Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
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Collection of regulogs for SAM-IV (RF00634) RNA regulatory element

The SAM-IV riboswitch was originally identified by bioinformatics as a conserved RNA-like structure located upstream of the sulfur metabolism genes in various Actinomycetales species [17621584]. Later, the SAM-IV riboswitch was shown to bind directly to S-adenosylmethionine (SAM) [18369181]. SAM is a common co-substrate involved in methyl group transfers and is synthesized from the methionine amino acid by the SAM synthase MetK. The SAM-IV-containing intergenic region upstream of the Streptomyces coelicolor gene SCO2146 was used for experimental validation of this genetic regulatory element. The SAM-IV aptamers are followed by predicted rho-independent transcription terminators, but many aptamers are near the predicted start of their downstream gene, suggesting the sequestration of the ribosome-binding site and inhibition translation of downstream genes. more

Phylum Regulog RNA regulons (studied genomes) RNA sites
Actinobacteria SAM-IV - Mycobacteriaceae 8 (9) 13