Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
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Collection of regulogs for SAH_riboswitch (RF01057) RNA regulatory element

The SAH riboswitch was originally identified by bioinformatics as a conserved RNA-like structure located upstream of the methionine metabolism genes in various Proteobacteria and in some Actinobacteria [17621584]. Later, the SAM-IV riboswitch was shown to bind directly to S-adenosylhomocysteine (SAH) [18374645]. S-adenosylmethionine (SAM) is a common co-substrate involved in methyl group transfers and is synthesized from the methionine amino acid by the SAM synthase MetK. SAH is produced upon SAM-dependent methylation, and the intracellular balance of the two species has to be closely monitored to maintain cellular homeostasis and avoid toxicity [6760211]. more

Phylum Regulog RNA regulons (studied genomes) RNA sites
Actinobacteria SAH_riboswitch - Mycobacteriaceae 6 (9) 6
Proteobacteria SAH_riboswitch - Burkholderia 8 (8) 8
Proteobacteria SAH_riboswitch - Pseudomonadaceae 7 (8) 7
Proteobacteria SAH_riboswitch - Ralstonia 6 (6) 6
Proteobacteria/Beta SAH_riboswitch - Comamonadaceae 11 (11) 21
Proteobacteria/Beta SAH_riboswitch - Various betaproteobacteria 11 (12) 14
Proteobacteria/Gamma SAH_riboswitch - Moraxellaceae 2 (4) 2
Proteobacteria/Gamma SAH_riboswitch - Xanthomonadales 3 (4) 3