrtR

Streptococcus sanguinis SK36
1 NrtR

Streptococcus gordonii str. Challis substr. CH1
1 NrtR

Streptococcus suis 05ZYH33
NAD biosynthesis
PadR TF PadR
1 PadR

Streptococcus gallolyticus UCN34
1 PadR

Lactococcus lactis subsp. lactis Il1403
Phenolic acid stress response
TF YwzG
1 YwzG

Streptococcus pyogenes M1 GAS
1 YwzG

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 YwzG

Streptococcus equi subsp. zooepidemicus MGCS10565
1 YwzG

Streptococcus uberis 0140J
1 YwzG

Streptococcus mutans UA159
1 YwzG

Streptococcus gallolyticus UCN34
1 YwzG

Streptococcus thermophilus CNRZ1066
1 YwzG

Streptococcus pneumoniae TIGR4
1 YwzG

Streptococcus mitis B6
1 YwzG

Streptococcus sanguinis SK36
1 YwzG

Streptococcus gordonii str. Challis substr. CH1
2 YwzG

Streptococcus suis 05ZYH33
Transport
PurR TF PurR
5 PurR

Streptococcus pyogenes M1 GAS
6 PurR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
5 PurR

Streptococcus equi subsp. zooepidemicus MGCS10565
5 PurR

Streptococcus uberis 0140J
3 PurR

Streptococcus agalactiae 2603V/R
3 PurR

Streptococcus mutans UA159
6 PurR

Streptococcus gallolyticus UCN34
3 PurR

Streptococcus thermophilus CNRZ1066
4 PurR

Streptococcus pneumoniae TIGR4
5 PurR

Streptococcus mitis B6
5 PurR

Streptococcus sanguinis SK36
5 PurR

Streptococcus gordonii str. Challis substr. CH1
4 PurR

Streptococcus suis 05ZYH33
13 PurR

Lactococcus lactis subsp. cremoris SK11
16 PurR

Lactococcus lactis subsp. lactis Il1403
Purine metabolism
ROK TF CelQ
2 CelQ

Streptococcus equi subsp. zooepidemicus MGCS10565
2 CelQ

Streptococcus pneumoniae TIGR4
2 CelQ

Streptococcus sanguinis SK36
2 CelQ

Streptococcus suis 05ZYH33
Cellobiose utilization
Rex TF Rex
10 Rex

Streptococcus pyogenes M1 GAS
10 Rex

Streptococcus dysgalactiae subsp. equisimilis GGS_124
11 Rex

Streptococcus equi subsp. zooepidemicus MGCS10565
10 Rex

Streptococcus uberis 0140J
10 Rex

Streptococcus agalactiae 2603V/R
9 Rex

Streptococcus mutans UA159
6 Rex

Streptococcus gallolyticus UCN34
6 Rex

Streptococcus thermophilus CNRZ1066
9 Rex

Streptococcus pneumoniae TIGR4
9 Rex

Streptococcus mitis B6
10 Rex

Streptococcus sanguinis SK36
9 Rex

Streptococcus gordonii str. Challis substr. CH1
5 Rex

Streptococcus suis 05ZYH33
6 Rex

Lactococcus lactis subsp. cremoris SK11
7 Rex

Lactococcus lactis subsp. lactis Il1403
Energy metabolism
RpiR TF GntR1
3 GntR1

Lactococcus lactis subsp. cremoris SK11
3 GntR1

Lactococcus lactis subsp. lactis Il1403
Gluconate utilization
TF MurR
1 MurR

Lactococcus lactis subsp. cremoris SK11
1 MurR

Lactococcus lactis subsp. lactis Il1403
N-acetylmuramate utilization
TF NanR
1 NanR

Streptococcus pyogenes M1 GAS
1 NanR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 NanR

Streptococcus equi subsp. zooepidemicus MGCS10565
1 NanR

Streptococcus uberis 0140J
1 NanR

Streptococcus agalactiae 2603V/R
3 NanR

Streptococcus pneumoniae TIGR4
3 NanR

Streptococcus mitis B6
1 NanR

Streptococcus sanguinis SK36
1 NanR

Streptococcus gordonii str. Challis substr. CH1
1 NanR

Streptococcus suis 05ZYH33
Sialic acid utilization
TF TagR
2 TagR

Streptococcus mutans UA159
Tagatose utilization
TetR TF FlrR
1 FlrR

Lactococcus lactis subsp. cremoris SK11
2 FlrR

Lactococcus lactis subsp. lactis Il1403
Drug resistance
TF PipR
2 PipR

Streptococcus pyogenes M1 GAS
2 PipR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
2 PipR

Streptococcus equi subsp. zooepidemicus MGCS10565
2 PipR

Streptococcus uberis 0140J
2 PipR

Streptococcus agalactiae 2603V/R
2 PipR

Streptococcus mutans UA159
2 PipR

Streptococcus gallolyticus UCN34
2 PipR

Streptococcus thermophilus CNRZ1066
2 PipR

Streptococcus pneumoniae TIGR4
2 PipR

Streptococcus mitis B6
1 PipR

Streptococcus sanguinis SK36
2 PipR

Streptococcus gordonii str. Challis substr. CH1
2 PipR

Streptococcus suis 05ZYH33
1 PipR

Lactococcus lactis subsp. cremoris SK11
2 PipR

Lactococcus lactis subsp. lactis Il1403
Phage infection protein
TF SczA
2 SczA

Streptococcus pyogenes M1 GAS
2 SczA

Streptococcus agalactiae 2603V/R
2 SczA

Streptococcus thermophilus CNRZ1066
2 SczA

Streptococcus pneumoniae TIGR4
2 SczA

Streptococcus mitis B6
2 SczA

Streptococcus sanguinis SK36
4 SczA

Streptococcus gordonii str. Challis substr. CH1
Zinc resistance
TF YxeR
1 YxeR

Lactococcus lactis subsp. cremoris SK11
1 YxeR

Lactococcus lactis subsp. lactis Il1403
Antibiotic resistance
XRE TF Rgg
3 Rgg

Streptococcus gallolyticus UCN34
1 Rgg

Streptococcus mitis B6
3 Rgg

Streptococcus sanguinis SK36
3 Rgg

Streptococcus gordonii str. Challis substr. CH1
Cell wall metabolism
RF00050 RNA FMN
1 FMN

Streptococcus pyogenes M1 GAS
1 FMN

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 FMN

Streptococcus equi subsp. zooepidemicus MGCS10565
1 FMN

Streptococcus uberis 0140J
2 FMN

Streptococcus agalactiae 2603V/R
1 FMN

Streptococcus mutans UA159
2 FMN

Streptococcus gallolyticus UCN34
1 FMN

Streptococcus thermophilus CNRZ1066
2 FMN

Streptococcus pneumoniae TIGR4
1 FMN

Streptococcus mitis B6
1 FMN

Streptococcus sanguinis SK36
1 FMN

Streptococcus gordonii str. Challis substr. CH1
1 FMN

Streptococcus suis 05ZYH33
1 FMN

Lactococcus lactis subsp. cremoris SK11
2 FMN

Lactococcus lactis subsp. lactis Il1403
Riboflavin biosynthesis
RF00059 RNA TPP
1 TPP

Streptococcus pyogenes M1 GAS
1 TPP

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 TPP

Streptococcus equi subsp. zooepidemicus MGCS10565
1 TPP

Streptococcus uberis 0140J
2 TPP

Streptococcus agalactiae 2603V/R
1 TPP

Streptococcus mutans UA159
2 TPP

Streptococcus gallolyticus UCN34
1 TPP

Streptococcus thermophilus CNRZ1066
4 TPP

Streptococcus pneumoniae TIGR4
1 TPP

Streptococcus mitis B6
1 TPP

Streptococcus sanguinis SK36
1 TPP

Streptococcus gordonii str. Challis substr. CH1
2 TPP

Streptococcus suis 05ZYH33
2 TPP

Lactococcus lactis subsp. cremoris SK11
2 TPP

Lactococcus lactis subsp. lactis Il1403
Thiamine biosynthesis
RF00080 RNA yybP-ykoY
1 yybP-ykoY

Streptococcus pyogenes M1 GAS
1 yybP-ykoY

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 yybP-ykoY

Streptococcus equi subsp. zooepidemicus MGCS10565
1 yybP-ykoY

Streptococcus uberis 0140J
1 yybP-ykoY

Streptococcus agalactiae 2603V/R
1 yybP-ykoY

Streptococcus mutans UA159
1 yybP-ykoY

Streptococcus gallolyticus UCN34
1 yybP-ykoY

Streptococcus thermophilus CNRZ1066
1 yybP-ykoY

Streptococcus pneumoniae TIGR4
1 yybP-ykoY

Streptococcus mitis B6
1 yybP-ykoY

Streptococcus sanguinis SK36
1 yybP-ykoY

Streptococcus gordonii str. Challis substr. CH1
1 yybP-ykoY

Streptococcus suis 05ZYH33
1 yybP-ykoY

Lactococcus lactis subsp. cremoris SK11
1 yybP-ykoY

Lactococcus lactis subsp. lactis Il1403
RF00114 RNA S15
1 S15

Streptococcus pyogenes M1 GAS
1 S15

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 S15

Streptococcus equi subsp. zooepidemicus MGCS10565
1 S15

Streptococcus uberis 0140J
1 S15

Streptococcus agalactiae 2603V/R
1 S15

Streptococcus mutans UA159
1 S15

Streptococcus gallolyticus UCN34
1 S15

Streptococcus thermophilus CNRZ1066
1 S15

Streptococcus pneumoniae TIGR4
1 S15

Streptococcus mitis B6
1 S15

Streptococcus sanguinis SK36
1 S15

Streptococcus gordonii str. Challis substr. CH1
1 S15

Streptococcus suis 05ZYH33
1 S15

Lactococcus lactis subsp. cremoris SK11
1 S15

Lactococcus lactis subsp. lactis Il1403
Ribosome biogenesis
RF00167 RNA Purine
1 Purine

Streptococcus pyogenes M1 GAS
1 Purine

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 Purine

Streptococcus uberis 0140J
1 Purine

Streptococcus agalactiae 2603V/R
1 Purine

Streptococcus gallolyticus UCN34
1 Purine

Streptococcus thermophilus CNRZ1066
1 Purine

Streptococcus pneumoniae TIGR4
1 Purine

Streptococcus mitis B6
1 Purine

Streptococcus gordonii str. Challis substr. CH1
1 Purine

Lactococcus lactis subsp. cremoris SK11
1 Purine

Lactococcus lactis subsp. lactis Il1403
Purine metabolism
RF00168 RNA Lysine
2 Lysine

Lactococcus lactis subsp. cremoris SK11
2 Lysine

Lactococcus lactis subsp. lactis Il1403
Lysine biosynthesis
RF00230 RNA T-box(Ala)
1 T-box(Ala)

Streptococcus pyogenes M1 GAS
1 T-box(Ala)

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 T-box(Ala)

Streptococcus equi subsp. zooepidemicus MGCS10565
1 T-box(Ala)

Streptococcus uberis 0140J
1 T-box(Ala)

Streptococcus agalactiae 2603V/R
1 T-box(Ala)

Streptococcus mutans UA159
1 T-box(Ala)

Streptococcus gallolyticus UCN34
1 T-box(Ala)

Streptococcus thermophilus CNRZ1066
1 T-box(Ala)

Streptococcus pneumoniae TIGR4
1 T-box(Ala)

Streptococcus mitis B6
1 T-box(Ala)

Streptococcus sanguinis SK36
1 T-box(Ala)

Streptococcus gordonii str. Challis substr. CH1
1 T-box(Ala)

Streptococcus suis 05ZYH33
1 T-box(Ala)

Lactococcus lactis subsp. cremoris SK11
1 T-box(Ala)

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
RNA T-box(Asn)
1 T-box(Asn)

Streptococcus mutans UA159
1 T-box(Asn)

Streptococcus sanguinis SK36
1 T-box(Asn)

Streptococcus gordonii str. Challis substr. CH1
Amino acid metabolism
RNA T-box(Asp)
1 T-box(Asp)

Lactococcus lactis subsp. cremoris SK11
1 T-box(Asp)

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
RNA T-box(Gly)
1 T-box(Gly)

Streptococcus pyogenes M1 GAS
1 T-box(Gly)

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 T-box(Gly)

Streptococcus equi subsp. zooepidemicus MGCS10565
1 T-box(Gly)

Streptococcus uberis 0140J
1 T-box(Gly)

Streptococcus agalactiae 2603V/R
1 T-box(Gly)

Streptococcus mutans UA159
1 T-box(Gly)

Streptococcus gallolyticus UCN34
1 T-box(Gly)

Streptococcus thermophilus CNRZ1066
1 T-box(Gly)

Streptococcus pneumoniae TIGR4
1 T-box(Gly)

Streptococcus mitis B6
1 T-box(Gly)

Streptococcus sanguinis SK36
1 T-box(Gly)

Streptococcus gordonii str. Challis substr. CH1
1 T-box(Gly)

Streptococcus suis 05ZYH33
1 T-box(Gly)

Lactococcus lactis subsp. cremoris SK11
1 T-box(Gly)

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
RNA T-box(His)
1 T-box(His)

Streptococcus mutans UA159
1 T-box(His)

Streptococcus gallolyticus UCN34
1 T-box(His)

Streptococcus sanguinis SK36
2 T-box(His)

Streptococcus gordonii str. Challis substr. CH1
1 T-box(His)

Lactococcus lactis subsp. cremoris SK11
1 T-box(His)

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
RNA T-box(Ile)
1 T-box(Ile)

Streptococcus pyogenes M1 GAS
1 T-box(Ile)

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 T-box(Ile)

Streptococcus equi subsp. zooepidemicus MGCS10565
1 T-box(Ile)

Streptococcus uberis 0140J
1 T-box(Ile)

Streptococcus agalactiae 2603V/R
1 T-box(Ile)

Streptococcus mutans UA159
1 T-box(Ile)

Streptococcus gallolyticus UCN34
1 T-box(Ile)

Streptococcus thermophilus CNRZ1066
1 T-box(Ile)

Streptococcus pneumoniae TIGR4
1 T-box(Ile)

Streptococcus mitis B6
1 T-box(Ile)

Streptococcus sanguinis SK36
1 T-box(Ile)

Streptococcus gordonii str. Challis substr. CH1
1 T-box(Ile)

Streptococcus suis 05ZYH33
1 T-box(Ile)

Lactococcus lactis subsp. cremoris SK11
1 T-box(Ile)

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
RNA T-box(Met)
1 T-box(Met)

Lactococcus lactis subsp. cremoris SK11
1 T-box(Met)

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
RNA T-box(Phe)
1 T-box(Phe)

Streptococcus pyogenes M1 GAS
1 T-box(Phe)

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 T-box(Phe)

Streptococcus equi subsp. zooepidemicus MGCS10565
1 T-box(Phe)

Streptococcus uberis 0140J
1 T-box(Phe)

Streptococcus agalactiae 2603V/R
1 T-box(Phe)

Streptococcus mutans UA159
1 T-box(Phe)

Streptococcus gallolyticus UCN34
1 T-box(Phe)

Streptococcus thermophilus CNRZ1066
1 T-box(Phe)

Streptococcus pneumoniae TIGR4
1 T-box(Phe)

Streptococcus mitis B6
1 T-box(Phe)

Streptococcus sanguinis SK36
1 T-box(Phe)

Streptococcus gordonii str. Challis substr. CH1
1 T-box(Phe)

Streptococcus suis 05ZYH33
1 T-box(Phe)

Lactococcus lactis subsp. cremoris SK11
1 T-box(Phe)

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
RNA T-box(Ser)
1 T-box(Ser)

Streptococcus pyogenes M1 GAS
1 T-box(Ser)

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 T-box(Ser)

Streptococcus equi subsp. zooepidemicus MGCS10565
1 T-box(Ser)

Streptococcus uberis 0140J
1 T-box(Ser)

Streptococcus agalactiae 2603V/R
1 T-box(Ser)

Streptococcus mutans UA159
1 T-box(Ser)

Streptococcus gallolyticus UCN34
1 T-box(Ser)

Streptococcus thermophilus CNRZ1066
1 T-box(Ser)

Streptococcus pneumoniae TIGR4
1 T-box(Ser)

Streptococcus mitis B6
1 T-box(Ser)

Streptococcus sanguinis SK36
1 T-box(Ser)

Streptococcus gordonii str. Challis substr. CH1
1 T-box(Ser)

Streptococcus suis 05ZYH33
1 T-box(Ser)

Lactococcus lactis subsp. cremoris SK11
1 T-box(Ser)

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
RNA T-box(Thr)
1 T-box(Thr)

Streptococcus pyogenes M1 GAS
1 T-box(Thr)

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 T-box(Thr)

Streptococcus equi subsp. zooepidemicus MGCS10565
1 T-box(Thr)

Streptococcus uberis 0140J
1 T-box(Thr)

Streptococcus agalactiae 2603V/R
1 T-box(Thr)

Streptococcus mutans UA159
1 T-box(Thr)

Streptococcus gallolyticus UCN34
1 T-box(Thr)

Streptococcus thermophilus CNRZ1066
1 T-box(Thr)

Streptococcus pneumoniae TIGR4
1 T-box(Thr)

Streptococcus mitis B6
1 T-box(Thr)

Streptococcus sanguinis SK36
1 T-box(Thr)

Streptococcus gordonii str. Challis substr. CH1
1 T-box(Thr)

Streptococcus suis 05ZYH33
1 T-box(Thr)

Lactococcus lactis subsp. cremoris SK11
1 T-box(Thr)

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
RNA T-box(Trp)
1 T-box(Trp)

Streptococcus pyogenes M1 GAS
1 T-box(Trp)

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 T-box(Trp)

Streptococcus equi subsp. zooepidemicus MGCS10565
1 T-box(Trp)

Streptococcus uberis 0140J
1 T-box(Trp)

Streptococcus mutans UA159
2 T-box(Trp)

Streptococcus gallolyticus UCN34
2 T-box(Trp)

Streptococcus thermophilus CNRZ1066
2 T-box(Trp)

Streptococcus pneumoniae TIGR4
1 T-box(Trp)

Streptococcus mitis B6
3 T-box(Trp)

Streptococcus sanguinis SK36
3 T-box(Trp)

Streptococcus gordonii str. Challis substr. CH1
2 T-box(Trp)

Streptococcus suis 05ZYH33
2 T-box(Trp)

Lactococcus lactis subsp. cremoris SK11
2 T-box(Trp)

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
RNA T-box(Val)
1 T-box(Val)

Streptococcus pyogenes M1 GAS
1 T-box(Val)

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 T-box(Val)

Streptococcus equi subsp. zooepidemicus MGCS10565
1 T-box(Val)

Streptococcus uberis 0140J
1 T-box(Val)

Streptococcus agalactiae 2603V/R
1 T-box(Val)

Streptococcus mutans UA159
1 T-box(Val)

Streptococcus gallolyticus UCN34
1 T-box(Val)

Streptococcus thermophilus CNRZ1066
1 T-box(Val)

Streptococcus pneumoniae TIGR4
1 T-box(Val)

Streptococcus mitis B6
1 T-box(Val)

Streptococcus sanguinis SK36
1 T-box(Val)

Streptococcus gordonii str. Challis substr. CH1
1 T-box(Val)

Streptococcus suis 05ZYH33
1 T-box(Val)

Lactococcus lactis subsp. cremoris SK11
1 T-box(Val)

Lactococcus lactis subsp. lactis Il1403
Amino acid metabolism
RF00380 RNA ykoK
1 ykoK

Streptococcus mitis B6
1 ykoK

Streptococcus sanguinis SK36
1 ykoK

Streptococcus gordonii str. Challis substr. CH1
1 ykoK

Lactococcus lactis subsp. cremoris SK11
1 ykoK

Lactococcus lactis subsp. lactis Il1403
Magnesium homeostasis
RF00504 RNA Glycine
1 Glycine

Streptococcus pyogenes M1 GAS
1 Glycine

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 Glycine

Streptococcus equi subsp. zooepidemicus MGCS10565
1 Glycine

Streptococcus uberis 0140J
1 Glycine

Streptococcus agalactiae 2603V/R
1 Glycine

Streptococcus mutans UA159
1 Glycine

Streptococcus gallolyticus UCN34
1 Glycine

Streptococcus thermophilus CNRZ1066
1 Glycine

Streptococcus pneumoniae TIGR4
1 Glycine

Streptococcus mitis B6
1 Glycine

Streptococcus sanguinis SK36
1 Glycine

Streptococcus suis 05ZYH33
Glycine metabolism
RF00515 RNA PyrR
3 PyrR

Streptococcus pyogenes M1 GAS
4 PyrR

Streptococcus dysgalactiae subsp. equisimilis GGS_124
4 PyrR

Streptococcus equi subsp. zooepidemicus MGCS10565
3 PyrR

Streptococcus uberis 0140J
5 PyrR

Streptococcus agalactiae 2603V/R
2 PyrR

Streptococcus mutans UA159
3 PyrR

Streptococcus gallolyticus UCN34
3 PyrR

Streptococcus thermophilus CNRZ1066
5 PyrR

Streptococcus pneumoniae TIGR4
5 PyrR

Streptococcus mitis B6
3 PyrR

Streptococcus sanguinis SK36
6 PyrR

Streptococcus gordonii str. Challis substr. CH1
6 PyrR

Streptococcus suis 05ZYH33
4 PyrR

Lactococcus lactis subsp. cremoris SK11
4 PyrR

Lactococcus lactis subsp. lactis Il1403
Pyrimidine metabolism
RF00522 RNA PreQ1
1 PreQ1

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 PreQ1

Streptococcus agalactiae 2603V/R
Queuosine biosynthesis
RF00555 RNA L13_leader
1 L13_leader

Streptococcus pyogenes M1 GAS
1 L13_leader

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 L13_leader

Streptococcus equi subsp. zooepidemicus MGCS10565
1 L13_leader

Streptococcus uberis 0140J
1 L13_leader

Streptococcus agalactiae 2603V/R
1 L13_leader

Streptococcus mutans UA159
1 L13_leader

Streptococcus gallolyticus UCN34
1 L13_leader

Streptococcus thermophilus CNRZ1066
1 L13_leader

Streptococcus pneumoniae TIGR4
1 L13_leader

Streptococcus mitis B6
1 L13_leader

Streptococcus sanguinis SK36
1 L13_leader

Streptococcus gordonii str. Challis substr. CH1
1 L13_leader

Streptococcus suis 05ZYH33
1 L13_leader

Lactococcus lactis subsp. cremoris SK11
1 L13_leader

Lactococcus lactis subsp. lactis Il1403
Ribosome biogenesis
RF00556 RNA L19_leader
1 L19_leader

Streptococcus pyogenes M1 GAS
1 L19_leader

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 L19_leader

Streptococcus equi subsp. zooepidemicus MGCS10565
1 L19_leader

Streptococcus uberis 0140J
1 L19_leader

Streptococcus agalactiae 2603V/R
1 L19_leader

Streptococcus mutans UA159
1 L19_leader

Streptococcus gallolyticus UCN34
1 L19_leader

Streptococcus thermophilus CNRZ1066
1 L19_leader

Streptococcus pneumoniae TIGR4
1 L19_leader

Streptococcus mitis B6
1 L19_leader

Streptococcus sanguinis SK36
1 L19_leader

Streptococcus suis 05ZYH33
1 L19_leader

Lactococcus lactis subsp. cremoris SK11
Ribosome biogenesis
RF00557 RNA L10_leader
1 L10_leader

Streptococcus pyogenes M1 GAS
1 L10_leader

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 L10_leader

Streptococcus equi subsp. zooepidemicus MGCS10565
1 L10_leader

Streptococcus uberis 0140J
1 L10_leader

Streptococcus agalactiae 2603V/R
1 L10_leader

Streptococcus mutans UA159
1 L10_leader

Streptococcus gallolyticus UCN34
1 L10_leader

Streptococcus thermophilus CNRZ1066
1 L10_leader

Streptococcus pneumoniae TIGR4
1 L10_leader

Streptococcus mitis B6
1 L10_leader

Streptococcus sanguinis SK36
1 L10_leader

Streptococcus gordonii str. Challis substr. CH1
1 L10_leader

Streptococcus suis 05ZYH33
1 L10_leader

Lactococcus lactis subsp. cremoris SK11
1 L10_leader

Lactococcus lactis subsp. lactis Il1403
Ribosome biogenesis
RF00558 RNA L20_leader
1 L20_leader

Streptococcus pyogenes M1 GAS
1 L20_leader

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 L20_leader

Streptococcus equi subsp. zooepidemicus MGCS10565
1 L20_leader

Streptococcus uberis 0140J
1 L20_leader

Streptococcus agalactiae 2603V/R
1 L20_leader

Streptococcus mutans UA159
1 L20_leader

Streptococcus gallolyticus UCN34
1 L20_leader

Streptococcus thermophilus CNRZ1066
1 L20_leader

Streptococcus pneumoniae TIGR4
1 L20_leader

Streptococcus mitis B6
1 L20_leader

Streptococcus sanguinis SK36
1 L20_leader

Streptococcus gordonii str. Challis substr. CH1
1 L20_leader

Streptococcus suis 05ZYH33
1 L20_leader

Lactococcus lactis subsp. cremoris SK11
1 L20_leader

Lactococcus lactis subsp. lactis Il1403
Ribosome biogenesis
RF00559 RNA L21_leader
1 L21_leader

Streptococcus pyogenes M1 GAS
1 L21_leader

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 L21_leader

Streptococcus equi subsp. zooepidemicus MGCS10565
1 L21_leader

Streptococcus uberis 0140J
1 L21_leader

Streptococcus agalactiae 2603V/R
1 L21_leader

Streptococcus mutans UA159
1 L21_leader

Streptococcus gallolyticus UCN34
1 L21_leader

Streptococcus thermophilus CNRZ1066
1 L21_leader

Streptococcus pneumoniae TIGR4
1 L21_leader

Streptococcus mitis B6
1 L21_leader

Streptococcus sanguinis SK36
1 L21_leader

Streptococcus gordonii str. Challis substr. CH1
1 L21_leader

Streptococcus suis 05ZYH33
1 L21_leader

Lactococcus lactis subsp. cremoris SK11
1 L21_leader

Lactococcus lactis subsp. lactis Il1403
Ribosome biogenesis
RF01054 RNA preQ1-II
1 preQ1-II

Streptococcus pyogenes M1 GAS
1 preQ1-II

Streptococcus dysgalactiae subsp. equisimilis GGS_124
1 preQ1-II

Streptococcus equi subsp. zooepidemicus MGCS10565
1 preQ1-II

Streptococcus uberis 0140J
1 preQ1-II

Streptococcus agalactiae 2603V/R
1 preQ1-II

Streptococcus mutans UA159
1 preQ1-II

Streptococcus gallolyticus UCN34
1 preQ1-II

Streptococcus pneumoniae TIGR4
1 preQ1-II

Streptococcus mitis B6
1 preQ1-II

Streptococcus sanguinis SK36
1 preQ1-II

Streptococcus gordonii str. Challis substr. CH1
1 preQ1-II

Streptococcus suis 05ZYH33
1 preQ1-II

Lactococcus lactis subsp. cremoris SK11
1 preQ1-II

Lactococcus lactis subsp. lactis Il1403
Queuosine biosynthesis
RF01831 RNA THF
1 THF

Streptococcus uberis 0140J
1 THF

Streptococcus mutans UA159
1 THF

Streptococcus gallolyticus UCN34
1 THF

Streptococcus suis 05ZYH33
Folate metabolism