Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 4.0 --

Collection of regulogs for SAM (RF00162) RNA regulatory element

The SAM riboswitch, also known as S-box, is a highly conserved RNA structure that is involved in regulation of methionine and cysteine metabolism in Bacteria. S-box serves as a riboswitch that binds directly to S-adenosylmethionine (SAM) to regulate gene expression via attenuation of transcription using formation of alternative secondary structures in the S-box region [10094622, 12702767, 12910260]. SAM is a common co-substrate involved in methyl group transfers and is synthesized from the methionine amino acid by the SAM synthase MetK. The alignment of 100 S-box leaders confirms high degree of conservation of the S-box primary and secondary structure [15215334]. more

Phylum Regulog RNA regulons (studied genomes) RNA sites
Actinobacteria SAM - Corynebacteriaceae 1 (8) 1
Chlorobiales SAM - Chlorobiales 11 (11) 14
Chloroflexi SAM - Chloroflexia 5 (5) 14
Cyanobacteria SAM - Cyanobacteria 2 (14) 2
Deinococcus-Thermus SAM - Deinococcus-Thermus 5 (5) 9
Firmicutes SAM - Bacillales 11 (11) 98
Firmicutes SAM - Clostridiaceae 19 (20) 72
Firmicutes SAM - Lactobacillaceae 2 (15) 2
Firmicutes SAM - Staphylococcaceae 7 (7) 40
Proteobacteria/delta SAM - Desulfovibrionales 4 (10) 4
Thermotogae SAM - Thermotogales 1 (11) 1